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zadetkov: 39
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  • BRCA locus-specific loss of... BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers
    Maxwell, Kara N; Wubbenhorst, Bradley; Wenz, Brandon M ... Nature communications, 08/2017, Letnik: 8, Številka: 1
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    Complete loss of BRCA1 or BRCA2 function is associated with sensitivity to DNA damaging agents. However, not all BRCA1 and BRCA2 germline mutation-associated tumors respond. Herein we report analyses ...
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  • A single dose of neoadjuvan... A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma
    Huang, Alexander C; Orlowski, Robert J; Xu, Xiaowei ... Nature medicine, 03/2019, Letnik: 25, Številka: 3
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    Immunologic responses to anti-PD-1 therapy in melanoma patients occur rapidly with pharmacodynamic T cell responses detectable in blood by 3 weeks. It is unclear, however, whether these early ...
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  • Identification of secreted ... Identification of secreted proteins that reflect autophagy dynamics within tumor cells
    Kraya, Adam A.; Piao, Shengfu; Xu, Xiaowei ... Autophagy, 01/2015, Letnik: 11, Številka: 1
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    Macroautophagy, a catabolic process of cellular self-digestion, is an important tumor cell survival mechanism and a potential target in antineoplastic therapies. Recent discoveries have implicated ...
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  • Analysis of matched primary... Analysis of matched primary and recurrent BRCA1/2 mutation-associated tumors identifies recurrence-specific drivers
    Shah, Jennifer B; Pueschl, Dana; Wubbenhorst, Bradley ... Nature communications, 11/2022, Letnik: 13, Številka: 1
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    Recurrence is a major cause of death among BRCA1/2 mutation carriers with breast (BrCa) and ovarian cancers (OvCa). Herein we perform multi-omic sequencing on 67 paired primary and recurrent BrCa and ...
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  • Evolution of delayed resist... Evolution of delayed resistance to immunotherapy in a melanoma responder
    Liu, David; Lin, Jia-Ren; Robitschek, Emily J ... Nature medicine, 06/2021, Letnik: 27, Številka: 6
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    Despite initial responses , most melanoma patients develop resistance to immune checkpoint blockade (ICB). To understand the evolution of resistance, we studied 37 tumor samples over 9 years from a ...
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  • Radiomics for characterizat... Radiomics for characterization of the glioma immune microenvironment
    Khalili, Nastaran; Kazerooni, Anahita Fathi; Familiar, Ariana ... NPJ precision oncology, 06/2023, Letnik: 7, Številka: 1
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    Increasing evidence suggests that besides mutational and molecular alterations, the immune component of the tumor microenvironment also substantially impacts tumor behavior and complicates treatment ...
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  • PTEN Loss and BRCA1 Promote... PTEN Loss and BRCA1 Promoter Hypermethylation Negatively Predict for Immunogenicity in BRCA-Deficient Ovarian Cancer
    Kraya, Adam A; Maxwell, Kara N; Eiva, Monika A ... JCO precision oncology, 02/2022, Letnik: 6
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    Ovarian cancers can exhibit a prominent immune infiltrate, but clinical trials have not demonstrated substantive response rates to immune checkpoint blockade monotherapy. We aimed to understand ...
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  • OpenPBTA: The Open Pediatri... OpenPBTA: The Open Pediatric Brain Tumor Atlas
    Shapiro, Joshua A.; Gaonkar, Krutika S.; Spielman, Stephanie J. ... Cell genomics, 07/2023, Letnik: 3, Številka: 7
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    Pediatric brain and spinal cancers are collectively the leading disease-related cause of death in children; thus, we urgently need curative therapeutic strategies for these tumors. To accelerate such ...
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zadetkov: 39

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