Ehlers-Danlos syndrome (EDS) constitutes a group of connective tissue diseases with variable organ dysfunction. We aimed to examine the comorbidity burden in patients with EDS.
A nationwide ...population-based cohort study linking data from Danish registers from the year 2000-2014. The EDS cohort was identified using the International Classification of Diseases version 10 (ICD-10) EDS code. The control cohort was formed from the Danish general population by randomly matching the EDS cohort in a ratio of 1:25 by sex and date of birth. Hospital contacts were used to identify the most frequently occurring ICD-10 codes. We investigated the frequencies of the disease categories and unique ICD-10 codes and compared these between the cohorts.
The EDS cohort included 1,319 patients and the control cohort 46,700 patients. All disease categories and ICD-10 codes were significantly more frequent within the EDS cohort, especially those related to common manifestations of EDS. Other comorbidities such as asthma, pneumonia, gastrointestinal functional disorders, and hernias were also significantly more common in the EDS cohort.
The most common comorbidities in Danish patients with EDS were gastrointestinal functional disorders, hernias, asthma, pneumonia, and osteoporosis. The causality between these comorbidities and EDS should be investigated further.
Implications for Rehabilitation
Ehlers-Danlos syndrome constitutes a group of connective tissue diseases causing a variable range of organ dysfunction.
The comorbidity burden for patients with Ehlers-Danlos syndrome was unexplored previously.
This study showed that the most common comorbidities in Danish patients with Ehlers-Danlos syndrome are gastrointestinal functional disorders, hernias, asthma, pneumonia, and osteoporosis.
Abstract
BL Lac objects emitting in the very high energy (VHE) regime are unique tools to peer into the properties of the extragalactic background light (EBL). However, due to the typical absence of ...features in their spectra, the determination of their redshifts has proven challenging. In this work, we exploit the superb spatial resolution delivered by the new Advanced Rayleigh guided Ground layer adaptive Optics System (ARGOS) at the Large Binocular Telescope to detect the host galaxy of HESS J1943+213, a VHE emitting BL Lac shining through the Galaxy. Deep H-band imaging collected during the ARGOS commissioning allowed us to separate the contribution of the nuclear emission and to unveil the properties of the host galaxy with unprecedented detail. The host galaxy is well fitted by a Sérsic profile with index of n ∼ 2 and total magnitude of HHost ∼ 16.15 mag. Under the assumption that BL Lac host galaxies are standard candles, we infer a redshift of z ∼ 0.21. In the framework of the current model for the EBL, this value is in agreement with the observed dimming of the VHE spectrum due to the annihilation of energetic photons on the EBL
ARGOS at the LBT Rabien, S.; Angel, R.; Barl, L. ...
Astronomy and astrophysics (Berlin),
01/2019, Letnik:
621
Journal Article
Recenzirano
Odprti dostop
Having completed its commissioning phase, the Advanced Rayleigh guided Ground-layer adaptive Optics System (ARGOS) facility is coming online for scientific observations at the Large Binocular ...Telescope (LBT). With six Rayleigh laser guide stars in two constellations and the corresponding wavefront sensing, ARGOS corrects the ground-layer distortions for both LBT 8.4 m eyes with their adaptive secondary mirrors. Under regular observing conditions, this set-up delivers a point spread function (PSF) size reduction by a factor of 2–3 compared to a seeing-limited operation. With the two LUCI infrared imaging and multi-object spectroscopy instruments receiving the corrected images, observations in the near-infrared can be performed at high spatial and spectral resolution. We discuss the final ARGOS technical set-up and the adaptive optics performance. We show that imaging cases with ground-layer adaptive optics (GLAO) are enhancing several scientific programmes, from cluster colour magnitude diagrams and Milky Way embedded star formation, to nuclei of nearby galaxies or extragalactic lensing fields. In the unique combination of ARGOS with the multi-object near-infrared spectroscopy available in LUCI over a 4 × 4 arcmin field of view, the first scientific observations have been performed on local and high-z objects. Those high spatial and spectral resolution observations demonstrate the capabilities now at hand with ARGOS at the LBT.
GRAVITY is a new instrument to coherently combine the light of the European Southern Observatory Very Large Telescope Interferometer to form a telescope with an equivalent 130 m diameter angular ...resolution and a collecting area of 200 m2. The instrument comprises fiber fed integrated optics beam combination, high resolution spectroscopy, built-in beam analysis and control, near-infrared wavefront sensing, phase-tracking, dual-beam operation, and laser metrology. GRAVITY opens up to optical/infrared interferometry the techniques of phase referenced imaging and narrow angle astrometry, in many aspects following the concepts of radio interferometry. This article gives an overview of GRAVITY and reports on the performance and the first astronomical observations during commissioning in 2015/16. We demonstrate phase-tracking on stars as faint as mK ≈ 10 mag, phase-referenced interferometry of objects fainter than mK ≈ 15 mag with a limiting magnitude of mK ≈ 17 mag, minute long coherent integrations, a visibility accuracy of better than 0.25%, and spectro-differential phase and closure phase accuracy better than 0.5°, corresponding to a differential astrometric precision of better than ten microarcseconds (μas). The dual-beam astrometry, measuring the phase difference of two objects with laser metrology, is still under commissioning. First observations show residuals as low as 50 μas when following objects over several months. We illustrate the instrument performance with the observations of archetypical objects for the different instrument modes. Examples include the Galactic center supermassive black hole and its fast orbiting star S2 for phase referenced dual-beam observations and infrared wavefront sensing, the high mass X-ray binary BP Cru and the active galactic nucleus of PDS 456 for a few μas spectro-differential astrometry, the T Tauri star S CrA for a spectro-differential visibility analysis, ξ Tel and 24 Cap for high accuracy visibility observations, and η Car for interferometric imaging with GRAVITY.
ARGOS at the LBT Rabien, S.; Angel, R.; Barl, L. ...
Astronomy and astrophysics (Berlin),
01/2019, Letnik:
621
Journal Article, Web Resource
Recenzirano
Odprti dostop
Having completed its commissioning phase, the Advanced Rayleigh guided Ground-layer adaptive Optics System (ARGOS) facility is coming online for scientific observations at the Large Binocular ...Telescope (LBT). With six Rayleigh laser guide stars in two constellations and the corresponding wavefront sensing, ARGOS corrects the ground-layer distortions for both LBT 8.4 m eyes with their adaptive secondary mirrors. Under regular observing conditions, this set-up delivers a point spread function (PSF) size reduction by a factor of 2–3 compared to a seeing-limited operation. With the two LUCI infrared imaging and multi-object spectroscopy instruments receiving the corrected images, observations in the near-infrared can be performed at high spatial and spectral resolution. We discuss the final ARGOS technical set-up and the adaptive optics performance. We show that imaging cases with ground-layer adaptive optics (GLAO) are enhancing several scientific programmes, from cluster colour magnitude diagrams and Milky Way embedded star formation, to nuclei of nearby galaxies or extragalactic lensing fields. In the unique combination of ARGOS with the multi-object near-infrared spectroscopy available in LUCI over a 4 × 4 arcmin field of view, the first scientific observations have been performed on local and high- z objects. Those high spatial and spectral resolution observations demonstrate the capabilities now at hand with ARGOS at the LBT.
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