The role of microcirculatory disorders is progressively being accepted in the pathogenesis of cardiovascular diseases.
The purpose of current study is to assess whether we can consider skin ...microcirculation disorders as a biomarker of cardiovascular events.
Group 1 consisted of healthy volunteers (n = 31); group 2 (n = 42) consisted of patients with diseases that increase the risk of cardiovascular events; group 3 (n = 39) included patients with the history of cardiovascular events. Skin microcirculation measurement was performed using laser Doppler flowmetry during the heating test.
LDF parameters reflecting the rapid response of microcirculation to heating ("Slope 120 s" and "Slope 180 s") significantly differed in three groups (p < 0.05). A decrease in the "Slope 180 s" parameter less than 0.5 PU/s is associated with cardiovascular events (sensitivity 69.2%, specificity 66.7%; the area under the ROC curve, 0.667; 95% confidence interval CI, 0.545-0.788, p = 0.01). Multivariable logistic regression analysis revealed that "Slope 180 s≤0.5 PU/s" was significantly related to cardiovascular events (adjusted odds ratio = 3.9, p = 0.019, CI 95% 1.2-12).
Reduced reactivity of the skin microcirculation may be useful as a biomarker of severe damage to the cardiovascular system and is promising as a risk factor for cardiovascular events.
Acquisition of new prophages that are able to increase the bacterial fitness by the lysogenic conversion is believed to be an important strategy of bacterial adaptation to the changing environment. ...However, in contrast to the factors determining the range of bacteriophage lytic activity, little is known about the factors that define the lysogenization host range. Bacteriophage phi24B is the paradigmal model of Stx-converting phages, encoding the toxins of the Shiga-toxigenic E. coli (STEC). This virus has been shown to lysogenize a wide range of E. coli strains that is much broader than the range of the strains supporting its lytic growth. Therefore, phages produced by the STEC population colonizing the small or large intestine are potentially able to lysogenize symbiotic E. coli in the hindgut, and these secondary lysogens may contribute to the overall patient toxic load and to lead to the emergence of new pathogenic STEC strains. We demonstrate, however, that O antigen effectively limit the lysogenization of the wild E. coli strains by phi24B phage. The lysogens are formed from the spontaneous rough mutants and therefore have increased sensitivity to other bacteriophages and to the bactericidal activity of the serum if compared to their respective parental strains.
The paper presents the results of studying the effect of modifying low-chromium hypoeutectic cast iron (chromium content about 1%) with boron- and barium-containing additives on its structure and ...hardness. The modification was carried out with carbothermicferroboron (0.08% of weight of the liquid metal); ferrosilicobarium (0.05% of weight of liquid metal); complex boron barium ferroalloy (0.14% by weight of liquid metal). The microstructure and properties were compared with a sample of unmodified cast iron of the same composition.
The Thixomet Pro software was used as the main method of the quantitative analysis of the microstructure that allows quantitative metallographic analyzing with high accuracy and repeatability.
The analysis of the results obtained shows a positive effect of modification on changes in the microstructure. In all the experimental samples, grinding and more uniform distribution of carbides, as well as transformation of the carbides morphology from dendritic to compact granular form, take place. Pearlite colonies in the modified cast iron are characterized by a higher degree of dispersion than in the reference sample. Such changes in the structure lead to increasing the hardness of the prototypes.
Low-chromium cast iron; Modification; Boron; Barium; Wear resistance; Hardness.
A platinum catalyst and a ruthenium catalyst were synthesized from a porous aromatic framework, namely PAF-30. The catalyst properties were examined in hydrogenation of phenol and guaiacol at ...80–250°C and at a hydrogen pressure of 30 atm in the presence of various solvents. Significant effects of the reaction medium, process conditions, and catalyst morphology on the reaction mechanism were demonstrated. Reaction conditions optimal for complete conversion of phenol and guaiacol to hydrogenation products were selected for both catalysts.
Abstract
Nowadays, in the agricultural industry, area monitoring is carried out using drones that are not linked to other devices such as ground-based automatic harvesters or drip irrigation systems. ...This results in a lot of time-consuming decision-making for harvesting ripe different crops or for pesticide treatment of areas of crops that need it immediately. This problem can be solved by using a monitoring system with heterogeneous robotic means, which allows the distribution of tasks between aerial robotic means. The purpose of this work is to optimize the algorithm of the control system for a group of robotic assets using a multigeneric decision-making approach. Many methods of operator decision support, control algorithms for solving the task of agricultural monitoring, used by scientific teams in the development of heterogeneous robotic means do not solve the problem in full. The approach is based on model optimization, namely the theory of auctions within the developed system, allowing to find a robotic system providing the maximum probability of fulfillment of the set task.
Presentation of the first Russian computer program (www.carotidscore.ru) for risk stratification of postoperative complications of carotid endarterectomy (CEE).
The present study is based on the ...analysis of a multicenter Russian database that includes 25,812 patients after CEE operated on from 01/01/2010 to 04/01/2022. The following types of CEE were implemented: 6814 classical CEE with plastic reconstruction of the reconstruction zone with a patch; 18,998 eversion CEE.
In the hospital postoperative period, 0.18% developed a lethal outcome, 0.14%-myocardial infarction, 0.35%-stroke. The combined endpoint was 0.68%. For each factor present in patients, a predictive coefficient was calculated. The prognostic coefficient was a numerical indicator reflecting the strength of the influence of each factor on the development of postoperative complications. Based on this formula, predictive coefficients were calculated for each factor present in patients in our study. The total contribution of these factors was reflected in "%" and denoted the risk of postoperative complications with a minimum value of 0% and a maximum of 100%. On the basis of the obtained calculations, a computer program CarotidSCORE was created. Its graphical interface is based on the QT framework (https://www.qt.io), which has established itself as one of the best solutions for desktop applications. It is possible not only to calculate the probability of developing a complication, but also to save all data about the patient in JSON format (for the patient's personal card and his anamnesis). The CarotidSCORE program contains 47 patient parameters, including clinical-demographic, anamnestic and angiographic characteristics. It allows you to choose one of the four types of CEE, which will provide an accurate stratification of the risk of complications for each of them in person.
CarotidSCORE (www.carotidscore.ru) is able to determine the likelihood of postoperative complications in patients undergoing CEE.
Platinum catalysts based on porous aromatic frameworks (PAF-30 and PAF-30–SO
3
H) have been synthesized. Properties of the obtained catalysts have been assessed via hydrogenation of guaiacol, ...veratrole, and pyrocatechol at 250°С and hydrogen pressure 3.0 MPa in isopropanol medium. It has been shown that the presence of acidic sites in the catalyst significantly increases the yield of deoxygenation products. The effect of the substrate structure on the rate of its hydrodeoxygenation and the mechanism of the occurring processes have been studied.
To improve the outcomes in patients with malignant obstructive jaundice using intraluminal stenting.
The present study included 62 patients with clinical symptoms of malignant obstructive jaundice. ...In the main group, we performed biliary stenting with self-expanding multi-perforated stents (Hanarostent Multi-hole Biliary). Microscopic perforations of these stents prevent migration and reduce the risk of blocking the cystic and main pancreatic ducts. In the control group, stenting was performed with fully and partially covered self-expanding stents.
Lower incidence of obstructive cholecystitis and acute pancreatitis in the main group was associated with multiperforated stents reducing the risk of blocking the main pancreatic and cystic ducts.
In our study, multiperforated stents excluded migration and reduced the incidence of complications (acute cholecystitis from 11.5 to 3.8%, acute pancreatitis from 15.3 to 7.7%).
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Metagenomics of the viromes associated with symbiotic microbial communities is a rapidly expanding field of research. Most of the relevant studies deal with the viral communities of human or animal ...feces. The novel technology of long-reads sequencing from Oxford Nanopore that became available during the last years provides outstanding new possibilities for research of uncultured viral communities. However, compared to classical NGS sequencing, this technology is much more sensitive to the quantity and quality of sequenced DNA. We developed a simple, cheap, and efficient protocol for extraction of total virome DNA from horse feces yielding the DNA samples suitable for long-read sequencing. This method can be adapted for the work with other difficult objects.
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