Abstract
Utilizing the unprecedented high-resolution Magnetospheric Multiscale mission data from 2015 September to 2017 December, we perform a statistical study of electron vortexes in the turbulent ...terrestrial magnetosheath. On the whole, 506 electron vortex events are successfully selected. Electron vortexes can occur at four known types of magnetic structures, including 78, 42, 26, and 39 electron vortexes observed during the crossings of the current sheets, magnetic holes, magnetic peaks, and flux ropes, respectively. Except for the four types of structures, the rest of the electron vortexes are in the “Others” category, defined as unknown structures. The electron vortexes mainly occur in the subsolar region, with only a few in the flank region. The total occurrence rate of all electron vortexes is 4.86 hr
–1
, with, on average, 3.65 events hr
−1
in the
X-Y
plane and 3.26 events hr
−1
in the
X-Z
plane. The durations of most of the electron vortexes concentrate within 0.5–1.5 s and are 1.09 s on average. The electron vortexes are ion-scale structures owing to the average scale of 2.05 ion gyroradius. In addition, the means, medians, and maxima of the energy dissipation
J
·
E
′ in the electron vortexes are almost positive, implying that the electron vortex may be a potential coherent structure or channel for turbulent energy dissipation. All these results reveal the statistical characteristics of electron vortexes in the magnetosheath and improve our understanding of energy dissipation in astrophysical and space plasmas.
Observation of the decay χcJ→Ω-Ω An, M. R.; Batozskaya, V.; Berger, N. ...
Physical review. D,
05/2023, Letnik:
107, Številka:
9
Journal Article
Recenzirano
Using an e+e- collision data sample of (27.08 ± 0.14) × 108 ψ(3686) events collected by the BESIII detector, we report the first observation of χcJ → $Ω^-\overline{Ω}^+$ (J = 0, 1, 2) decays with ...significances of 5.6σ, 6.4σ, and 18σ, respectively, where the χcJ mesons are produced in the radiative ψ(3686) decays. The branching fractions are determined to be B(χc0 → $Ω^-\overline{Ω}^+$) = (3.51 ± 0.54 ± 0.29) × 10-5, B(χc1 → $Ω^-\overline{Ω}^+$) = (1.49 ± 0.23 ± 0.10) × 10-5, and B(χc2→ $Ω^-\overline{Ω}^+$) = (4.52 ± 0.24 ± 0.18) × 10-5, where the first and second uncertainties are statistical and systematic, respectively.
Purpose
To explore the regulatory relationship between Chloride intracellular channel 1 (CLIC1) and Angiomotin (AMOT)-p130, and reveal the role of AMOT-p130 in gastric cancer (GC).
Methods
...Immunohistochemistry was performed to analyze the expression of CLIC1 and AMOT-p130 in GC tissues and adjacent tissues. The expression of AMOT-p130 upon CLIC1 silencing was analyzed using RT-PCR, western blot, and immunofluorescence in GC cells. Transwell and wound-healing assays were performed to detect migration and invasion in GC cells. The changes in EMT-related proteins were detected using western blot.
Results
Our study found that high CLIC1 expression was significantly associated with low AMOT-p130 expression in GC tissues. Silencing CLIC1 expression in MGC-803 cells (MGC-803 CLIC1 KO) and AGS cells (AGS CLIC1 KO) decreased the invasive and migratory abilities of tumor cells, which were induced by the upregulation of AMOT-p130. Subsequently, we demonstrated that AMOT-p130 inhibits the invasive and migratory abilities of GC cells by inhibiting epithelial–mesenchymal transition.
Conclusions
Our study suggests that AMOT-p130 could inhibit epithelial–mesenchymal transition in GC cells. CLIC1 may participate in the metastatic progression of GC by downregulating the expression of AMOT-p130.
Mutations in the kinase domain of epidermal growth factor receptor (EGFR) are associated with clinical responsiveness to gefitinib in patients with non-small-cell lung cancers (NSCLC). Recently, we ...have identified many novel EGFR mutations in NSCLC tissues. In this study, we found that gefitinib could suppress the tyrosine phosphorylation of most EGFR mutants better than the wild-type receptor. However, gefitinib had quite variable growth-suppressive effects on different EGFR mutant-expressing cells. All tested EGFR mutants have high basal phosphorylation at multiple tyrosine residues. Upon EGF stimulation, the mutated EGFRs did not have apparently stronger phosphorylation at tyrosines 845, 992, 1,068, and 1,173 than the wild-type receptor. However, stronger phosphorylation at tyrosine 1,045 was observed in the S768I, L861Q, E709G, and G719S mutants. The E746-A750 deletion mutant was less responsive to EGF than the wild-type and other mutant receptors. The S768I, L861Q, E709G, and G719S mutants were refractory to EGF-induced ubiquitination and had more sustained tyrosine phosphorylation. E709G and G719S also lacked EGF-induced receptor downregulation. Our results indicate that, in addition to sensitivity to gefitinib, EGFR mutations also caused various changes in EGFR's regulatory mechanisms, which may contribute to the constitutive activation of EGFR mutants and oncogenesis in NSCLC.
Based on 10.64 fb − 1 of e + e − collision data taken at center-of-mass energies between 4.237 and 4.699 GeV with the BESIII detector, we study the leptonic D s + decays using the e + e − → D s * + D ...s * − process. The branching fractions of D s + → ℓ + ν ℓ ( ℓ = μ , τ ) are measured to be B D s + → μ + ν μ = ( 0.547 ± 0.02 6 stat ± 0.01 6 syst ) % and B D s + → τ + ν τ = ( 5.60 ± 0.1 6 stat ± 0.2 0 syst ) % , respectively. The product of the decay constant and Cabibbo-Kobayashi-Maskawa matrix element | V c s | is determined to be f D s + | V c s | = ( 246.5 ± 5.9 stat ± 3.6 syst ± 0.5 input ) μ ν and f D s + | V c s | = ( 252.7 ± 3.6 stat ± 4.5 syst ± 0.6 input ) τ ν MeV , respectively. Taking the value of | V c s | from a global fit in the Standard Model, we obtain f D s + = ( 253.2 ± 6.0 stat ± 3.7 syst ± 0.6 input ) μ ν and f D s + = ( 259.6 ± 3.7 stat ± 4.6 syst ± 0.6 input ) τ ν MeV , respectively. Conversely, taking the value for f D s + from the latest lattice quantum chromodynamics calculation, we obtain | V c s | = ( 0.986 ± 0.02 3 stat ± 0.01 4 syst ± 0.00 3 input ) μ ν and | V c s | = ( 1.011 ± 0.01 4 stat ± 0.01 8 syst ± 0.00 3 input ) τ ν , respectively. Published by the American Physical Society 2024
The singly Cabibbo-suppressed decay D+s → K + π + π − π 0 is observed by using a data set corresponding to an integrated luminosity of 6.32 fb − 1 recorded by the BESIII detector at the ...centre-of-mass energies between 4.178 and 4.226 GeV. The first amplitude analysis of D+s → K + π + π − π 0 reveals the sub-structures in this decay and determines the fractions and relative phases of different intermediate processes. The dominant intermediate process is D+s → K *0 ρ + , with a fit fraction of (40 . 5 ± 2 . 8 stat . ± 1 . 5 syst . )%. With the detection efficiency based on our amplitude analysis, the absolute branching fraction for D+s → K + π + π − π 0 is measured to be (9 . 75 ± 0 . 54 stat . ± 0 . 17 syst . ) × 10 − 3 .
Based on ( 2712.4 ± 14.3 ) × 10 6 ψ ( 3686 ) events, we investigate four hadronic decay modes of the P -wave charmonium spin-singlet state h c ( 1 P 1 ) → h + h − π 0 / η ( h = π or K ) via the ...process ψ ( 3686 ) → π 0 h c at BESIII. The h c → π + π − π 0 decay is observed with a significance of 9.6 σ after taking into account systematic uncertainties. Evidences for h c → K + K − π 0 and h c → K + K − η are found with significances of 3.5 σ and 3.3 σ , respectively, after considering the systematic uncertainties. The branching fractions of these decays are measured to be B ( h c → π + π − π 0 ) = ( 1.36 ± 0.16 ± 0.14 ) × 10 − 3 , B ( h c → K + K − π 0 ) = ( 3.26 ± 0.84 ± 0.36 ) × 10 − 4 , and B ( h c → K + K − η ) = ( 3.13 ± 1.08 ± 0.38 ) × 10 − 4 , where the first uncertainties are statistical and the second are systematic. No significant signal of h c → π + π − η is found, and the upper limit of its decay branching fraction is determined to be B ( h c → π + π − η ) < 4.0 × 10 − 4 at the 90% confidence level. Published by the American Physical Society 2024
Study of the decays χ c J → Λ Λ ¯ ω Bao, H. -R.; Bianchi, F.; Chen, Y. B. ...
Physical review. D,
08/2024, Letnik:
110, Številka:
3
Journal Article
Recenzirano
Using
(
27.12
±
0.14
)
×
10
8
ψ
(
3686
)
events collected with the BESIII detector, we present the first observation of the decays
χ
c
J
→
Λ
Λ
¯
ω
, where
J
=
0
, 1, 2, with statistical significances ...of
11.7
σ
,
11.2
σ
, and
11.8
σ
. The branching fractions of these decays are determined to be
B
(
χ
c
0
→
Λ
Λ
¯
ω
)
=
(
2.37
±
0.22
±
0.25
)
×
10
−
4
,
B
(
χ
c
1
→
Λ
Λ
¯
ω
)
=
(
1.01
±
0.10
±
0.11
)
×
10
−
4
, and
B
(
χ
c
2
→
Λ
Λ
¯
ω
)
=
(
1.40
±
0.13
±
0.17
)
×
10
−
4
, where the first uncertainties are statistical and the second are systematic. We observe no clear intermediate structures.
<supplementary-material>
<copyright-statement>Published by the American Physical Society</copyright-statement>
2024
</supplementary-material>
Using a data sample of e+e− collision data with an integrated luminosity of 2.93 fb−1 taken at the center-of-mass energy s=3.773 GeV with the BESIII detector operating at the BEPCII storage rings, we ...measure the absolute branching fractions of the two-body hadronic decays D+→π+π0, K+π0, π+η, K+η, π+η′, K+η′, KS0π+, KS0K+, and D0→π+π−, K+K−, K∓π±, KS0π0, KS0η, KS0η′. Our results are consistent with previous measurements within uncertainties. Among them, the branching fractions for D+→π+π0, K+π0, π+η, π+η′, KS0π+, KS0K+ and D0→KS0π0, KS0η, KS0η′ are determined with improved precision compared to the world average values.
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