The IceCube Neutrino Observatory has established the existence of a high-energy all-sky neutrino flux of astrophysical origin. This discovery was made using events interacting within a fiducial ...region of the detector surrounded by an active veto and with reconstructed energy above 60 TeV, commonly known as the high-energy starting event sample (HESE). We revisit the analysis of the HESE sample with an additional 4.5 years of data, newer glacial ice models, and improved systematics treatment. This paper describes the sample in detail, reports on the latest astrophysical neutrino flux measurements, and presents a source search for astrophysical neutrinos. We give the compatibility of these observations with specific isotropic flux models proposed in the literature as well as generic power-law-like scenarios. Assuming νe: νμ: ντ= 1 : 1 : 1 , and an equal flux of neutrinos and antineutrinos, we find that the astrophysical neutrino spectrum is compatible with an unbroken power law, with a preferred spectral index of 2.87−0.19+0.20 for the 68% confidence interval.
This Letter presents the results from pointlike neutrino source searches using ten years of IceCube data collected between April 6, 2008 and July 10, 2018. We evaluate the significance of an ...astrophysical signal from a pointlike source looking for an excess of clustered neutrino events with energies typically above ∼1 TeV among the background of atmospheric muons and neutrinos. We perform a full-sky scan, a search within a selected source catalog, a catalog population study, and three stacked Galactic catalog searches. The most significant point in the northern hemisphere from scanning the sky is coincident with the Seyfert II galaxy NGC 1068, which was included in the source catalog search. The excess at the coordinates of NGC 1068 is inconsistent with background expectations at the level of 2.9σ after accounting for statistical trials from the entire catalog. The combination of this result along with excesses observed at the coordinates of three other sources, including TXS 0506+056, suggests that, collectively, correlations with sources in the northern catalog are inconsistent with background at 3.3σ significance. The southern catalog is consistent with background. These results, all based on searches for a cumulative neutrino signal integrated over the 10 years of available data, motivate further study of these and similar sources, including time-dependent analyses, multimessenger correlations, and the possibility of stronger evidence with coming upgrades to the detector.
We report on the first measurement of the astrophysical neutrino flux using particle showers (cascades) in IceCube data from 2010–2015. Assuming standard oscillations, the astrophysical neutrinos in ...this dedicated cascade sample are dominated (∼90 %) by electron and tau flavors. The flux, observed in the sensitive energy range from 16 TeV to 2.6 PeV, is consistent with a single power-law model as expected from Fermi-type acceleration of high energy particles at astrophysical sources. We find the flux spectral index to be γ = 2.53 ± 0.07 and a flux normalization for each neutrino flavor of ϕastro = 1.66+0.25 −0.27 at E0 = 100 TeV , in agreement with IceCube's complementary muon neutrino results and with all-neutrino flavor fit results. In the measured energy range we reject spectral indices γ ≤ 2.28 at ≥ 3 σ significance level. Because of high neutrino energy resolution and low atmospheric neutrino backgrounds, this analysis provides the most detailed characterization of the neutrino flux at energies below ∼100 TeV compared to previous IceCube results. Results from fits assuming more complex neutrino flux models suggest a flux softening at high energies and a flux hardening at low energies (p value ≥ 0.06). The sizable and smooth flux measured below ∼100 TeV remains a puzzle. In order to not violate the isotropic diffuse gamma-ray background as measured by the Fermi Large Area Telescope, it suggests the existence of astrophysical neutrino sources characterized by dense environments which are opaque to gamma rays.
To cite this article: Laatikainen T, von Hertzen L, Koskinen J‐P, Mäkelä MJ, Jousilahti P, Kosunen TU, Vlasoff T, Ahlström M, Vartiainen E, Haahtela T. Allergy gap between Finnish and Russian Karelia ...on increase. Allergy 2011; 66: 886–892.
Background: Multinational time‐trend analyses of atopic disease have shown that the East–West gradients in prevalence are shrinking. We set out to clarify whether the disparities in the occurrence of atopy and atopic diseases in Finnish and Russian Karelia during the past 10 years have diminished and how the prevalence of atopy has evolved with successive years of birth.
Methods: Two surveys with identical methodology were performed in 1997/1998 and 2007. The study population comprised randomly selected adults, aged 25–54 years, from Finnish and Russian Karelia. Serum samples were collected for total and specific IgE measurements. Clinical data were obtained by questionnaires.
Results: Sensitization rates to birch pollen increased from 7.8% to 14.8% (P < 0.001) and to cat from 6.1% to 10.8% (P < 0.001) in Finland. In Russia, no significant increase was found. Contrary to this, total IgE remained stable in Finland but decreased significantly (P < 0.001) in Russia. Analyses based on years of birth revealed that the prevalence of sensitization to allergens increased with successive birth years in Finland, but remained stable in Russia. Over the 10 years, self‐reported physician‐diagnosed asthma increased from 5.5% to 8.1% (P = 0.05) and hay fever from 8.1% to 13.2% (P < 0.001) in Finland.
Conclusions: Disparities in the prevalence of atopy and atopic disease between Finnish and Russian Karelia have further grown. The ‘allergy epidemic’ continues in Finland and is mainly attributable to the years of birth effect shown in atopy prevalence. In Russia, no signs of the epidemic are discernible, although the decrease in total IgE may indicate a change in environmental exposure.
Standardized Map of Iodine Status in Europe Ittermann, Till; Albrecht, Diana; Arohonka, Petra ...
Thyroid (New York, N.Y.),
09/2020, Letnik:
30, Številka:
9
Journal Article
Recenzirano
Odprti dostop
Knowledge about the population's iodine status is important, because it allows adjustment of iodine supply and prevention of iodine deficiency. The validity and comparability of iodine-related ...population studies can be improved by standardization, which was one of the goals of the EUthyroid project. The aim of this study was to establish the first standardized map of iodine status in Europe by using standardized urinary iodine concentration (UIC) data.
We established a gold-standard laboratory in Helsinki measuring UIC by inductively coupled plasma mass spectrometry. A total of 40 studies from 23 European countries provided 75 urine samples covering the whole range of concentrations. Conversion formulas for UIC derived from the gold-standard values were established by linear regression models and were used to postharmonize the studies by standardizing the UIC data of the individual studies.
In comparison with the EUthyroid gold-standard, mean UIC measurements were higher in 11 laboratories and lower in 10 laboratories. The mean differences ranged from -36.6% to 49.5%. Of the 40 postharmonized studies providing data for the standardization, 16 were conducted in schoolchildren, 13 in adults, and 11 in pregnant women. Median standardized UIC was <100 μg/L in 1 out of 16 (6.3%) studies in schoolchildren, while in adults 7 out of 13 (53.8%) studies had a median standardized UIC <100 μg/L. Seven out of 11 (63.6%) studies in pregnant women revealed a median UIC <150 μg/L.
We demonstrate that iodine deficiency is still present in Europe, using standardized data from a large number of studies. Adults and pregnant women, particularly, are at risk for iodine deficiency, which calls for action. For instance, a more uniform European legislation on iodine fortification is warranted to ensure that noniodized salt is replaced by iodized salt more often. In addition, further efforts should be put on harmonizing iodine-related studies and iodine measurements to improve the validity and comparability of results.
Pim family kinases are small constitutively active serine/threonine-specific kinases, elevated levels of which have been detected in human hematopoietic malignancies as well as in solid tumours. ...While we and others have previously shown that the oncogenic Pim kinases stimulate survival of hematopoietic cells, we now examined their putative role in regulating motility of adherent cancer cells. For this purpose, we inhibited Pim kinase activity using a small molecule compound, 1,10-dihydropyrrolo2,3-acarbazole-3-carbaldehyde (DHPCC-9), which we had recently identified as a potent and selective inhibitor for all Pim family members.
We now demonstrate that the Pim kinase inhibitor DHPCC-9 is very effective also in cell-based assays. DHPCC-9 impairs the anti-apoptotic effects of Pim-1 in cytokine-deprived myeloid cells and inhibits intracellular phosphorylation of Pim substrates such as Bad. Moreover, DHPCC-9 slows down migration and invasion of cancer cells derived from either prostate cancer or squamocellular carcinoma patients. Silencing of Pim expression reduces cell motility, while Pim overexpression enhances it, strongly suggesting that the observed effects of DHPCC-9 are dependent on Pim kinase activity. Interestingly, DHPCC-9 also abrogates NFATc-dependent migration of cancer cells, implying that NFATc factors mediate at least part of the pro-migratory effects of Pim kinases.
Altogether, our data indicate that DHPCC-9 is not only a powerful tool to investigate physiological effects of the oncogenic Pim family kinases, but also an attractive molecule for drug development to inhibit invasiveness of Pim-overexpressing cancer cells.
•We propose a Bayesian data augmentation scheme for analyzing ERGM with partially observed data.•We demonstrate estimation and predictive distributions for three quarters of ties unobserved.•We ...demonstrate analysis when a particularly influential attribute is only partially observed.
We consider partially observed network data as defined in Handcock and Gile (2010). More specifically we introduce an elaboration of the Bayesian data augmentation scheme of Koskinen et al. (2010) that uses the exchange algorithm (Caimo and Friel, 2011) for inference for the exponential random graph model (ERGM) where tie variables are partly observed. We illustrate the generating of posteriors and unobserved tie-variables with empirical network data where 74% of the tie variables are unobserved under the assumption that some standard assumptions hold true. One of these assumptions is that covariates are fixed and completely observed. A likely scenario is that also covariates might only be partially observed and we propose a further extension of the data augmentation algorithm for missing attributes. We provide an illustrative example of parameter inference with nearly 30% of dyads affected by missing attributes (e.g. homophily effects). The assumption that all actors are known is another assumption that is liable to be violated so that there are “covert actors”. We briefly discuss various aspects of this problem with reference to the Sageman (2004) data set on suspected terrorists. We conclude by identifying some areas in need of further research.
AbstractObjectiveTo examine whether physical inactivity is a risk factor for dementia, with attention to the role of cardiometabolic disease in this association and reverse causation bias that arises ...from changes in physical activity in the preclinical (prodromal) phase of dementia.DesignMeta-analysis of 19 prospective observational cohort studies.Data sourcesThe Individual-Participant-Data Meta-analysis in Working Populations Consortium, the Inter-University Consortium for Political and Social Research, and the UK Data Service, including a total of 19 of a potential 9741 studies.Review methodThe search strategy was designed to retrieve individual-participant data from prospective cohort studies. Exposure was physical inactivity; primary outcomes were incident all-cause dementia and Alzheimer’s disease; and the secondary outcome was incident cardiometabolic disease (that is, diabetes, coronary heart disease, and stroke). Summary estimates were obtained using random effects meta-analysis.ResultsStudy population included 404 840 people (mean age 45.5 years, 57.7% women) who were initially free of dementia, had a measurement of physical inactivity at study entry, and were linked to electronic health records. In 6.0 million person-years at risk, we recorded 2044 incident cases of all-cause dementia. In studies with data on dementia subtype, the number of incident cases of Alzheimer’s disease was 1602 in 5.2 million person-years. When measured <10 years before dementia diagnosis (that is, the preclinical stage of dementia), physical inactivity was associated with increased incidence of all-cause dementia (hazard ratio 1.40, 95% confidence interval 1.23 to 1.71) and Alzheimer’s disease (1.36, 1.12 to 1.65). When reverse causation was minimised by assessing physical activity ≥10 years before dementia onset, no difference in dementia risk between physically active and inactive participants was observed (hazard ratios 1.01 (0.89 to 1.14) and 0.96 (0.85 to 1.08) for the two outcomes). Physical inactivity was consistently associated with increased risk of incident diabetes (hazard ratio 1.42, 1.25 to 1.61), coronary heart disease (1.24, 1.13 to 1.36), and stroke (1.16, 1.05 to 1.27). Among people in whom cardiometabolic disease preceded dementia, physical inactivity was non-significantly associated with dementia (hazard ratio for physical activity assessed >10 before dementia onset 1.30, 0.79 to 2.14).ConclusionsIn analyses that addressed bias due to reverse causation, physical inactivity was not associated with all-cause dementia or Alzheimer’s disease, although an indication of excess dementia risk was observed in a subgroup of physically inactive individuals who developed cardiometabolic disease.
Compressed sheath regions form ahead of interplanetary coronal mass ejections (ICMEs) that are sufficiently faster than the preceding solar wind. The turbulent sheath regions are important drivers of ...magnetospheric activity, but due to their complex internal structure, relatively little is known on the distribution of the magnetic field and plasma variations in them. In this paper we investigate ultra low frequency (ULF) fluctuations in the interplanetary magnetic field (IMF) and in dynamic pressure (Pdyn) using a superposed epoch analysis of 41 sheath regions observed during solar cycle 23. We find strongest fluctuation power near the shock and in the vicinity of the ICME leading edge. The IMF and Pdyn ULF power have different profiles within the sheath; the former is enhanced in the leading part of the sheath, while the latter is increased in the trailing part of the sheath. We also find that the ICME properties affect the level and distribution of the ULF power in sheath regions. For example, sheath regions associated with strong or fast ICMEs, or those that are crossed at intermediate distances from the center, have strongest ULF power and large variation in the power throughout the sheath region. The weaker or slower ICMEs, or those that are crossed centrally, have in general considerably weaker ULF power with relatively smooth profiles. The strong and abrupt decrease of the IMF ULF power at the ICME leading edge could be used to distinguish the ICME from the preceding sheath plasma.
Context.
Exoplanetary upper atmospheres are low density environments where radiative processes can compete with collisional ones and introduce non-local thermodynamic equilibrium (NLTE) effects into ...transmission spectra.
Aims.
We develop a NLTE radiative transfer framework capable of modelling exoplanetary transmission spectra over a wide range of planetary properties.
Methods.
We adapted the NLTE spectral synthesis code Cloudy to produce an atmospheric structure and atomic transmission spectrum in both NLTE and local thermodynamic equilibrium (LTE) for the hot Jupiter HD 209458b, given a published
T
–
P
profile and assuming solar metallicity. Selected spectral features, including H
α
, Na
I
D, He
I
λ
10 830, Fe
I
and
II
ultra-violet (UV) bands, and C, O, and Si UV lines, are compared with literature observations and models where available. The strength of NLTE effects are measured for individual spectral lines to identify which features are most strongly affected.
Results.
The developed modelling framework that computes NLTE synthetic spectra reproduces literature results for the He
I
λ
10 830 triplet, the Na
I
D lines, and the forest of Fe
I
lines in the optical. Individual spectral lines in the NLTE spectrum exhibit up to 40% stronger absorption relative to the LTE spectrum.
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