Pursuits of wisdom Cooper, John M
2012., 20120527, 2012, 2012-05-27
eBook
This is a major reinterpretation of ancient philosophy that recovers the long Greek and Roman tradition of philosophy as a complete way of life--and not simply an intellectual discipline. ...Distinguished philosopher John Cooper traces how, for many ancient thinkers, philosophy was not just to be studied or even used to solve particular practical problems. Rather, philosophy--not just ethics but even logic and physical theory--was literally to be lived. Yet there was great disagreement about how to live philosophically: philosophy was not one but many, mutually opposed, ways of life. Examining this tradition from its establishment by Socrates in the fifth century BCE through Plotinus in the third century CE and the eclipse of pagan philosophy by Christianity,Pursuits of Wisdomexamines six central philosophies of living--Socratic, Aristotelian, Stoic, Epicurean, Skeptic, and the Platonist life of late antiquity.
The book describes the shared assumptions that allowed these thinkers to conceive of their philosophies as ways of life, as well as the distinctive ideas that led them to widely different conclusions about the best human life. Clearing up many common misperceptions and simplifications, Cooper explains in detail the Socratic devotion to philosophical discussion about human nature, human life, and human good; the Aristotelian focus on the true place of humans within the total system of the natural world; the Stoic commitment to dutifully accepting Zeus's plans; the Epicurean pursuit of pleasure through tranquil activities that exercise perception, thought, and feeling; the Skeptical eschewal of all critical reasoning in forming their beliefs; and, finally, the late Platonist emphasis on spiritual concerns and the eternal realm of Being.
Pursuits of Wisdomis essential reading for anyone interested in understanding what the great philosophers of antiquity thought was the true purpose of philosophy--and of life.
Intended as a companion to the Fundamentals of Forensic DNA Typing volume published in 2009, Advanced Topics in Forensic DNA Typing: Methodology contains 18 chapters with 4 appendices providing ...up-to-date coverage of essential topics in this important field and citation to more than 2800 articles and internet resources. The book builds upon the previous two editions of John Butler's internationally acclaimed Forensic DNA Typing textbook with forensic DNA analysts as its primary audience. This book provides the most detailed information written to-date on DNA databases, low-level DNA, validation, and numerous other topics including a new chapter on legal aspects of DNA testing to prepare scientists for expert witness testimony. Over half of the content is new compared to previous editions. A forthcoming companion volume will cover interpretation issues.
Contains the latest information - hot-topics and new technologiesWell edited, attractively laid out, and makes productive use of its four-color formatAuthor John Butler is ranked as the number one "high-impact author in legal medicine and forensic science, 2001 to 2011" by ScienceWatch.com
The Great Recession, institutional dysfunction, a growing divide between urban and rural prospects, and failed efforts to effectively address immigration have paved the way for a populist backlash ...that disrupts the postwar bargain between political elites and citizens. Whether today's populism represents a corrective to unfair and obsolete policies or a threat to liberal democracy itself remains up for debate. Yet this much is clear: these challenges indict the triumphalism that accompanied liberal democratic consolidation after the collapse of the Soviet Union. To respond to today's crisis, good leaders must strive for inclusive economic growth while addressing fraught social and cultural issues, including demographic anxiety, with frank attention. Although reforms may stem the populist tide, liberal democratic life will always leave some citizens unsatisfied. This is a permanent source of vulnerability, but liberal democracy will endure so long as citizens believe it is worth fighting for.
Patients with relapsed or refractory mantle-cell lymphoma who have disease progression during or after the receipt of Bruton's tyrosine kinase (BTK) inhibitor therapy have a poor prognosis. KTE-X19, ...an anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, may have benefit in patients with relapsed or refractory mantle-cell lymphoma.
In a multicenter, phase 2 trial, we evaluated KTE-X19 in patients with relapsed or refractory mantle-cell lymphoma. Patients had disease that had relapsed or was refractory after the receipt of up to five previous therapies; all patients had to have received BTK inhibitor therapy previously. Patients underwent leukapheresis and optional bridging therapy, followed by conditioning chemotherapy and a single infusion of KTE-X19 at a dose of 2×10
CAR T cells per kilogram of body weight. The primary end point was the percentage of patients with an objective response (complete or partial response) as assessed by an independent radiologic review committee according to the Lugano classification. Per the protocol, the primary efficacy analysis was to be conducted after 60 patients had been treated and followed for 7 months.
A total of 74 patients were enrolled. KTE-X19 was manufactured for 71 patients and administered to 68. The primary efficacy analysis showed that 93% (95% confidence interval CI, 84 to 98) of the 60 patients in the primary efficacy analysis had an objective response; 67% (95% CI, 53 to 78) had a complete response. In an intention-to-treat analysis involving all 74 patients, 85% had an objective response; 59% had a complete response. At a median follow-up of 12.3 months (range, 7.0 to 32.3), 57% of the 60 patients in the primary efficacy analysis were in remission. At 12 months, the estimated progression-free survival and overall survival were 61% and 83%, respectively. Common adverse events of grade 3 or higher were cytopenias (in 94% of the patients) and infections (in 32%). Grade 3 or higher cytokine release syndrome and neurologic events occurred in 15% and 31% of patients, respectively; none were fatal. Two grade 5 infectious adverse events occurred.
KTE-X19 induced durable remissions in a majority of patients with relapsed or refractory mantle-cell lymphoma. The therapy led to serious and life-threatening toxic effects that were consistent with those reported with other CAR T-cell therapies. (Funded by Kite, a Gilead company; ZUMA-2 ClinicalTrials.gov number, NCT02601313.).
HCI Models, Theories, and Frameworks provides a thorough pedagological survey of the science of Human-Computer Interaction (HCI). HCI spans many disciplines and professions, including anthropology, ...cognitive psychology, computer graphics, graphical design, human factors engineering, interaction design, sociology, and software engineering. While many books and courses now address HCI technology and application areas, none has addressed HCI's multidisciplinary foundations with much scope or depth. This text fills a huge void in the university education and training of HCI students as well as in the lifelong learning and professional development of HCI practitioners. Contributors are leading researchers in the field of HCI. If you teach a second course in HCI, you should consider this book. This book provides a comprehensive understanding of the HCI concepts and methods in use today, presenting enough comparative detail to make primary sources more accessible. Chapters are formatted to facilitate comparisons among the various HCI models. Each chapter focuses on a different level of scientific analysis or approach, but all in an identical format, facilitating comparison and contrast of the various HCI models. Each approach is described in terms of its roots, motivation, and type of HCI problems it typically addresses. The approach is then compared with its nearest neighbors, illustrated in a paradigmatic application, and analyzed in terms of its future. This book is essential reading for professionals, educators, and students in HCI who want to gain a better understanding of the theoretical bases of HCI, and who will make use of a good background, refresher, reference to the field and/or index to the literature. * Contributors are leading researchers in the field of Human-Comptuter Interaction * Fills a major gap in current literature about the rich scientific foundations of HCI * Provides a thorough pedogological survey of the science of HCI
Some blame the violence and unrest in the Muslim world on Islam itself, arguing that the religion and its history is inherently bloody. Others blame the United States, arguing that American attempts ...to spread democracy by force have destabilized the region, and that these efforts are somehow radical or unique. Challenging these views, The Clash of Ideas in World Politics reveals how the Muslim world is in the throes of an ideological struggle that extends far beyond the Middle East, and how struggles like it have been a recurring feature of international relations since the dawn of the modern European state.
John Hobson challenges the ethnocentric bias of mainstream accounts of the Rise of the West. It is often assumed that since Ancient Greek times Europeans have pioneered their own development, and ...that the East has been a passive by-stander in the story of progressive world history. Hobson argues that there were two processes that enabled the Rise of the 'Oriental West'. First, each major developmental turning point in Europe was informed in large part by the assimilation of Eastern inventions (e.g. ideas, technologies and institutions) which diffused from the more advanced East across the Eastern-led global economy between 500–1800. Second, the construction of European identity after 1453 led to imperialism, through which Europeans appropriated many Eastern resources (land, labour and markets). Hobson's book thus propels the hitherto marginalised Eastern peoples to the forefront of the story of progress in world history.
"One of the most important political books of 2018."-Rod Dreher,American ConservativeOf the three dominant ideologies of the twentieth century-fascism, communism, and liberalism-only the last ...remains. This has created a peculiar situation in which liberalism's proponents tend to forget that itisan ideology and not the natural end-state of human political evolution. As Patrick Deneen argues in this provocative book, liberalism is built on a foundation of contradictions: it trumpets equal rights while fostering incomparable material inequality; its legitimacy rests on consent, yet it discourages civic commitments in favor of privatism; and in its pursuit of individual autonomy, it has given rise to the most far-reaching, comprehensive state system in human history. Here, Deneen offers an astringent warning that the centripetal forces now at work on our political culture are not superficial flaws but inherent features of a system whose success is generating its own failure.
Understanding the evolution of eukaryotic cellular complexity is one of the grand challenges of modern biology. It has now been firmly established that mitochondria and plastids, the classical ...membrane-bound organelles of eukaryotic cells, evolved from bacteria by endosymbiosis. In the case of mitochondria, evidence points very clearly to an endosymbiont of α-proteobacterial ancestry. The precise nature of the host cell that partnered with this endosymbiont is, however, very much an open question. And while the host for the cyanobacterial progenitor of the plastid was undoubtedly a fully-fledged eukaryote, how — and how often — plastids moved from one eukaryote to another during algal diversification is vigorously debated. In this article I frame modern views on endosymbiotic theory in a historical context, highlighting the transformative role DNA sequencing played in solving early problems in eukaryotic cell evolution, and posing key unanswered questions emerging from the age of comparative genomics.
Archibald reviews our current understanding of how key features of the eukaryotic cell evolved, placing an emphasis on mitochondria and plastids as well as explaining the historical events that gave rise to the endosymbiotic model.
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