Described are the acylation binding of trans-lactam 1 to porcine pancreatic elastase, the selection of the SO2Me activating group for the lactam N which also confers metabolic stability in hamster ...liver microsomes, the introduction of aqueous solubility through the piperidine salt 9, the in vivo oral activity of 9 and its bioavailability, and the introduction of 9 as an intracellular neutrophil elastase inhibitor.
Freedom and the Rule of Law takes a critical look at the historical beginnings of law in the United States, and how that history has influenced current trends regarding law and freedom. Anthony ...Peacock has compiled articles that examine the relationship between freedom and the rule of law in America. Although this is a theme that has been a perennial one since America's founding, it is also one of particular importance today, and this book explains how history makes this apparent. The rule of law is fundamental to all liberal constitutional regimes whose political orders recognize the equal natural rights of all, and whose purpose is to protect those natural rights in addition to the general welfare. The rule of law was essential to achieving both of these ends and to reconciling them where necessary. But just how free is America today? It was certainly within the contemplation of the Founders that the federal judiciary would have a significant role in interpreting the Constitution, federal laws, and treaties, but it would be difficult to argue that those who framed and ratified the Constitution contemplated a role for the courts, particularly for the United States Supreme Court, of the magnitude they have today. The writers take the reader far back into history to the very roots of American Law by examining the English common law roots that provided the foundation for the rule of law in America. This book explores these phenomena and other recent developments in American freedom through history.
The type of deformation under investigation is indicated by fig. 1. A rectangular plate ABCD is deformed into the shape A'B'C'D'. The two opposing edges AB, CD are shifted horizontally without ...alteration of length into the position A'B', C'D', the other boundaries AD, BC being kept free from external stress. In a paper which appeared in the 'Proc. Royal Society', December 28, 1911, Prof. E. G. Coker investigated this same type of deformation using optical methods to determine the distribution of stress along the centre line OX. He found that if the plate was square the shear stress along OX was distributed in a munner which was approximately parabolic. As the ratio of AD to AB decreased the curve of distribution first of all became flat-topped, and for yet smaller ratios two distinct humps made their appearance.
Oscillations in a bridge caused by the passage of a locomotive Inglis, Charles Edward
Proceedings of the Royal Society of London. Series A, Containing papers of a mathematical and physical character,
03/1928, Letnik:
118, Številka:
779
Journal Article
For purposes of bridge design it is all important to be able to predict with a reasonable degree of accuracy the state of oscillation which will be set up when a given locomotive crosses a bridge at ...any specified speed. A large amount of experimental data relating to impact effects on bridges has been accumulated, but in default of an underlying theory sufficiently comprehensive in character to account for the phenomena observed, the conclusions emerging from experimental results have been somewhat disappointing and vague. The problem is one which most essentially calls for the closest possible cooperation between mathematical analysis and practical experiment. At the present stage experiment has outrun theory, and it was with the object of redressing, in some measure, this lack of balance that the following theoretical investigation was undertaken.
Reversal of auditory localization Willey, C. F; Inglis, E; Pearce, C. H
Journal of experimental psychology,
02/1937, Letnik:
20, Številka:
2
Journal Article
"In this experiment two observers wore pseudophones continuously, except at night, for one week; a third observer wore a pseudophone for three days. Purely auditory localization (without the aid of ...visual cues) remained reversed throughout the experiment. No progressive adaptation of socalled "visual-auditory localization' was found. Movement of the head and body resulted in more exact reversals, rather than in normal or objectively correct localizations. The authors believe those instances of normal localization which occurred during the experiment are to be attributed to a temporary repression of auditory localizing cues resulting from the counter influence of association and empathy, rather than to visual knowledge of the position of the object. Reversal with vision was invariable except when association and empathy appeared to be involved. The results . . . are definitely opposed to the view that auditory localization can be radically altered within the space of a few days. Such normal localization as occurred under the conditions of the experiment does not seem to represent a fundamental reorganization of auditory habits."
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