The E6 oncoprotein from high-risk genus alpha human papillomaviruses (α-HPVs), such as HPV 16, has been well characterized with respect to the host-cell proteins it interacts with and corresponding ...signaling pathways that are disrupted due to these interactions. Less is known regarding the interacting partners of E6 from the genus beta papillomaviruses (β-HPVs); however, it is generally thought that β-HPV E6 proteins do not interact with many of the proteins known to bind to α-HPV E6. Here we identify p300 as a protein that interacts directly with E6 from both α- and β-HPV types. Importantly, this association appears much stronger with β-HPV types 5 and 8-E6 than with α-HPV type 16-E6 or β-HPV type 38-E6. We demonstrate that the enhanced association between 5/8-E6 and p300 leads to p300 degradation in a proteasomal-dependent but E6AP-independent manner. Rather, 5/8-E6 inhibit the association of AKT with p300, an event necessary to ensure p300 stability within the cell. Finally, we demonstrate that the decreased p300 protein levels concomitantly affect downstream signaling events, such as the expression of differentiation markers K1, K10 and Involucrin. Together, these results demonstrate a unique way in which β-HPV E6 proteins are able to affect host-cell signaling in a manner distinct from that of the α-HPVs.
A
bstract
The cross section of the process
e
+
e
−
→
π
+
π
−
has been measured in the Spherical Neutral Detector (SND) experiment at the VEPP-2000
e
+
e
−
collider VEPP-2000 in the energy region 525
...<
s
<
883 MeV. The measurement is based on data with an integrated luminosity of about 4.6 pb
−
1
. The systematic uncertainty of the cross section determination is 0.8% at
s
>
0
.
600 GeV. The
ρ
meson parameters are obtained as
m
ρ
= 775
.
3 ± 0
.
5 ± 0
.
6 MeV, Γ
ρ
= 145
.
6 ± 0
.
6 ± 0
.
8 MeV,
B
ρ
→
e
+
e−
×
B
ρ
→
π
+
π−
= (4
.
89 ± 0
.
02 ± 0
.
04) × 10
−
5
, and the parameters of the
e
+
e
−
→
ω
→
π
+
π
−
process, suppressed by
G
-parity, as
B
ω
→
e
+
e−
×
B
ω
→
π
+
π−
= (1
.
32 ± 0
.
06 ± 0
.
02) × 10
−
6
and and
ϕ
ρω
= 110
.
7 ± 1
.
5 ± 1
.
0 degrees.
In future electron-positron colliders, such as FC-ee and CEPC, it is planned to accurately measure the beam energy by resonance depolarization. In this paper, we propose an alternative approach based ...on the rapid resonant rotation of the spins into the horizontal plane of the ring and their subsequent free rotation around the equilibrium vertical direction. The frequency of free coherent spin precession is proposed to be measured by the beats of the number of scattering events of electrons interacting with circularly polarized laser light. Fourier analysis of the number of electrons dropped out of the ring aperture to determine the frequency of free precession. In this paper, spin dynamics is simulated at all stages of the process, taking into account synchrotron oscillations and energy diffusion, and statistical estimates of the accuracy of determining the frequency of spin precession for beam parameters in FCC-ee are made.
The Budker Institute of Nuclear Physics, Siberian Branch, Russian Academy of Sciences (BINP SB RAS), plans to create the Super Charm-Tau Factory (SCTF) accelerator complex, it will operate in a wide ...energy range of 2
E
= 2–5 GeV in c.m. and have design luminosity of
L
= 1 × 10
35
cm
–2
s
–1
. As part of the physical program, it is proposed to carry out the experiment by measuring the Weinberg running weak mixing angle for the J/ψ meson energy. Due to the smallness of the predicted effect, it is necessary to exclude the influence of systematic errors from unpredictable changes in the magnet lattice and the beam background. To do this, we have to organize frequent changes in sign of the longitudinal polarization of the electron beam at the interaction point. In this paper we have investigated the possibility of the spin-flip using the spin RF-rotator in a colliding electron ring with three Siberian snakes. Based on the simulation results, conclusions about the possibility of using this approach are made.
Slow resonant extraction from the synchrotron makes it possible to provide relatively stable beams for a long time. The principle of slow extraction is intentionally exciting the third-order ...resonance by controlling detuning and sextupole strength with the gradual release of particles from inside to outside a stable separatrix. The Budker Institute of Nuclear Physics (BINP) develops the ion synchrotron for a wide range of technological applications. This paper describes slow resonant extraction from an ion synchrotron with betatron oscillation excitation by a transverse RF field.
The process
e
+
e
-
→
n
n
¯
is studied in the experiment at the VEPP-2000
e
+
e
-
collider with the SND detector. The technique of the time measurements in the multichannel NaI(Tl) electromagnetic ...calorimeter is used to select
n
n
¯
events. The value of the measured cross section in the center-of-mass energy range from 1.894 to 2 GeV varies from 0.5 to 0.35 nb. The effective neutron timelike form factor is derived from the measured cross section and compared with the proton form factor. The ratio of the neutron electric and magnetic form factors is obtained from the analysis of the antineutron polar angle distribution and found to be consistent with unity.
The process
e
+
e
-
→
η
η
γ
is studied in the center-of-mass energy range 1.17–2.00 GeV using data with an integrated luminosity of 201 pb
-
1
collected by the SND detector at the VEPP-2000
e
+
e
-
...collider. The
e
+
e
-
→
η
η
γ
cross section is measured for the first time. It is shown that the dominant mechanism of this reaction is the transition through the
ϕ
η
intermediate state. Our result on the
e
+
e
-
→
η
η
γ
cross section is consistent with the
e
+
e
-
→
ϕ
η
measurement in the
ϕ
→
K
+
K
-
mode. The search for radiative processes contributing to the
e
+
e
-
→
η
η
γ
cross section is performed, and no significant signal is observed.
Results are presented from measuring the
cross section and effective neutron timelike form factor. Data are collected in 2020–2021 at the VEPP-2000
collider in the 1891 to 2007 MeV center-of-mass ...range of energies. The general purpose nonmagnetic SND detector is used to detect neutron–antineutron events. The time-of-flight approach is used to select
events. The measured cross section is 0.4–0.6 nbn. The neutron form factor in the investigated range of energies varies from 0.3 to 0.2.
Study of the Process in the Energy Range GeV Achasov, M. N.; Barnyakov, A. Yu; Beloborodov, K. I. ...
Physics of atomic nuclei,
2023/12, Letnik:
86, Številka:
6
Journal Article
Recenzirano
The
cross section is measured in the center-of-mass energy range from 1.07 to 2.00 GeV in the decay channel
,
. The data set with an integrated luminosity of 242 pb
accumulated in the experiment with ...the SND detector at the VEPP-2000
collider is analyzed.
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