Abstract
We investigate the stellar populations for a sample of 161 massive, mainly quiescent galaxies at 〈
z
obs
〉 = 0.8 with deep Keck/DEIMOS rest-frame optical spectroscopy (HALO7D survey). With ...the fully Bayesian framework
Prospector
, we simultaneously fit the spectroscopic and photometric data with an advanced physical model (including nonparametric star formation histories, emission lines, variable dust attenuation law, and dust and active galactic nucleus emission), together with an uncertainty and outlier model. We show that both spectroscopy and photometry are needed to break the dust–age–metallicity degeneracy. We find a large diversity of star formation histories: although the most massive (
M
⋆
> 2 × 10
11
M
⊙
) galaxies formed the earliest (formation redshift of
z
f
≈ 5–10 with a short star formation timescale of
τ
SF
≲ 1 Gyr), lower-mass galaxies have a wide range of formation redshifts, leading to only a weak trend of
z
f
with
M
⋆
. Interestingly, several low-mass galaxies have formation redshifts of
z
f
≈ 5–8. Star-forming galaxies evolve about the star-forming main sequence, crossing the ridgeline several times in their past. Quiescent galaxies show a wide range and continuous distribution of quenching timescales (
τ
quench
≈ 0–5 Gyr) with a median of
〈
τ
quench
〉
=
1.0
−
0.9
+
0.8
Gyr
and of quenching epochs of
z
quench
≈ 0.8–5.0 (
〈
z
quench
〉
=
1.3
−
0.4
+
0.7
). This large diversity of quenching timescales and epochs points toward a combination of internal and external quenching mechanisms. In our sample, rejuvenation and “late bloomers” are uncommon. In summary, our analysis supports the “grow-and-quench” framework and is consistent with a wide and continuously populated diversity of quenching timescales.
Meta-analyses of colorectal cancer risk factors Johnson, Constance M.; Wei, Caimiao; Ensor, Joe E. ...
CCC. Cancer causes & control/CCC, Cancer causes & control,
06/2013, Letnik:
24, Številka:
6
Journal Article
Recenzirano
Odprti dostop
Purpose: Demographic, behavioral, and environmental factors have been associated with increased risk of colorectal cancer (CRC). We reviewed the published evidence and explored associations between ...risk factors and CRC incidence. Methods: We identified 12 established non-screening CRC risk factors and performed a comprehensive review and meta-analyses to quantify each factor's impact on CRC risk. We used random-effects models of the logarithms of risks across studies: inverse-variance weighted averages for dichotomous factors and generalized least squares for dose–response for multi-level factors. Results: Significant risk factors include inflammatory bowel disease (RR = 2.93, 95 % CI 1.79–4.81); CRC history in first-degree relative (RR = 1.80, 95 % CI 1.61–2.02); body mass index (BMI) to overall population (RR = 1.10 per 8 kg/m² increase, 95 % CI 1.08–1.12); physical activity (RR = 0.88, 95 % CI 0.86–0.91 for 2 standard deviations increased physical activity score); cigarette smoking (RR = 1.06, 95 % CI 1.03–1.08 for 5 pack-years); and consumption of red meat (RR = 1.13, 95 % CI 1.09–1.16 for 5 servings/week), fruit (RR = 0.85, 95 % CI 0.75–0.96 for 3 servings/day), and vegetables (RR = 0.86, 95 % CI 0.78–0.94 for 5 servings/day). Conclusions: We developed a comprehensive risk modeling strategy that incorporates multiple effects to predict an individual's risk of developing CRC. Inflammatory bowel disease and history of CRC in first-degree relatives are associated with much higher risk of CRC. Increased BMI, red meat intake, cigarette smoking, low physical activity, low vegetable consumption, and low fruit consumption were associated with moderately increased risk of CRC.
We employ measurements of the Delta *a/Fe ratio derived from low-resolution (R ~ 2000) spectra of 17,277 G-type dwarfs from the SEGUE survey to separate them into likely thin- and thick-disk ...subsamples. Both subsamples exhibit strong gradients of orbital rotational velocity with metallicity, of opposite signs, --20 to --30 km s--1 dex--1 for the thin-disk and +40 to +50 km s--1 dex--1 for the thick-disk population. The rotational velocity is uncorrelated with Galactocentric distance for the thin-disk subsample and exhibits a small trend for the thick-disk subsample. The rotational velocity decreases with distance from the plane for both disk components, with similar slopes (--9.0 ? 1.0 km s--1 kpc--1). Thick-disk stars exhibit a strong trend of orbital eccentricity with metallicity (about --0.2 dex--1), while the eccentricity does not change with metallicity for the thin-disk subsample. The eccentricity is almost independent of Galactocentric radius for the thin-disk population, while a marginal gradient of the eccentricity with radius exists for the thick-disk population. Both subsamples possess similar positive gradients of eccentricity with distance from the Galactic plane. The shapes of the eccentricity distributions for the thin- and thick-disk populations are independent of distance from the plane, and include no significant numbers of stars with eccentricity above 0.6. Among several contemporary models of disk evolution that we consider, radial migration appears to have played an important role in the evolution of the thin-disk population, but possibly less so for the thick disk, relative to the gas-rich merger or disk heating scenarios. We emphasize that more physically realistic models and simulations need to be constructed in order to carry out the detailed quantitative comparisons that our new data enable.
Medical record abstraction (MRA) is often cited as a significant source of error in research data, yet MRA methodology has rarely been the subject of investigation. Lack of a common framework has ...hindered application of the extant literature in practice, and, until now, there were no evidence-based guidelines for ensuring data quality in MRA. We aimed to identify the factors affecting the accuracy of data abstracted from medical records and to generate a framework for data quality assurance and control in MRA.
Candidate factors were identified from published reports of MRA. Content validity of the top candidate factors was assessed via a four-round two-group Delphi process with expert abstractors with experience in clinical research, registries, and quality improvement. The resulting coded factors were categorized into a control theory-based framework of MRA. Coverage of the framework was evaluated using the recent published literature.
Analysis of the identified articles yielded 292 unique factors that affect the accuracy of abstracted data. Delphi processes overall refuted three of the top factors identified from the literature based on importance and five based on reliability (six total factors refuted). Four new factors were identified by the Delphi. The generated framework demonstrated comprehensive coverage. Significant underreporting of MRA methodology in recent studies was discovered.
The framework generated from this research provides a guide for planning data quality assurance and control for studies using MRA. The large number and variability of factors indicate that while prospective quality assurance likely increases the accuracy of abstracted data, monitoring the accuracy during the abstraction process is also required. Recent studies reporting research results based on MRA rarely reported data quality assurance or control measures, and even less frequently reported data quality metrics with research results. Given the demonstrated variability, these methods and measures should be reported with research results.
Abstract Background Using regulatory focus theory, an intervention of daily weight loss-sustaining messages was developed and tested for acceptability, feasibility, and efficacy on helping people ...sustain weight loss. Methods Participants (n = 120) were randomized to a promotion, prevention, or an attention-control text message group after completion of a weight loss program. Participants completed baseline assessments, and reported their weight at 1 and 3 months postbaseline. Results Participants found the message content and intervention acceptable and valuable. A minimum of one message per day delivered at approximately 8:00 am was deemed the optimal delivery time and frequency. The sustained weight loss rate at month 3 for the control, promotion, and prevention groups was 90%, 95%, and 100%, respectively. Medium-to-large effects were observed for the promotion and prevention groups at month 1 and for prevention at month 3 relative to controls. The mean weight loss for promotion and prevention was 15 pounds, compared with 10 in the controls at month 3. Conclusion A clinically significant decrease in mean weight, higher rate of sustained weight loss, and medium-to-large effects on sustained weight loss occurred in the promotion and prevention interventions. Tools such as this text message-based intervention that are constructed and guided by evidence-based content and theoretical constructs show promise in helping people sustain healthy behaviors that can lead to improved health outcomes.
•Coping behaviors by aging LGBTQ adults influence healthcare utilization•Social support remains a protective factor for aging LGBTQ adults utilizing healthcare•Significant differences exist among ...aging LGBTQ adults utilizing healthcare•Aging LGBTQ adults may delay seeking treatment because of provider discrimination
This systematic review was conducted to identify, synthesize, and elucidate the coping mechanisms described by aging lesbian, gay, bisexual, transgender, and queer (LGBTQ) adults (60+) when utilizing healthcare.
A comprehensive literature search was conducted in Embase and Ovid databases to identify studies of aging LGBTQ adults using coping mechanisms during healthcare utilization. Qualitative and quantitative studies published in English between 1969 and 2020 were included and assessed with COREQ, STROBE Statement, and CASP instruments.
Of 227 articles identified, six were included in the review. The final synthesis revealed that coping mechanisms were associated with social support, social network size, provider competency, and disclosure management. Frequency of appointments varied when seeking healthcare, and one study indicated delay in treatment.
This systematic review highlights various coping mechanisms associated with healthcare utilization and supports the need to develop research uniquely focused on aging LGBTQ adults.
Spectroscopic and photometric data for likely member stars of five Galactic globular clusters (M3, M53, M71, M92, and NGC 5053) and three open clusters (M35, NGC 2158, and NGC 6791) are processed by ...the current version of the SEGUE Stellar Parameter Pipeline (SSPP), in order to determine estimates of metallicities and radial velocities (RVs) for the clusters. These results are then compared to values from the literature. We find that the mean metallicity (Fe/H) and mean radial velocity (RV) estimates for each cluster are almost all within 2 Delta *s of the adopted literature values; most are within 1 Delta *s. We also demonstrate that the new version of the SSPP achieves small, but noteworthy, improvements in Fe/H estimates at the extrema of the cluster metallicity range, as compared to a previous version of the pipeline software. These results provide additional confidence in the application of the SSPP for studies of the abundances and kinematics of stellar populations in the Galaxy.
Self-management and lifestyle interventions are a key factor in treatment outcomes for persons with bipolar disorder (BD). A virtual environment (VE), due to it's ability to provide flexibility of ...involvement in its platform, may be an alternative to face-to-face treatment to provide support for self-management. The purpose of this study is to explore how a VE, developed for chronic illness self-management, may be modified to promote self-management and lifestyle changes in those with BD.
This study used a qualitative description design with focus groups. Data were collected via minimally structured interviews and analyzed using thematic content analysis. A total of seven focus groups were conducted, and the sample consisted of 30 adults with BD. Age range was 21–77 years with 21 females, seven males, and two non-binary individuals.
Five themes emerged from the findings: Self-management and lifestyle interventions with regards to (1) mental health; (2) holistic health; (3) role of peers; (4) involvement of the family; (5) technological aspects of the VE.
Focus group participants suggested that the VE may be an efficacious way to enhance self-management and promote lifestyle interventions in those with BD. Research is needed to adapt such platforms to the need of the patients and examine its' effect on health outcomes.
•A virtual environment (VE) for chronic disease self-management has shown promising results in the field of diabetes.•Such as VE may be adapted to enhance self-management and lifestyle changes in those with bipolar disorder (BD).•Support for BD may be provided in the areas of mental and physical health, financial literacy, and job support.•The roles of peer support and family involvement in self-management may also be considered in the adaptation.
This research explored baby boomer gay men's experiences with primary healthcare and their perspectives of future long-term care. Baby boomer gay men's perspectives about primary healthcare remain ...understudied in the United States. A descriptive qualitative study was conducted with 30 baby boomer men in the Southwest USA. We used semi-structured interviews to assess participants' initiation and maintenance of primary healthcare, disclosure of sexual orientation to providers, and perspectives about future healthcare needs, including long-term care. Data were analyzed with a latent thematic analysis. We found baby boomer gay men anticipate discrimination because of their sexual orientation whenever they establish healthcare with new providers. Participants identified circumstantial comfort in the new healthcare setting as a key motivator to disclose their sexual orientation. Thus, baby boomer gay men specifically sought gay or gay-friendly healthcare providers to ease the burden of managing disclosure and to permit free discussion of their sexual orientation and healthcare needs. Participants faced recurring anticipation of rejection and discrimination from healthcare providers, which extends to their perceptions of current healthcare encounters and future long-term care placement. Healthcare providers would benefit from understanding the practice implications of this dynamic. Future research on primary healthcare inclusivity is needed.This research explored baby boomer gay men's experiences with primary healthcare and their perspectives of future long-term care. Baby boomer gay men's perspectives about primary healthcare remain understudied in the United States. A descriptive qualitative study was conducted with 30 baby boomer men in the Southwest USA. We used semi-structured interviews to assess participants' initiation and maintenance of primary healthcare, disclosure of sexual orientation to providers, and perspectives about future healthcare needs, including long-term care. Data were analyzed with a latent thematic analysis. We found baby boomer gay men anticipate discrimination because of their sexual orientation whenever they establish healthcare with new providers. Participants identified circumstantial comfort in the new healthcare setting as a key motivator to disclose their sexual orientation. Thus, baby boomer gay men specifically sought gay or gay-friendly healthcare providers to ease the burden of managing disclosure and to permit free discussion of their sexual orientation and healthcare needs. Participants faced recurring anticipation of rejection and discrimination from healthcare providers, which extends to their perceptions of current healthcare encounters and future long-term care placement. Healthcare providers would benefit from understanding the practice implications of this dynamic. Future research on primary healthcare inclusivity is needed.
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