Lysyl oxidase (LOX) oxidizes the side chain of peptidyl lysine converting specific lysine residues to residues of alpha-aminoadipic-delta-semialdehyde. This posttranslational chemical change permits ...the covalent crosslinking of the component chains of collagen and those of elastin, thus stabilizing the fibrous deposits of these proteins in the extracellular matrix. Four LOX-like (LOXL) proteins with varying degrees of similarity to LOX have been described, constituting a family of related proteins. LOX is synthesized as a preproprotein which emerges from the cell as proLOX and then is processed to the active enzyme by proteolysis. In addition to elastin and collagen, LOX can oxidize lysine within a variety of cationic proteins, suggesting that its functions extend beyond its role in the stabilization of the extracellular matrix. Indeed, recent findings reveal that LOX and LOXL proteins markedly influence cell behavior including chemotactic responses, proliferation, and shifts between the normal and malignant phenotypes.
Traumatic brain injury (TBI) is a significant problem in older adults. In persons aged 65 and older, TBI is responsible for more than 80,000 emergency department visits each year; three‐quarters of ...these visits result in hospitalization as a result of the injury. Adults aged 75 and older have the highest rates of TBI‐related hospitalization and death. Falls are the leading cause of TBI for older adults (51%), and motor vehicle traffic crashes are second (9%). Older age is known to negatively influence outcome after TBI. Although geriatric and neurotrauma investigators have identified the prognostic significance of preadmission functional ability, comorbidities, sex, and other factors such as cerebral perfusion pressure on recovery after illness or injury, these variables remain understudied in older adults with TBI. In the absence of good clinical data, predicting outcomes and providing care in the older adult population with TBI remains problematic. To address this significant public health issue, a refocusing of research efforts on this population is justified to prevent TBI in the older adult and to discern unique care requirements to facilitate best patient outcomes.
Recent advances in diamond detector development Kagan, H.
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
04/2005, Letnik:
541, Številka:
1
Journal Article
Recenzirano
Chemical Vapor Deposition (CVD) diamond is being developed as radiation hard material for replacement or upgrade to present detectors in extreme radiation environments. During the past few years ...devices have been manufactured and tested with fast, radiation-hard electronics. In this paper we discuss the present status and recent progress achieved.
Capacitive micromachined ultrasonic transducers (CMUTs) are usually composed of large arrays of closely packed cells. In this work, we use an equivalent circuit model to analyze CMUT arrays with ...multiple cells. We study the effects of mutual acoustic interactions through the immersion medium caused by the pressure field generated by each cell acting upon the others. To do this, all the cells in the array are coupled through a radiation impedance matrix at their acoustic terminals. An accurate approximation for the mutual radiation impedance is defined between two circular cells, which can be used in large arrays to reduce computational complexity. Hence, a performance analysis of CMUT arrays can be accurately done with a circuit simulator. By using the proposed model, one can very rapidly obtain the linear frequency and nonlinear transient responses of arrays with an arbitrary number of CMUT cells. We performed several finite element method (FEM) simulations for arrays with small numbers of cells and showed that the results are very similar to those obtained by the equivalent circuit model.
Diamond radiation detectors may be forever Kagan, H.
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
07/2005, Letnik:
546, Številka:
1
Journal Article
Recenzirano
Chemical Vapor Deposition (CVD) diamond particle detectors have been developed as a radiation tolerant replacement or upgrade to present detectors in extreme radiation environments. During the past ...few years devices have been manufactured and tested with fast, radiation-hard electronics. In this paper, we discuss the present status and recent progress achieved.
The high luminosity upgrade of Large Hadron Collider will increase its luminosity by an order of magnitude increasing with it the density of particles on the detector. For protecting the inner ...detectors of experiments and for monitoring the delivered luminosity, a radiation hard beam monitor is being developed. Text describes the proposed system’s principles of operation and its design. It details on the poly-crystalline chemical vapor deposition diamonds as sensor material, a dedicated radiation hard ASIC, as well as on electronics and data processing. The latter finally offers beam abort and luminosity measurement functionalities of the system.
PDF
