Background
With improved short-term surgical outcomes, laparoscopic distal gastrectomy has rapidly gained popularity. However, the safety and feasibility of laparoscopic total gastrectomy (LTG) has ...not yet been proven due to the difficulty of the technique. This single-arm prospective multi-center study was conducted to evaluate the use of LTG for clinical stage I gastric cancer.
Methods
Between October 2012 and January 2014, 170 patients with pathologically proven, clinical stage I gastric adenocarcinoma located at the proximal stomach were enrolled. Twenty-two experienced surgeons from 19 institutions participated in this clinical trial. The primary end point was the incidence of postoperative morbidity and mortality at postoperative 30 days. The severity of postoperative complications was categorized according to Clavien–Dindo classification, and the incidence of postoperative morbidity and mortality was compared with that in a historical control.
Results
Of the enrolled patients, 160 met criteria for inclusion in the full analysis set. Postoperative morbidity and mortality rates reached 20.6% (33/160) and 0.6% (1/160), respectively. Fifteen patients (9.4%) had grade III or higher complications, and three reoperations (1.9%) were performed. The incidence of morbidity after LTG in this trial did not significantly differ from that reported in a previous study for open total gastrectomy (18%).
Conclusions
LTG performed by experienced surgeons showed acceptable postoperative morbidity and mortality for patients with clinical stage I gastric cancer.
Activated macrophages have the potential to be ideal targets for imaging inflammation. However, probe selectivity over non-activated macrophages and probe delivery to target tissue have been ...challenging. Here, we report a small molecule probe specific for activated macrophages, called CDg16, and demonstrate its application to visualizing inflammatory atherosclerotic plaques in vivo. Through a systematic transporter screen using a CRISPR activation library, we identify the orphan transporter Slc18b1/SLC18B1 as the gating target of CDg16.
As communication systems that employ millimeter wave (mmWave) frequency bands must use large antenna arrays to overcome the severe propagation loss of mmWave signals, hybrid beamforming has been ...considered as an integral component of mmWave communications. Recently, intelligent reflecting surface (IRS) has been proposed as an innovative technology that can significantly improve the performance of mmWave communication systems through the use of low-cost passive reflecting elements. In this paper, we study IRS-aided mmWave multiple-input multiple-output (MIMO) systems with hybrid beamforming architectures. We first exploit the sparse-scattering structure and large dimension of mmWave channels to develop the joint design of IRS reflection matrix and hybrid beamformer for narrowband MIMO systems. Then, we generalize the proposed joint design to broadband MIMO systems with orthogonal frequency division multiplexing (OFDM) modulation by leveraging the angular sparsity of frequency-selective mmWave channels. Simulation results demonstrate that the proposed joint designs can significantly enhance the spectral efficiency of the systems of interest and achieve superior performance over the existing designs.
A MoSe2 p–n diode with a van der Waals homojunction is demonstrated by stacking undoped (n‐type) and Nb‐doped (p‐type) semiconducting MoSe2 synthesized by chemical vapor transport for Nb ...substitutional doping. The p–n diode reveals an ideality factor of ≈1.0 and a high external quantum efficiency (≈52%), which increases in response to light intensity due to the negligible recombination rate at the clean homojunction interface.
Iontronic graphene tactile sensors (i‐GTS) composed of a top floating graphene electrode and an ionic liquid droplet pinned on a bottom graphene grid, which can dramatically enhance the performance ...of capacitive‐type tactile sensors, are presented. When mechanical stress is applied to the top floating electrode, the i‐GTS operates in one of the following three regimes: air–air, air–electric double layer (EDL) transition, or EDL–EDL. Once the top electrode contacts the ionic liquid in the i‐GTS, the spreading behavior of the ionic liquid causes a capacitance transition (from a few pF to over hundreds of pF). This is because EDLs are formed at the interfaces between the electrodes and the ionic liquid. In this case, the pressure sensitivity increases to ≈31.1 kPa−1 with a gentle touch. Under prolonged application of pressure, the capacitance increases gradually, mainly due to the contact line expansion of the ionic liquid bridge pinned on the graphene grid. The sensors exhibit outstanding properties (response and relaxation times below 80 ms, and stability over 300 cycles) while demonstrating ultimate signal‐to‐noise ratios in the array tests. The contact‐induced spreading behavior of the ionic liquid is the key for boosting the sensor performance.
Iontronic graphene tactile sensors represent a new class of high‐performance wearable sensory platforms that reflect not only an unprecedented level of pressure sensing capabilities but also novel sensing principles based on spreading of ions pinned on a graphene grid, which demonstrates a more advanced tactile interface for emerging human‐interactive technologies.
Plant leaves undergo a series of developmental changes from leaf primordium initiation through growth and maturation to senescence throughout their life span. Although the mechanisms underlying leaf ...senescence have been intensively elucidated, our knowledge of the interrelationship between early leaf development and senescence is still fragmentary.
We isolated the oresara15-1Dominant (ore15-1D) mutant, which had an extended leaf longevity and an enlarged leaf size, from activation-tagged lines of Arabidopsis. Plasmid rescue identified that ORE15 encodes a PLANT A/T-RICH SEQUENCE- AND ZINC-BINDING PROTEIN family transcription factor. Phenotypes of ore15-1D and ore15-2, a loss-of-function mutant, were evaluated through physiological and anatomical analyses. Microarray, quantitative reverse transcription polymerase chain reaction, and chromatin immunoprecipitation as well as genetic analysis were employed to reveal the molecular mechanism of ORE15 in the regulation of leaf growth and senescence.
ORE15 enhanced leaf growth by promoting the rate and duration of cell proliferation in the earlier stage and suppressed leaf senescence in the later stage by modulating the GROWTH-REGULATING FACTOR (GRF)/GRF-INTERACTING FACTOR regulatory pathway.
Our study highlighted a molecular conjunction through ORE15 between growth and senescence, which are two temporally separate developmental processes during leaf life span.
The rapid and sensitive classification of bacteria is the first step of bacterial community research and the treatment of infection. Herein, a fluorescent probe BacGO is presented, which shows the ...best universal selectivity for Gram‐positive bacteria among known probes with a minimum staining procedure for sample detection and enrichment of the live bacteria. BacGO could also be used to assess of the Gram status in the bacterial community from wastewater sludge. Furthermore, BacGO could sensitively and selectively detect a Gram‐positive bacterial infection, not only in vitro but also using an in vivo keratitis mouse model. BacGO provides an unprecedented research tool for the study of dynamic bacterial communities and for clinical application.
BacGO, a novel Gram‐positive bacterial probe, was developed from a library of fluorescent molecules with a boronic‐acid motif that binds to peptidoglycan on the Gram‐positive bacterial cell wall. BacGO can be used to identify Gram‐positive bacteria in diverse, highly complex samples, and is an attractive alternative to Gram staining.
The atomic‐scale synthesis of artificial oxide heterostructures offers new opportunities to create novel states that do not occur in nature. The main challenge related to synthesizing these ...structures is obtaining atomically sharp interfaces with designed termination sequences. In this study, it is demonstrated that the oxygen pressure (PO2) during growth plays an important role in controlling the interfacial terminations of SrRuO3/BaTiO3/SrRuO3 (SRO/BTO/SRO) ferroelectric (FE) capacitors. The SRO/BTO/SRO heterostructures are grown by a pulsed laser deposition method. The top SRO/BTO interface, grown at high PO2 (around 150 mTorr), usually exhibits a mixture of RuO2–BaO and SrO–TiO2 terminations. By reducing PO2, the authors obtain atomically sharp SRO/BTO top interfaces with uniform SrO–TiO2 termination. Using capacitor devices with symmetric and uniform interfacial termination, it is demonstrated for the first time that the FE critical thickness can reach the theoretical limit of 3.5 unit cells.
Ferroelectric SrRuO3/BaTiO3/SrRuO3 capacitors with atomically sharp interfaces are realized by adjusting pulsed laser deposition growth conditions and altering the thermodynamic surface stability of BaTiO3. The interface atomic structure is designed to have a symmetric SrO–TiO2 atomic sequence at the top and bottom interfaces, and the resulting ferroelectric capacitor exhibits a robust ferroelectricity down to a thickness of ≈1.4 nm.
Novel carbon‐based microporous nanoplates containing numerous heteroatoms (H‐CMNs) are fabricated from regenerated silk fibroin by the carbonization and activation of KOH. The H‐CMNs exhibit superior ...electrochemical performance, displaying a specific capacitance of 264 F/g in aqueous electrolytes, a specific energy of 133 Wh/kg, a specific power of 217 kW/kg, and a stable cycle life over 10000 cycles.
Ionogels are good candidates for flexible electronics owing to their excellent mechanical and electrical properties, including stretchability, high conductivity, and stability. In this study, ...conducting ionogels comprising a double network (DN) of poly(N‐isopropylacrylamide‐co‐N,N′‐diethylacrylamide)/chitosan which are further reinforced by the ionic and covalent crosslinking of the chitosan network by tripolyphosphate and glutaraldehyde, respectively, are prepared. Based on their excellent mechanical properties and high conductivity, the developed DN ionogels are envisioned as stretchable ionic conductors for extremely stretchable alternating‐current electroluminescent (ACEL) devices. The ACEL device fabricated with the developed ionogel exhibits stable working operation under an ultrahigh elongation of over 1200% as well as severe mechanical deformations such as bending, rolling, and twisting. Furthermore, the developed ACEL devices also display stable luminescence over 1000 stretch/release cycles or at temperatures as harsh as 200 °C.
A super stretchable electroluminescent device is successfully fabricated with double‐network ionogel as a soft electrode owing to its excellent mechanical robustness and electrical conductivity. The fabricated device exhibits extremely stable light‐emitting operation even at high elongation as well as demonstrating mechanical, electrical, and thermal stability, which can be applied to new types of stretchable light display and sensors.
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