Abstract High expression of KIAA0101 (p15PAF /OEATC-1) which contains a proliferating cell nuclear antigen (PCNA)-binding motif, a key factor in DNA repair and/or apoptosis and cell cycle regulation, ...has been observed in a variety of human malignancies. The aim of this study was to observe the expression of KIAA0101 in human non-small-cell lung cancer (NSCLC), explore its clinicopathological significance and evaluate KIAA0101 expression as a potential prognostic marker. KIAA0101 transcript was found to be overexpressed in the great majority of lung cancers by semi-quantitative RT-PCR. A total of 357 NSCLCs were analyzed immunohistochemically on tissue microarrays. High-level KIAA0101 expression was observed in 33.9% (121 of 357 cases), and correlated with male gender ( P < 0.0001), tumor progression (pT status) ( P = 0.0008), lymph node metastasis (pN status) ( P = 0.0003), non-adenocarcinoma histological classification ( P < 0.0001), and smoking history ( P < 0.0001), but not with patient age or pleural invasion. Patients with tumors displaying high-level KIAA0101 expression showed significantly shorter survival ( P < 0.0001, log-rank test). Similarly, gender, pT status, pN status, pleural invasion, histological classification, and smoking history were significant prognostic markers in univariate Cox survival analysis. Importantly, high-level KIAA0101 expression was also identified as an independent prognostic factor by multivariate analysis ( P = 0.0320). These results provide additional information for determining postoperative adjuvant treatment of NSCLC.
Abstract High-level expression of mitotic arrest defective protein 2 (MAD2), a central component of the spindle assembly checkpoint, has been observed in a variety of human malignancies. Aim of the ...present study was to observe the expression of MAD2 in human non-small-cell lung cancer (NSCLC) and explore its clinicopathologic significance and evaluate MAD2 expression as a prognostic marker. MAD2 transcript was found to be overexpressed in the great majority of lung cancers by semi-quantitative RT-PCR. A total of 358 NSCLCs were analyzed immunohistochemically on tissue microarrays. High-level MAD2 expression was observed in 26.3% (94 of 358 cases), and correlated with male sex ( P = 0.0002), tumor progression (pT status) ( P = 0.0009), visceral or parietal pleural invasion ( P = 0.0151), non-adenocarcinoma, histological classification ( P < 0.0001), and smoking history ( P = 0.0022), but not with patient age or lymph node metastasis (pN status). Patients with tumors displaying high-level MAD2 expression showed significantly shorter survival ( P < 0.0001, log-rank test). Similarly, gender, pT status, pN status, pleural invasion, histological classification, and smoking history were significant prognostic markers in univariate Cox survival analysis. Importantly, high-level MAD2 expression was also identified as an independent prognostic factor by multivariate analysis ( P = 0.0076). These results provide additional prognostic information for surgical treatment of NSCLC.
Single distant metastases after radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) are rare. There are no guidelines for treating patients without liver tumors after resecting lung ...metastases.
Here, we report a patient with HCC recurring as a single lung metastasis 14 months after RFA. A 76-year-old woman with primary biliary cholangitis without hepatitis B virus or hepatitis C virus infection had been treated by RFA for a single 16-mm-sized HCC lesion in liver S8. Fourteen months thereafter, despite lack of intrahepatic recurrence, a single new 26-mm-sized mass was found in S10 of the right lung. The patient underwent right lower lobectomy. The histopathological diagnosis was HCC metastasis. Because no residual disease could be found, she was followed up without any additional treatment after surgery. She remains alive with no signs of recurrence 3 years later.
HCC patients who relapse with lung metastases but without intrahepatic recurrence after RFA are extremely rare, especially when RFA is used to treat HCC lesions <30 mm. However, it should be noted that, although rare, HCC may recur in the form of extrahepatic metastases after RFA. Furthermore, it is suggested that, as in the presently-described case, at least some patients without intrahepatic recurrence whose lung metastases are completely resected have a good prognosis even without additional treatment for HCC.
The patient was an 80-year-old woman with combined pulmonary fibrosis and emphysema. She was diagnosed with pulmonary pleomorphic carcinoma in the right upper lobe, which relapsed 18 months after the ...operation. Computed tomography showed a mass in contact with the posterior wall of the lower part of the stomach. The patient was treated with two cycles of pembrolizumab, but the disease progressed. She was treated with S-1 as second-line therapy, resulting in tumor-shrinking after two cycles. Progression was not observed over the next twelve months. We report a rare case involving S-1 after immune checkpoint inhibitor treatment.
We report herein the rare case of a patient with dendriform pulmonary ossification (DPO) who developed spontaneous pneumothorax. A 33-year-old male with a history of bronchial asthma presented with ...pneumothorax of the left lung. An intraoperative inspection revealed no findings of bullae in the entire left lung, but inflammatory pleural changes were identified on the interlobular surface of the left lower lobe. In addition, hard, twig-like configurations were clearly palpable in the subpleural parenchyma and were resected. A histological examination showed acicular bone formations containing myeloid tissue and marrow fat in the lung. DPO was thus diagnosed, and the bony spines were considered to have caused a rupture of the elastic fiber layer of the visceral pleura. DPO may thus have been directly responsible for the pneumothorax in this case.
Background. In cases of bronchial hemorrhaging occurring in a patient who is allergic to the contrast agent, bronchial artery embolization is difficult. Case. A 70-year-old woman with hemoptysis and ...dyspnea presented to a hospital. After the injection of contrast agent prior to chest computed tomography (CT), her blood pressure suddenly decreased, and airway narrowing occurred because of anaphylactic shock accompanied by a rash. Adrenaline and prednisolone were injected to improve the symptoms. Bronchoscopy revealed bleeding with clots in the right upper lobe bronchus, and chest CT showed an area of consolidation with diameter of 33×22 mm in the right upper lobe S1. Bronchial hemorrhaging from right upper lobe S1 was diagnosed. A reassessment CT scan showed no abnormal shadow in the right upper lobe, and no special findings were found on bronchoscopy. The patient was therefore referred to our hospital for further follow-up. In cases of the sudden occurrence of respiratory tract bleeding in a patient with contrast allergy, it is difficult to perform bronchial artery embolization. We therefore recommended she undergo elective surgery to avoid suffocation caused by sudden bronchial hemorrhaging. The patient agreed with our suggestion. Right upper lobectomy through video-assisted thoracic surgery was performed. No pathological findings, such as arteriovenous fistula or aneurysm, were observed except for hemorrhaging in the lung tissue and lymph nodes at about 10 mm in S1a. The postoperative course was uneventful, and the patient was discharged from the hospital 16 days after the operation. Conclusion. Our case shows that respiratory tract bleeding in a patient with contrast agent allergy can be safely treated with elective surgery.
A Case of Castleman's Disease with Myasthenia Gravis Ishikawa, Keidai; Kato, Tatsuya; Aragaki, Masato ...
Annals of Thoracic and Cardiovascular Surgery,
2014, 2014-00-00, 20140101, Letnik:
20, Številka:
Supplement
Journal Article
Odprti dostop
A rare case of Castleman's disease with myasthenia gravis is reported. A 55-year-old woman with bilateral ptosis, speech impairment, and severe dyspnea had been previously diagnosed with myasthenia ...gravis. Computed tomography showed a 5 cm × 3 cm paratracheal mass in the mediastinum, thought to be an ectopic thymoma. Two days after surgical resection, the patient suddenly developed dyspnea. Postoperative myasthenic crisis was diagnosed, and plasmapheresis was performed. Her general condition improved, and her subsequent course was uneventful. The final pathological diagnosis was mediastinal solitary Castleman's disease, hyaline vascular type. Castleman's disease with myasthenia gravis is especially rare. One of the serious complications is postoperative myasthenic crisis. For patients with myasthenia gravis, the rate of postoperative myasthenic crisis seems significantly higher in Castleman's disease patients than in patients with thymic epithelial tumors. Castleman's disease with myasthenia gravis is discussed along with a review of the literature.
Bronchopleural fistulas associated with empyema can occur as life-threatening sequelae after pulmonary resection, occurring most frequently after pneumonectomy. Three bronchopleural fistulas, 5-6 mm ...in diameter, were successfully treated using a fibrin glue-coated collagen patch (FGCCP) and fibrin glue (FG) at the site of a bronchopleural fistula. Through the clinical experiences, we introduce the methodology to perform the endobronchial closure of bronchopleural fistulas.Data were collected by reviewing the clinical charts of patients diagnosed with post-lobectomy bronchopleural fistula at Sapporo Minami-Sanjo Hospital from June 2004 to December 2010. Bronchopleural fistula was diagnosed by means of endoscopic visualization. Three cases of post-lobectomy and one case of post-pneumonectomy bronchopleural fistula were collected.A FGCCP fragment was packed within the fistula, and the fragment grasped with the forceps was kept in this position for approximately a minute, a time during which a FGCCP becomes adhesive, and the patch fragment was released. After releasing the patch fragment, the FG was applied directly on the FGCCP using a two-channel catheter.There have been few reports of the bronchoscopic closure of bronchopleural fistulas using a FGCCP and FG. Closure of small bronchopleural fistulas with the application of a FGCCP and FG may offer a valuable therapeutic alternative.
Objective
This study investigated how fluorodeoxyglucose (FDG) uptake on PET in the primary tumor may predict intratumoral vessel invasion (IVI) in it.
Methods
A total of 512 patients with lung ...neoplasms determined by a surgical procedure and histopathological diagnosis had undergone FDG-PET scanning.
Results
Among the 440 cases confirmed to be malignant, the maximum standardized uptake value (SUV
max
) was significantly lower in IVI-negative cases than IVI-positive cases (
P
< 0.001). In the substudy on adenocarcinoma (AC), SUV
max
was significantly lower in IVI-negative cases too (
P
< 0.001), but SUV
max
in squamous cell carcinoma was without significant difference. In addition, IVI was associated with a significantly higher probability of lymph node metastasis (
P
< 0.001).
Conclusions
This study indicates that a malignant lung tumor with higher SUV
max
has a significantly higher probability of IVI and lymph node metastasis, particularly if the malignancy is an AC.
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