Background: Tazarotene, a potent acetylenic retinoid for topical use, might be expected to benefit photodamaged skin, including improving the classical signs of fine wrinkles, mottled ...hyperpigmentation, and roughness. Objective: Our purpose was to determine the efficacy and safety of tazarotene 0.1% gel in the treatment of photodamaged dorsal forearm skin. Methods: Ten healthy female volunteers, aged 45 to 65 years, with moderately photodamaged forearm skin applied tazarotene 0.1% gel to one arm and vehicle gel to the other once daily for 12 weeks. The study was a double-blind, randomized, paired-comparison evaluation conducted at a single site. Results: Tazarotene showed beneficial effects for several efficacy variables. It was more efficacious than vehicle in reducing skin roughness and fine wrinkling based on objective measurements. Tazarotene also corrected epidermal atrophy and atypia and improved skin hydration properties. Conclusion: In this 12-week pilot study tazarotene redressed abnormalities associated with photo-damaged skin. (J Am Acad Dermatol 2000;43:656-63.)
Developing sustainable software for the scientific community requires expertise in software engineering and domain science. This can be challenging due to the unique needs of scientific software, the ...insufficient resources for software engineering practices in the scientific community, and the complexity of developing for evolving scientific contexts. While open‐source software can partially address these concerns, it can introduce complicating dependencies and delay development. These issues can be reduced if scientists and software developers collaborate. We present a case study wherein scientists from the SuperNova Early Warning System collaborated with software developers from the Scalable Cyberinfrastructure for Multi‐Messenger Astrophysics project. The collaboration addressed the difficulties of open‐source software development, but presented additional risks to each team. For the scientists, there was a concern of relying on external systems and lacking control in the development process. For the developers, there was a risk in supporting a user‐group while maintaining core development. These issues were mitigated by creating a second Agile Scrum framework in parallel with the developers' ongoing Agile Scrum process. This Agile collaboration promoted communication, ensured that the scientists had an active role in development, and allowed the developers to evaluate and implement the scientists' software requirements. The collaboration provided benefits for each group: the scientists actuated their development by using an existing platform, and the developers utilized the scientists' use‐case to improve their systems. This case study suggests that scientists and software developers can avoid scientific computing issues by collaborating and that Agile Scrum methods can address emergent concerns.
A search for a diffuse flux of astrophysical muon neutrinos, using data collected by the ANTARES neutrino telescope is presented. A (0.83×2π) sr sky was monitored for a total of 334 days of ...equivalent live time. The searched signal corresponds to an excess of events, produced by astrophysical sources, over the expected atmospheric neutrino background. The observed number of events is found compatible with the background expectation. Assuming an E−2 flux spectrum, a 90% c.l. upper limit on the diffuse νμ flux of E2Φ90%=5.3×10−8 GeVcm−2s−1sr−1 in the energy range 20 TeV–2.5 PeV is obtained. Other signal models with different energy spectra are also tested and some rejected.
The multi-PMT optical module for KM3NeT Löhner, H.; Dorosti-Hasankiadeh, Q.; Heine, E. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
08/2013, Letnik:
718
Journal Article
Recenzirano
In the future neutrino telescope KM3NeT a novel type of optical module (OM) will be employed to optimize the sensitivity to Cherenkov photons and maximize the environmental background suppression. ...The multi-PMT OM, a pressure-resistant glass sphere containing 31 photomultiplier tubes (PMTs) of 3-in. diameter, has been developed and prototyped including electronics for high-voltage generation, signal digitization and optical signal transmission. Monte-Carlo simulations show that a multi-PMT OM configuration requires three times less OMs to achieve the same performance as conventional OMs hosting 10-in. PMTs.
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