In the present study, have been investigated for antifungal potential against two phytopathogens namely and . Inhibitory potential of methanolic extract of the plant was analyzed by poisoned food ...technique in which different concentrations of test material were prepared in sterilized potato dextrose agar. Results of the investigation revealed that has potential activity against both the test pathogens with IC value of 1±0.02 mg/mL and 0.95±0.019 mg/mL against and respectively. To conclude, leaves of amla possess potential antifungal activity and may be used as a resource of biocides in pesticide and food industry.
Assessment of depression in diabetic patients Kotwal, Shivwani D.; Kour, Navneet; Gadda, Irfan R. ...
International journal of research in medical sciences,
10/2023, Letnik:
11, Številka:
11
Journal Article
Odprti dostop
Background: Diabetes is one of the most common chronic conditions in the world. The worldwide prevalence of diabetes mellitus (DM) has risen dramatically over the past two decades because of ...increasing obesity and reduced activity levels. The purpose of this study was to show the association between depression and diabetes.
Methods: It was a cross-study. The study included 240 patients who were chosen randomly with no gender bias. A convenient subject of 240 diabetic patients was interviewed.
Results: Out of the total 240 diabetic patients, included in this study, the majority of patients, 52.63% in the age group of 60 years had depression with a Hamilton score of >19 while 47.37% of patients in the age of 40 to 50 years had Hamilton score of >19. 84.21% of males had depression with a Hamilton score >19 as compared to females who had a Hamilton score of 15.79%. The patients within the age group of 40-59 have 2.5 times more risk of having depression as compared to the age group of 20 to 39 and patients in the age group >60 years have 4.23 times higher risk of depression as compared to patients in the age group of 20 to 39 years. The association between gender and depression shows that males have a higher rate of depression (78.17%) as compared to females (21.81%) with an odd's ratio of 3.0.
Conclusions: Our study showed a high prevalence of depression and anxiety in male patients and the elderly age group. Planning and implementation of screening for mental health issues in the elderly population diagnosed with a lifestyle disease-such as type 2 diabetes mellitus-with existing comorbidities should be recognized as one of the most important goals of the public health system. It seems necessary to involve medical teams in the screening process to verify the symptoms, promptly establish the diagnosis, and initiate the appropriate depression treatment. In diabetic patients, depression remains underdiagnosed and an important aspect of the diabetic specialists would be the awareness of this quite common co-morbidity.
Antibacterial efficacy of amla leaves Sharma, Vikas; Heer, Arti; Kour, Navneet ...
International journal of pharmaceutical chemistry and analysis,
9/2023, Letnik:
10, Številka:
3
Journal Article
Odprti dostop
The present study was carried out to evaluate antibacterial potential of methanolic extract from amla leaves via agar-well diffusion method against two gram positive ( subtilis MTCC2389, MTCC7443) ...and three gram negative (MTCC4821, MTCC2127, MTCC7162) strains. Susceptibility of plant extract was tested by serial microdilution method (MIC) and agar well diffusion method was determined. The extract showed maximum zone of inhibition against (17.6 mm) followed by (16.5 mm) and (16.2 mm). However, activity was also reported against (15.5 mm) and (15 mm). The different concentrations of extract (10μl and 20μl) were used and the minimum inhibitory concentration (MIC) ranging from 62.5 to 2000 μg/ml was compared with the standard drug Chloramphenicol (5μg). The MIC of methanolic extract was found 550 μg/ml against and The results of present study revealed that leaves of amla possesses antibacterial potential and source of new antibiotics. Therefore, medicinal plants are finding their way into pharmaceuticals, neutralceuticals and food Supplements that could be useful in chemotherapy to control infectious diseases.
Amla possesses antifungal potential against and Sharma, Vikas; Heer, Arti; Kour, Navneet ...
Current Trends in Pharmacy and Pharmaceutical Chemistry,
8/2022, Letnik:
4, Številka:
3
Journal Article
Odprti dostop
The present study was carried out to evaluate antifungal activity of methanolic extract from Emblica officinalis leaves against three phytopathogens viz., Alternaria alternate, Bipolaris specifera ...and Curvuleria lunata.
Inhibitory potential of methanolic extract was analyzed by poisoned food technique in which different concentrations of test material were prepared in sterilized potato dextrose agar.
Results of the present study revealed that Embilica officinalis has potential activity against the three test pathogens with IC value of 0.91±0.01 mg/mL, 1±0.015 mg/mL and 1.1±0.0152 mg/mL against Bipolaris specifera, Alternaria alternata and Curvuleria lunata respectively.
Amla has some potential antifungal activity for the prevention and treatment of fungal infections.
This study was designed to identify cytotoxic compounds from Carissa carandas extract. The cytotoxic activity of extract and fractions were assessed against eight cancer cell lines. The chloroform ...fraction obtained from methanolic extract exhibited significant activity against MCF-7, HT-29, A-549 with IC
50
values of 3.98 µg/mL (MCF-7), 1.28µg/mL (HT-29) and 1.48 µg/mL (A-549) respectively. Further investigation led to the isolation of novel compound carissic acid (CA), which was confirmed by detailed spectroscopy studies. CA exhibited notable activity with IC
50
values of 3.47 µM for A-549, 2.65 µM for HT-29 and 13.58 ± 0.59 µM for MCF-7 cells. CAcaused chromatin condensation with decrease of mitochondrial membrane potential and also confirmed cell death via Reactive Oxygen Species (ROS) generation and significantly decreased the colony formation in dose-dependent manner. The overall findings suggested that CA demonstrates cytotoxic effect by inhibiting cell proliferation and promoting apoptosis in lung (A-549) carcinoma cell line.
Background: The medicinal properties of Syzygium sp., especially the antidiabetic property, date back to the ancient times. However, in the recent past, extracts from different parts of the Syzygium ...sp. have demonstrated promising anticancer activities in diverse cancer types, and now, attempts are being made to identify the active phytochemicals.
Aims and Objectives: In this study, we intended to test the anticancer properties of phytochemicals extracted from the fruit of Syzygium cumini plant in ovarian cancer cells.
Materials and Methods: A total of nine phytochemicals extracted from the S. cumini fruits using chloroform were tested for their anticancer activity in the ovarian cancer cell line PA-1. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide tetrazolium assay was performed to calculate the 50% inhibition (IC50) concentration and cell cytotoxicity values. Cell scratch assay was performed to assess the proliferation inhibition activity of the phytochemicals. Cisplatin was used as positive control.
Results: Out of the nine phytochemicals tested, quercetin (QC), gallic acid (GA), and oleanolic acid (OA) were found active. QC and GA were most effective with more than 90% cell cytotoxicity at 2.5 µ g/ml and above concentrations and OA moderately effective up to 5 µg/ml serial concentrations. Cell proliferation was significantly inhibited by QC and GA and moderately but significantly by OA.
Conclusion: Our data demonstrate the anticancer activity of QC, GA, and OA phytochemicals, which is consistent with the previous reports. However, this is the first report showing the anticancer activity of these phytochemicals derived from S. cumini in the ovarian cancer cells. These data suggest that there is a potential to develop these phytochemicals as anticancer therapeutic agents either as monotherapeutic agents or in combination with commonly used chemotherapeutic agents, which needs to be explored.
Face-masks are currently turning into a fundamental piece of our clothing standard, without a doubt. While the West wasn't entirely ok with face-masks in the pre-COVID-19 period, East Asians were all ...the more inviting of them. Controlling a respiratory contamination at source by a mask is an entrenched procedure. The utilization of masks followed by certain precautionary measure is a piece of a thorough bundle of the avoidance and control gauges that can restrain the spread of any respiratory viral maladies, including COVID-19. Subsequently the fundamental point of the examination is to illuminate the mask, their utilization and guidelines to be followed during this pandemic period. Numerous nations have suggested the utilization of fabric mask/face covers for the overall population. Right now, the boundless utilization of mask by healthy individuals in the network setting isn't yet upheld by high calibre or direct logical proof and there are likely advantages and damages to consider. Any mask worn for everyday assurance against COVID-19 will be flawed, at any rate for the current pandemic time.
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