Sensorineural hearing loss (SNHL) has been reported rarely in patients with meningeal carcinomatosis (MC). We summarized the clinical data of eight MC patients with SNHL and 35 patients reported from ...publications. In the eight patients with SNHL, the medium onset age was 48 (range from 37 to 66) years and six (75%) were male. Seven (87.5%) suffered from headaches as the initial symptom, and they experienced SNHL during the first two months after the occurrence of headaches (0.5 to 2 months, average 1.5 months). The audiogram configuration was flat in three patients (37.5%) and showed total deafness in five patients (62.5%). The damage of cranial nerves VI (abducens) was observed in six patients (75%), and four patients (50%) had cranial nerves VII (facial) injury during the disease course. The percentage of damage of cranial nerves was higher than the patients without SNHL (VIth, 75.0% vs. 13.3%, p = 0.002 and VIIth 50.0% vs. 6.7%, p = 0.012). Four (50%) patients suffered from lung adenocarcinoma as primary tumor, two (25%) experienced stomach adenocarcinoma, one had colon cancer, and one patient was unknown. The symptom of SNHL improved after individualized therapy in four patients (focal radiotherapy and chemotherapy for three patients and whole brain radiotherapy for one patient), but all passed away from 2 to 11 months after diagnosis. Total deafness and flat hearing loss in audiogram were the common types of SNHL resulting from MC. MC patients with SNHL were more likely to suffer from the damage of other cranial nerves, especially to cranial nerves VI and VII. Treatment might improve SNHL, but not improve the case fatality rate.
Immune-mediated cerebellar ataxias (IMCAs) are common in paraneoplastic cerebellar degeneration (PCD) but rarely occur in patients with neuronal surface antibodies (NSAbs). Although cerebellar ...ataxias (CAs) associated with anti-NMDAR and anti-CASPR2 have been reported in a few cases, they have never been studied systematically. This study aimed to analyze the characteristics of anti-NSAbs-associated CAs.
A retrospective investigation was conducted to identify patients using the keywords
and
. We collected the clinical data of 14 patients diagnosed with anti-NSAbs-associated CAs.
The median age was 33 years (16-66), and the male-to-female ratio was 4:3. Nine were positive for NMDAR-Ab, two for LGI1-Ab, two for CASPR2-Ab, and one for AMPA2R-Ab. CAs were initial symptoms in three patients and presented during the first two months of the disease course (10 days on average) among the rest of the patients. After the immunotherapy, two cases were free from symptoms, and eight cases recovered satisfactorily (10/14, 71.4%). Compared with other causes of IMCAs, anti-NSAbs were more frequently associated with additional extra-cerebellar symptoms (85.7%), mostly seizures (78.6%) and mental abnormalities (64.3%). In the CSF analysis, pleocytosis was detected in ten patients (71.4%) and oligoclonal bands (OB) were observed in nine patients (64.3%). Moreover, compared with PCD and anti-GAD65-Ab-associated CAs, anti-NSAbs-associated CAs showed a better response to immunotherapy.
IMCAs are rare and atypical in autoimmune encephalitis with neuronal surface antibodies. Compared with other forms of IMCAs, more symptoms of encephalopathy, a higher rate of pleocytosis and positive OB in CSF, and positive therapeutic effect were the key features of anti-NSAbs-associated CAs.
Rational design and fabrication of composite electrode materials via heteroatom doping and integrating with other components are of significance to improve their energy storage capacity. Herein, the ...Mo- introduced nickel sulfide thin sheets decorated with Ni–Co Layered Double Hydroxide sheets (Mo–NiS2@NiCo-LDH) grown directly on Ni foam were successfully constructed thought multistep hydrothermal method. The well-designed 2D/2D coupling structure, with interconnected thin sheets, can provide abundant uniform mesoporous structure to facilitate the electrolyte penetration and more redox active sites during energy storage process. The resulting Mo–NiS2 electrode possesses a high capacity of 207.9 mAh g−1 (1663.2 F g−1) at 1 A g−1. After integrating with NiCo-LDH, the Mo–NiS2@NiCo-LDH electrode exhibits a high capacity of 325.6 mAh g−1 (2604.8 F g−1) at 1 A g−1. Furthermore, the assembled asymmetric supercapacitor (Mo–NiS2@NiCo-LDH//AC) achieving high energy density of 38.1 W h kg−1 at a power density of 800.0 W kg−1, showing excellent cycling performance. And the fabricated aqueous Ni–Zn battery (Mo–NiS2@NiCo-LDH//Zn) shows a high capacity of 274.9 mAh g−1 at 1 A g−1 and exhibits a reversible capacity of 182.3 mAh g−1 after 700 cycles at 4 A g−1. The excellent electrochemical performance of Mo–NiS2@NiCo-LDH arises from the synergistic contributions from Mo-introduced nickel sulfide thin sheets and Ni–Co Layered Double Hydroxide nanosheets.
Display omitted
•Mo–NiS2@NiCo-LDH was successfully constructed by multistep hydrothermal method.•The Mo–NiS2@NiCo-LDH shows a high capacity of 325.6 mAh g−1 at 1 A g−1.•The Mo–NiS2@NiCo-LDH//AC asymmetric device shows excellent performance.•The Mo–NiS2@NiCo-LDH//Zn battery shows high capacity by powering a red LED.
•V2O5 yolk-shell microsphere with hierarchical structure as aqueous Li+ battery anode.•V2O5 yolk-shell microspheres show high capacity and ultrafast rate capability.•V2O5 yolk-shell microspheres ...exhibit a fast electrochemical kinetics.•V2O5//LiMn2O4 aqueous Li+ full cells achieve favorable cycle life.
Aqueous rechargeable lithium-ion batteries (ARLBs) are promising candidates in grid-scale energy storage systems due to their high safety and low cost. However, it remains a major challenge to develop advanced anode materials with favorable specific capacity and long cycle life. Herein, we fabricate V2O5 yolk-shell microspheres with hierarchical nanostructure as anode material of ARLBs. Annealing temperature-dependent experiments are carried out to investigate the evolution of crystallinity, morphology and structure of the samples. As the annealing temperature varies from 300 °C to 350 °C to 400 °C, the building blocks of microspheres gradually change from nanoplates to nanoclusters to larger nanoparticles. The electrochemical performances of different samples are compared and analyzed. In half-cell tests, the sample annealed at 350 °C (VO-350) achieves a high capacity of 258.6 mA h g − 1 at 0.5 A g − 1 and ultrafast rate capabilities such as 149.7 mA h g − 1 at 15 A g − 1. In full-cell tests, the VO-350//LiMn2O4 coin cells exhibit favorable cycle life with a capacity retention of 71.5% after 500 cycles at 1 A g − 1 and ultrafast rate capabilities such as 87.4 mA h g − 1 at 15 A g − 1. In addition, the electrochemical kinetics and energy storage mechanism of V2O5 in ARLBs are investigated.
Display omitted
The case with staphylococcus aureus meningitis accompanied by intracranial hemorrhage and cerebral infarction is very rare and cerebrovascular complications are often associated with poor outcome.
We ...describe the clinical characteristics and laboratory data of a patient with meningitis accompanied by cerebrovascular complications.
The patient, a young male, was admitted to hospital with 3 weeks of fever, 10 days of slow reaction and 2 days of left limb strength decline. Neurological examination showed cognitive dysfunction, left central hemiplegia and meningeal irritation sign. Brain Imaging examination revealed intracranial hemorrhage and multiple cerebral infarction. The elevated leucocyte and protein, as well as low glucose of cerebrospinal fluid was observed. Cerebrospinal fluid and foot blister culture both suggested staphylococcus aureus infection. With the treatment of meropenem and glucocorticoid, the condition of our patient was improved.
Detection of pathogenic bacteria is the gold standard of diagnosis, and timely diagnosis and treatment for pathogens are the keys to a good prognosis for patients.
•ZIF-67 derived CoNi2S4/Carbon/MXene composites are fabricated.•The CoNi2S4 have a structure of the hollow nanocages.•Ti3C2Tx MXene adding are operated to reduce the reunion phenomenon and improve ...the conductivity of the composites.•Carbonization process are operated to improve the conductivity and structure stability of the composites.•The CNS/C/MXene electrode exhibits high rate capability and cycling stability.
Supercapacitors have received widespread attention from scientific researchers due to the advantages of high power density, fast charging/discharging rate and long cycle life. Among them, the development of high performance and high safety electrode materials are important research topics in the field of supercapacitors. Herein, zeolitic imidazolate framework (ZIF) derivatives is a good candidate material for supercapacitors electrode because of its controllable pore rate, constant cavity and larger specific area. However, the reunion phenomenon and the damaged structure during the reaction seriously affected its electrochemical properties, especially its stability. To solve this problem, the few-layer MXene was added into ZIF-67 to inhibit the reunion of single materials and the carbonization process was operated to improve its conductivity and structure stability. In addition, the CoNi2S4/carbon/MXene (CNS/C/MXene) obtained by the solvent thermal method successfully inherited the hollow cages structure and rough surface from the precursor, expressing a better electrochemical performance. In three-electrode system, the CNS/C/MXene electrode can exhibit the specific capacitance of 1221.6 F g−1 (169.7 mAh g−1) at 1 A g−1 and still maintain a high capacitance of 966.4 F g−1 (134.2 mAh g−1) at 20 A g−1 (79.1 % of the former). After assembling it with activated carbon into asymmetric supercapacitor, the device can provide a high energy density of 19.82 Wh kg−1 at a power density of 469.31 W kg−1 and maintain about 71.17 % of the initial capacitance after 30,000 cycles under a current density of 20 A g−1, representing excellent cycle stability and rate capability.
Display omitted
Aqueous zinc-ion batteries (AZIBs) are considered as an attractive alternative to lithium-ion batteries. Although the vanadium pentoxide (V2O5) cathode exhibits high theoretical capacity of 589 mA h ...g–1 for zinc-storage, it suffers from capacity decay and sluggish Zn2+ diffusion kinetics due to the strong electrostatic interactions with Zn2+, slight dissolution in aqueous electrolytes, and low electronic conductivity. Herein, the polyaniline and alkali-earth cation (Mg2+, Ca2+) cointercalated V2O5 composites (PVO-Mg, PVO-Ca) are fabricated to boost the zinc ion storage performance of vanadium oxide cathodes. PVO-Mg exhibits an enlarged interlayer distance of 14.15 Å and a tremelliform nanoarchitecture composed of nanosheets. The intercalated polyaniline and alkali-earth cations not only expand the Zn2+ diffusion channels but also form a pillar net which can improve the structural stability and electronic conductivity of the layered structure, contributing to superior electrochemical kinetics, interfacial kinetics, and Zn2+ diffusion kinetics. Moreover, ex situ X-ray diffraction results of PVO-Mg show a nearly constant interlayer distance during the insertion and extraction of Zn2+, which indicates that polyaniline and Mg2+ firmly support the layered framework and prevent the expansion and contraction of the interlayer distance. Ex situ X-ray photoelectron spectroscopy results of PVO-Mg reveal the highly reversible formations of Zn x (CF3SO3) y (OH)2x−y ·nH2O on the electrode surface and Zn2+ inserted PVO-Mg inside the electrode, as well as a H+ and Zn2+ insertion/extraction process during which the polyaniline serves as a H+ reservoir and a capacity contributor. Consequently, the PVO-Mg electrode exhibits high capacity (387.0 mA h g–1 at 0.5 A g–1), ultrafast rate capability (199.3 mA h g–1 at 30 A g–1), improved cycling stability, and high reversibility and would be a promising cathode for high performance AZIBs.
Rational design and fabrication of efficient electrode materials can significantly enhance the electrochemical performance of supercapacitors and alkaline Zn-based batteries, especially under high ...current density. Herein, the crystalline/amorphous nickel–cobalt phosphide@nickel–cobalt boride core–shell nanospheres (NiCoP@NiCo–B) are successfully synthesized by integrating the nanosheet-assembled NiCoP hollow nanospheres (core) with amorphous NiCo–B (shell). Meanwhile, the crystalline NiCoP core can provide stable mechanical support, and the amorphous NiCo–B shell favors the electrolyte ion diffusion. The well-designed NiCoP@NiCo–B heterostructure demonstrates strong interface interactions, abundant redox active sites, and fast charge transfer/transport kinetics. The optimal electrode (NiCoP@NiCo–B-70) delivers a specific capacity as high as 193.1 mAh g–1 at 1 A g–1 and ultrahigh rate capability (87.4% of the initial specific capacity at 20 A g–1). The assembled NiCoP@NiCo–B-70//AC asymmetric supercapacitor reaches an energy density of 40.8 Wh kg–1 and power density of 400.0 W kg–1. Furthermore, the NiCoP@NiCo–B-70//Zn battery shows a high output voltage platform and a discharge capacity of 194.5 mAh g–1 at a current density of 1 A g–1 as well as outstanding rate capability. The results indicate that the synthesized crystalline/amorphous core–shell heterostructure holds great potential for practical applications in next-generation aqueous energy storage devices.
PDF
