We compare for the first time the influence of different Yb:YAG gain media on the performance of a large-area, high average-power laser system with an output energy of up to 6 J. Monocrystalline ...slabs grown by a new technique without central growth defect are compared with ceramics. Small signal gain, maximum output energy and thermal lensing are compared for ceramic slabs with co-sintered amplified spontaneous emission (ASE) absorber cladding, monocrystalline slab with and without optically bonded ASE absorber cladding, and surface structured monocrystalline slabs. We show that these large monocrystals with optically bonded absorber cladding have similar performance to cladded ceramics, so far the only material for high-energy Yb:YAG lasers.
Massive stars lose a significant fraction of mass during their evolution. However, the corresponding mass-loss rates are rather uncertain, especially for evolved stars. To improve this, we calculated ...global line-driven wind models for Galactic B supergiants. Our models predict radial wind structure and particularly the mass-loss rates and terminal velocities directly from basic stellar parameters. The hydrodynamic structure of the flow is consistently determined from the photosphere in nearly hydrostatic equilibrium to supersonically expanding wind. The radiative force is derived from the solution of the radiative transfer equation in the comoving frame. We provide a simple formula that predicts theoretical mass-loss rates as a function of stellar luminosity and effective temperature. The mass-loss rate of B supergiants slightly decreases with temperature down to about 22.5 kK, where the region of recombination of Fe
IV
to Fe
III
starts to appear. In this region, which is about 5 kK wide, the mass-loss rate gradually increases by a factor of about 6. The increase of the mass-loss rate is associated with a gradual decrease of terminal velocities by a factor of about 2. We compared the predicted wind parameters with observations. While the observed wind terminal velocities are reasonably reproduced by the models, the situation with mass-loss rates is less clear. The mass-loss rates derived from observations that are uncorrected for clumping are by a factor of 3 to 9 higher than our predictions on cool and hot sides of the studied sample, respectively. These observations can be reconciled with theory assuming a temperature-dependent clumping factor that is decreasing toward lower effective temperatures. On the other hand, the mass-loss rate estimates that are not sensitive to clumping agree with our predictions much better. Our predictions are by a factor of about 10 lower than the values currently used in evolutionary models appealing for reconsideration of the role of winds in the stellar evolution.
Inflammation is a complex process involving distinct but overlapping biochemical and molecular events that are highly regulated. Pulsed electromagnetic field (PEMF) therapy is increasingly used to ...treat pain and edema associated with inflammation following surgery involving soft tissue. However, the molecular and cellular effects of PEMF therapy on pathways involved in the resolution of inflammation are poorly understood. Using cell culture lines relevant to trauma-induced inflammation of the skin (human dermal fibroblasts, human epidermal keratinocytes, and human mononuclear cells), we investigated the effect of PEMF on gene expression involved in the acute and resolution phases of inflammation. We found that PEMF treatment was followed by changes in the relative amount of messenger (m)RNAs encoding enzymes involved in heme catabolism and removal of reactive oxygen species, including an increase in heme oxygenase 1 and superoxide dismutase 3 mRNAs, in all cell types examined 2 hours after PEMF treatment. A relative increase in mRNAs encoding enzymes involved in lipid mediator biosynthesis was also observed, including an increase in arachidonate 12- and 15-lipoxygenase mRNAs in dermal fibroblasts and epidermal keratinocytes, respectively. The relative amount of both of these lipoxygenase mRNAs was elevated in mononuclear cells following PEMF treatment relative to nontreated cells. PEMF treatment was also followed by changes in the mRNA levels of several cytokines. A decrease in the relative amount of interleukin 1 beta mRNA was observed in mononuclear cells, similar to that previously reported for epidermal keratinocytes and dermal fibroblasts. Based on our results, we propose a model in which PEMF therapy may promote chronic inflammation resolution by mediating gene expression changes important for inhibiting and resolving inflammation.
Context. Blue supergiant stars are known to display photometric and spectroscopic variability that is suggested to be linked to stellar pulsations. Pulsational activity in massive stars strongly ...depends on the star’s evolutionary stage and is assumed to be connected with mass-loss episodes, the appearance of macroturbulent line broadening, and the formation of clumps in the wind. Aims. To investigate a possible interplay between pulsations and mass-loss, we carried out an observational campaign of the supergiant 55 Cyg over a period of five years to search for photospheric activity and cyclic mass-loss variability in the stellar wind. Methods. We modeled the H, He i, Si ii, and Si iii lines using the nonlocal thermal equilibrium atmosphere code FASTWIND and derived the photospheric and wind parameters. In addition, we searched for variability in the intensity and radial velocity of photospheric lines and performed a moment analysis of the line profiles to derive frequencies and amplitudes of the variations. Results. The Hα line varies with time in both intensity and shape, displaying various types of profiles: P Cygni, pure emission, almost complete absence, and double or multiple peaked. The star undergoes episodes of variable mass-loss rates that change by a factor of 1.7–2 on different timescales. We also observe changes in the ionization rate of Si ii and determine a multiperiodic oscillation in the He i absorption lines, with periods ranging from a few hours to 22.5 days. Conclusions. We interpret the photospheric line variations in terms of oscillations in p-, g-, and strange modes. We suggest that these pulsations can lead to phases of enhanced mass loss. Furthermore, they can mislead the determination of the stellar rotation. We classify the star as a post-red supergiant, belonging to the group of α Cyg variables.
Context. Mass-loss rate is one of the most important stellar parameters. Mass loss via stellar winds may influence stellar evolution and modifies stellar spectrum. Stellar winds of subluminous hot ...stars, especially subdwarfs, have not been studied thoroughly. Aims. We aim to provide mass-loss rates as a function of subdwarf parameters and to apply the formula for individual subdwarfs, to predict the wind terminal velocities, to estimate the influence of the magnetic field and X-ray ionization on the stellar wind, and to study the interaction of subdwarf wind with mass loss from Be and cool companions. Methods. We used our kinetic equilibrium (NLTE) wind models with the radiative force determined from the radiative transfer equation in the comoving frame (CMF) to predict the wind structure of subluminous hot stars. Our models solve stationary hydrodynamical equations, that is the equation of continuity, equation of motion, and energy equation and predict basic wind parameters. Results. We predicted the wind mass-loss rate as a function of stellar parameters, namely the stellar luminosity, effective temperature, and metallicity. The derived wind parameters (mass-loss rates and terminal velocities) agree with the values derived from the observations. The radiative force is not able to accelerate the homogeneous wind for stars with low effective temperatures and high surface gravities. We discussed the properties of winds of individual subdwarfs. The X-ray irradiation may inhibit the flow in binaries with compact components. In binaries with Be components, the winds interact with the disk of the Be star. Conclusions. Stellar winds exist in subluminous stars with low gravities or high effective temperatures. Despite their low mass-loss rates, they are detectable in the ultraviolet spectrum and cause X-ray emission. Subdwarf stars may lose a significant part of their mass during the evolution. The angular momentum loss in magnetic subdwarfs with wind may explain their low rotational velocities. Stellar winds are especially important in binaries, where they may be accreted on a compact or cool companion.
The spectrum of the Be star HD 161306 is shown to vary periodically with a period of ~100 days. The radial velocity of the He i 6678 Å emission peak varying in antiphase to the radial velocity of the ...Hα emission wings component suggests that the star is a binary similar to φ Per, 59 Cyg, or FY CMa, i.e. a radiatively interacting Be binary – a rare case among Be stars. This type of object is also called a φ Per-type binary or Be + sdO binaries. The range of radial-velocity variations of the strong emission peak in the helium line observed in HD 161306 is about 180 km s-1, similar to what is observed for these systems. We therefore conclude that HD 161306 may represent another case of a Be star with a hot subdwarf companion.
Context. In wind-powered X-ray binaries, the radiatively driven stellar wind from the primary may be inhibited by the X-ray irradiation. This creates the feedback that limits the X-ray luminosity of ...the compact secondary. Wind inhibition might be weakened by the effect of small-scale wind inhomogeneities (clumping) possibly affecting the limiting X-ray luminosity. Aims. We study the influence of X-ray irradiation on the stellar wind for different radial distributions of clumping. Methods. We calculate hot star wind models with external irradiation and clumping using our global wind code. The models are calculated for different parameters of the binary. We determine the parameters for which the X-ray wind ionization is so strong that it leads to a decrease of the radiative force. This causes a decrease of the wind velocity and even of the mass-loss rate in the case of extreme X-ray irradiation. Results. Clumping weakens the effect of X-ray irradiation because it favours recombination and leads to an increase of the wind mass-loss rate. The best match between the models and observed properties of high-mass X-ray binaries (HMXBs) is derived with radially variable clumping. We describe the influence of X-ray irradiation on the terminal velocity and on the mass-loss rate in a parametric way. The X-ray luminosities predicted within the Bondi-Hoyle-Lyttleton theory agree nicely with observations when accounting for X-ray irradiation. Conclusions. The ionizing feedback regulates the accretion onto the compact companion resulting in a relatively stable X-ray source. The wind-powered accretion model can account for large luminosities in HMXBs only when introducing the ionizing feedback. There are two possible states following from the dependence of X-ray luminosity on the wind terminal velocity and mass-loss rate. One state has low X-ray luminosity and a nearly undisturbed wind, and the second state has high X-ray luminosity and exhibits a strong influence of X-rays on the flow.
To statistically evaluate published clinical efficacy data related to the use of pulsed radio frequency energy (PRFE) therapy in 3 clinical applications.
Numerous clinical studies have reported ...efficacy outcomes for PRFE therapy use in the palliative treatment of both postoperative and nonpostoperative pain and edema, and for its use as an adjunctive wound-healing (WH) therapeutic. Although diverse in design and endpoint, these studies are amenable to systematic review using both a vote-counting and P-value combination meta-analytic technique.
A meta-analysis of efficacy outcomes reported in clinical trials was performed using a vote-counting procedure. In addition, when possible, the sum of logs method of P-value combination was used to determine a significance level for the combined evidence within each endpoint and clinical area.
Of the 186 clinical articles identified after application of selection criteria, there were 25 controlled trials that met criteria for inclusion in vote-counting and P-value combination methods and were used for formal statistical analysis. In total, 1332 patients receiving PRFE treatment were studied. Vote-counting procedure applied to clinical outcomes from controlled studies resulted in a greater number of positive outcomes than neutral outcomes, and zero negative outcomes, for each of the clinical application groups evaluated. The sum of logs P-value method found statistically significant improvement in pain, reduction in edema, and improvement in WH outcomes.
On the basis of statistical evaluation of published clinical efficacy data, there is strong statistical evidence that PRFE therapy is effective in the treatment of postoperative and nonpostoperative pain and edema and in WH applications.
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