This paper presents a comprehensive study of the lateral compressive response of hexagonal honeycomb panels from the initial elastic regime to a fully crushed state. Expanded aluminum alloy honeycomb ...panels with a cell size of 9.53
mm, a relative density of 0.026, and a height of 15.9
mm are laterally compressed quasi statically between rigid platens under displacement control. The cells buckle elastically and collapse at a higher stress due to inelastic action. Deformation then first localizes at mid-height and the cells crush by progressive formation of folds; associated with each fold family is a stress undulation. The response densifies when the whole panel height is consumed by folds. The buckling and crushing events are simulated numerically using finite element models involving periodic domains of a single or several characteristic cells. The models idealize the microstructure as hexagonal, with double walls in one direction. The nonlinear behavior is initiated by elastic buckling while inelastic collapse that leads to the localization observed in the experiments occurs at a significantly higher load. The collapse stress is found to be mildly sensitive to various problem imperfections. The subsequent folding can be reproduced numerically using periodic domains but requires a fine mesh capable of capturing the complexity of the folds. The calculated crushing response is shown to better resemble measured ones when a 4
×
4 cell domain is used. However, the average crushing stress can be captured with engineering accuracy even from a single cell domain.
A high‐quality ZnO nanorod array (NRA) has been successfully grown on a Si wafer by a wet‐chemical process, where the Si wafer was dip‐coated with 4 nm sized ZnO nanoparticles as a buffer and seed ...layer prior to the crystal growth. It is found that the as‐prepared ZnO NRA has a threshold power density of ∼ 70 kW cm–2, which is comparable to the lowest one determined for ZnO NRAs on Al2O3 substrates (40 kW cm–2). The ultraviolet lasing efficiency of the ZnO NRAs is thus similar for both substrates.
This study is concerned with the understanding and modeling of the compressive response of open cell foams. The response starts with a nearly linear elastic regime which terminates into a limit load ...followed by an extensive load plateau. The plateau, which is responsible for the excellent energy absorption capacity of foams, is followed by a second stiff branch. Results from polyester urethane open cell foams with relative densities of about 0.025 are used to illustrate this behavior using experiments coupled with several levels of modeling. The experiments include characterization of the microstructure and the properties of the base material and measurement of the compressive response of the foams of various cell sizes.
A sequence of models for predicting the complete response of such foam is developed. The foam is idealized to be periodic using the space-filling Kelvin cell assigned the major geometric characteristics found in the foams tested. The cells are elongated in the rise direction, the ligaments are assumed to be straight, to have Plateau border cross-sections and nonuniform cross-sectional area distribution. The ligaments are modeled as shear-deformable extensional beams and the base material is assumed to be linearly elastic. Prediction of the initial elastic moduli are addressed in Part I. Closed form expressions for the material constants are presented as well as results using a FE model of the characteristic cell. Comparison between measurements and predictions is very favorable. The paper finishes with results from a limited parametric study of the elastic moduli. The results demonstrate that inclusion of the geometric complexities mentioned above is essential for successful prediction of the moduli of such foams. The nonlinear parts of the response including the foam crushing behavior are addressed in Part II.
We report the observation of new properties of primary cosmic rays He, C, and O measured in the rigidity (momentum/charge) range 2 GV to 3 TV with 90×10^{6} helium, 8.4×10^{6} carbon, and 7.0×10^{6} ...oxygen nuclei collected by the Alpha Magnetic Spectrometer (AMS) during the first five years of operation. Above 60 GV, these three spectra have identical rigidity dependence. They all deviate from a single power law above 200 GV and harden in an identical way.
We report on the observation of new properties of secondary cosmic rays Li, Be, and B measured in the rigidity (momentum per unit charge) range 1.9 GV to 3.3 TV with a total of 5.4×10^{6} nuclei ...collected by AMS during the first five years of operation aboard the International Space Station. The Li and B fluxes have an identical rigidity dependence above 7 GV and all three fluxes have an identical rigidity dependence above 30 GV with the Li/Be flux ratio of 2.0±0.1. The three fluxes deviate from a single power law above 200 GV in an identical way. This behavior of secondary cosmic rays has also been observed in the AMS measurement of primary cosmic rays He, C, and O but the rigidity dependences of primary cosmic rays and of secondary cosmic rays are distinctly different. In particular, above 200 GV, the secondary cosmic rays harden more than the primary cosmic rays.
TMPRSS4 is a novel type II transmembrane serine protease found at the cell surface that is highly expressed in pancreatic, colon and gastric cancer tissues. However, the biological functions of ...TMPRSS4 in cancer are unknown. Here we show, using reverse transcription-PCR, that TMPRSS4 is highly elevated in lung cancer tissues compared with normal tissues and is also broadly expressed in a variety of human cancer cell lines. Knockdown of TMPRSS4 by small interfering RNA treatment in lung and colon cancer cell lines was associated with reduction of cell invasion and cell-matrix adhesion as well as modulation of cell proliferation. Conversely, the invasiveness, motility and adhesiveness of SW480 colon carcinoma cells were significantly enhanced by TMPRSS4 overexpression. Furthermore, overexpression of TMPRSS4 induced loss of E-cadherin-mediated cell-cell adhesion, concomitant with the induction of SIP1/ZEB2, an E-cadherin transcriptional repressor, and led to epithelial-mesenchymal transition events, including morphological changes, actin reorganization and upregulation of mesenchymal markers. TMPRSS4-overexpressing cells also displayed markedly increased metastasis to the liver in nude mice upon intrasplenic injection. Taken together, these studies suggest that TMPRSS4 controls the invasive and metastatic potential of human cancer cells by facilitating an epithelial-mesenchymal transition; TMPRSS4 may be a potential therapeutic target for cancer treatment.
BACKGROUND AND PURPOSEThe safety and efficacy of tirofiban during endovascular therapy in patients undergoing intravenous thrombolysis with recombinant IV tPA remain unclear. This study aimed to ...investigate the safety and efficacy of intra-arterial tirofiban use during endovascular therapy in patients treated with IV tPA. MATERIALS AND METHODSUsing a multicenter registry, we enrolled patients with acute ischemic stroke who underwent endovascular therapy. Safety outcomes included postprocedural parenchymal hematoma type 2 and/or thick subarachnoid hemorrhage, intraventricular hemorrhage, and 3-month mortality. Efficacy outcomes included the successful reperfusion rate, postprocedural reocclusion, and good outcomes at 3 months (mRS scores of 0-2). The tirofiban effect on the outcomes was evaluated using a multivariable analysis while adjusting for potential confounders. RESULTSAmong enrolled patients, we identified 314 patients with stroke (279 and 35 patients in the no tirofiban and tirofiban groups, respectively) due to an intracranial artery occlusion who underwent endovascular therapy with intravenous thrombolysis. A multivariable analysis revealed no association of intra-arterial tirofiban with postprocedural parenchymal hematoma type and/or thick subarachnoid hemorrhage (adjusted OR, 1.07; 95% CI, 0.20-4.10; P = .918), intraventricular hemorrhage (adjusted OR, 0.43; 95% CI, 0.02-2.85; P = .467), and 3-month mortality (adjusted OR, 0.38; 95% CI, 0.04-1.87; P = .299). Intra-arterial tirofiban was not associated with good outcome (adjusted OR, 2.22; 95% CI, 0.89 -6.12; P = .099). CONCLUSIONSUsing intra-arterial tirofiban during endovascular therapy after IV tPA could be safe.
We report on the effects of carbon content on the martensitic transformation and its contribution to the work-hardening behavior of Fe–Mn–C steels during tensile deformation based on analysis by ...X-ray diffraction, electron backscatter diffraction and transmission electron microscopy. Austenite/ε-martensite dual-phase Fe–17Mn–C (wt.%) steels containing different carbon contents (0.01, 0.10, 0.20 wt.%) were investigated before, during and after tensile deformation. Before deformation, the transformation of austenite to thermally induced ε-martensite on cooling was suppressed as the carbon content increases. To precisely monitor microstructural changes during deformation, stepwise loading experiments were carried out in combination with electron backscatter diffraction analysis. This approach revealed that with increasing carbon content, the kinetics of transformation of γ phase to deformation stimulated ε-martensite became faster, while that of ε-martensite to α’-martensite was sluggish. We attribute this controversial effect to an increased γ grain size by the microstructural refinement of thermally induced ε-martensite and the reduction of solid solution strengthening effects by the redistribution of solute carbon. In addition, the dependence of deformation-induced ε-martensite on the loading direction differed from that of α’-martensite, and the evolution of α’ morphology was controlled by achieving appropriate levels of strain during stepwise loading. Based on the observations at the surface and inside the bulk after deformation, insights into various deformation-driven displacive phenomena, such as the formation of α’-martensite at the nonintersecting parts of two εinitial bands, the presence of nanotwinned bundles inside austenite, cementite precipitation inside α’-martensite, and the origin of the serrated flow in strain–stress curves, were obtained. Therefore, the present study is able assist in identifying whether the deformation-induced martensitic transformation varied as a function of carbon content and the resulting fracture behavior, thereby enabling us to understand the work-hardening behavior of these steels.
We report the observation of new properties of primary cosmic rays, neon (Ne), magnesium (Mg), and silicon (Si), measured in the rigidity range 2.15 GV to 3.0 TV with 1.8 × 106 Ne , 2.2 × 106 Mg , ...and 1.6 × 106 Si nuclei collected by the Alpha Magnetic Spectrometer experiment on the International Space Station. The Ne and Mg spectra have identical rigidity dependence above 3.65 GV. The three spectra have identical rigidity dependence above 86.5 GV, deviate from a single power law above 200 GV, and harden in an identical way. Unexpectedly, above 86.5 GV the rigidity dependence of primary cosmic rays Ne, Mg, and Si spectra is different from the rigidity dependence of primary cosmic rays He, C, and O. This shows that the Ne, Mg, and Si and He, C, and O are two different classes of primary cosmic rays.
This work examines the use of image surveillance UAVs for relay communication between ground users and a remote base station (BS). UAVs take aerial images of the surveillance region and forward them ...to the BS while serving the uplink transmission demands of ground users. We first consider the single-UAV scenario and jointly determine the UAV's trajectory, task assignment, user association, and rate allocation by maximizing the sum-log-throughput of the users subject to constraints on the surveillance coverage, image transmission requirements, and relay capacity. The resulting mixed-integer nonlinear programming problem is solved by an inexact block coordinate descent (BCD) algorithm where we inherit ideas from the exact penalty method for mathematical programming with equilibrium constraints to relax the integer constraints and the successive convex approximation approach to address the non-convexity of the trajectory optimization problem. Then, we extend the proposed framework to the case with multiple UAVs that are dispatched to cover a wide surveillance region. The UAVs may complete both relay and surveillance tasks more efficiently through cooperation and proper task allocation for UAVs. A similar BCD algorithm is adopted to solve the problem. Numerical simulations are provided to demonstrate the effectiveness of the proposed scheme over several baseline methods.
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