Abstract
We present the discovery of TOI 540 b, a hot planet slightly smaller than Earth orbiting the low-mass star 2MASS J05051443-4756154. The planet has an orbital period of
P
= 1.239149 days ...(±170 ms) and a radius of
, and is likely terrestrial based on the observed mass–radius distribution of small exoplanets at similar insolations. The star is 14.008 pc away and we estimate its mass and radius to be
and
, respectively. The star is distinctive in its very short rotational period of
hr and correspondingly small Rossby number of 0.007 as well as its high X-ray-to-bolometric luminosity ratio of
based on a serendipitous XMM-Newton detection during a slew operation. This is consistent with the X-ray emission being observed at a maximum value of
as predicted for the most rapidly rotating M dwarfs. TOI 540 b may be an alluring target to study atmospheric erosion due to the strong stellar X-ray emission. It is also among the most accessible targets for transmission and emission spectroscopy and eclipse photometry with the James Webb Space Telescope, and may permit Doppler tomography with high-resolution spectroscopy during transit. This discovery is based on precise photometric data from the Transiting Exoplanet Survey Satellite and ground-based follow-up observations by the MEarth team.
Orange II (O-II), a water-soluble ionic azo dye, aggregates and eventually forms needle-like crystals at concentrations greater than 0.15 M. However, when equimolar amounts of γ-cyclodextrin (γ-CD) ...are added to solutions containing O-II at 0.025 M or higher, the solution’s appearance rapidly changes presenting a viscous, birefringent liquid, a lyotropic liquid crystalline solution. Birefringence is absent when viewing aqueous solutions of only O-II or γ-CD at concentrations greater than 0.03 M. Using ultraviolet–visible (UV–vis) and fluorescence spectroscopy, coupled with conductivity measurements, we postulate a structure for the basic “building block” of the self-assembly that eventually gives rise to a rodlike superstructure, leading to the formation of a lyotropic liquid crystalline phase.
Abstract
We present an estimate of the occurrence rate of hot Jupiters (7
R
⊕
≤
R
p
≤ 2
R
J
, 0.8 ≤
P
b
≤ 10 days) around early-type M dwarfs based on stars observed by the Transiting Exoplanet ...Survey Satellite (TESS) during its primary mission. We adopt stellar parameters from the TESS Input Catalog and construct a sample of 60,819 M dwarfs with 10.5 ≤
T
mag
≤ 13.5, effective temperatures 2900 ≤
T
eff
≤ 4000 K, and stellar masses 0.45 ≤
M
*
≤ 0.65
M
⊙
. We conduct a uninformed transit search using a detection pipeline based on the box least square search and characterize the searching completeness through an injection and recovery experiment. We combine a series of vetting steps including light centroid measurement, odd/even and secondary eclipse analysis, rotation and transit period synchronization tests as well as inspecting the ground-based photometric, spectroscopic, and imaging observations. Finally, we find a total of nine planet candidates, all of which are known TESS objects of interest. We obtain an occurrence rate of 0.27% ± 0.09% for hot Jupiters around early-type M dwarfs that satisfy our selection criteria. Compared with previous studies, the occurrence rate of hot Jupiters around early-type M dwarfs is smaller than all measurements for FGK stars, although they are consistent within 1
σ
–2
σ
. There is a trend that the occurrence rate of hot Jupiters has a peak at G dwarfs and falls toward both hotter and cooler stars. Combining results from transit, radial velocity, and microlensing surveys, we find that hot Jupiters around early-type M dwarfs possibly show a steeper decrease in the occurrence rate per logarithmic semimajor axis bin (
dN
/
d
log
10
a
) when compared with FGK stars.
We perform a study of stellar flares for the 24,809 stars observed with 2 minute cadence during the first two months of the TESS mission. Flares may erode exoplanets' atmospheres and impact their ...habitability, but might also trigger the genesis of life around small stars. TESS provides a new sample of bright dwarf stars in our galactic neighborhood, collecting data for thousands of M dwarfs that might host habitable exoplanets. Here, we use an automated search for flares accompanied by visual inspection. Then, our public allesfitter code robustly selects the appropriate model for potentially complex flares via Bayesian evidence. We identify 1228 flaring stars, 673 of which are M dwarfs. Among 8695 flares in total, the largest superflare increased the stellar brightness by a factor of 16.1. Bolometric flare energies range from 1031.0 to 1036.9 erg, with a median of 1033.1 erg. Furthermore, we study the flare rate and energy as a function of stellar type and rotation period. We solidify past findings that fast rotating M dwarfs are the most likely to flare and that their flare amplitude is independent of the rotation period. Finally, we link our results to criteria for prebiotic chemistry, atmospheric loss through coronal mass ejections, and ozone sterilization. Four of our flaring M dwarfs host exoplanet candidates alerted on by TESS, for which we discuss how these effects can impact life. With upcoming TESS data releases, our flare analysis can be expanded to almost all bright small stars, aiding in defining criteria for exoplanet habitability.
The lipid envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an essential component of the virus; however, its molecular composition is undetermined. Addressing this ...knowledge gap could support the design of antiviral agents as well as further our understanding of viral-host protein interactions, infectivity, pathogenicity, and innate immune system clearance. Lipidomics revealed that the virus envelope comprised mainly phospholipids (PLs), with some cholesterol and sphingolipids, and with cholesterol/phospholipid ratio similar to lysosomes. Unlike cellular membranes, procoagulant amino-PLs were present on the external side of the viral envelope at levels exceeding those on activated platelets. Accordingly, virions directly promoted blood coagulation. To investigate whether these differences could enable selective targeting of the viral envelope in vivo, we tested whether oral rinses containing lipid-disrupting chemicals could reduce infectivity. Products containing PL-disrupting surfactants (such as cetylpyridinium chloride) met European virucidal standards in vitro; however, components that altered the critical micelle concentration reduced efficacy, and products containing essential oils, povidone-iodine, or chlorhexidine were ineffective. This result was recapitulated in vivo, where a 30-s oral rinse with cetylpyridinium chloride mouthwash eliminated live virus in the oral cavity of patients with coronavirus disease 19 for at least 1 h, whereas povidone-iodine and saline mouthwashes were ineffective. We conclude that the SARS-CoV-2 lipid envelope i) is distinct from the host plasma membrane, which may enable design of selective antiviral approaches; ii) contains exposed phosphatidylethanolamine and phosphatidylserine, which may influence thrombosis, pathogenicity, and inflammation; and iii) can be selectively targeted in vivo by specific oral rinses.
We present a visible-light full orbital phase curve of the transiting planet WASP-18b measured by the TESS mission. The phase curve includes the transit, secondary eclipse, and sinusoidal modulations ...across the orbital phase shaped by the planet's atmospheric characteristics and the star-planet gravitational interaction. We measure the beaming (Doppler boosting) and tidal ellipsoidal distortion phase modulations and show that the amplitudes of both agree with theoretical expectations. We find that the light from the planet's dayside hemisphere occulted during secondary eclipse, with a relative brightness of ppm, is dominated by thermal emission, leading to an upper limit on the geometric albedo in the TESS band of 0.048 ( ). We also detect the phase modulation due to the planet's atmosphere longitudinal brightness distribution. We find that its maximum is well aligned with the substellar point to within 2 9 ( ). We do not detect light from the planet's nightside hemisphere, with an upper limit of 43 ppm ( ), which is 13% of the dayside brightness. The low albedo, lack of atmospheric phase shift, and inefficient heat distribution from the day to night hemispheres that we deduce from our analysis are consistent with theoretical expectations and similar findings for other strongly irradiated gas giant planets. This work demonstrates the potential of TESS data for studying the full orbital phase curves of transiting systems. Finally, we complement our study by looking for transit timing variations (TTVs) in the TESS data combined with previously published transit times, although we do not find a statistically significant TTV signal.
Selective oxidation of primary carbon-hydrogen bonds with oxygen is of crucial importance for the sustainable exploitation of available feedstocks. To date, heterogeneous catalysts have either shown ...low activity and/or selectivity or have required activated oxygen donors. We report here that supported gold-palladium (Au-Pd) nanoparticles on carbon or TiO₂ are active for the oxidation of the primary carbon-hydrogen bonds in toluene and related molecules, giving high selectivities to benzyl benzoate under mild solvent-free conditions. Differences between the catalytic activity of the Au-Pd nanoparticles on carbon and TiO₂ supports are rationalized in terms of the particle/support wetting behavior and the availability of exposed corner/edge sites.
Summary Accelerating progress in the fight against tuberculosis will require a drastic shift from a strategy focused on control to one focused on elimination. Successful disease elimination campaigns ...are characterised by locally tailored responses that are informed by appropriate data. To develop such a response to tuberculosis, we suggest a three-step process that includes improved collection and use of existing programmatic data, collection of additional data (eg, geographic information, drug resistance, and risk factors) to inform tailored responses, and targeted collection of novel data (eg, sequencing data, targeted surveys, and contact investigations) to improve understanding of tuberculosis transmission dynamics. Development of a locally targeted response for tuberculosis will require substantial investment to reconfigure existing systems, coupled with additional empirical data to evaluate the effectiveness of specific approaches. Without adoption of an elimination strategy that uses local data to target hotspots of transmission, ambitious targets to end tuberculosis will almost certainly remain unmet.
Cognitive disturbances in schizophrenia have been linked to a lower density of dendritic spines on pyramidal neurons in the prefrontal cortex (PFC). Complement component C4, which has previously been ...found at higher levels in schizophrenia, marks synapses for phagocytosis by microglia. Thus, elevated consumption of dendritic spines by microglia mediated through excessive complement activity may play a role in lower spine density in schizophrenia. However, it is unclear if microglia themselves have the molecular capacity for enhanced phagocytosis of spines in schizophrenia.
Transcript levels for complement components and microglia-specific phagocytic markers were quantified using quantitative PCR in the PFC of 62 matched pairs of schizophrenia and unaffected comparison subjects and in antipsychotic-exposed monkeys.
Relative to comparison subjects, schizophrenia subjects had higher mRNA levels for C4 (+154 %); C1q (+69 %), which initiates the classical complement pathway that includes C4; and for microglia-specific markers that enable phagocytic activity including TAM receptor tyrosine kinases Axl (+27 %) and MerTK (+27 %) and lysosome-associated glycoprotein CD68 (+27 %) (all p ≤ .042). Transcript levels for microglial phagocytic markers were correlated with C4 mRNA levels in schizophrenia subjects (all r ≥ 0.31, p ≤ .015). We also found further evidence consistent with microglial activation in schizophrenia, including higher mRNA levels for THIK1 (TWIK-related halothane-inhibited potassium channel: +30 %) and lower mRNA levels for the purinergic receptor P2Y12 (−27 %) (all p ≤ .016). Transcript levels were unchanged in antipsychotic-exposed monkeys.
These results are consistent with the presence of increased complement activity and an elevated molecular capacity of microglia for phagocytosis in the same schizophrenia subjects.
Abstract
AU Mic is a young (∼24 Myr), pre-main-sequence M dwarf star that was observed in the first month of science observations of the Transiting Exoplanet Survey Satellite (TESS) and reobserved 2 ...years later. This target has photometric variability from a variety of sources that is readily apparent in the TESS light curves; spots induce modulation in the light curve, flares are present throughout (manifesting as sharp rises with slow exponential decay phases), and transits of AU Mic b may be seen by eye as dips in the light curve. We present a combined analysis of both TESS Sector 1 and Sector 27 AU Mic light curves including the new 20 s cadence data from TESS Year 3. We compare flare rates between both observations and analyze the spot evolution, showing that the activity levels increase slightly from Sector 1 to Sector 27. Furthermore, the 20 s data collection allows us to detect more flares, smaller flares, and better resolve flare morphology in white light as compared to the 2 minute data collection mode. We also refine the parameters for AU Mic b by fitting three additional transits of AU Mic b from Sector 27 using a model that includes stellar activity. We show that the transits exhibit clear transit timing variations with an amplitude of ∼80 s. We also detect three transits of a 2.8
R
⊕
planet, AU Mic c, which has a period of 18.86 days.
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