We investigate the cosmic evolution of the absolute and specific star formation rate (SFR, sSFR) of galaxies as derived from a spatially resolved study of the stellar populations in a set of 366 ...nearby galaxies from the Calar Alto Legacy Integral Field Area (CALIFA) survey. The sample spans stellar masses from M⋆ ~ 109 to 1012M⊙ and a wide range of Hubble types. The analysis combines images obtained with the Galaxy Evolution Explorer (GALEX; far-ultraviolet and near-ultraviolet) and Sloan Digital Sky Survey (SDSS; u, g, r, i, z) with the 4000 Å break, Hβ, and MgFe′ indices measured from the CALIFA data cubes to constrain parametric models for the star formation history (SFH), which are then used to study the cosmic evolution of the SFR density (ρSFR), the sSFR, the main sequence of star formation (MSSF), and the stellar mass density (ρ⋆). Several SFH laws are used to fit the observational constrains. A delayed-τ model, SFR ∝ (t0 − t)exp(−(t0 − t)∕τ), provides the best results, in good agreement with those obtained from cosmological surveys. Our main results from this model are that (a) the mass currently in the inner (≤0.5 half-light radius, HLR) regions formed at earlier epochs than the mass in the outer (1–2 HLR) regions of galaxies. The time since the onset of the star formation is longer in the inner regions (t0 ~ 13−10 Gyr) than in the outer ones (t0 ~ 11−9 Gyr) for all the morphologies, while the e-folding timescale τ in the inner region is similar to or shorter than in the outer regions. These results confirm that galaxies of any Hubble type grow inside-out. (b) The sSFR declines rapidly as the Universe evolves, and faster for early- than for late-type galaxies, and for the inner than for the outer regions of galaxies. (c) The evolution of ρSFR and ρ⋆ agrees well with results from cosmological surveys, particularly with the recent results from the Galaxy And Mass Assembly (GAMA), the G10-Cosmological Evolution Survey (COSMOS), and the 3D Hubble Space Telescope (HST) survey. At low redshift, z ≤ 0.5, most star formation takes place in the outer regions of late spiral galaxies, while at z > 2, the inner regions of the progenitors of the current E and S0 are the main contributors to ρSFR. (d) Similarly, the inner regions of galaxies are the main contributor to ρ⋆ at z > 0.5, growing their mass faster than the outer regions, with a lookback time at 50% ρ⋆ of t50 ~ 9 and 6 Gyr for the inner and outer regions. (e) The MSSF follows a power law at high redshift, with the slope evolving with time but always remaining sub-linear, in good agreement with the Illustris simulation. (f) In agreement with galaxy surveys at different redshifts, the average SFH of CALIFA galaxies indicates that galaxies grow their mass mainly in a mode that is well represented by a delayed-τ model, with the peak at z ~ 2 and an e-folding time of ~3.9 Gyr.
Abstract
The Calar Alto Legacy Integral Field Area (CALIFA) survey, a pioneer in integral field spectroscopy legacy projects, has fostered many studies exploring the information encoded on the ...spatially resolved data on gaseous and stellar features in the optical range of galaxies. We describe a value-added catalogue of stellar population properties for CALIFA galaxies analysed with the spectral synthesis code starlight and processed with the pycasso platform. Our public database (http://pycasso.ufsc.br/, mirror at http://pycasso.iaa.es/) comprises 445 galaxies from the CALIFA Data Release 3 with COMBO data. The catalogue provides maps for the stellar mass surface density, mean stellar ages and metallicities, stellar dust attenuation, star formation rates, and kinematics. Example applications both for individual galaxies and for statistical studies are presented to illustrate the power of this data set. We revisit and update a few of our own results on mass density radial profiles and on the local mass–metallicity relation. We also show how to employ the catalogue for new investigations, and show a pseudo Schmidt–Kennicutt relation entirely made with information extracted from the stellar continuum. Combinations to other databases are also illustrated. Among other results, we find a very good agreement between star formation rate surface densities derived from the stellar continuum and the H α emission. This public catalogue joins the scientific community’s effort towards transparency and reproducibility, and will be useful for researchers focusing on (or complementing their studies with) stellar properties of CALIFA galaxies.
Abstract
The role of major mergers in galaxy evolution is investigated through a detailed characterization of the stellar populations, ionized gas properties and star formation rates (SFR) in the ...early-stage merger luminous infrared galaxies (LIRGs) IC 1623 W and NGC 6090, by analysing optical integral field spectroscopy and high-resolution Hubble Space Telescope imaging. The spectra were processed with the starlight full spectral fitting code, and the emission lines measured in the residual spectra. The results are compared with non-interacting control spiral galaxies from the Calar Alto Legacy Integral Field Area survey. Merger-induced star formation is extended and recent, as revealed by the young ages (50–80 Myr) and high contributions to light of young stellar populations (50–90 per cent), in agreement with merger simulations in the literature. These early-stage mergers have positive central gradients of the stellar metallicity, with an average ∼0.6 Z⊙. Compared to non-interacting spirals, they have lower central nebular metallicity, and flatter profiles, in agreement with the gas inflow scenario. We find that they are dominated by star formation, although shock excitation cannot be discarded in some regions, where high velocity dispersion is found (170–200 km s−1). The average SFR in these early-stage mergers (∼23–32 M⊙ yr−1) is enhanced with respect to main-sequence Sbc galaxies by factors of 6–9, slightly above the predictions from classical merger simulations, but still possible in about 15 per cent of major galaxy mergers, where U/LIRGs belong.
Summary
Previously, we found a substantial number of regulatory T cells (Tregs) and fewer senescent and T helper type 17 (Th17) and a decrease in interstitial fibrosis (IF) in 12‐month graft biopsies ...in belatacept versus cyclosporin (CNI)‐treated patients Belatacept Evaluation of Nephroprotection and Efficacy as First‐line Immunosuppression Trial (BENEFIT) study. Seven years after kidney transplantation (KT), mean estimated glomerular filtration rate (eGFR), patient and graft survival were significantly higher with belatacept versus CNI treatment. The aim of this study was to determine whether the immunophenotypes of inflammatory and regulatory cell subsets infiltrating the grafts contribute to the BENEFIT’s clinical findings a decade after KT. Twenty‐three adult patients with functionally stable KT treated with belatacept and 10 treated with CNI were enrolled. Biopsies were analyzed by histomorphometry and immunohistochemistry for proliferation, senescence, apoptosis, inflammatory and regulatory cell markers in a blinded manner. Significantly lower percentages of inflammatory/fibrogenic cells interleukin (IL)‐22+/Th17/Th2/M1 macrophages were observed in patients treated with belatacept than in patients treated with CNI. By contrast, remarkably higher percentages of regulatory cells Tregs/Bregs/ plasmacytoid dendritic regulatory cells (pDCregs)/M2 were found in belatacept‐treated patients than in CNI‐treated patients. Conspicuously lower percentages of apoptosis and senescence and higher proliferation markers were found in belatacept‐treated patients than in CNI‐treated patients. Consequently, there was significantly more inflammation in the microvascular compartments as well as increased tubular atrophy and IF in CNI‐treated patients. These findings strongly suggest that regulatory mechanisms, along with the absence of deleterious effects of CNI, contribute to the long‐term graft histology and function stability in patients treated with belatacept.
Hypothetical immunological mechanisms involved in histological and functional differences in kidney transplant recipients treated with belatacept versus CNI.
We present an extended version of the spectral synthesis code starlight designed to incorporate both λ-by-λ spectra and photometric fluxes in the estimation of stellar population properties of ...galaxies. The code is tested with simulations and data for 260 galaxies culled from the Calar Alto Legacy Integral Field Area (CALIFA) survey, spatially matching the 3700–7000 Å optical data cubes to Galaxy Evolution Explorer (GALEX) near-ultraviolet (NUV) and far-ultraviolet (FUV) images. The sample spans E–Sd galaxies with masses from 109 to 1012 M⊙ and stellar populations all the way from star-forming to old, passive systems. Comparing results derived from purely optical fits with those which also consider the NUV and FUV data we find that the following. (1) The new code is capable of matching the input ultraviolet (UV) data within the errors while keeping the quality of the optical fit essentially unchanged. (2) Despite being unreliable predictors of the UV fluxes, purely optical fits yield stellar population properties which agree well with those obtained in optical+UV fits for nearly 90 per cent of our sample. (3) The addition of UV constraints has little impact on properties such as stellar mass and dust optical depth. Mean stellar ages and metallicities also remain nearly the same for most galaxies, the exception being low-mass, late-type galaxies, which become older and less enriched due to rearrangements of their youngest populations. (4) The revised ages are better correlated with observables such as the 4000 Å break index, and the NUV − r and u − r colours, an empirical indication that the addition of UV constraints helps mitigating the effects of age–metallicity–extinction degeneracies.
ABSTRACT
We present QUIJOTE intensity and polarization maps in four frequency bands centred around 11, 13, 17, and 19 GHz, and covering approximately 29 000 deg2, including most of the northern sky ...region. These maps result from 9000 h of observations taken between May 2013 and June 2018 with the first QUIJOTE multifrequency instrument (MFI), and have angular resolutions of around 1°, and sensitivities in polarization within the range 35–40 µK per 1° beam, being a factor ∼2–4 worse in intensity. We discuss the data processing pipeline employed, and the basic characteristics of the maps in terms of real space statistics and angular power spectra. A number of validation tests have been applied to characterize the accuracy of the calibration and the residual level of systematic effects, finding a conservative overall calibration uncertainty of 5 per cent. We also discuss flux densities for four bright celestial sources (Tau A, Cas A, Cyg A, and 3C274), which are often used as calibrators at microwave frequencies. The polarization signal in our maps is dominated by synchrotron emission. The distribution of spectral index values between the 11 GHz and WMAP 23 GHz map peaks at β = −3.09 with a standard deviation of 0.14. The measured BB/EE ratio at scales of ℓ = 80 is 0.26 ± 0.07 for a Galactic cut |b| > 10°. We find a positive TE correlation for 11 GHz at large angular scales (ℓ ≲ 50), while the EB and TB signals are consistent with zero in the multipole range 30 ≲ ℓ ≲ 150. The maps discussed in this paper are publicly available.
ABSTRACT
We derive linearly polarized astrophysical component maps in the Northern Sky from the QUIJOTE-MFI data at 11 and 13 GHz in combination with the Wilkinson Microwave Anisotropy Probe K and Ka ...bands (23 and 33 GHz) and all Planck polarized channels (30–353 GHz), using the parametric component separation method B-SeCRET. The addition of QUIJOTE-MFI data significantly improves the parameter estimation of the low-frequency foregrounds, especially the estimation of the synchrotron spectral index, βs. We present the first detailed βs map of the Northern Celestial Hemisphere at a smoothing scale of 2°. We find statistically significant spatial variability across the sky. We obtain an average value of −3.08 and a dispersion of 0.13, considering only pixels with reliable goodness of fit. The power-law model of the synchrotron emission provides a good fit to the data outside the Galactic plane but fails to track the complexity within this region. Moreover, when we assume a synchrotron model with uniform curvature, cs, we find a value of cs = −0.0797 ± 0.0012. However, there is insufficient statistical significance to determine which model is favoured, either the power law or the power law with uniform curvature. Furthermore, we estimate the thermal dust spectral parameters in polarization. Our cosmic microwave background, synchrotron, and thermal dust maps are highly correlated with the corresponding products of the PR4 Planck release, although some large-scale differences are observed in the synchrotron emission. Finally, we find that the βs estimation in the high signal-to-noise synchrotron emission areas is prior-independent, while, outside these regions, the prior governs the βs estimation.
Summary
The relation between age and mortality after hip fracture was analyzed in elderly patients. 5.5% of the 31,884 patients died. Compared to those 65–74 years old, the multivariate OR for ...mortality for those 75–84 and ≥85 were 2.11 (95% CI: 1.61–2.77) and 4.10 (95% CI: 3.14–5.35).
Purpose
To analyze the impact of Elixhauser comorbidities on the relation between age and mortality after hip fracture in elderly patients.
Methods
Cross-sectional study of the population ≥65 years old hospitalized in Spain in 2013 with a diagnosis of fall-related hip fracture in the Basic Minimum Set Data (BMSD). The impact of Elixhauser comorbidities on the association between mortality and age groups (65–74, 75–84, ≥85) was analyzed by logistic regression models with progressive adjustment for demographic variables and comorbidities introduced individually.
Results
We identified 31,884 patients, 5.5% of which died during hospitalization. Compared with those 65–74 years old, the multivariate OR of mortality for those 75–84 and ≥85 years old decreased from 2.23 (95% CI: 1.71–2.90) and 4.57 (95% CI: 3.54–5.90) to 2.11 (95% CI: 1.61–2.77) and 4.10 (95% CI: 3.14–5.35), respectively after adjustment for comorbidities. The OR of mortality for men was 1.77 (95% CI: 1.58–1.98) compared to women. The comorbidities with higher OR for mortality were congestive heart failure (OR: 3.88; 95% CI: 3.42–4.41), metastasis (OR: 3.44; 95% CI: 2.27–5.20), fluid and electrolyte disorders (OR: 2.95; 95% CI: 2.47–3.52), coagulation deficiencies (OR: 2.87; 95% CI: 2.08–3.96), and liver disease (OR: 2.40; 95% CI: 1.82–3.17).
Conclusions
The association between age and mortality after hip fracture remains after adjusting for numerous comorbidities. However, some potentially controllable disorders are associated with an increased risk for mortality, thus, improving their management could benefit survival.
In this paper, we present Q-U-I JOint Tenerife Experiment (QUIJOTE) 10–20 GHz observations (194 h in total over ≈250 deg2) in intensity and polarisation of G159.6-18.5, one of the most widely studied ...regions harbouring anomalous microwave emission (AME). By combining with other publicly available intensity data, we achieve the most precise spectrum of the AME measured to date in an individual region, with 13 independent data points between 10 and 50 GHz being dominated by this emission. The four QUIJOTE data points provide the first independent confirmation of the downturn of the AME spectrum at low frequencies, initially unveiled by the COSMOlogical Structures On Medium Angular Scales experiment in this region. Our polarisation maps, which have an angular resolution of ≈1° and a sensitivity of ≈ 25 μK beam−1, are consistent with zero polarisation. We obtain upper limits on the polarisation fraction of Π < 6.3 and <2.8 per cent (95 per cent C.L.), respectively, at 12 and 18 GHz (ΠAME < 10.1 and <3.4 per cent with respect to the residual AME intensity), a frequency range where no AME polarisation observations have been reported to date. The combination of these constraints with those from other experiments confirm that all the magnetic dust models based on single-domain grains, and most of those considering randomly oriented magnetic inclusions, predict higher polarisation levels than is observed towards regions with AME. Also, neither of the two considered models of electric dipole emission seems to be compatible with all the observations together. More stringent constraints of the AME polarisation at 10–40 GHz are necessary to disentangle between different models, to which future QUIJOTE data will contribute.
Background and purpose
BSCL2 heterozygote mutations are a common cause of distal hereditary motor neuropathies (dHMNs). A series of BSCL2 patients is presented and clinical, neurophysiological and ...muscle magnetic resonance imaging (MRI) findings are correlated.
Methods
Twenty‐six patients from five families carrying the p.N88S mutation were identified. Age of onset, clinical phenotype (dHMN, Charcot–Marie–Tooth, spastic paraplegia), physical examination, disability measured as a modified Rankin Scale score and neurophysiological findings were collected. A whole body muscle MRI had been performed in 18 patients. The pattern of muscle involvement on T1‐weighted and short time inversion recovery sequences was analysed. Hierarchical analysis using heatmaps and an MRI Composite Score were generated. Statistical analysis was carried out with STATA SE v.15 (TX, USA).
Results
The mean age was 51.54 ± 19.94 years and 14 patients were men. dHMN was the most common phenotype (50%) and five patients (19.23%) showed no findings on examination. Disease onset was commonly in childhood and disability was low (modified Rankin Scale score 1.34 ± 1.13) although median time since onset of disease was 32 years (range 10–47). Charcot–Marie–Tooth‐like patients were more disabled and disability correlated with age. On muscle MRI, thenar eminence, soleus and tibialis anterior were most frequently involved, irrespective of clinical phenotype. MRI Composite Score was strongly correlated with disability.
Conclusion
Patients with the p.N88S BSCL2 gene mutation are phenotypically variable, although dHMN is most frequent and generally slowly progressive. Muscle MRI pattern is consistent regardless of phenotype and correlates with disease severity, probably serving as a reliable outcome measure for future clinical trials.
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