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zadetkov: 140
1.
  • Bevacizumab-induced hyperte... Bevacizumab-induced hypertension: Clinical presentation and molecular understanding
    Li, Megan; Kroetz, Deanna L. Pharmacology & therapeutics, 02/2018, Letnik: 182
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    Bevacizumab is a vascular endothelial growth factor-A-specific angiogenesis inhibitor indicated as an adjunct to chemotherapy for the treatment of several types of cancer. Hypertension is commonly ...
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2.
  • Clinical Pharmacokinetics o... Clinical Pharmacokinetics of Paclitaxel Monotherapy: An Updated Literature Review
    Stage, Tore B; Bergmann, Troels K; Kroetz, Deanna L Clinical pharmacokinetics, 01/2018, Letnik: 57, Številka: 1
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    Paclitaxel is an anticancer agent efficacious in the treatment of ovarian, breast, and lung cancer. Due to a strong link between the pharmacokinetics and therapeutic efficacy of paclitaxel, we ...
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3.
  • A genome-wide association s... A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101
    Baldwin, R Michael; Owzar, Kouros; Zembutsu, Hitoshi ... Clinical cancer research, 09/2012, Letnik: 18, Številka: 18
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    Sensory peripheral neuropathy is a common and sometimes debilitating toxicity associated with paclitaxel therapy. This study aims to identify genetic risk factors for the development of this ...
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4.
  • Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics
    Innocenti, Federico; Kroetz, Deanna L; Schuetz, Erin ... Journal of clinical oncology, 06/2009, Letnik: 27, Številka: 16
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    We aim to identify genetic variation, in addition to the UGT1A1*28 polymorphism, that can explain the variability in irinotecan (CPT-11) pharmacokinetics and neutropenia in cancer patients. ...
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5.
  • ABCC4 is regulated by micro... ABCC4 is regulated by microRNA-124a and microRNA-506
    Markova, Svetlana M.; Kroetz, Deanna L. Biochemical pharmacology, 02/2014, Letnik: 87, Številka: 3
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    Multidrug resistance protein 4 (MRP4, ABCC4) is an efflux membrane transporter expressed in renal tubules, hepatocytes, brain capillaries, prostate and blood cells. MRP4 drives energy dependent ...
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6.
  • Apical Shear Stress Enhance... Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing
    Jayagopal, Aishwarya; Brakeman, Paul R; Soler, Peter ... The Journal of pharmacology and experimental therapeutics, 06/2019, Letnik: 369, Številka: 3
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    Active transport by renal proximal tubules plays a significant role in drug disposition. During drug development, estimates of renal excretion are essential to dose determination. Kidney bioreactors ...
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7.
  • Abacavir Pharmacogenetics -... Abacavir Pharmacogenetics - From Initial Reports to Standard of Care
    Martin, Michael A.; Kroetz, Deanna L. Pharmacotherapy, July 2013, Letnik: 33, Številka: 7
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    Abacavir is a nucleoside analogue reverse transcriptase inhibitor indicated for the treatment of human immunodeficiency virus infection as part of a multidrug, highly active antiretroviral therapy ...
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8.
  • Role for Drug Transporters ... Role for Drug Transporters in Chemotherapy‐Induced Peripheral Neuropathy
    Stage, Tore B.; Hu, Shuiying; Sparreboom, Alex ... Clinical and translational science, March 2021, Letnik: 14, Številka: 2
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    Chemotherapy‐induced peripheral neuropathy (CIPN) is a common and dose‐limiting toxicity to widely used chemotherapeutics. Although the exact molecular mechanism of chemotherapy‐induced peripheral ...
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9.
  • New and Emerging Research o... New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium
    Giacomini, Kathleen M.; Yee, Sook W.; Koleske, Megan L. ... Clinical pharmacology and therapeutics, September 2022, Letnik: 112, Številka: 3
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    Enabled by a plethora of new technologies, research in membrane transporters has exploded in the past decade. The goal of this state‐of‐the‐art article is to describe recent advances in research on ...
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10.
  • Organic Anion Transporter P... Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug–Drug Interaction and Associated Biomarker Levels in Healthy Volunteers
    Yee, Sook Wah; Giacomini, Marilyn M.; Shen, Hong ... Clinical and translational science, July 2019, Letnik: 12, Številka: 4
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    Understanding transporter‐mediated drug–drug interactions is an integral part of risk assessment in drug development. Recent studies support the use of hexadecanedioate (HDA), tetradecanedioate ...
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zadetkov: 140

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