The results of observational investigation by prescription of the fixed combination perindopril + amlodipin produced by to the uncontrollable hypertension patients by the previous therapy are ...described in the given article. In Kazan population 50 patients at the age of 32 to 92 with essential hypertension having blood pressure level of 140/90 mm/hg. Were included into the investigation. Before these patients took different groups of antihypertension preparation (including perindopril). The preparation was prescribed in different fixed dosage depending on duration of hypertension, quantity of taken hypertension groups of preparations and blood pressure level. Then during 1, 2, 3 months of treatment the physician had the possibility to determine the dosage necessary to prescribe. The prescription of perindopril in combination with amlodipin during 3 months led to certain lowering of systolic and diastolic arterial pressure for 38.2 and 11.6 mm/hg accordingly and 80% of patients had the required pressure level of (<140/90 mm/hg). Moreover, the frequency of heart beat reduced and necessary increase of patient compliance for treatment took place. Taking the preparation only 31% of patients had unwilling effects but it didnt require the abolition of the antihypertension therapy till the end of observation. As a result, the investigation confirmed the high efficiency, good perception, improvement of patient compliance for treatment by prescribing the fixed combination perindopril + amlodipin.
Despite significant progress in understanding the pathogenesis and treatment of viral diseases, the influenza virus alone causes up to three to five million severe cases and 250-500 thousand deaths ...annually. However, respiratory viruses can affect not only the respiratory system, but also cause complications in the cardiovascular system. For example, acute coronary syndrome, myocarditis, pericarditis, exacerbation of chronic heart failure, acute heart failure, pulmonary embolism, and arrhythmias. This review provides information on the incidence of cardiovascular complications that occurred in association with acute respiratory viral infections (COVID-19, influenza, respiratory syncytial virus infection, adenovirus, and rhinovirus infections), and the mechanisms of respiratory virus impact on the cardiovascular system. Understanding these mechanisms may allow to predict the potential cardiovascular complications in patients with respiratory infections and take prompt measures to prevent them as soon as possible especially in case of life-threatening events.
Articular disturbances of temporo-mandibular joint (TMJ) combined with dentofacial anomalies (DFA) decrease the quality of life. The objective of the study was ti determine dental quality of life in ...patients with "internal disturbances" of TMJ combined with DFA. Questionnaire survey (Oral Health Impact Profile OHIP-14-RU) of 96 young patients was carried out. The patients were treated due to DFA combined with "internal disturbances" of TMJ. It should be pointed out that patients with hyperdivergent skeletal pattern have the most evident trend towards setting the quality of life to zero in dental sphere. Moreover, the trend is more evident in the case of patients with dento-alveolar types of occlusion anomalies. Patients with dento-alveolar type of open occlusion have maximum points in "Psychological discomfort", "Psychological disability", and "Social disability". Patients with distal occlusion and hyperdivergence of jaw bones have maximum points in "Psychological disability" and "Social incapacity". Patients with the combination of distal occlusion and deep incisal occlusion have maximum points in "Psychological discomfort" and "Social disability". Patients with "internal disturbances" of TMJ combined with DFA reveal a negative shift of questionnaire information. The maximal rates were revealed in "Psychological disability" and "Social disability", the minimal ones--in "Functional limitation" and "Handicap".
A mixed columnar-equiaxed solidification model is used to predict the macrosegregation in high grade steel ingots. In this model, three phases are considered: the melt; the columnar phase, which is ...assumed to be stationary; and the equiaxed phase, which is free to move. With this approach, the model is able to simulate the evolution of the primary solid phase distributions including the columnar-to-equiaxed transition, the melt convection and the grain sedimentation, and their influence on the macrosegregation. Thermodynamic information of a ternary alloy (Fe-C-Cr) is simplified by the piecewise linearization of the phase diagram around the suitable compositions in the ferritic and austenitic regions. As a result, macrosegregation of carbon and chromium has been analyzed. As the first step, the validation of the numerical model was performed on a benchmark ingot of a laboratory scale. Computed macrosegregation and primary structure were compared with measurements and good agreement was obtained.
The benefits of supplemental administration of intravenous magnesium in patients with ST-elevation myocardial infarction (STEMI) are controversial. Despite promising results from work in animals and ...the ready availability of this simple, inexpensive treatment, conflicting results have been reported in clinical trials. Our aim was to compare short-term mortality in patients with STEMI who received either intravenous magnesium sulphate or placebo.
We did a randomised, double-blind trial in 6213 patients with acute STEMI who were assigned a 2 g intravenous bolus of magnesium sulphate administered over 15 min, followed by a 17 g infusion of magnesium sulphate over 24 h (n=3113), or matching placebo (n=3100). Our primary endpoint was 30-day all-cause mortality. At randomisation, patients were stratified by their eligibility for reperfusion therapy. The first stratum included patients who were aged 65 years or older and eligible for reperfusion therapy, and the second stratum included patients of any age who were not eligible for reperfusion therapy. Analysis was by intention-to-treat.
At 30 days, 475 (15·3%) patients in the magnesium group and 472 (15·2%) in the placebo group had died (odds ratio 1·0, 95% Cl 0·9–1·2, p=0·96). No benefit or harm of magnesium was observed in eight prespecified subgroup analyses of patients and in 15 additional exploratory subgroup analyses. After adjustment for factors shown to effect mortality risk in a multivariate regression model, no benefit of magnesium was observed (1·0, 0·8–1·1, p=0·53).
Early administration of magnesium in high-risk patients with STEMI has no effect on 30-day mortality. In view of the totality of the available evidence, in current coronary care practice there is no indication for the routine administration of intravenous magnesium in patients with STEMI.
The use of beta-blockers is an important component of therapy of cardiovascular pathology (e.g. coronary heart disease, arterial hypertension) in menopausal women. Comparative data on the efficiency ...of lokren and carvedilol for the correction of grade 2 AH are presented.
Heart rhythm variability on myocardial infarction (MI) day 1, 3, 7 and 11 was assessed mathematically to study function of the autonomic nervous system in 101 MI patients. The initial autonomic ...tonicity (IAT), autonomic reactivity (AR) and autonomic maintenance (AM) were studied. Depending on the site of the infarction in the myocardium, different type of autonomic homeostasis were identified. Moderate sympathicotonia, sympathicotonic type of AR and adequate AM irrespective of IM location were found most favourable in relation to the MI course and prognosis. The spectral analysis of the heart rhythm showed a significant shift of the frequency spectrum in the inferior MI to high frequencies and in anterior MI--to low frequencies. Autonomic dysfunction score is higher in the anterior MI. Psychoemotional state of the patients was determined by Spilberg-Khanin test evaluating reactive and personality anxieties. These characteristics were moderate and high in patients with MI and effort angina, respectively. The study of selective beta-adrenoblockers effect on heart rhythm variability proved that lokren (betaxolol) in a dose of 10 mg/day significantly and positively influences heart rhythm and objective status of the patients. Less effective is betacard (atenolol). Nebivolol is not indicated in acute MI. Significant correlations are found between the findings of IAT mathematical analysis, psychoemotional features of the patients and complications of MI. Parameters of an unfavourable course and outcome of MI are described.
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