This randomized, double-blind, placebo-controlled study evaluates the effect of the corticotropin (4-9) analogue Org 2766 on the neuropathy-free interval in patients receiving vincristine (VCR) ...containing chemotherapy for Hodgkin's or non-Hodgkin's lymphoma.
In a longitudinal design, 150 patients were evaluated by interview, neurological examination, and neurophysiological techniques. Patients with an expected cumulative VCR dose of at least 8 mg received a single dose of Org 2766 or placebo before and after each intravenous VCR injection and 3-4 weeks after cessation of VCR. The final patient assessment was performed 1 month after discontinuation of study medication. The neuropathy-free interval as the major end point of this study was defined as the first occurrence of bilateral paresthesias and expressed as the administered cumulative VCR dose. This bi-center study represents the largest cohort of patients monitored for the effect of an ACTH-analogue on VCR neurotoxicity.
A total of 147 patients were included in the final analysis. No significant differences were observed between the placebo and actively treated group for the major and secondary endpoints.
Contrary to a single previous pilot study in patients receiving VCR-based chemotherapy, in our study the ACTH (4-9) analogue Org 2766 did not provide protection from VCR-induced neuropathy.
The physics motivation and the conceptual design of the PIONEER experiment, a next-generation rare pion decay experiment testing lepton flavor universality and CKM unitarity, are described. Phase I ...of the PIONEER experiment, which was proposed and approved at Paul Scherrer Institut, aims at measuring the charged-pion branching ratio to electrons vs.\ muons, \(R_{e/\mu}\), 15 times more precisely than the current experimental result, reaching the precision of the Standard Model (SM) prediction at 1 part in \(10^4\). Considering several inconsistencies between the SM predictions and data pointing towards the potential violation of lepton flavor universality, the PIONEER experiment will probe non-SM explanations of these anomalies through sensitivity to quantum effects of new particles up to the PeV mass scale. The later phases of the PIONEER experiment aim at improving the experimental precision of the branching ratio of pion beta decay (BRPB), \(\pi^+\to \pi^0 e^+ \nu (\gamma)\), currently at \(1.036(6)\times10^{-8}\), by a factor of three (Phase II) and an order of magnitude (Phase III). Such precise measurements of BRPB will allow for tests of CKM unitarity in light of the Cabibbo Angle Anomaly and the theoretically cleanest extraction of \(|V_{ud}|\) at the 0.02\% level, comparable to the deduction from superallowed beta decays.
PIONEER: Studies of Rare Pion Decays PIONEER Collaboration; Altmannshofer, W; Binney, H ...
arXiv (Cornell University),
03/2022
Paper, Journal Article
Odprti dostop
A next-generation rare pion decay experiment, PIONEER, is strongly motivated by several inconsistencies between Standard Model (SM) predictions and data pointing towards the potential violation of ...lepton flavor universality. It will probe non-SM explanations of these anomalies through sensitivity to quantum effects of new particles even if their masses are at very high scales. Measurement of the charged-pion branching ratio to electrons vs. muons \(R_{e/\mu}\) is extremely sensitive to new physics effects. At present, the SM prediction for \(R_{e/\mu}\) is known to 1 part in \(10^4\), which is 15 times more precise than the current experimental result. An experiment reaching the theoretical accuracy will test lepton flavor universality at an unprecedented level, probing mass scales up to the PeV range. Measurement of pion beta decay, \(\pi^+\to \pi^0 e^+ \nu (\gamma)\), with 3 to 10-fold improvement in sensitivity, will determine \(V_{ud}\) in a theoretically pristine manner and test CKM unitarity, which is very important in light of the recently emerged tensions. In addition, various exotic rare decays involving sterile neutrinos and axions will be searched for with unprecedented sensitivity. The experiment design benefits from experience with the recent PIENU and PEN experiments at TRIUMF and the Paul Scherrer Institut (PSI). Excellent energy and time resolutions, greatly increased calorimeter depth, high-speed detector and electronics response, large solid angle coverage, and complete event reconstruction are all critical aspects of the approach. The PIONEER experiment design includes a 3\(\pi\) sr 25 radiation length calorimeter, a segmented low gain avalanche detector stopping target, a positron tracker, and other detectors. Using intense pion beams, and state-of-the-art instrumentation and computational resources, the experiments can be performed at the PSI ring cyclotron.
This white paper presents opportunities afforded by the Fermilab Booster Replacement and its various options. Its goal is to inform the design process of the Booster Replacement about the accelerator ...needs of the various options, allowing the design to be versatile and enable, or leave the door open to, as many options as possible. The physics themes covered by the paper include searches for dark sectors and new opportunities with muons.
We describe the installation, commissioning, and characterization of the new
injection kicker system in the Muon $g-2$ Experiment (E989) at Fermilab, which
makes a precision measurement of the muon ...magnetic anomaly. Three Blumlein
pulsers drive each of the 1.27-m-long non-ferric kicker magnets, which reside
in a storage ring vacuum (SRV) that is subjected to a 1.45 T magnetic field.
The new system has been redesigned relative to Muon $g-2$'s predecessor
experiment, and we present those details in this manuscript.
MAGIS-100 is a next-generation quantum sensor under construction at Fermilab that aims to explore fundamental physics with atom interferometry over a 100-meter baseline. This novel detector will ...search for ultralight dark matter, test quantum mechanics in new regimes, and serve as a technology pathfinder for future gravitational wave detectors in a previously unexplored frequency band. It combines techniques demonstrated in state-of-the-art 10-meter-scale atom interferometers with the latest technological advances of the world's best atomic clocks. MAGIS-100 will provide a development platform for a future kilometer-scale detector that would be sufficiently sensitive to detect gravitational waves from known sources. Here we present the science case for the MAGIS concept, review the operating principles of the detector, describe the instrument design, and study the detector systematics.
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