Academics' conceptions of teaching (ACTs) and academics' teaching approaches (ATAs) are essential factors in informing academics' teaching behaviors. However, empirical evidence from longitudinal ...research exploring the causal link between ACTs and ATAs is lacking. In the current study, we employed a cross-lagged panel model approach in three waves to assess four hypotheses (i.e. stability, causal, reversed, and reciprocal models) concerning the causal association between ACTs and ATAs. For the data collection from 115 academics (60.9% female), we used the Conceptions of Teaching and Learning and the Revised Approaches to Teaching Inventory. Our findings indicated that ATAs were a causal predictor of ACTs, not vice-versa, regardless of participants' gender and teaching responsibilities. Specific ATAs (i.e. student-centered or teacher-centered) predicted complementary ACTs in time. Our results reveal that conceptual changes in academics can be possible after observing the positive effects of a specific teaching method on student learning. Therefore, academic developers should help academics (especially novice teachers) accurately distinguish student-centered from teacher-centered teaching behaviors and learn how to apply specific student-centered teaching methods in conjunction with self-reflective techniques. More empirical longitudinal studies with sound designs are needed to understand better the multi-directional nature and influence between ACTs and ATAs over time.
We have been conducting the Giant Metrewave Radio Telescope High Resolution Southern Sky (GHRSS) survey for the last four years and have discovered 18 pulsars to date. The GHRSS survey is an ...off-Galactic-plane survey at 322 MHz in a region of the sky (decl. range −40° to −54°) complementary to other ongoing low-frequency surveys. In this paper we report the discovery of three pulsars (PSRs), J1239−48, J1516−43, and J1726−52. We also present timing solutions for three pulsars previously discovered with the GHRSS survey: PSR J2144−5237, a millisecond pulsar with a period P = 5 ms in a 10 days orbit around a ≤0.18 M companion; PSR J1516−43, a mildly recycled P = 36 ms pulsar in a 228 days orbit with a companion of mass ∼0.4 M ; and the P = 320 ms PSR J0514−4408, which we show is a source of pulsed γ-ray emission. We also report radio polarimetric observations of three of the GHRSS discoveries, PSRs J0418−4154, J0514−4408, and J2144−5237.
IntroductionSchizophrenia (SCZ) is a chronic neuropsychiatric disorder possessing a multifactorial nature and dual facets of symptoms with a core underlying genetic mechanism that is still obscure. ...Lately, genomic studies revealed numerous single nucleotide polymorphisms (SNPs) that are non-coding and influence ribonucleic acid (RNA) expression, particularly its splicing.ObjectivesConsidering that next-generation sequencing (NGS) protocols focus upon long-read sequencing as opposed to conventional RNA sequencing methodologies once with the advent of Oxford Nanopore Technologies’ (ONT) MinION, we primarily aimed to gather and review all evidence into how this approach may deepen and further offer insight into SCZ still undiscovered domain.MethodsThe relevant literature searches were performed using distinct combinations of keywords including “schizophrenia” alongside „Nanopore”, “MinION”, and “Oxford Nanopore Technologies” on four databases (PubMed/Medline, ISI Web of Knowledge, Scopus, and ScienceDirect). We implied the entries to strictly “research articles” written in English as inclusion criteria.ResultsBy restricting the returned results starting with the year when the platform was officially launched, a total of n = 69 studies were displayed between the pre-established interval (2014 – 2022). If taken per database, n = 2 were identified in PubMed/Medline, n = 7 in ISI Web of Knowledge, n = 4 in Scopus, and n = 56 in ScienceDirect. In chronological order, n = 0 were published in 2014, n = 3 in 2015, n = 7 in 2016, n = 7 in 2017, n = 9 in 2018, n = 3 in 2019, n = 7 in 2020, n = 19 in 2021 and n = 14 in 2022. Finally, per the strategy applied, n = 49 were returned for “schizophrenia” + “Nanopore” from which n = 2 in PubMed/Medline, n = 5 in ISI Web of Knowledge, n = 4 in Scopus, and n = 38 in ScienceDirect. For “schizophrenia” + “MinION, there was a cumulative number of n = 5, from which we had n = 0 in PubMed/Medline, n = 0 in ISI Web of Knowledge, n = 0 in Scopus, and n = 5 in ScienceDirect. Finally, for “schizophrenia” + “Oxford Nanopore Technologies” were displayed n = 15, and the situation was n = 0 in PubMed/Medline, n = 2 in ISI Web of Knowledge, n = 0 in Scopus, and n = 13 in ScienceDirect.ConclusionsWe presently assist to a fulminant ascension in the literature, with applicability in other fields. Perhaps as cornerstone stands a recent publication in which the authors reveal the risk of the Calcium Voltage-Gated Channel Subunit Alpha1 C (CACNA1C) gene involved, being identified thirty-eight novel exons and two hundred and forty-one novel transcripts following RNA purification from six regions (cerebellum, striatum, and dorsolateral prefrontal cortex) among which targeted were cingulate, occipital and parietal cortexes.Disclosure of InterestNone Declared
Introduction
Zebrafish (
Danio rerio
) has evolved over the years as a preferred organism due to its vast repertoire in research fields that mimic a targeted phenotype, particularly behavioral ...typologies and specific attributes comparable to murine models and relatively high homology with humans. Considering this consideration, different pharmacological treatments have been tested and proven that under different concentrations may trigger schizophrenia (SCZ)-like symptoms.
Objectives
Starting from the actual stage of knowledge according to which agents used as N-methyl-D-aspartate (NMDA) inhibitors (MK-801, ketamine, and phencyclidine) alongside psychedelic (mescaline, lysergic acid diethylamide), psychoactive substances (amphetamine), and non- and essential amino acids (proline and methionine), we aimed to reunite and review all existing evidence. This approach may offer an updated and critical overview regarding the possible future directions surrounding these compounds regarding the pharmaco-dynamics/kinetics.
Methods
To ensure the coverage of all relevant literature, we performed searches in four databases (PubMed/Medline, ISI Web of Knowledge, Scopus, and ScienceDirect) per combinations of keywords: “schizophrenia” with “MK-801”, “ketamine”, “phencyclidine”, “mescaline”, “lysergic acid diethylamide”, “amphetamine”, “proline”, “methionine”, and “zebrafish”. Eligible studies had to be “research article(s)” written in English.
Results
A total of n = 246 studies were returned during the established interval (2010 – 2022). Precisely, n = 16 were identified in PubMed/Medline, n = 16 in ISI Web of Knowledge, n = 17 in Scopus, and n = 197 in ScienceDirect per database. If taken per year, n = 13 were published in 2010, n = 12 in 2011, n = 15 in 2012, n = 24 in 2013, n = 21 in 2014, n = 21 in 2015, n = 32 in 2016, n = 8 in 2017, n = 12 in 2018, n = 9 in 2019, n = 17 in 2020, n = 34 in 2021, and n = 28 in 2022. Depending on the combination of keywords, we had the following situation: n = 65 for “schizophrenia+MK-801+zebrafish”, n = 42 for “schizophrenia+ketamine+zebrafish”, n = 21 for “schizophrenia+phencyclidine+zebrafish”, n = 4 for “schizophrenia+mescaline+zebrafish”, n = 5 for “schizophrenia+lysergic acid diethylamide+zebrafish”, n = 36 for “schizophrenia+amphetamine+zebrafish”, n = 37 for “schizophrenia+proline+zebrafish”, n = 36 for “schizophrenia+ methionine+zebrafish”.
Conclusions
There can be seen an uprising trend in the current literature of studies focused on the administration of MK-801, ketamine, amphetamine, proline, methionine, and phencyclidine aiming to trigger SCZ-like symptoms as opposed to mescaline and lysergic acid diethylamide. Most of the data is contradicting, with either a decrease/increase in behavior (locomotion, aggression, sociability, circling behavior, and memory deficits), which is why additional studies are mandatory.
Disclosure of Interest
None Declared
In this paper we aim to show the workflow and the technical systems used for Open Skies missions as well as the use of this Multi Sensor System for civil applications. While missions conducted and ...analyzed under the force of Open Skies Treaty is a technical and administrative one, the very complex sensor system enables various civil missions for a wide range of tasks. Especially the combination with LiDAR gives new opportunities. We describe typical Open Skies work steps besides civil tasks that need as calibration, accuracy estimations and adjusted workflows especially with the LiDAR data and different camera setups.
Quantum computers are expected to have a dramatic impact on numerous fields due to their anticipated ability to solve classes of mathematical problems much more efficiently than their classical ...counterparts. This particularly applies to domains involving integer factorization and discrete logarithms, such as public key cryptography. In this paper, we consider the threats a quantum-capable adversary could impose on Bitcoin, which currently uses the Elliptic Curve Digital Signature Algorithm (ECDSA) to sign transactions. We then propose a simple but slow commit–delay–reveal protocol, which allows users to securely move their funds from old (non-quantum-resistant) outputs to those adhering to a quantum-resistant digital signature scheme. The transition protocol functions even if ECDSA has already been compromised. While our scheme requires modifications to the Bitcoin protocol, these can be implemented as a soft fork.
The LiDAR point clouds are usually processed in Universal Transvers Mercator projection. The transformation to a national coordinate system is frequently made with low accuracy with the help of the ...generic transformation implemented in the actual softwares. An accurate and precise transformation for LiDAR files in the national coordinate systems of Romania (planimetric system Stereographic 1970 and altimetric system Black Sea 1975) is not yet available. The National Center for Cartography (NCC) from Romania developed a software for precise transformation, but it works only for certain patterns of the text files and for a maximum number of points of about 1 million. Because of this, the use of point clouds in precision work was not possible, using only extracts of low-density grid points in text format. In this research we develop an algorithm which use the precise transformation of NCC to realise an accurate transformation of the LiDAR point clouds in the national coordinate systems. The algorithm is then implemented in an innovative software to transform the LiDAR *LAS files, using the common version 1.2. The software is a batch processing application, which it can process big LiDAR data without blocking. Moreover, the application is capable to apply with accuracy and precision the last published national quasigeoid to the LiDAR point files. In the end, the obtained LiDAR point cloud are more suitable to be used in any domain, because of the accurate and precise transformation in the Romanian coordinate systems.
The biodiesel is being promoted worldwide as an important alternative to petrodiesel fuel due mainly to availability, low emissions and simple industrial production from renewable sources. Analysis ...of thermal properties is important showing the distillation and decomposition of the fuel function of temperature providing the temperature range of the combustion processes. In this paper physical and thermal properties of walnut oil were analyzed using Thermogravimetry (TGA/DTG). According to the thermograms the walnut oil presents the highest thermal stability in comparison with diesel fuel and walnut oil biodiesel.
When cells encounter substantial DNA damage, critical cell cycle events are halted while DNA repair mechanisms are activated to restore genome integrity. Genomic integrity also depends on proper ...assembly and function of the bipolar mitotic spindle, which is required for equal chromosome segregation. Failure to execute either of these processes leads to genomic instability, aging, and cancer. Here, we show that following DNA damage in the breast cancer cell line MCF-7, the centrosome protein centrin2 moves from the cytoplasm and accumulates in the nucleus in a xeroderma pigmentosum complementation group C protein (XPC)-dependent manner, reducing the available cytoplasmic pool of this key centriole protein and preventing centrosome amplification. MDA-MB 231 cells do not express XPC and fail to move centrin into the nucleus following DNA damage. Reintroduction of XPC expression in MDA-MB 231 cells rescues nuclear centrin2 sequestration and reestablishes control against centrosome amplification, regardless of mutant p53 status. Importantly, the capacity to repair DNA damage was also dependent on the availability of centrin2 in the nucleus. These observations show that centrin and XPC cooperate in a reciprocal mechanism to coordinate centrosome homeostasis and DNA repair and suggest that this process may provide a tractable target to develop treatments to slow progression of cancer and aging.
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