To evaluate the toxicity and clinical outcome in patients with locally advanced cervical cancer (LACC) treated with whole pelvic conventional radiation therapy (WP-CRT) versus intensity modulated ...radiation therapy (WP-IMRT).
Between January 2010 and January 2012, 44 patients with International Federation of Gynecology and Obstetrics (FIGO 2009) stage IIB-IIIB squamous cell carcinoma of the cervix were randomized to receive 50.4 Gy in 28 fractions delivered via either WP-CRT or WP-IMRT with concurrent weekly cisplatin 40 mg/m(2). Acute toxicity was graded according to the Common Terminology Criteria for Adverse Events, version 3.0, and late toxicity was graded according to the Radiation Therapy Oncology Group system. The primary and secondary endpoints were acute gastrointestinal toxicity and disease-free survival, respectively.
Of 44 patients, 22 patients received WP-CRT and 22 received WP-IMRT. In the WP-CRT arm, 13 patients had stage IIB disease and 9 had stage IIIB disease; in the IMRT arm, 12 patients had stage IIB disease and 10 had stage IIIB disease. The median follow-up time in the WP-CRT arm was 21.7 months (range, 10.7-37.4 months), and in the WP-IMRT arm it was 21.6 months (range, 7.7-34.4 months). At 27 months, disease-free survival was 79.4% in the WP-CRT group versus 60% in the WP-IMRT group (P=.651), and overall survival was 76% in the WP-CRT group versus 85.7% in the WP-IMRT group (P=.645). Patients in the WP-IMRT arm experienced significantly fewer grade ≥2 acute gastrointestinal toxicities (31.8% vs 63.6%, P=.034) and grade ≥3 gastrointestinal toxicities (4.5% vs 27.3%, P=.047) than did patients receiving WP-CRT and had less chronic gastrointestinal toxicity (13.6% vs 50%, P=.011).
WP-IMRT is associated with significantly less toxicity compared with WP-CRT and has a comparable clinical outcome. Further studies with larger sample sizes and longer follow-up times are warranted to justify its use in routine clinical practice.
Guar gum–nano zinc oxide (GG/nZnO) biocomposite was used as an adsorbent for enhanced removal of Cr(VI) from aqueous solution. The maximum adsorption was achieved at 50min contact time, 25mg/L Cr(VI) ...conc., 1.0g/L adsorbent dose and 7.0 pH. Langmuir, Freundlich, Dubinin–Kaganer–Radushkevich and Temkin isotherm models were used to interpret the experimental data. The data obeyed both Langmuir and Freundlich models (R2=0.99) indicating a multilayer adsorption of Cr(VI) onto the heterogeneous surface. The linear plots of Temkin isotherm showed adsorbent-adsorbate interactions. Moreover, the energy obtained from DKR isotherm (1.58–2.24kJ/mol) indicated a physical adsorption of the metal ions onto the adsorbent surface, which implies more feasibility of the regeneration of the adsorbent. GG/nZnO biocomposite adsorbent showed an improved adsorption capacity for Cr(VI) (qm=55.56mg/g) as compared to other adsorbents reported in the literature. Adsorption process followed pseudo-second order kinetics; controlled by both liquid-film and intra-particle diffusion mechanisms. Thermodynamic parameters (ΔGo, ΔHo and ΔSo) reflected the feasibility, spontaneity and exothermic nature of adsorption. The results suggested that GG/nZnO biocomposite is economical, eco-friendly and capable to remove Cr(VI) from natural water resources.
The strain-driven interfacial coupling between the ferromagnetic and ferroelectric constituents of magnetoelectric (ME) composites makes them potential candidates for novel multifunctional devices. ...ME composites in the form of thin-film heterostructures show promising applications in miniaturized ME devices. This article reports the recent advancement in ME thin-film devices, such as highly sensitive magnetic field sensors, ME antennas, integrated tunable ME inductors, and ME band-pass filters, is discussed. (Pb
Zr
)TiO
(PZT), Pb(Mg
Nb
)O
-PbTiO
(PMN-PT), Aluminium nitride (AlN), and Al
Sc
N are the most commonly used piezoelectric constituents, whereas FeGa, FeGaB, FeCo, FeCoB, and Metglas (FeCoSiB alloy) are the most commonly used magnetostrictive constituents in the thin film ME devices. The ME field sensors offer a limit of detection in the fT/Hz
range at the mechanical resonance frequency. However, below resonance, different frequency conversion techniques with AC magnetic or electric fields or the delta-E effect are used. Noise floors of 1-100 pT/Hz
at 1 Hz were obtained. Acoustically actuated nanomechanical ME antennas operating at a very-high frequency as well as ultra-high frequency (0.1-3 GHz) range, were introduced. The ME antennas were successfully miniaturized by a few orders smaller in size compared to the state-of-the-art conventional antennas. The designed antennas exhibit potential application in biomedical devices and wearable antennas. Integrated tunable inductors and band-pass filters tuned by electric and magnetic field with a wide operating frequency range are also discussed along with miniaturized ME energy harvesters.
Display omitted
•Waste dry cell battery electrodes were used for graphene synthesis using electrochemical exfoliation route.•Significant yield (88%) of graphene oxide was achieved.•This method opens ...the path for both waste management and low cost production of graphene.•Current approach can be extended for large scale synthesis of graphene.
Utilization of extracted graphite rods from discharged dry cell batteries for synthesis of graphene oxide / graphene serves two purposes, one is waste management which supports environmental safety and the second is low cost production of graphene oxide / graphene which are highly promising 2D materials in various fields of research. In the present work, a sustainable feasibility for the synthesis of graphene oxide / graphene from graphite rods of waste dry cell batteries is demonstrated. The graphite rods separated from the waste dry cell batteries were subjected to electrochemical exfoliation (ECE) in an acidic media. The graphene oxide (GO) obtained from this method was subjected to reduction heat treatment under argon atmosphere at suitable temperature and time period. Finally, the reduced graphene oxide (rGO) i.e., graphene was characterized using XRD, FTIR, Raman Spectroscopy, TGA, BET, SEM and TEM. The few layer graphene structure is supposed to be less defective in comparison to similar exfoliation techniques due to less oxygen-functional groups associated with the intermediate graphene oxide.
The ongoing COVID-19 pandemic has created an alarming situation due to extensive loss of human lives and economy, posing enormous threat to global health security. Till date, no antiviral drug or ...vaccine against SARS-CoV-2 has reached the market, although a number of clinical trials are under way. The viral 3-chymotrypsin-like cysteine protease (3CL
), playing pivotal roles in coronavirus replication and polyprotein processing, is essential for its life cycle. In fact, 3CL
is already a proven drug discovery target for SARS- and MERS-CoVs. This underlines the importance of 3CL protease in the design of potent drugs against COVID-19.
We have collected one hundred twenty-seven relevant literatures to prepare the review article. PubMed, Google Scholar and other scientific search engines were used to collect the literature based on keywords, like "SARS-CoVs-3CL protease," "medicinal plant and anti-SARS-CoVs-3CL protease" published during 2003-2020. However, earlier publications related to this topic are also cited for necessary illustration and discussion. Repetitive articles and non-English studies were excluded.
From the literature search, we have enlisted medicinal plants reported to inhibit coronavirus 3CL protease. Some of the plants like
L. (syn.
Fort.)
(L.) Siebold and Zucc.,
L., and
L. have exhibited strong anti-3CL
activity. We have also discussed about the phytochemicals with encouraging antiviral activity, such as, bavachinin, psoralidin, betulinic acid, curcumin and hinokinin, isolated from traditional medicinal plants.
Currently, searching for a plant-derived novel drug with better therapeutic index is highly desirable due to lack of specific treatment for SARS-CoV-2. It is expected that in-depth evaluation of medicinally important plants would reveal new molecules with significant potential to inhibit coronavirus 3CL protease for development into approved antiviral drug against COVID-19 in future.
Among the various forms of natural energies, heat is the most prevalent and least harvested energy. Scavenging and detecting stray thermal energy for conversion into electrical energy can provide a ...cost-effective and reliable energy source for modern electrical appliances and sensor applications. Along with this, flexible devices have attracted considerable attention in scientific and industrial communities as wearable and implantable harvesters in addition to traditional thermal sensor applications. This review mainly discusses thermal energy conversion through pyroelectric phenomena in various lead-free as well as lead-based ceramics and polymers for flexible pyroelectric energy harvesting and sensor applications. The corresponding thermodynamic heat cycles and figures of merit of the pyroelectric materials for energy harvesting and heat sensing applications are also briefly discussed. Moreover, this study provides guidance on designing pyroelectric materials for flexible pyroelectric and hybrid energy harvesting.
Increased demand for a carbon-neutral sustainable energy scheme augmented by climatic threats motivates the design and exploration of novel approaches that reserve intermittent solar energy in the ...form of chemical bonds in molecules and materials. In this context, inspired by biological processes, artificial photosynthesis has garnered significant attention as a promising solution to convert solar power into chemical fuels from abundantly found H2O. Among the two redox half-reactions in artificial photosynthesis, the four-electron oxidation of water according to 2H2O → O2 + 4H+ + 4e– comprises the major bottleneck and is a severe impediment toward sustainable energy production. As such, devising new catalytic platforms, with traditional concepts of molecular, materials and biological catalysis and capable of integrating the functional architectures of the natural oxygen-evolving complex in photosystem II would certainly be a value-addition toward this objective. In this review, we discuss the progress in construction of ideal water oxidation catalysts (WOCs), starting with the ingenuity of the biological design with earth-abundant transition metal ions, which then diverges into molecular, supramolecular and hybrid approaches, blurring any existing chemical or conceptual boundaries. We focus on the geometric, electronic, and mechanistic understanding of state-of-the-art homogeneous transition-metal containing molecular WOCs and summarize the limiting factors such as choice of ligands and predominance of environmentally unrewarding and expensive noble-metals, necessity of high-valency on metal, thermodynamic instability of intermediates, and reversibility of reactions that create challenges in construction of robust and efficient water oxidation catalyst. We highlight how judicious heterogenization of atom-efficient molecular WOCs in supramolecular and hybrid approaches put forth promising avenues to alleviate the existing problems in molecular catalysis, albeit retaining their fascinating intrinsic reactivities. Taken together, our overview is expected to provide guiding principles on opportunities, challenges, and crucial factors for designing novel water oxidation catalysts based on a synergy between conventional and contemporary methodologies that will incite the expansion of the domain of artificial photosynthesis.
This study analyses the energy absorption and stiffness behaviour of 3D-printed supportless, closed-cell lattice structures. The unit cell design is bioinspired by the sea urchin morphology having ...organism-level biomimicry. This gives rise to an open-cell lattice structure that can be used to produce two different closed-cell structures by closing the openings with thin or thick walls, respectively. In the design phase, the focus is placed on obtaining the same relative density with all structures. The present study demonstrates that closure of the open-cell lattice structure enhances the mechanical properties without affecting the functional requirements. Thermoplastic polyurethane (TPU) is used to produce the structures via additive manufacturing (AM) using fused filament fabrication (FFF). Uniaxial compression tests are performed to understand the mechanical and functional properties of the structures. Numerical models are developed adopting an advanced material model aimed at studying the hysteretic behaviour of the hyperelastic polymer. The study strengthens design principles for closed-cell lattice structures, highlighting the fact that a thin membrane is the best morphology to enhance structural properties. The results of this study can be generalised and easily applied to applications where functional requirements are of key importance, such as in the production of lightweight midsole shoes.
The properties of each lattice structure are a function of four basic lattice factors, namely the morphology of the unit cell, its tessellation, relative density, and the material properties. The ...recent advancements in additive manufacturing (AM) have facilitated the easy manipulation of these factors to obtain desired functionalities. This review attempts to expound on several such strategies to manipulate these lattice factors. Several design-based grading strategies, such as functional grading, with respect to size and density manipulation, multi-morphology, and spatial arrangement strategies, have been discussed and their link to the natural occurrences are highlighted. Furthermore, special emphasis is given to the recently designed tessellation strategies to deliver multi-functional lattice responses. Each tessellation on its own acts as a novel material, thereby tuning the required properties. The subsequent section explores various material processing techniques with respect to multi-material AM to achieve multi-functional properties. The sequential combination of multiple materials generates novel properties that a single material cannot achieve. The last section explores the scope for combining the design and process strategies to obtain unique lattice structures capable of catering to advanced requirements. In addition, the future role of artificial intelligence and machine learning in developing function-specific lattice properties is highlighted.
We drive reversible photoinduced switching of single azobenzene-functionalized molecules isolated in tailored alkanethiolate monolayer matrices on Au{111}. We designed molecular tethers to suppress ...excited-state quenching from the metal substrate and formed rigid assemblies of single tethered azobenezene molecules in the domains of monolayer to limit steric constraints and tip-induced and stochastic switching effects. Single molecules were reversibly photoisomerized between trans and cis conformations by cycling exposure to visible and UV light. Trans and cis conformations were imaged as high (2.1 ± 0.3 Å) and low (0.7 ± 0.2 Å) protrusions in STM images and were assigned to the on and off states of the molecule, respectively.
PDF
