In this work, we report evolution of atomic clusters in a highly under-expanded supersonic jet of Argon. A high resolution and sensitive Rayleigh scattering based experimental set-up is designed to ...overcome the limitations encountered in conventional set-ups. Further, the measurement range could be extended from a few nozzle diameters to 50 nozzle diameters. Simultaneously, we had been able to generate 2D profiles of the distribution of clusters inside the jet. This paves the way to track the growth of clusters along the flow direction experimentally, which until now was limited to few nozzle diameters. The results show that spatial distribution of clusters inside the supersonic core deviates considerably from the prediction of the free expansion model. We exploit this to estimate cluster growth along the expansion direction. Further, it is observed that the growth of the clusters gets saturated after a certain distance from the nozzle. At the jet boundary, we see substantial cluster strengthening immediately upstream of barrel shock while the normal shock exhibits disintegration of clusters. These observations are noticed for the first time, which, we believe will further the understanding of cluster dynamics in a supersonic jet.
Impaired cerebral autoregulation may predispose patients to cerebral hypoperfusion during cardiopulmonary bypass (CPB). The purpose of this study was to identify risk factors for impaired ...autoregulation during coronary artery bypass graft, valve surgery with CPB, or both and to evaluate whether near-infrared spectroscopy (NIRS) autoregulation monitoring could be used to identify this condition.
Two hundred and thirty-four patients were monitored with transcranial Doppler and NIRS. A continuous, moving Pearson’s correlation coefficient was calculated between mean arterial pressure (MAP) and cerebral blood flow (CBF) velocity, and between MAP and NIRS data, to generate the mean velocity index (Mx) and cerebral oximetry index (COx), respectively. Functional autoregulation is indicated by an Mx and COx that approach zero (no correlation between CBF and MAP); impaired autoregulation is indicated by an Mx and COx approaching 1. Impaired autoregulation was defined as an Mx ≥0.40 at all MAPs during CPB.
Twenty per cent of patients demonstrated impaired autoregulation during CPB. Based on multivariate logistic regression analysis, time-averaged COx during CPB, male gender, PaCO2, CBF velocity, and preoperative aspirin use were independently associated with impaired CBF autoregulation. Perioperative stroke occurred in six of 47 (12.8%) patients with impaired autoregulation compared with five of 187 (2.7%) patients with preserved autoregulation (P=0.011).
Impaired CBF autoregulation occurs in 20% of patients during CPB. Patients with impaired autoregulation are more likely than those with functional autoregulation to have perioperative stroke. Non-invasive monitoring autoregulation may provide an accurate means to predict impaired autoregulation.
Clinical trials registration. www.clinicaltrials.gov (NCT00769691).
The Nainital-Cape Survey Joshi, S; Martinez, P; Chowdhury, S ...
Astronomy and astrophysics (Berlin),
06/2016, Letnik:
590
Journal Article
Recenzirano
Odprti dostop
Context. The Nainital-Cape Survey is a dedicated ongoing survey program to search for and study pulsational variability in chemically peculiar (CP) stars to understand their internal structure and ...evolution. Aims. The main aims of this survey are to find new pulsating Ap and Am stars in the northern and southern hemisphere and to perform asteroseismic studies of these new pulsators. Methods. The survey is conducted using high-speed photometry. The candidate stars were selected on the basis of having Stromgren photometric indices similar to those of known pulsating CP stars. Results. Over the last decade a total of 337 candidate pulsating CP stars were observed for the Nainital-Cape Survey, making it one of the longest ground-based surveys for pulsation in CP stars in terms of time span and sample size. The previous papers of this series presented seven new pulsating variables and 229 null results. In this paper we present the light curves, frequency spectra and various astrophysical parameters of the 108 additional CP stars observed since the last reported results. We also tabulated the basic physical parameters of the known roAp stars. As a part of establishing the detection limits in the Nainital-Cape Survey, we investigated the scintillation noise level at the two observing sites used in this survey, Sutherland and Nainital, by comparing the combined frequency spectra stars observed from each location. Our analysis shows that both the sites permit the detection of variations of the order of 0.6 milli-magnitude (mmag) in the frequency range 1-4 mHz, Sutherland is on average marginally better.
A measurement of the Higgs boson mass is presented based on the combined data samples of the ATLAS and CMS experiments at the CERN LHC in the H arrow right gamma gamma and H arrow right ZZ arrow ...right 4scriptl decay channels. The results are obtained from a simultaneous fit to the reconstructed invariant mass peaks in the two channels and for the two experiments. The measured masses from the individual channels and the two experiments are found to be consistent among themselves. The combined measured mass of the Higgs boson is mH=125.09+ or -0.21 (stat)+ or -0.11 (syst) GeV.
To establish a surveillance network for cardiovascular diseases (CVD) risk factors in industrial settings and estimate the risk factor burden using standardized tools.
We conducted a baseline ...cross-sectional survey (as part of a CVD surveillance programme) of industrial populations from 10 companies across India, situated in close proximity to medical colleges that served as study centres. The study subjects were employees (selected by age and sex stratified random sampling) and their family members. Information on behavioural, clinical and biochemical determinants was obtained through standardized methods (questionnaires, clinical measurements and biochemical analysis). Data collation and analyses were done at the national coordinating centre.
We report the prevalence of CVD risk factors among individuals aged 20-69 years (n = 19 973 for the questionnaire survey, n = 10 442 for biochemical investigations); mean age was 40 years. The overall prevalence of most risk factors was high, with 50.9% of men and 51.9% of women being overweight, central obesity was observed among 30.9% of men and 32.8% of women, and 40.2% of men and 14.9% of women reported current tobacco use. Self-reported prevalence of diabetes (5.3%) and hypertension (10.9%) was lower than when measured clinically and biochemically (10.1% and 27.7%, respectively). There was marked heterogeneity in the prevalence of risk factors among the study centres.
There is a high burden of CVD risk factors among industrial populations across India. The surveillance system can be used as a model for replication in India as well as other developing countries.
Software Defined Networking (SDN) is the novel networking paradigm where decoupling of the control plane from the data plane has its inherent advantages. Controller Placement Problem (CPP) involves ...placing the optimal number of controllers at the appropriate locations while meeting prerequisites such as latency, load balancing, energy and computational time. To achieve scalability, deployment of multiple controllers on large-scale SDN is one of the key challenges. CPP can be addressed as a multi-objective combinatorial optimization problem whose solution is a trade-off between multiple optimization parameters. In this paper, a novel population-based meta-heuristic algorithm viz. Naked Mole-Rat (NMR) Algorithm has been proposed to optimize the location for controller placement based on Switch-Controller (SC), Controller-Controller (CC) latency while maintaining load balancing among the controllers. The ideas and mechanisms are illustrated using two publicly available standard topologies viz. Ernet and Savvis. The controller localization approach implemented with NMR algorithm has slightly a better result as compared with the Bat algorithm.
The genus
Usnea
Adans. (Parmeliaceae; lichenized Ascomycetes) is a typical group of mostly pale grayish-green fruticoselichens that grow as leafless mini-shrubs. More than 360 species of
Usnea
are ...known in the world.
Usnea
has long been thought to have treat various illnesses in addition to its historical use as dyes, cosmetics, preservatives, and deodorants, particularly in eastern countries such as China, Japan, Taiwan, India and Europe. The current review focuses on the traditional uses and phytochemistry aspects of different
Usnea
species, and discusses the pharmacological findings and toxicology of their extracts and isolated compounds. The available compilation of data will provide a new base for future perspectives and highlight the need for further studies of this potent herbal source to harvest more beneficial therapeutic drugs. Nineteen species of the genus
Usnea
are found to be important folk medicines all over the world. It is evident from the comparative analysis of the searched literature that the genus
Usnea
has been used for various purposes for centuries and its long and traditional medicinal history was well documented in the past. As per ancient records and recent scientific literature, the species of genus
Usnea
have been used as promising traditional medicines, exerting an array of therapeutic properties to relieve sore throats, bronchitis, cold, flu, infection, and indigestion. Phytochemical analysis confirms the general presence of a wide range of metabolites, polysaccharides, fatty acids, phenolic acids, flavonoids, terpenes, sterols, depsides, depsidones, and benzofurans. As specific constituents, usnic acid, polyphenols, and depsides have been considered as main efficacy component for antibacterial and antifungal activities. In addition, pharmacological analysis also revealed that other pure compounds and crude extracts of
Usnea
species prove to be significant anti-cancer, anti-proliferative, anti-oxidant, anti-viral, anti-inflammatory, anti-ulcer, hepatoprotective, and anti-genotoxic agents. However, there is a need for more precise investigations to examine the clinical value of both isolated pure compounds and crude extracts and to elucidate their mechanisms of action. Apart from clinical validation and elucidation of their mechanism of action, biosafety studies of the compounds are also important to legitimately use the potential bioactive compounds for the further development of future lead drugs.
The genus
Usnea
Adans. (Parmeliaceae; lichenized Ascomycetes) is a typical group of mostly pale grayish-green fruticoselichens that grow as leafless mini-shrubs.
A ZK60 magnesium alloy was processed by equal-channel angular pressing (ECAP) at 473
K to produce a grain size of ∼0.8
μm and it was then tested under dynamic conditions at strain rates up to 4.0
×
...10
3
s
−1 using a split-Hopkinson bar. The stress–strain curves in dynamic testing exhibited upwards concave curvature suggesting the occurrence of twinning. Examination by transmission electron microscopy showed that dislocation slip played a major role in the flow behavior with dislocation accumulation as the main source of work hardening. An identification of Burgers vectors revealed the extensive presence of prismatic dislocations. Rod-shaped Mg
1(Zn,Zr)
1 precipitates present in the as-received alloy become fragmented and overaged during ECAP.
Persistent inflammation can trigger altered epigenetic, inflammatory, and bioenergetic states. Inflammatory bowel disease (IBD) is an idiopathic disease characterized by chronic inflammation of the ...gastrointestinal tract, with evidence of subsequent metabolic syndrome disorder. Studies have demonstrated that as many as 42% of patients with ulcerative colitis (UC) who are found to have high-grade dysplasia, either already had colorectal cancer (CRC) or develop it within a short time. The presence of low-grade dysplasia is also predictive of CRC. Many signaling pathways are shared among IBD and CRC, including cell survival, cell proliferation, angiogenesis, and inflammatory signaling pathways. Current IBD therapeutics target a small subset of molecular drivers of IBD, with many focused on the inflammatory aspect of the pathways. Thus, there is a great need to identify biomarkers of both IBD and CRC, that can be predictive of therapeutic efficacy, disease severity, and predisposition to CRC. In this study, we explored the changes in biomarkers specific for inflammatory, metabolic, and proliferative pathways, to help determine the relevance to both IBD and CRC. Our analysis demonstrated, for the first time in IBD, the loss of the tumor suppressor protein Ras associated family protein 1A (RASSF1A), via epigenetic changes, the hyperactivation of the obligate kinase of the NOD2 pathogen recognition receptor (receptor interacting protein kinase 2 RIPK2), the loss of activation of the metabolic kinase, AMP activated protein kinase (AMPKα1), and, lastly, the activation of the transcription factor and kinase Yes associated protein (YAP) kinase, that is involved in proliferation of cells. The expression and activation status of these four elements are mirrored in IBD, CRC, and IBD-CRC patients and, importantly, in matched blood and biopsy samples. The latter would suggest that biomarker analysis can be performed non-invasively, to understand IBD and CRC, without the need for invasive and costly endoscopic analysis. This study, for the first time, illustrates the need to understand IBD or CRC beyond an inflammatory perspective and the value of therapeutics directed to reset altered proliferative and metabolic states within the colon. The use of such therapeutics may truly drive patients into remission.
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