In the title complex {systematic name: aquap‐phenylenebis(dioxyacetato)‐κOtetrakis(1H‐imidazole‐κN3)nickel(II) monohydrate}, Ni(C10H8O6)(C3H4N2)4(H2O)·H2O, the NiII atom shows a distorted ...octahedral configuration, defined by one carboxyl O atom of the benzene‐1,3‐dioxyacetate group, four N atoms from four imidazole ligands and one water molecule. A three‐dimensional supramolecular network is constructed by hydrogen‐bonding and π–π stacking interactions.
In mammals, the circadian clock coordinates cell physiological processes including inflammation. Recent studies suggested a crosstalk between these two pathways. However, the mechanism of how ...inflammation affects the clock is not well understood. Here, we investigated the role of the proinflammatory transcription factor NF-kappaB in regulating clock function. Using a combination of genetic and pharmacological approaches, we show that perturbation of the canonical NF-kappaB subunit RELA in the human U2OS cellular model altered core clock gene expression. While RELA activation shortened period length and dampened amplitude, its inhibition lengthened period length and caused amplitude phenotypes. NF-kappaB perturbation also altered circadian rhythms in the master suprachiasmatic nucleus (SCN) clock and locomotor activity behavior under different light/dark conditions. We show that RELA, like the clock repressor CRY1, repressed the transcriptional activity of BMAL1/CLOCK at the circadian E-box cis-element. Biochemical and biophysical analysis showed that RELA binds to the transactivation domain of BMAL1. These data support a model in which NF-kB competes with CRY1 and coactivator CBP/p300 for BMAL1 binding to affect circadian transcription. This is further supported by chromatin immunoprecipitation analysis showing that binding of RELA, BMAL1 and CLOCK converges on the E-boxes of clock genes. Taken together, these data support a significant role for NF-kappaB in directly regulating the circadian clock and highlight mutual regulation between the circadian and inflammatory pathways.
To explore the effects of resistance training with elastic band at home on muscle function and walking ability of severely burned children.
A prospective non-randomized controlled study was ...conducted. From January 2022 to April 2023, 40 children with severe burns who met the inclusion criteria were admitted to Tongren Hospital of Wuhan University & Wuhan Third Hospital. According to the willingness of the children or their families, the children were assigned to conventional rehabilitation group and combined rehabilitation group. During the study, 8 children dropped out of the study, 17 children were finally included in the conventional rehabilitation group with 6 males and 11 females, aged (8.5±2.4) years, and 15 children were included in the combined rehabilitation group with 5 males and 10 females, aged (9.6±2.5) years. The children in the 2 groups received conventional burn rehabilitation treatment in the hospital, including active and passive activity training, scar massage, and pressure therapy. The chi
IKBKB/IKKβ, as the core catalytic subunit of IκB kinase complex, participates in mediation of the classical NF-κB pathway, which has been linked to inflammation and tumorigenesis. Previous studies ...have shown that single nucleotide polymorphisms in IKBKB have been related to gastric cancer, but how they associate to the clinical outcome is not yet clear. In this study, we retrospectively investigated the associations between single nucleotide polymorphisms located in IKBKB and gastric cancer survival.
IKBKB rs2272736 was genotyped in 1210 patients with primary gastric cancer in a Han Chinese population, and the relationships between rs2272736 and overall survival were evaluated. We conducted Cox proportional hazards regression, which was performed to estimate the effects of single nucleotide polymorphisms on the overall survival of patients, adjusted for potential confounding variables.
We found that patients with rs2272736 A allele in IKBKB had significantly prolonged overall survival time compared to those with the G allele (HR = 0.83, 95% CI = 0.68-1.00,
= 0.050). In addition, AA genotype was demonstrated to have reduced risk of death for gastric cancer compared with that associated with the GG/GA genotypes, which was more common in patients with cardiac carcinoma, well-differentiated and moderately differentiated tumors, TNM Ⅰ/Ⅱ stages and intestinal type.
Our findings have shown that single nucleotide polymorphism rs2272736 in IKBKB may be a promising prognostic biomarker which should promote personalized treatment.
This letter attempts to comment on the article by Xu et al. Materials Characterization 105 (2015) 90–94 in the aspects about the sizes of matrix precipitates (MPts) and Cr-bearing dispersoids in 7075 ...Al alloy.
A method of ultrasound‐assisted reduction of a nickel‐ammonia complex with borohydride in aqueous solution was used to prepare NiMoB/MCM‐41 and NiMoB/SBA‐15 supported amorphous alloy catalysts. These ...catalysts were used to upgrade bio‐oil at mild temperatures ranging from 100 to 160 °C and recycling of these two supported catalysts and of unsupported NiMoB was carried out. Then, fresh and third time used catalysts were characterized by X‐ray diffraction, X‐ray photoelectron spectra, and transmission electron microscopy. Quantitative results were obtained from the analysis of gas chromatography/mass spectrometry. Through mild upgrading, 1‐hydroxy‐2‐propanone, furfural, and 2‐methoxy‐4‐vinylphenol in the bio‐oil were converted to relevant alcohols and saturated phenols. The conversion rates were 45.7, 71.5, and 57.1 %, respectively, when crude bio‐oil was upgraded using NiMoB/MCM‐41 at 160 °C. The two supported catalysts, especially NiMoB/MCM‐41, had smaller amorphous NiMoB particles and exhibited more uniform dispersion on mesoporous silica, leading to higher reaction activity and stability than unsupported NiMoB. Deactivation of these catalysts resulted from the reduction of Ni0, B0, and Mo4+ species on the surface, the transition from the amorphous to the crystalline state, particle agglomeration, and coke deposition on the surface.
The mild hydrogenation of bio‐oil is a crucial step in the production of bio fuel. Here, NiMoB catalysts were used to determine the effects of temperature and catalyst recycling on the process. Higher temperature led to smaller concentrations of unsaturated compounds but more serious particle agglomeration and coking. A suitable catalyst support increased catalytic activity and stability.
Cockscomb seeds-derived carbon dots (CSCDs) were fabricated by hydrothermal method with common cockscomb seeds. The prepared CSCDs exhibit selectively antibacterial properties towards Gram-positive ...bacterias, such as Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis). Then, the CSCDs were separated to three groups with lipophilic, amphipathic and hydrophilic ones by simple gradient extraction. Interestingly, the three groups of CSCDs exhibited different antibacterial activities, and the amphipathic CSCDs(ACSCDs) showed best bacterial inhibition. This phenomenon might stem from the surface properties of the amphipathic CSCDs, which have both hydrophilic region and hydrophilic region on the surface. The structure might help the samples to penetrate the bacterial membrane more easily, and finally cause apoptosis. This work not only supplied a novel antibacterial carbon dots, but also further revealed that surface chemistry might be an important factor which could affect the bactericidal performance of carbon dots.
Myeloid leukemia factor (MLF) plays an important role in the development of Drosophila. It is reported that MLF could inhibit white spot syndrome virus (WSSV) replication in shrimp. However, the ...function and mechanism of MLF in shrimp antibacterial immunity are still elusive. In this study, we found MjMLF could be upregulated by Vibro anguillarum challenge in hemocytes, gills, and intestine of kuruma shrimp. RNAi assay showed that MjMLF could facilitate bacterial clearance in shrimp, and it was beneficial for shrimp survival post V. anguillarum infection. Pull down assay showed that rMjMLF could bind to rMj14-3-3 in vitro. Some antimicrobial peptide genes could be regulated by MjMLF. The results indicated that MjMLF might participate in the anti-bacterial immune reaction of shrimp.
![NF-[kappa]B modifies the ma...](http://api.summon.serialssolutions.com/2.0.0/image/issn/XR4PS5YY4K/1553-7390/small "NF-[kappa]B modifies the mammalian circadian clock through interaction with the core clock protein BMAL1")
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