Abstract Impulsivity is central to borderline personality disorder (BPD). Response inhibition, addressing the ability to suppress or stop actions, is one aspect of behavioral impulse control which is ...frequently used to assess impulsivity. BPD patients display deficits in response inhibition under stress condition or negative emotions. We assessed whether response inhibition and its neural underpinnings are impaired in BPD when tested in an emotionally neutral setting and when co-morbid attention-deficit/hyperactivity disorder (ADHD) is excluded. To this end, we studied response inhibition in unmedicated BPD patients and healthy controls (HC) in two independent samples using functional magnetic resonance imaging during Simon-, Go/nogo-, and Stopsignal tasks. BPD patients and HC did not differ significantly in their performance in the Go/nogo and the Stopsignal tasks. Response interference in the Simon task was increased in BPD patients in one sample, but this could not be replicated in the second sample. In both samples, no significant differences in brain activation patterns during any of the tasks were present while the neural impulse control network was robustly activated during the inhibition tasks in both groups. Our results provide evidence that under emotionally neutral conditions response inhibition is not impaired in patients with BPD without co-occurring ADHD.
We present a novel dynamic approach for solid-fluid coupling by joining two different numerical methods: the boundary-element method (BEM) and the finite element method (FEM). The FEM results ...describe the thermomechanical evolution of the solid while the fluid is solved with the BEM. The bidirectional feedback between the two domains evolves along a Lagrangian interface where the FEM domain is embedded inside the BEM domain. The feedback between the two codes is based on the calculation of a specific drag tensor for each boundary on finite element. The approach is presented here to solve the complex problem of the descent of a cold subducting oceanic plate into a hot fluid-like mantle. The coupling technique is shown to maintain the proper energy dissipation caused by the important secondary induced mantle flow induced by the lateral migrating of the subducting plate. We show how the method can be successfully applied for modelling the feedback between deformation of the oceanic plate and the induced mantle flow. We find that the mantle flow drag is singular at the edge of the retreating plate causing a distinct hook shape. In nature, such hooks can be observed at the northern end of the Tonga trench and at the southern perimeter, of the South American trench.
Modelling subduction involves solving the dynamic interaction between a rigid (solid yet deformable) plate and the fluid (easily deformable) mantle. Previous approaches neglected the solid-like ...behavior of the lithosphere by only considering a purely fluid description. However, over the past 5 years, a more self-consistent description of a mechanically differentiated subducting plate has emerged. The key feature in this mechanical description is incorporation of a strong core which provides small resistance to plate bending at subduction zones while simultaneously providing adequate stretching resistance such that slab pull drives forward plate motion. Additionally, the accompanying numerical approaches for simulating large-scale lithospheric deformation processes coupled to the underlying viscous mantle flow, have been become available. Here we put forward three fundamentally different numerical strategies, each of which is capabable of treating the advection of mechanically distinct materials that describe the subducting plate. We demonstrate their robustness by calculating the numerically challenging problem of subduction of a 6000
km wide slab at high-resolution in three-dimensions, the successfuly achievement of which only a few codes in the world can presently even attempt. In spite of the differences of the approaches, all three codes pass the simple qualitative test of developing an “S-bend” trench curvature previously observed in similar models. While reproducing this emergent feature validates that the lithosphere–mantle interaction has been correctly modelled, this is not a numerical benchmark in the traditional sense where the objective is for all codes to achieve exact agreement on a unique numerical solution. However, we do provide some quantitative comparisons such as trench and plate kinematics in addition to discussing the strength and weaknesses of the individual approaches. Consequently, we believe these developed algorithms can now be applied to study the parameters involved in the dynamics of subduction and offer a toolbox to be used by the entire geoscience community.
Zusammenfassung
Hintergrund
Lärmbelästigung geht mit gesundheitlicher Beeinträchtigung und reduziertem Wohlbefinden einher. Die subjektive Lärmbelästigung steht im Zusammenhang mit der objektiven ...Lärmbelastung sowie individuellen und regionalen Faktoren.
Fragestellung
Wie viele Teilnehmende der NAKO Gesundheitsstudie fühlen sich durch nächtlichen Verkehrslärm belästigt und welche Faktoren stehen damit im Zusammenhang?
Material und Methoden
Diese Querschnittsanalyse basiert auf Daten von 86.080 NAKO-Teilnehmenden aus 18 Studienzentren, die von 2014 bis 2017 untersucht wurden. Um die Beziehungen zwischen individuellen und regionalen Faktoren und Verkehrslärmbelästigung in den Kategorien nicht belästigt, leicht/mittel und stark/sehr stark belästigt zu untersuchen, wurden multinomiale logistische Regressionsmodelle mit wechselseitiger Adjustierung der Faktoren verwendet.
Ergebnisse
Zwei Drittel der Teilnehmenden fühlten sich nicht durch Verkehrslärm belästigt; jeder Zehnte berichtete von starker/sehr starker Belästigung, mit den höchsten Anteilen in Berlin-Mitte und Leipzig. Die stärksten Assoziationen mit Lärmbelästigung wurden für Faktoren der individuellen Wohnsituation beobachtet, wie z. B. die Position des Schlafraums zur Hauptstraße (OR für leicht/mittel belästigt: 4,26 95 % KI: 4,01; 4,52; OR für stark/sehr stark belästigt: 13,36 95 % KI: 12,47; 14,32 im Vergleich zu Garten/Innenhof). Teilnehmende im Alter von 40–60 Jahren oder der mittleren und niedrigen Einkommensklasse fühlten sich eher durch Verkehrslärm belästigt als jüngere bzw. ältere Teilnehmende oder solche mit hoher Einkommensklasse.
Diskussion
Teilnehmende der NAKO Gesundheitsstudie wiesen Unterschiede in der Belästigung durch nächtlichen Verkehrslärm in Bezug auf individuelle und regionale Faktoren auf.
Abstract
Objectives: Animal and clinical studies implicated opioid dysfunction in the pathogenesis of alcohol abuse and dependence. The π-opioid antagonist naltrexone reduces craving, eventually ...modulated by hypothalamic-pituitary-adrenal axis. Altered cortisol response to opioid receptor blockade not only in alcohol dependent persons, but also in persons with a family history of alcohol dependency was reported. Methods: Twenty patients with alcohol dependence who had undergone detoxification were recruited. Naloxone (3.2 mg/70 kg body weight) having a very similar receptor profile to naltrexone and placebo were administered in cross-over fashion on two separate days 48 h apart. Mood and craving was assessed with well-established instruments (Alcohol Craving Questionnaire (ACQ), Profile of Mood Scale (POMS)). Both patients and raters were blind to all treatments. Twelve patients were first treated with naloxone, eight were first treated with placebo. Results: No significant differences were found between the placebo and naloxone groups according to ACQ and POMS. Cortisol levels were significantly higher in naloxone group. Conclusions: We could not replicate the result, that blocking of the endogenous opioid system leads to reduced craving in alcohol-dependent individuals, while increase of cortisol after naloxone challenge is the expected biological effect of opioid receptor blockade on the hypothalamic-pituitary-adrenal (HPA) axis.
ADHD is a serious risk factor for co-occurring psychiatric disorders and negative psychosocial consequences in adulthood. Previous trials on psychotherapeutic concepts for adult ADHD are based on ...behavioural (cognitive behavioural and dialectical behavioural) psychotherapeutic approaches and showed significant effects. The aim of our study group (COMPAS) is to carry out a first randomized and controlled multicentre study to evaluate the effects of a disorder tailored psychotherapy in adult ADHD compared to clinical management in combination with psychopharmacological treatment or placebo. A total of 448 adults with ADHD according to DSM-IV will be treated at seven university sites in Germany. In a four-arm design, patients are randomized to a manualized dialectical behavioural therapy (DBT) based group programme plus methylphenidate or placebo or clinical management plus methylphenidate or placebo with weekly sessions in the first 12 weeks and monthly sessions thereafter. Therapists are graduated psychologists or physicians. Treatment integrity is established by independent supervision. Primary endpoint (ADHD symptoms measured by the Conners Adult Rating Scale) is rated by interviewers blind to the treatment allocation. Intention-to-treat analysis will be performed within a linear regression model (Current Controlled Trials ISRCTN54096201). The trial is funded by the German Federal Ministry of Research and Education (01GV0606) and is part of the German network for the treatment of ADHD in children and adults (ADHD-NET).
From point defects to plate tectonic faults Regenauer-Lieb, K.; Hobbs, B.; Yuen, D. A. ...
Philosophical magazine (Abingdon, England),
07/2006, Letnik:
86, Številka:
21-22
Journal Article
Recenzirano
Odprti dostop
Understanding and explaining emergent constitutive laws in the multi-scale evolution from point defects, dislocations and two-dimensional defects to plate tectonic scales is an arduous challenge in ...condensed matter physics. The Earth appears to be the only planet known to have developed stable plate tectonics as a means to get rid of its heat. The emergence of plate tectonics out of mantle convection appears to rely intrinsically on the capacity to form extremely weak faults in the top 100 km of the planet. These faults have a memory of at least several hundred millions of years, yet they appear to rely on the effects of water on line defects. This important phenomenon was first discovered in laboratory and dubbed "hydrolytic weakening". At the large scale it explains cycles of co-located resurgence of plate generation and consumption (the Wilson cycle), but the exact physics underlying the process itself and the enormous spanning of scales still remains unclear. We present an attempt to use the multi-scale non-equilibrium thermodynamic energy evolution inside the deforming lithosphere to move phenomenological laws to laws derived from basic scaling quantities, develop self-consistent weakening laws at lithospheric scale and give a fully coupled deformation-weakening constitutive framework. At meso- to plate scale we encounter in a stepwise manner three basic domains governed by the diffusion/reaction time scales of grain growth, thermal diffusion and finally water mobility through point defects in the crystalline lattice. The latter process governs the planetary scale and controls the stability of its heat transfer mode.
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