We examined 663 patients who were admitted to the clinic by ambulance, for determine the factors of clinical deterioration and progression of ischemic stroke in the acute period of the first 24-72 ...hours. Among the patients received in the acute period, a fatal out come occurred in 7.23% (48) patients, men- 45.8% and women - 54.2%.At the time of admission to the hospital, almost 96.7% of patients with acute ischemic stroke had a disorder of consciousness from stunning to coma. The most significant risk factors for the development of ischemic stroke among 663 patients were arterial hypertension - 80.1%, chronic heartfailure - 57.9%, coronary heart disease - 25.5%, atrial fibrillation - 19.5%, type 2 diabetesmellitus 12.5%. In accordance with the international criteria of TOAST (1993), pathogenetic mechanisms of the development of isch- emic stroke have been determined in patients. Atherothrombotic stroke developed in 303 (45.7%), cardioembolic stroke in 185 (27.9%) patients, lacunar stroke in 167 (25.2%) patients, undefined genesis stroke in 8 (1.2%) patients.The progression of neurological deficiency in ischemic stroke is a bad prognostic factor.
The goal of the research is an exploration of the possible algorithm for science visualization problems in interpolation of the visualization arrays of subsets. The subject of the study is a tricubic ...spline interpolation method (cubic spline interpolation). The methodology of the research is a programming the work of the mathematical model on a c# language with the use of windows presentation forms for the presentation mode work. The results of the study and its' application are important for the science visualization in medicine for the DICOM computer tomography data. Moreover, the applications of the work are relevant for the interpolation of the particle physics interactions. In conclusion, numerical methods study the construction, application and theoretical substantiation of algorithms for the approximate solution of various classes of mathematical problems. Currently, most computational algorithms are focused on the use of high-speed computers. It should be noted some features of numerical methods. First, numerical methods are characterized by multiplicity, i.e., the ability to solve the same problem by various methods. Secondly, the newly emerging natural science problems and the rapid development of computing technology force us to overestimate the importance of existing algorithms and lead to the creation of new ones.
The subject of the research is a constriction and inner architecture of the hybrid intelligent system for the healthcare called "Lazar". The goal of the study is to present all the inner layers of ...the construction of the hybrid intelligent system for the healthcare. The methodology of the study is a representation of the work of the modules and their structure within one intelligent system: it's triggers, productive rules work and data analysis modules. The results of the study are presented on a Table 1. It is important representation of the system's core. This field of computer science, which is engaged in the development of intelligent computer systems, i.e. systems that have the capabilities that we traditionally associate with the human mind - understanding the language, learning, the ability to reason, solve problems, etc. A. N. Kolmogorov: "Any material system with which one can discuss the problems of science for a long time ..." is intellectual. A. Turing: If in the process of dialogue people fail to establish that one of the participants is a machine, then such a machine has intelligence.
The object of the research is a multilayer perceptron which is being considered as a base neural network for the generative adversary neural network. The goal of the study is to make a neural network ...and make observations about how it can possibly work on a problem with separating: linear separable, semi separable and not separable subsets. The methodology of the study is a representation of the mathematical model of the multilayer perceptron on a python programming language. The results of the study are represented on the figures 2 - 5. The future application of the results are relevant for the further analysis in high particle physics for the track identification problem. Conclusions on the research are mostly based on the results with the tasks of separating objects, the accuracy of the dividing subsets is important for the future basis analysis on the subsets.
We examined 663 patients who were admitted to the clinic by ambulance, for determine the factors of clinical deterioration and progression of ischemic stroke in the acute period of the first 24-72 ...hours. Among the patients received in the acute period, a fatal out come occurred in 7.23% (48) patients, men- 45.8% and women - 54.2%.At the time of admission to the hospital, almost 96.7% of patients with acute ischemic stroke had a disorder of consciousness from stunning to coma. The most significant risk factors for the development of ischemic stroke among 663 patients were arterial hypertension - 80.1%, chronic heartfailure - 57.9%, coronary heart disease - 25.5%, atrial fibrillation - 19.5%, type 2 diabetesmellitus 12.5%. In accordance with the international criteria of TOAST (1993), pathogenetic mechanisms of the development of isch- emic stroke have been determined in patients. Atherothrombotic stroke developed in 303 (45.7%), cardioembolic stroke in 185 (27.9%) patients, lacunar stroke in 167 (25.2%) patients, undefined genesis stroke in 8 (1.2%) patients.The progression of neurological deficiency in ischemic stroke is a bad prognostic factor.
Background
The role of miRNA in tissue affected by stroke is actively studied, but it remains unclear which miRNAs and target genes are involved in the development of stroke.
Methods
The MirTarget ...program defines the following features of a miRNA binding to a mRNA: the binding start site, the location of the binding site in mRNA, the free energy of a miRNA binding with a mRNA, and the interaction schemes of miRNA and mRNA.
Results
The interaction of 6565 miRNAs with mRNAs of stroke candidate genes was determined. The association of the mRNAs of stroke candidate genes with miRNAs depends on the level of gene expression. Some highly expressed candidate genes are targets of miR-619-5p and miR-5095, which have binding sites located on overlapping mRNA nucleotide sequences (clusters). miR-619-5p and miR-5095 bind to mRNA of 15 genes. Clusters for the binding of miR-1273f,d,e are in mRNAs of highly expressed genes. The start sites of miR-1273d and miR-1273e binding in all clusters are in sequences with one and ten nucleotides, respectively. The clusters of multiple miR-574-5p and ID00470.5p-miR binding sites and the clusters of the miR-466, ID01030.3p-miR, and ID00436.3p-miR binding sites are in mRNAs of some genes expressed at low levels.
Conclusion
The organization of miRNA binding sites into clusters reduces the length of mRNA and creates competition between miRNAs for binding to mRNA of a target gene. The characteristics of miRNA associations with target genes can be used to recommend markers for a diagnosis of stroke.
External pressures, like political, economic and technological factors, as well as competition at labour and education markets have challenged higher education institutions to reconsider their ...organizational structures and internal management approach to provide better quality education, to attract more potential stakeholders, as well as to sustain their positions at local and global markets. The responsiveness of universities to such pressures and uncertainties is diverse. There are dozens of research identifying current best quality management practices. However, this paper makes an emphasis on the analysis of one of the streams of economic scienceinstitutionalism as an innovative approach to effective internal management in HEIs. Institutionalism is a direction in economic thought that places the main emphasis on the analysis of institutions, which is defined as norms, restrictions and principles of behaviour ("rules of the game") within an organization. In general, institutionalism is so diverse that its study as a whole is almost meaningless because there are different trends in institutionalism itself. Some prefer isomorphic elements of new institutionalism, whereas other stress on processes of differentiation between universities. Nevertheless, despite a growing tendency of an isomorphic strategy of successful universities and effective organizational strategies, there is a lack of research conducted on the application of elements of institutionalism in higher education, as a successful approach to effective internal quality management. The central idea of this paper is to analyze the existing body of literature related to the application of institutionalism in higher education through systematic literature review.
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