Buildings consume nearly 40% of primary energy production globally. Certified green buildings substantially reduce energy consumption on a per square foot basis and they also focus on indoor ...environmental quality. However, the co-benefits to health through reductions in energy and concomitant reductions in air pollution have not been examined.We calculated year by year LEED (Leadership in Energy and Environmental Design) certification rates in six countries (the United States, China, India, Brazil, Germany, and Turkey) and then used data from the Green Building Information Gateway (GBIG) to estimate energy savings in each country each year. Of the green building rating schemes, LEED accounts for 32% of green-certified floor space and publically reports energy efficiency data. We employed Harvard's Co-BE Calculator to determine pollutant emissions reductions by country accounting for transient energy mixes and baseline energy use intensities. Co-BE applies the social cost of carbon and the social cost of atmospheric release to translate these reductions into health benefits. Based on modeled energy use, LEED-certified buildings saved $7.5B in energy costs and averted 33MT of CO
, 51 kt of SO
, 38 kt of NO
, and 10 kt of PM
from entering the atmosphere, which amounts to $5.8B (lower limit = $2.3B, upper limit = $9.1B) in climate and health co-benefits from 2000 to 2016 in the six countries investigated. The U.S. health benefits derive from avoiding an estimated 172-405 premature deaths, 171 hospital admissions, 11,000 asthma exacerbations, 54,000 respiratory symptoms, 21,000 lost days of work, and 16,000 lost days of school. Because the climate and health benefits are nearly equivalent to the energy savings for green buildings in the United States, and up to 10 times higher in developing countries, they provide an important and previously unquantified societal value. Future analyses should consider these co-benefits when weighing policy decisions around energy-efficient buildings.
Abstract
Building electrification is essential to many full-economy decarbonization pathways. However, current decarbonization modeling in the United States (U.S.) does not incorporate seasonal ...fluctuations in building energy demand, seasonal fluctuations in electricity demand of electrified buildings, or the ramifications of this extra demand for electricity generation. Here, we examine historical energy data in the U.S. to evaluate current seasonal fluctuation in total energy demand and management of seasonal fluctuations. We then model additional electricity demand under different building electrification scenarios and the necessary increases in wind or solar PV to meet this demand. We found that U.S. monthly average total building energy consumption varies by a factor of 1.6×—lowest in May and highest in January. This is largely managed by fossil fuel systems with long-term storage capability. All of our building electrification scenarios resulted in substantial increases in winter electrical demand, enough to switch the grid from summer to winter peaking. Meeting this peak with renewables would require a 28× increase in January wind generation, or a 303× increase in January solar, with excess generation in other months. Highly efficient building electrification can shrink this winter peak—requiring 4.5× more generation from wind and 36× more from solar.
The landscape of guided bronchoscopy for the sampling of pulmonary parenchymal lesions is evolving rapidly. Shape-sensing robotic-assisted bronchoscopy (ssRAB) recently was introduced as means to ...allow successful sampling of traditionally challenging lesions.
What are the feasibility, diagnostic yield, determinants of diagnostic sampling, and safety of ssRAB in patients with pulmonary lesions?
Data from 131 consecutive ssRAB procedures performed at a US-based cancer center between October 2019 and July 2020 were captured prospectively and analyzed retrospectively. Definitions of diagnostic procedures were based on prior standards. Associations of procedure- and lesion-related factors with diagnostic yield were examined by univariate and multivariate generalized linear mixed models.
A total of 159 pulmonary lesions were targeted during 131 ssRAB procedures. The median lesion size was 1.8 cm, 59.1% of lesions were in the upper lobe, and 66.7% of lesions were beyond a sixth-generation airway. The navigational success rate was 98.7%. The overall diagnostic yield was 81.7%. Lesion size of ≥ 1.8 cm and central location were associated significantly with a diagnostic procedure in the univariate analysis. In the multivariate model, lesions of ≥ 1.8 cm were more likely to be diagnostic compared with lesions < 1.8 cm, after adjusting for lung centrality (OR, 12.22; 95% CI, 1.66-90.10). The sensitivity and negative predictive value of ssRAB for primary thoracic malignancies were 79.8% and 72.4%, respectively. The overall complication rate was 3.0%, and the pneumothorax rate was 1.5%.
This study was the first to provide comprehensive evidence regarding the usefulness and diagnostic yield of ssRAB in the sampling of pulmonary parenchymal lesions. ssRAB may represent a significant advancement in the ability to access and sample successfully traditionally challenging pulmonary lesions via the bronchoscopic approach, while maintaining a superb safety profile. Lesion size seems to remain the major predictor of a diagnostic procedure.
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In September-October 2015, El Niño and positive Indian Ocean Dipole conditions set the stage for massive fires in Sumatra and Kalimantan (Indonesian Borneo), leading to persistently hazardous levels ...of smoke pollution across much of Equatorial Asia. Here we quantify the emission sources and health impacts of this haze episode and compare the sources and impacts to an event of similar magnitude occurring under similar meteorological conditions in September-October 2006. Using the adjoint of the GEOS-Chem chemical transport model, we first calculate the influence of potential fire emissions across the domain on smoke concentrations in three receptor areas downwind-Indonesia, Malaysia, and Singapore-during the 2006 event. This step maps the sensitivity of each receptor to fire emissions in each grid cell upwind. We then combine these sensitivities with 2006 and 2015 fire emission inventories from the Global Fire Assimilation System (GFAS) to estimate the resulting population-weighted smoke exposure. This method, which assumes similar smoke transport pathways in 2006 and 2015, allows near real-time assessment of smoke pollution exposure, and therefore the consequent morbidity and premature mortality, due to severe haze. Our approach also provides rapid assessment of the relative contribution of fire emissions generated in a specific province to smoke-related health impacts in the receptor areas. We estimate that haze in 2015 resulted in 100 300 excess deaths across Indonesia, Malaysia and Singapore, more than double those of the 2006 event, with much of the increase due to fires in Indonesia's South Sumatra Province. The model framework we introduce in this study can rapidly identify those areas where land use management to reduce and/or avoid fires would yield the greatest benefit to human health, both nationally and regionally.
Concurrent loss-of-function mutations in STK11 and KEAP1 in lung adenocarcinoma (LUAD) are associated with aggressive tumor growth, resistance to available therapies, and early death. We investigated ...the effects of coordinate STK11 and KEAP1 loss by comparing co-mutant with single mutant and wild-type isogenic counterparts in multiple LUAD models. STK11/KEAP1 co-mutation results in significantly elevated expression of ferroptosis-protective genes, including SCD and AKR1C1/2/3, and resistance to pharmacologically induced ferroptosis. CRISPR screening further nominates SCD (SCD1) as selectively essential in STK11/KEAP1 co-mutant LUAD. Genetic and pharmacological inhibition of SCD1 confirms the essentiality of this gene and augments the effects of ferroptosis induction by erastin and RSL3. Together these data identify SCD1 as a selective vulnerability and a promising candidate for targeted drug development in STK11/KEAP1 co-mutant LUAD.
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•STK11/KEAP1 co-mutation promotes cell proliferation, independent of KRAS status•NRF2 activity is enhanced in STK11/KEAP1 co-mutation beyond KEAP1 loss alone•STK11 and KEAP1 mutations each independently promote ferroptosis protection•SCD1 protects STK11/KEAP1 co-mutant LUAD from ferroptosis and is essential for survival
Wohlhieter et al. explore the global changes in gene expression and oncogenic signaling pathways driven by concurrent loss of function in two tumor suppressor genes, STK11 and KEAP1. They identify a molecular vulnerability, in which co-mutant cells depend on ferroptosis protective mechanisms for survival, and highlight SCD1 as an essential gene and promising drug target.
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•Aviation landing and takeoff (LTO) emissions impact air quality in the U.S.•Air quality-related health impacts from LTO emissions increase from 2011 to 2016.•Alternate jet fuels ...reduce some precursors, but air quality health impacts remain.•Nitrogen dioxide is responsible for 91% of total premature mortalities.
Aviation emissions from landing and takeoff operations (LTO) can degrade local and regional air quality leading to adverse health outcomes in populations near airports and downwind. In this study we aim to quantify the air quality and health-related impacts from commercial LTO emissions in the continental U.S. for two recent years’ inventories, 2011 and 2016. We quantify the LTO-attributable PM2.5, O3, and NO2 concentrations and health outcomes for mortality and multiple morbidity health endpoints. We also quantify the impacts from two scenarios representing a nation-wide implementation of 5% or 50% blends of sustainable alternative jet fuels. We estimate 80 (68–93) and 88 (75–100) PM2.5-attributable and 610 (310–920) and 1,100 (570–1,700) NO2-attributable premature mortalities in 2011 and 2016, respectively. We estimate a net decrease of 28 (14–56) and 54 (27–110) in O3-attributable premature mortalities across the U.S. in 2011 and 2016, respectively due to the large O3 titration effects near the airports. We also find that the asthma exacerbations due to NO2 exposures from LTO emissions increase from 100,000 (2,500–200,000) in 2011 to 170,000 (4,400–340,000) in 2016. Implementing a 5% or 50% blend of sustainable alternative jet fuel in 2016 results in a 1% or 18% reduction, respectively in PM2.5-attributable premature mortalities. Monetizing the value of avoided total premature mortalities, we find that a 50%-blended sustainable alternative jet fuel results in a 19% decrease in PM2.5 damages per ton of fuel burned and a 2% decrease in total damages per ton of fuel burned as compared to damages from traditional jet fuel. We also quantify health impacts by state and find California to be the most impacted by LTO emissions. We find that LTO-attributable PM2.5 and NO2 premature mortalities increase by 10% and 80%, respectively from 2011 to 2016 and that NO2-attributable premature mortalities are responsible for 91% of total LTO-attributable premature mortalities in both 2011 and 2016. And since we find LTO-attributable NO2 to be unaffected by the implementation of sustainable alternative jet fuels, additional approaches focused on NOX reductions in the combustor are needed to mitigate the air quality-related health impacts from LTO emissions.
Traffic congestion is a significant issue in urban areas in the United States and around the world. Previous analyses have estimated the economic costs of congestion, related to fuel and time wasted, ...but few have quantified the public health impacts or determined how these impacts compare in magnitude to the economic costs. Moreover, the relative magnitudes of economic and public health impacts of congestion would be expected to vary significantly across urban areas, as a function of road infrastructure, population density, and atmospheric conditions influencing pollutant formation, but this variability has not been explored.
In this study, we evaluate the public health impacts of ambient exposures to fine particulate matter (PM2.5) concentrations associated with a business-as-usual scenario of predicted traffic congestion. We evaluate 83 individual urban areas using traffic demand models to estimate the degree of congestion in each area from 2000 to 2030. We link traffic volume and speed data with the MOBILE6 model to characterize emissions of PM2.5 and particle precursors attributable to congestion, and we use a source-receptor matrix to evaluate the impact of these emissions on ambient PM2.5 concentrations. Marginal concentration changes are related to a concentration-response function for mortality, with a value of statistical life approach used to monetize the impacts.
We estimate that the monetized value of PM2.5-related mortality attributable to congestion in these 83 cities in 2000 was approximately $31 billion (2007 dollars), as compared with a value of time and fuel wasted of $60 billion. In future years, the economic impacts grow (to over $100 billion in 2030) while the public health impacts decrease to $13 billion in 2020 before increasing to $17 billion in 2030, given increasing population and congestion but lower emissions per vehicle. Across cities and years, the public health impacts range from more than an order of magnitude less to in excess of the economic impacts.
Our analyses indicate that the public health impacts of congestion may be significant enough in magnitude, at least in some urban areas, to be considered in future evaluations of the benefits of policies to mitigate congestion.
Abstract
Local and state policymakers have become increasingly interested in developing policies that both reduce greenhouse gas (GHG) emissions and improve local air quality, along with public ...health. Interest in developing transportation-related policies has grown as transportation became the largest contributing sector to GHG emissions in the United States in 2017. Information on current emissions and health impacts, along with trends over time, is helpful to policymakers who are developing strategies to reduce emissions and improve public health, especially in areas with high levels of transportation-related emissions. Here, we provide a comprehensive assessment of the public health and climate social costs of on-road emissions by linking emissions data generated by the U.S. Environmental Protection Agency to reduced complexity models that provide impacts per ton emitted for pollutants which contribute to ambient fine particulate matter, and the social costs of GHG emissions from on-road transportation. For 2017, social costs totaled $184 billion (min: $78 billion; max: $280 billion) for all on-road emissions from the eight health and climate pollutants that we assessed in the continental U.S. (in $2017 USD). Within this total social cost estimate, health pollutants constituted $93 billion of the social costs (min: $52 billion; max: $146 billion), and climate pollutants constituted $91 billion (min: $26 billion; max: $134 billion). The majority of these social costs came from CO
2
followed by NO
x
emissions from privately owned individual vehicles in urban counties (CO
2
contributed $51 billion and NO
x
contributed $16 billion in social costs from individual vehicles in urban counties). However, it is important to note that not all the attention should be placed solely on individual vehicles. Although the climate social costs of individual vehicle emissions are higher than those from commercial vehicles in urban counties (by two to eight times depending on the climate pollutant), the health social costs of individual vehicle emissions are roughly equal to those from commercial vehicles in urban counties. Regardless of each pollutant’s contributions to the social costs, the highest social benefits from reducing 1 ton of CO
2
and its co-pollutants would occur in urban counties, given their high population density.
Scientifically assess impacts of sustainable investments Vörösmarty, C J; Osuna, V Rodríguez; Koehler, D A ...
Science (American Association for the Advancement of Science),
02/2018, Letnik:
359, Številka:
6375
Journal Article
Recenzirano
Metrics can inform investors wary of “green washing”
The practice of selecting and managing financial assets based on their social and environmental performance is undergoing rapid growth and ...fundamental change. Investors are increasingly pressed by asset owners to prove how one company's practices are materially more or less sustainable than those of another. Yet, the basic information that companies declare is hardly standardized and is difficult to verify, with unreliable assertions (
1
) that are widely criticized as “green washing.” Metrics are mainly restricted to documenting changes to internal business practices but offer limited guidance on whether a company's actions, products, and services promote human well-being or preserve environmental integrity in the external, real-world domain, fueling reluctance on the part of otherwise enthusiastic investors (
2
,
3
). It is here where science can play an important role. Our consortium of an asset owner, an asset manager, and two research universities is designing a next generation of traceable indicators to quantify external context and impact of investments and place these into a decision-making framework useful to investors. Tests of these science-based sustainability metrics are under way on a $2.1 billion portfolio of public equities invested on behalf of a large European pension fund.
Full cost accounting for the life cycle of coal Epstein, Paul R.; Buonocore, Jonathan J.; Eckerle, Kevin ...
Annals of the New York Academy of Sciences,
February 2011, Letnik:
1219, Številka:
1
Journal Article
Recenzirano
Each stage in the life cycle of coal—extraction, transport, processing, and combustion—generates a waste stream and carries multiple hazards for health and the environment. These costs are external ...to the coal industry and are thus often considered “externalities.” We estimate that the life cycle effects of coal and the waste stream generated are costing the U.S. public a third to over one‐half of a trillion dollars annually. Many of these so‐called externalities are, moreover, cumulative. Accounting for the damages conservatively doubles to triples the price of electricity from coal per kWh generated, making wind, solar, and other forms of nonfossil fuel power generation, along with investments in efficiency and electricity conservation methods, economically competitive. We focus on Appalachia, though coal is mined in other regions of the United States and is burned throughout the world.
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