Neuroendocrine malignancy of the larynx are rare but represents the first nonsquamous tumor in this localization. The World Health Organization (WHO) classifies these tumors into 3 groups: typical ...carcinoid, atypical carcinoid tumor, and small cell neuroendocrine carcinoma (SmCC). SmCC have an aggressive natural history characterized by widespread metastasis. Treatment is based on concomitant or sequential chemoradiation. We report herein the case of a 69 years old men, who presented with laryngeal small cell neuroendocrine carcinoma revealed by progressive dysphonia and cervical lymphadenopathy. The diagnosis was confirmed by biopsy and histopathological study. Pre-treatment workup was negative for metastatic disease. He has received chemotherapy based on etoposide and cisplatin followed by chemoradiation. The evolution was marked by the development of metachronous lung metastasis. Unfortunately, the patient passed away during a chemotherapy-induced myelosuppression after the first palliative chemotherapy cure.
Neuroendocrine carcinoma of the cervix (NECC) represents a rare and aggressive subtype of cervical cancer, comprising only a small fraction of cases. Here, we present a case report of a 32-year-old ...woman diagnosed with small cell NECC, detailing her clinical presentation, diagnostic workup, treatment course, and post-treatment outcomes. Despite its rarity, NECC poses significant diagnostic and therapeutic challenges due to its aggressive nature and distinct biological properties. Histological and immunohistochemical analyses play pivotal roles in diagnosis, with NECC often characterized by positive staining for specific protein markers. Treatment strategies for NECC depend on various factors, including cancer stage, patient characteristics, and tumor biology. While primary radical surgery has shown efficacy for early-stage NECC, advanced cases may necessitate a multimodal approach involving chemotherapy and radiotherapy. We compare our findings with existing literature, discussing the evolving landscape of NECC management and highlighting the need for individualized treatment approaches. Given the scarcity of randomized trials, managing NECC remains a complex endeavor, underscoring the importance of further research and collaborative efforts in optimizing patient outcomes.
This report describes a case of gliosarcoma (GS), a rare primary malignant brain tumor with a biphasic histological pattern. The patient was a 70-year-old male who presented with gradual memory ...impairment without signs of increased intracranial pressure. Magnetic resonance imaging (MRI) revealed a heterogeneous right frontal lesion with significant edema, suggestive of a glial tumor. The patient underwent a biopsy, which identified a pseudo-encapsulated, highly vascularized tumor. Histopathological examination showed a malignant, dense tumor proliferation composed of a glial component positive for GFAP and a sarcomatous component positive for vimentin, confirming the diagnosis of GS. The characteristic imaging features of GS, including hypointensity on T2-weighted MRI and ring-like enhancement, were also observed in this case. The patient was treated with maximal safe surgical resection followed by concurrent radiation therapy (60 Gy in 30 fractions) and temozolomide chemotherapy, as per the standard Stupp protocol for glioblastoma. Despite this multimodal approach, the prognosis for GS remains poor, with a median survival time comparable to glioblastoma. This case report illustrates the clinicopathological features of this rare and aggressive primary brain tumor, highlighting the importance of accurate diagnosis and multidisciplinary management. Ongoing research is needed to elucidate the pathogenesis and identify novel therapeutic targets to improve outcomes for patients with gliosarcoma.
This comprehensive case report presents a 65-year-old male with olfactory neuroblastoma, notable for its rarity and diagnostic challenges. The patient's clinical history includes significant smoking, ...alcohol consumption, and comorbidities. The initial presentation involved nasal obstruction, pain, and recurrent epistaxis, leading to a detailed imaging assessment revealing an extensive and infiltrative tumor. The biopsy confirmed grade II olfactory neuroblastoma. A thorough multidisciplinary discussion guided the treatment strategy, involving neoadjuvant chemotherapy with CISPLATIN and ETOPOSIDE. Remarkably, the patient exhibited a 30% reduction in tumor volume after three cycles, setting the stage for surgical intervention. The subsequent surgical excision revealed a high-grade tumor invading multiple structures, emphasizing the aggressive nature of olfactory neuroblastoma. Postoperative radiotherapy, intended for the positive margins and involved lymph nodes, was implemented, accompanied by manageable toxicities. The case highlights the intricate decision-making process in managing olfactory neuroblastoma, considering tumor extent, grade, and therapeutic response. In conclusion, this case underscores the need for a personalized and multidisciplinary approach to olfactory neuroblastoma, integrating chemotherapy, surgery, and radiotherapy. Despite the absence of established guidelines, the case offers insights into therapeutic decision-making, emphasizing the importance of ongoing clinical and imaging monitoring for optimal long-term outcomes.
The radio-induced stromal sarcoma (RISS) is a rare clinical entity, being the second most common type of uterine mesenchymal neoplasm after leiomyosarcoma. Its incidence increases as survival after ...radiotherapy improves, and it often poses a therapeutic challenge. We report the case of a 58-year-old patient, followed since 2014 for initially classified stage IIb squamous cell carcinoma of the uterine cervix, treated with external pelvic radiotherapy and brachytherapy. After 6 years of surveillance, the patient presented with persistent pelvic pain. Clinical examination and pelvic MRI revealed the presence of a tumoral process in the uterine cervix with suspicious thickening of the endometrium. Morphological and immunohistochemical pathological study of the lesion confirmed its tumoral nature, indicative of a high-grade stromal sarcoma. Radiotherapy can induce malignant tumors after a latent period of several years. Radio-induced gynecological sarcomas are most often associated with a poor prognosis, emphasizing the need for careful and close monitoring after pelvic irradiation.
