Burgeoning urbanization, development and human activities have led to reduced opportunities for nature experience in quiet acoustic environments. Increasing noise affects both humans and wildlife ...alike.
We experimentally altered human‐caused sound levels in a paired study using informational signs that encouraged quiet behaviours in week‐on, week‐off blocks on the trail system of Muir Woods National Monument, California, USA to test if the soundscape influences both wildlife and human experiences.
Using continuous measurements from acoustic recording units (n = 13) spatially distributed within the park, we found signs significantly lowered sound levels by approximately 1.2 decibels (A‐weighted), thereby increasing listening area by 24% and bird availability by approximately 5.8% for every 1 decibel decrease.
Visitor‐intercept surveys (n = 537) revealed that our mitigation increased the number of birds perceived by visitors, rankings of soundscape pleasantness, and importantly, preferences for soundscape management.
By lowering human‐caused sound levels, we created an acoustic environment equivalent to a ~21% reduction in visitors. The positive feedback cycle we describe may lead to increased conservation support in a time when the extinction of nature experience looms.
A free Plain Language Summary can be found within the Supporting Information of this article.
A free Plain Language Summary can be found within the Supporting Information of this article.
Corona cooling was detected previously from stacking a series of short type I bursts that occurred during the low/hard state of an atoll outburst. Type I bursts are hence regarded as sharp probes ...used to better our understanding of the basic properties of the corona. The first Chinese X-ray satellite, Insight-HXMT, has a large detection area at hard X-rays that provides a unique opportunity to move further in this research field. We report the first detection of corona cooling by Insight-HXMT from a single short type I burst appearing during the flare of 4U 1636-536. This type I X-ray burst has a duration of ∼13 s and hard X-ray shortage is detected with a significance of 6.2 in 40-70 keV. A cross-correlation analysis between the light curves of the soft and hard X-ray band shows that the corona shortage lags the burst emission by 1.6 1.2 s. These results are consistent with those derived previously from stacking a large amount of bursts detected by RXTE/PCA within a series of flares of 4U 1636-536. Moreover, the broad bandwidth of Insight-HXMT also allows, for the first time, one to infer the burst influence upon the continuum spectrum via performing the spectral fitting of the burst, which points to the finding that hard X-ray shortage appears at around 40 keV in the continuum spectrum. These results suggest that the evolution of the corona, along with the outburst/flare of NS XRB, may be traced via analyzing a series of embedded type I bursts using Insight-HXMT.
We report the first measurements of transverse single-spin asymmetries for inclusive jet and jet+π± production at midrapidity from transversely polarized proton-proton collisions at s=500 GeV. The ...data were collected in 2011 with the STAR detector sampled from 23 pb−1 integrated luminosity with an average beam polarization of 53%. Asymmetries are reported for jets with transverse momenta 6<pT<55 GeV/c and pseudorapidity |η|<1. Presented are measurements of the inclusive-jet azimuthal transverse single-spin asymmetry, sensitive to twist-3 initial-state quark-gluon correlators; the Collins asymmetry, sensitive to quark transversity coupled to the polarized Collins fragmentation function; and the first measurement of the “Collins-like” asymmetry, sensitive to linearly polarized gluons. Within the present statistical precision, inclusive-jet and Collins-like asymmetries are small, with the latter allowing the first experimental constraints on gluon linear polarization in a polarized proton. At higher values of jet transverse momenta, we observe the first nonzero Collins asymmetries in polarized-proton collisions, with a statistical significance of greater than 5σ. The results span a range of x similar to results from semi-inclusive deep-inelastic scattering but at much higher Q2. The Collins results enable tests of universality and factorization breaking in the transverse momentum-dependent formulation of perturbative quantum chromodynamics.
Multiple myeloma (MM) is an incurable malignancy of terminally differentiated B-lymphoid cells. Here, we investigate the role of Fas apoptosis inhibitory molecule (FAIM) in MM. We demonstrate that ...insulin-like growth factor 1 (IGF-1) treatment upregulated FAIM expression in MM cells in a dose-dependent manner. Silencing of FAIM expression attenuates Akt signaling downstream of IGF-1 and compromises the viability of MM cells. We further showed that IGF-1 stimulation of MM cells leads to enhanced expression of IRF4, a known 'addictive' factor for MM. This upregulation of IRF4 expression by IGF-1 treatment of MM cells is abrogated when FAIM expression is silenced or Akt activation is inhibited. Thus, FAIM modulates IGF-1-induced Akt activation and IRF4 expression and has a role in MM cell survival. Consistent with these findings, FAIM expression is shown to be higher in plasma cells of symptomatic MM patients compared with normal individuals or patients with premalignant conditions. Moreover, a higher level of FAIM expression is shown to correlate with poorer survival outcomes of newly diagnosed MM patients treated with stem cell transplantation or relapsed MM patients treated in clinical trials with Bortezomib. Thus taken together, our study reveals a novel, as well as clinically relevant role for FAIM in MM.
ABSTRACT
Based on Insight-HXMT data, we report on the pulse fraction evolution during the 2017–2018 outburst of the newly discovered first Galactic ultraluminous X-ray (ULX) source Swift ...J0243.6+6124. The pulse fractions of 19 observation pairs selected in the rising and fading phases with similar luminosity are investigated. The results show a general trend of the pulse fraction increasing with luminosity and energy at supercritical luminosity. However, the relative strength of the pulsation between each pair evolves strongly with luminosity. The pulse fraction in the rising phase is larger at luminosity below 7.71 × 1038 erg s−1, but smaller at above. A transition luminosity is found to be energy independent. Such a phenomenon is first confirmed by Insight-HXMT observations and we speculate that it may have relation with the radiation-pressure-dominated accretion disc.
Seasonal dormancy in deciduous fruit trees is a complex physiological state, which is regulated by many plant hormones and genes. Abscisic acid (ABA) and gibberellic acid (GA
3
) are known to be ...particularly important in controlling dormancy. We measured the concentrations of these two hormones in flower buds (collected during para-, endo-, and eco-dormancy, and at the dormancy-release stage) and vegetative buds (collected monthly from 20 November 2012 to 20 February 2013) of two cultivars of Japanese apricot (Prunus mume Sieb. et Zucc), 'Bungo' and 'Taoxingmei', using liquid chromatography and tandem mass spectrometry (LC-MS/MS). Levels of expression of two zinc-finger family genes CCCH and C2H2 and the GA20ox (gibberellin 20 oxidase) gene (GenBank Accession No. Pm013607), as candidates for dormancy-controlling genes, were analysed at each sampling time using real-time RT-quantitative PCR (RT-qPCR). Expression analyses indicated that both zinc-finger family genes exhibited high transcript levels in flower buds of both cultivars during para-dormancy, concomitant with high ABA concentrations. The zinc-finger family genes were relatively highly expressed in vegetative buds of both cultivars on 20 November 2012 (autumn). In addition, high concentration of GA
3
in flower buds at the dormancy-release stage suggested that GA
3
plays an important role in controlling the release of bud dormancy. High levels of expression of the GA20ox gene during eco-dormancy and at the dormancy-release stage might have a prominent effect on dormancy-release by regulating gibberellin (GA) signalling in Japanese apricot. These results will contribute to increasing our understanding of ABA- and GA-mediated seasonal dormancy mechanisms in Japanese apricot.
ABSTRACT
We report on our analysis of the 2019 outburst of the X-ray accreting pulsar 4U 1901+03 observed with Insight-HXMT and NICER. Both spectra and pulse profiles evolve significantly in the ...decaying phase of the outburst. Dozens of flares are observed throughout the outburst. They are more frequent and brighter at the outburst peak. We find that the flares, which have a duration from tens to hundreds of seconds, are generally brighter than the persistent emission by a factor of ∼1.5. The pulse-profile shape during the flares can be significantly different from that of the persistent emission. In particular, a phase shift is clearly observed in many cases. We interpret these findings as direct evidence of changes of the pulsed beam pattern, due to transitions between the sub- and supercritical accretion regimes on a short time-scale. We also observe that at comparable luminosities the flares’ pulse profiles are rather similar to those of the persistent emission. This indicates that the accretion on the polar cap of the neutron star is mainly determined by the luminosity, i.e. the mass accretion rate.
MiRNA has been found to have therapeutic effect on corneal damage. This paper aimed to study the effect of miR-205-3p on corneal damage induced by ultraviolet (UV) radiation.
HCE cells were exposed ...to UV light and transfected. Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) and Western blot were used to determine miRNA/mRNA and protein expression. CCK-8 assay, Edu incorporation experiment, and flow cytometry were used to separately measure cell activity, proliferation and apoptosis. LC3 puncta were researched by immunofluorescence experiment. TNF-α, IL-6 and IL-1β levels in cells were detected by enzyme-linked immunosorbent assay (ELISA) kit. MDA, SOD, and GSH-PX levels were measured using detection kits. Reactive oxygen species (ROS) level was reflected by detecting DCFH-DA density. Luciferase activity assay was performed to verify the regulating relationship between miR-205-3p and TLR4.
UV radiation decreased HCE cell viability, proliferation, and increased HCE cell apoptosis and autophagy (all p < 0.01). When exposed UV radiation, the overexpression of miR-205-3p group elevated HCE cells viability, proliferation and weakened HCE cells apoptosis and autophagy (all p < 0.01). MiR-205-3p inhibited inflammation and oxidative stress in HCE cells induced by UV radiation (p < 0.01). MiR-205-3p directly inhibited TLR4 expression. The upregulation of TLR4 significantly reversed the effects of miR-205-3p on HCE cells phenotypes induced by UV radiation (p < 0.01).
MiR-205-3p protected HCE cells from UV damage by inhibiting autophagy via targeting TLR4.
Particle production sensitive to nonfactorizable and nonperturbative processes that contribute to the underlying event associated with a high transverse momentum ( pT) jet in proton + proton ...collisions at √s = 200 GeV is studied with the STAR detector. Each event is divided into three regions based on the azimuthal angle with respect to the highest- p T jet direction: in the leading jet direction ("Toward"), opposite to the leading jet ("Away"), and perpendicular to the leading jet ("Transverse"). In the Transverse region, the average charged particle density is found to be between 0.4 and 0.6 and the mean transverse momentum, ⟨pT⟩, between 0.5 and 0.7 GeV/c for particles with pT > 0.2 GeV/c at mid-pseudorapidity (|η| < 1) and jet pT > 15 GeV / c . Both average particle density and ⟨pT⟩depend weakly on the leading jet pT. Closer inspection of the Transverse region hints that contributions to the underlying event from initial- and final-state radiation are significantly smaller in these collisions than at the higher energies, up to 13 TeV, recorded at the LHC. Underlying event measurements associated with a high-pT jet will contribute to our understanding of QCD processes at hard and soft scales at RHIC energies, as well as provide constraints to modeling of underlying event dynamics.
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