We report the discovery of two transiting exoplanets from the WASP survey, WASP-150b and WASP-176b. WASP-150b is an eccentric (\(e\) = 0.38) hot Jupiter on a 5.6 day orbit around a \(V\) = 12.03, F8 ...main-sequence host. The host star has a mass and radius of 1.4 \(\rm M_{\odot}\) and 1.7 \(\rm R_{\odot}\) respectively. WASP-150b has a mass and radius of 8.5 \(\rm M_J\) and 1.1 \(\rm R_J\), leading to a large planetary bulk density of 6.4 \(\rm \rho_J\). WASP-150b is found to be \(\sim3\) Gyr old, well below its circularisation timescale, supporting the eccentric nature of the planet. WASP-176b is a hot Jupiter planet on a 3.9 day orbit around a \(V\) = 12.01, F9 sub-giant host. The host star has a mass and radius of 1.3 \(\rm M_{\odot}\) and 1.9 \(\rm R_{\odot}\). WASP-176b has a mass and radius of 0.86 \(\rm M_J\) and 1.5 \(\rm R_J\) respectively, leading to a planetary bulk density of 0.23 \(\rm \rho_J\).
Uptake ofl-3Hglutamate by monolayers of fibroblasts cultured from human embryonic skin has been studied in the presence of several nonradioactive structural analogs of glutamate and aspartate. ...Results have suggested that the structural specificities of glutamate transporters in cultured human fibroblasts are similar to those of glutamate transporters in the mammalian brain. Only subtle differences have been detected: in the mammalian cerebral cortex, enantiomers ofthreo-3-hydroxyaspartate are almost equipotent as inhibitors ofl-3Hglutamate uptake while, in human fibroblasts, thed-isomer has been found to be an order of magnitude less potent than the correspondingl-isomer. Kinetic analysis of a model in which substrates are recognized by the glutamate transporter binding site(s) as both α- and β-amino acids indicated that such a mechanism cannot explain the apparent negative cooperativity characterizing the effects ofd- andl-aspartate. Molecular modeling has been used to estimate the optimum conformation ofl-glutamate as it interacts with the transporter(s). Flow cytometry has indicated that all fibroblasts in culture express at least moderate levels of four glutamate transporters cloned from human brain. Small subpopulations (<3%) of cells, however, were strongly labeled with antibodies against EAAT1 (GLAST) and EAAT2 (GLT-1) transporters. We conclude that these two transporters—known to be strongly expressed in brain tissue—can be principally responsible for the “high affinity” transport of glutamate also in nonneural cells.
High-density oligonucleotide arrays were used to compare gene expression of rat hearts from control, untreated diabetic, and diabetic groups treated with islet cell transplantation (ICT), protein ...kinase C (PKC)beta inhibitor ruboxistaurin, or ACE inhibitor captopril. Among the 376 genes that were differentially expressed between untreated diabetic and control hearts included key metabolic enzymes that account for the decreased glucose and increased free fatty acid utilization in the diabetic heart. ICT or insulin replacements reversed these gene changes with normalization of hyperglycemia, dyslipidemia, and cardiac PKC activation in diabetic rats. Surprisingly, both ruboxistaurin and ACE inhibitors improved the metabolic gene profile (confirmed by real-time RT-PCR and protein analysis) and ameliorated PKC activity in diabetic hearts without altering circulating metabolites. Functional assessments using Langendorff preparations and (13)C nuclear magnetic resonance spectroscopy showed a 36% decrease in glucose utilization and an impairment in diastolic function in diabetic rat hearts, which were normalized by all three treatments. In cardiomyocytes, PKC inhibition attenuated fatty acid-induced increases in the metabolic genes PDK4 and UCP3 and also prevented fatty acid-mediated inhibition of basal and insulin-stimulated glucose oxidation. Thus, PKCbeta or ACE inhibitors may ameliorate cardiac metabolism and function in diabetes partly by normalization of fuel metabolic gene expression directly in the myocardium.
The long-term preservation of collections relies above all on the environment in which they are stored and displayed. The museum building is the first line of defence, and often the only line of ...defence for a majority of museums worldwide. Temperature and relative humidity are major problems which need to be addressed by tropical museum buildings, and reliable monitoring can be of assistance in making informed decisions to overcome these problems. This paper describes the monitoring and evaluation of two museum buildings in the tropics: comparing the behaviour of air-conditioned and non air-conditioned storage spaces at the Fiji Museum, and determining the contribution of moisture rising through the floor at the Vanuatu Cultural Centre.
Post-Communist Economic Systems King, Lawrence P; Szelényi, Iván
The Handbook of Economic Sociology, Second Edition,
07/2010
Book Chapter
In the first edition of thisHandbookwe wrote a chapter under the title “The Socialist Economic System.” This chapter can be read as a follow-up to, or a new section of, the previous one since our aim ...now is to describe the economic systems that have emerged with the sudden collapse (as happened in Eastern Europe) or gradual erosion (as is currently the case in East Asia) of the socialist economic system. The chapter in the first edition was about the emergence of a distinctive social structure and economy that accompanied development under the Soviet model of total state
We report the results of the first prospective, multicenter study of acute carbon monoxide (CO) poisoning in pregnancy. We collected and followed cases of CO poisoning occurring during pregnancy ...between December 1985 and March 1989. The sources of CO were malfunctioning furnaces (n = 16), hot water heaters (n = 7), car fumes (n = 6), and methylene chloride inhalation (n = 3). Pregnancy outcome was adversely affected in 3 of 5 pregnancies with severe toxicity; two stillbirths, and one cerebral palsy with tomographic findings consistent with ischemic damage. All adverse outcome occurred in cases treated with high flow oxygen, whereas the 2 cases of severe toxicity with normal outcomes followed hyperbaric oxygen therapy. All 31 babies exposed in utero to mild or moderate CO poisoning exhibited normal physical and neurobehavioral development. Severe maternal CO toxicity was associated with significantly more adverse fetal cases when compared to mild maternal toxicity (P less than 0.001). It is concluded that while severe CO poisoning poses serious short- and long-term fetal risk, mild accidental exposure is likely to result in normal fetal outcome. Because fetal accumulation of CO is higher and its elimination slower than in the maternal circulation, hyperbaric oxygen may decrease fetal hypoxia and improve outcome.
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