A NiO–graphene hybrid film with 3D hierarchically porous structure has been rationally designed and constructed through a series of controlled fabrication processes. Multilayered porous graphene ...sheet network with the pore size of several micrometers is created via a so-called “on-water spreading” method, which is facile, economical, efficient and scalable. Then, the cross-like NiO nanoflakes film is uniformly grown onto the porous graphene sheet framework by a chemical bath deposition. The NiO–graphene hybrid film exhibits specific capacitance of 540 F g−1 at 2 A g−1 with 80% capacitance retention after 2000 cycles in 2 M KOH aqueous solution, which is much higher than that achieved from the bare NiO nanoflakes film (370 F g−1, with 66% capacitance retention). Moreover, chronoamperometry and electrochemical impedance spectroscopy measurements reveal that the NiO–graphene hybrid demonstrates enhanced reaction kinetics with about only 50% of respond time for NiO/NiOOH reaction and 79% of charge-transfer resistance compared with those of the bare NiO film. The proposed strategy could offer an effective way to fabricate graphene-based electrode materials for applications in various energy-storage devices.
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•Multilayered graphene network was fabricated via the on-water spreading method.•The NiO–graphene hybrid film exhibits hierarchically porous structure.•The hybrid film shows better pseudocapacitive performance than the bare NiO film.
A gas-filled recoil separator, SHANS2 (Spectrometer for Heavy Atoms and Nuclear Structure-2), with five magnets arranged in a Qv-D-Qh-Qv-D configuration is constructed at the China Accelerator ...Facility for Superheavy Elements (CAFE2) of the Institute of Modern Physics (IMP) in Lanzhou. It is dedicated to the study of the heavy nuclei produced in heavy-ion-induced fusion evaporation reactions, especially to the experiments on the superheavy elements with cross-sections lower than 1 pb. The maximum magnetic rigidity of the main dipole magnet is designed to be 2.5 T m. The detailed design of the SHANS2 and the results of several test experiments are presented.
Based on an e+e− collision data sample corresponding to an integrated luminosity of 567 pb−1 taken at the center-of-mass energy of s=4.6 GeV with the BESIII detector, we measure the absolute ...branching fraction of the inclusive decay Λc+→Λ+X to be B(Λc+→Λ+X)=(38.2−2.2+2.8±0.9)% using the double-tag method, where X refers to any possible final state particles. In addition, we search for direct CP violation in the charge asymmetry of this inclusive decay for the first time, and obtain ACP≡B(Λc+→Λ+X)−B(Λ¯c−→Λ¯+X)/B(Λc+→Λ+X)+B(Λ¯c−→Λ¯+X)=(2.1−6.6+7.0±1.6)%, a statistically limited result with no evidence of CP violation.
Growing evidence has shown that long non-coding RNAs (lncRNAs) can serve as prospective markers for survival in patients with gastric cancer (GC). In this study, we mainly focused on the potential ...roles of LINC00511 in the development process of GC.
RT-PCR was used to detect the expressions of LINC00511 and miR-124-3p in GC tumor tissues, adjacent tissues and GC cell lines. Furthermore, correlations between LINC00511 with miR-124-3p, and miR-124-3p with EZH2, were analyzed by Correlation analysis. Moreover, the overall survival (OS) of patients was analyzed using Kaplan-Meier method. Additionally, proliferation ability was measured by CCK-8 assay and invasion ability of GC cell line was detected by transwell assay. Besides, Western blot was performed to measure protein levels of GC tissues and GC cell lines. Finally, Dual-Luciferase reporter assay was performed to prove the potential binding sites between LINC00511 and miR-124-3p, miR-124-3p and EZH2.
We found that LINC00511 was significantly increased in GC tissues and GC cell lines, which was associated with tumor growth, metastasis and predicted poor diagnosis of GC patients. MiR-124-3p was decreased in GC tissues and GC cell lines, which was negatively correlated with LINC00511 and EZH2. Furthermore, EZH2 was increased in GC tissues and GC cell lines, which was positively correlated with LINC00511. Moreover, LINC00511 inhibition repressed cell proliferation and invasion in MKN28 cells, the protein levels of Cyclin D1, ICAM-1, VCAM-1 and N-cadherin were repressed, while E-cadherin was increased. Besides, Luciferase gene reporter assay indicated that LINC00511 could sponge with miR-124-3p, which could directly target at EZH2, an oncogenic gene. We found that miR-124-3p/EZH2 axis regulated cell proliferation and invasion in MKN28 cells. Finally, the inhibited cell proliferation and invasion abilities were eliminated following with miR-124-3p inhibition in MKN28 cells with LINC00511 knockdown.
According to the results, we found that LINC00511 was increased in GC tissues, which was associated with the poor OS in patients with GC. We uncovered a previously unappreciated LINC00511/miR-124-3p/EZH2 signaling axis in promoting cell proliferation and invasion in GC patients and GC cell lines, which suggested that it might be a potential target for treating human GC.
To evaluate the efficacy and prognostic factors of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with secondary acute myeloid leukemia (sAML) .
In this multicenter, ...retrospective clinical study, adult patients aged ≥18 years who underwent allo-HSCT for sAML at four centers of the Zhejiang Hematopoietic Stem Cell Transplantation Collaborative Group from January 2014 to November 2022 were included, and the efficacy and prognostic factors of allo-HSCT were analyzed.
A total of 95 patients were enrolled; 66 (69.5%) had myelodysplastic syndrome-acute myeloid leukemia (MDS-AML) , 4 (4.2%) had MDS/MPN-AML, and 25 (26.3%) had therapy-related AML (tAML) . The 3-year CIR, LFS, and overall survival (OS) rates were 18.6% (95%
10.2%-27.0%) , 70.6% (95%
60.8%-80.4%) , and 73.3% (95%
63.9%-82.7%) , respectively. The 3-year CIRs of the M-AML group (including MDS-AML and MDS/MPN-AML) and the tAML group were 20.0% and 16.4%, respectively (
=0.430) . The 3-year LFSs were 68.3% and 75.4%, respectivel
It is well established that the tumor suppressor p53 plays major roles in regulating apoptosis and cell cycle progression. In addition, recent studies have demonstrated that p53 is actively involved ...in regulating cell differentiation in muscle, the circulatory system and various carcinoma tissues. We have recently shown that p53 also controls lens differentiation. Regarding the mechanism, we reveal that p53 directly regulates c-Maf and Prox1, two important transcription factors to control cell differentiation in the ocular lens. In the present study, we present further evidence to show that p53 can regulate lens differentiation by controlling expression of the differentiation genes coding for the lens crystallins. First, the αA and βA3/A1 gene promoters or introns all contain putative p53 binding sites. Second, gel mobility shifting assays revealed that the p53 protein in nuclear extracts from lens epithelial cells directly binds to the p53 binding sites found in these crystallin gene promoters or introns. Third, exogenous wild type p53 induces dose-dependent expression of the luciferase reporter gene driven by different crystallin gene promoters and the exogenous dominant negative mutant p53 causes dose-dependent inhibition of the same crystallin genes. Fourth, ChIP assays revealed that p53 binds to crystallin gene promoters in vivo. Finally, in the p53 knockout mouse lenses, expression levels of various crystallins were found down-regulated in comparison with those from the wild type mouse lenses. Together, our results reveal that p53 directly regulates expression of different sets of genes to control lens differentiation.
KEY MESSAGE : We report a new stripe rust resistance gene on chromosome 7AS in wheat and molecular markers useful for transferring it to other wheat genotypes. Several new races of the stripe rust ...pathogen have established throughout the wheat growing regions of China in recent years. These new races are virulent to most of the designated seedling resistance genes limiting the resistance sources. It is necessary to identify new genes for diversification and for pyramiding different resistance genes in order to achieve more durable resistance. We report here the identification of a new resistance gene, designated as Yr61, in Chinese wheat cultivar Pindong 34. A mapping population of 208 F₂ plants and 128 derived F₂:₃ lines in a cross between Mingxian 169 and Pindong 34 was evaluated for seedling stripe rust response. A genetic map consisting of eight resistance gene analog polymorphism (RGAP), two sequence-tagged site (STS) and four simple sequence repeat (SSR) markers was constructed. Yr61 was located on the short arm of chromosome 7A and flanked by RGAP markers Xwgp5467 and Xwgp5765 about 1.9 and 3.9 cM in distance, which were successfully converted into STS markers STS5467 and STS5765b, respectively. The flanking STS markers could be used for marker-assisted selection of Yr61 in breeding programs.
We report an amplitude analysis and branching fraction measurement of D+s → K+K−π+ decay using a data sample of 3.19 fb−1 recorded with BESIII detector at a center-of-mass energy of 4.178 GeV. We ...perform a model-independent partial wave analysis in the low K+K− mass region to determine the K+K− S-wave line shape, followed by an amplitude analysis of our very pure high-statistics sample. With the detection efficiency based on the amplitude analysis results, the absolute branching fraction is measured to be B(D+s → K+K− π+) = (5.47 ± 0.0 8stat ± 0.13sys)%.
Using a data sample of ${e}^{+}{e}^{{-}}$ collisions corresponding to an integrated luminosity of $567\text{ }\text{ }{\mathrm{pb}}^{{-}1}$ collected at a center-of-mass energy of $\sqrt{s}=4.6\text{ ...}\text{ }\mathrm{GeV}$ with the BESIII detector, we measure the absolute branching fraction of the inclusive semileptonic ${\mathrm{{\Lambda}}}_{c}^{+}$ decay with a double-tag method. We obtain $\mathcal{B}({\mathrm{{\Lambda}}}_{c}^{+}{\rightarrow}X{e}^{+}{{\nu}}_{e})=(3.95\pm{}0.34\pm{}0.09)%$, where the first uncertainty is statistical and the second systematic. Using the known ${\mathrm{{\Lambda}}}_{c}^{+}$ lifetime and the charge-averaged semileptonic decay width of nonstrange charmed mesons (${D}^{0}$ and ${D}^{+}$), we obtain the ratio of the inclusive semileptonic decay widths $\mathrm{{\Gamma}}({\mathrm{{\Lambda}}}_{c}^{+}{\rightarrow}X{e}^{+}{{\nu}}_{e})/\overline{\mathrm{{\Gamma}}}(D{\rightarrow}X{e}^{+}{{\nu}}_{e})=1.26\pm{}0.12$.
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