R73; AIM: To establish the prognosis and feasibility of en-bloc vascular resection of stage n pancreatic adenocarcinoma of the head and uncinate process.METHODS: We retrospectively analyzed 87 ...patients with stage Ⅱ pancreatic adenocarcinoma, who were subjected to pancreaticoduodenectomy (PD) and pylorus-preserving PD (PPPD) between 1996 and 2006 in Chang Gung Memorial Hospital, Taiwan. Twelve and 75 patients underwent PD/PPPD with and without resection of portal vein/superior mesenteric vein (PV/SMV), respectively.RESULTS: The overall 1- and 3-year survival rates of patients undergoing PD/PPPD with and without vascular resection were 50.0% and 16.7%, and 44.4% and 12.2%, respectively. Morbidity and mortality rates in the PV/SMV resection vs non-resection group were 50.0% and 0.0%, and 40.0% and 2.7%, respectively. In multivariate analysis, serum bilirubin, histologicaldifferentiation and adjuvant chemotherapy were independent prognostic factors that influenced survival.CONCLUSION: In stage Ⅱ adenocarcinoma of the pancreatic head and uncinate process, serum bilirubin, histological differentiation and adjuvant chemotherapy were independent prognostic factors, and en-bloc vascular resection is a feasible option in carefully selected patients.
Time-to-contact (TTC), the time for an object to collide with the observer's plane, is a powerful tool for path planning: it is potentially more informative than the depth, velocity, and acceleration ...of objects in the scene -- even for humans. TTC presents several advantages, including requiring only a monocular, uncalibrated camera. However, regressing TTC for each pixel is not straightforward, and most existing methods make over-simplifying assumptions about the scene. We address this challenge by estimating TTC via a series of simpler, binary classifications. We predict with low latency whether the observer will collide with an obstacle within a certain time, which is often more critical than knowing exact, per-pixel TTC. For such scenarios, our method offers a temporal geofence in 6.4 ms -- over 25x faster than existing methods. Our approach can also estimate per-pixel TTC with arbitrarily fine quantization (including continuous values), when the computational budget allows for it. To the best of our knowledge, our method is the first to offer TTC information (binary or coarsely quantized) at sufficiently high frame-rates for practical use.
Gallbladder carcinoma is the most common malignancy of the biliary tract, while the clinical features of cystic duct carcinoma remain unexplored.
Clinicopathological data of 8 cases of cystic duct ...carcinoma were retrospectively analyzed.
The sample included 5 men and 3 women, with a mean age of 66+/-10 years (range, 49-79 years). Clinical manifestations included jaundice (n=6) and/or abdominal pain (n=6). Two of the patients presented as acute cholecystitis. Preoperative work-ups included ultrasonography (n=8), computed tomography (n=7), and endoscopic retrograde cholangiography (n=6)/or magnetic resonance cholangiography (n=2). Meanwhile, the preoperative diagnoses included cystic duct neoplasms (n=3), common hepatic duct neoplasms (n=4), and gallstones with acute cholecystitis (n=1). Radical procedures, including cholecystectomy, resection of extrahepatic bile duct, and lymph node dissection, were performed in six patients, while palliative cholecystectomy was performed in the remaining two. Notably, five of eight cases displayed lymph node metastasis along the hepaticoduodenal ligament. Median survival was 15 months (range, 6 to 26 months). Two cases with no lymph node metastasis were alive and disease free at 23 months and 26 months, respectively.
Cystic duct carcinoma is rare. Neoplasm of the cystic duct should be suspected in patients presenting with cystic duct obstruction accompanied by distended nonfunctioning gallbladder without evidence of stone impaction in the cystic duct. The prognosis of cystic duct carcinoma remains dismal. However, for those patients in whom tumors are detected in early stage, curative radical resections possibly provide the chance of potential curable.
Magnetic atoms at surfaces are a rich model system for solid-state magnetic bits exhibiting either classical or quantum behaviour. Individual atoms, however, are difficult to arrange in regular ...patterns. Moreover, their magnetic properties are dominated by interaction with the substrate, which, as in the case of Kondo systems, often leads to a decrease or quench of their local magnetic moment. Here, we show that the supramolecular assembly of Fe and 1,4-benzenedicarboxylic acid molecules on a Cu surface results in ordered arrays of high-spin mononuclear Fe centres on a 1.5nm square grid. Lateral coordination with the molecular ligands yields unsaturated yet stable coordination bonds, which enable chemical modification of the electronic and magnetic properties of the Fe atoms independently from the substrate. The easy magnetization direction of the Fe centres can be switched by oxygen adsorption, thus opening a way to control the magnetic anisotropy in supramolecular layers akin to that used in metallic thin films.
Terbinafine (TB, lamisil
®), a promising world widely used oral-anti-fungal agent, has been used in the treatment of superficial mycosis. In this study, we found that apoptosis but not cell growth ...arrest was induced by TB (1
μM, for 24
h) in human promyelocytic leukemia (HL60) cells. The apoptotic effect induced by TB in the HL60 cell was not through the general differentiation mechanisms evidenced by evaluation of three recognized markers, including CD11b, CD33, and morphological features. In addition, our results also revealed that TB-induced apoptosis was not through the cellular surface CD 95 receptor-mediated signaling pathway. We found that the mitochondria membrane in the TB-treated HL60 cells was dissipated by decreasing of the electrochemical gradient (Δ
Ψ
m) led to leakage of cytochrome
c from mitochondria into cytosol. Such effects were completely blocked by in vitro transfection of the HL60 cells with Bcl-2 overexpression plasmid (HL60/Bcl-2). However, our data found that TB-mediated apoptosis could not be completely prevented in the Bcl-2 over expressed (HL60/Bcl-2) cells. Such results implied that additional mediators (such as caspase-9) other than mitochondria membrane permeability might contribute to the TB-induced cellular apoptosis signaling. This hypothesis was supported by the evidence that administration of caspases-9 specific inhibitor (z-LEHD-fmk) blocked the TB-induced apoptosis. Our studies highlight the molecular mechanisms of TB-induced apoptosis in human promyelocytic leukemia (HL60) cells.
Estimating a mesh from an unordered set of sparse, noisy 3D points is a challenging problem that requires carefully selected priors. Existing hand-crafted priors, such as smoothness regularizers, ...impose an undesirable trade-off between attenuating noise and preserving local detail. Recent deep-learning approaches produce impressive results by learning priors directly from the data. However, the priors are learned at the object level, which makes these algorithms class-specific and even sensitive to the pose of the object. We introduce meshlets, small patches of mesh that we use to learn local shape priors. Meshlets act as a dictionary of local features and thus allow to use learned priors to reconstruct object meshes in any pose and from unseen classes, even when the noise is large and the samples sparse.
Quantum Zeno and anti-Zeno effects are studied in an asymmetric nonlinear optical coupler composed of a probe waveguide and a system waveguide. The system is a nonlinear waveguide operating under ...non-degenerate hyper-Raman process, while both the pump modes in the system are constantly interacting with the probe waveguide. The effect of the presence of probe on the temporal evolution of the system in terms of the number of photons in Stokes and anti-Stokes modes as well as phonon number is quantified as Zeno parameter. The negative (positive) values of the Zeno parameter in the specific mode are considered as the signatures of the quantum Zeno (anti-Zeno)effect in that mode of the system. It is observed that the phase mismatch in Stokes and anti-Stokes generation processes can be controlled to induce a transition between quantum Zeno and anti-Zeno effects for both off-resonant and resonant hyper-Raman process. However, in case of off-resonant hyper-Raman process in the system waveguide, the frequency detuning parameters can also be used analogously to cause the desired crossover. Further, the general nature of the physical system and the perturbative technique used here allowed us to analytically study the possibilities of observing quantum Zeno and anti-Zeno effects in a large number of special cases, including situations where the process is spontaneous, partially spontaneous and/or the system is operated under degenerate hyper-Raman process, or a simple Raman process.
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