Introduction: Chitosan is one of the natural polymers can generally consider as a biocompatible and biodegradable polycationicpolymer, which has minimum immunogenicity and low cytotoxicity. ...Therefore, chitosan and its derivatives may represent potentially safe cationic carriers for use in gene delivery. Materials andMethods: Chitosan with 90.1 DD% obtained by deacetylation ofchitin extracted from local shrimp shells. Graft copolymerizationof L-lactide onto chitosan was carried out at room temperature byring opening polymerization under a nitrogen atmosphere to prepare chitosan-g-poly (N-lactide) graft copolymer. It was obtainedin good yield and characterized by FTIR. The samples purity andconcentration were detected using both Nanodrop UV-spectroscopy and agarose gel electrophoresis techniques. The humanheat shock proteins gene, hsp-70, was used as a model of humangenes to study the effect of chitosan-g-poly (N-lactide) graft copolymer. Results and Discussion: The results revealed that chitosan-g-poly (N-lactide) graft copolymers had safety effect on theDNA, and binding with it. the human heat shock proteins gene,hsp-70, was used as a model of human genes to study the effectof chitosan-g-poly (N-lactide) graft copolymer, it shows a goodbinding ability the human gene, implies that it might be used inbiomedical applications in the future. Conclusions: Grafting ofL-lactide onto chitosn by ring opening polymerization was confirmed by FTIR. The repared polymer hase safety effectson human DNA and genes. The chitosan-g-poly (N-lactide) graftcopolymer has shown highly efficiency to electrostatic interactionwith human DNA and gene, implying that it is suitable to be usedas DNA and gene delivery.
The NA62 RICH detector Anzivino, G.; Bucci, F.; Carassiti, V. ...
2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC),
10/2013
Conference Proceeding
The main goal of the NA62 experiment is the measurement of the K + → π + νν̅ branching ratio with a precision better than 10%. One of the key element of NA62 is the Ring Imaging CHerenkov detector ...(RICH). It will identify pions and muons in the momentum range between 15 and 35 GeV/c, with a muon rejection factor better than 10 -2 . The RICH will also measure the particle arrival time with a precision better than 100 ps to disentangle accidental time associations of beam particles with pions and will provide the reference time and a fast signal for the NA62 trigger system. We present the final design of the detector and the status of the construction. Finally, we recall the results of the beam tests of the RICH prototype.
Nimesulide is one of the types of non-steroidal anti-inflammatory drugs, widely used as analgesic and antipyretic. It is classified as class II drugs according to BCS guidance because of low ...solubility in water that leads to decrease in dissolution rate. So the objective of this study was to decrease particle size, increase solubility and dissolution rate of nimesulide by preparation of nimesulide nanoparticles using solvent/antisolvent precipitation method by addition of organic solution of drug onto the solution of stabilizer. The size of nimesulide nanoparticles were studied and considered by particle size analyzer, drug content and loading efficiency. The freeze dried nanoparticles were characterized by field emission electron microscope, X-Ray powder diffraction, differential scanning calorimetry and saturated solubility measurement. Tablet was manufactured by direct compression. The tablets were evaluated for drug release to measure the effect of nanoparticles on the dissolution improvement of drug.
The CDF calorimeter upgrade for Run IIb Kuhlmann, S.; Frisch, H.; Cordelli, M. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
02/2004, Letnik:
518, Številka:
1
Journal Article
Recenzirano
Odprti dostop
The physics program at the Fermilab Tevatron Collider will continue to explore the high-energy frontier of particle physics until the commissioning of the LHC at CERN. The luminosity increase ...provided by the Main Injector will require upgrades beyond those implemented for the first stage (Run IIa) of the Tevatron's Run II physics program. The upgrade of the CDF calorimetry includes: (1) the replacement of the slow gas detectors on the front face of the Central Calorimeter with a faster scintillator version which has a better segmentation, and (2) the addition of timing information to both the Central and EndPlug Electromagnetic Calorimeters to filter out cosmic ray and beam related backgrounds.
An incompressible liquid flow in the gap between two coaxial cylinders, such that the inner rotating (wavy) cylinder has a periodically varying radius along the axial direction while the outer ...stationary cylinder has a constant radius, is studied experimentally and theoretically. Basic attention is focused on the symmetry-breaking phenomenon of the vortex flow arising from the rotation of the inner wavy cylinder. It is found that the symmetry-breaking phenomenon of the vortical flow structures in this geometry is accompanied by the occurrence of a self-induced axial pressure gradient. A theoretical formulation of the problem of periodic vortical flow prevailing in such a geometry having large axial length is presented. The comparison between the computed and the experimental results is presented and the underlying phenomena are discussed. PUBLICATION ABSTRACT
The CDF MiniPlug calorimeters at the Tevatron Goulianos, K.; Gallinaro, M.; Hatakeyama, K. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
02/2004, Letnik:
518, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Two MiniPlug calorimeters, designed to measure the energy and lateral position of particles in the pseudorapidity region of 3.6<|
η|<5.1 of the CDF detector, have been installed as part of the Run II ...CDF upgrade at the Tevatron collider. Detector performance and first results from p̄p collision data are presented.
The CDF MiniPlug calorimeters Goulianos, K; Gallinaro, M; Hatakeyama, K ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
01/2003, Letnik:
496, Številka:
2
Journal Article
Recenzirano
Odprti dostop
Two MiniPlug calorimeters, designed to measure the energy and lateral position of particles in the (forward) pseudorapidity region of 3.6<|
η|<5.1 of the CDF detector, have been recently installed as ...part of the Run II CDF upgrade at the Tevatron
p
̄
p
collider. In this paper we describe the final design of the MiniPlugs and present results from a cosmic ray test, in which a light yield of approximately
100
pe/
MIP
was obtained, exceeding our design requirements.
Abstract The TOTEM collaboration at the CERN LHC has measured the differential cross-section of elastic proton–proton scattering at $$\sqrt{s} = 8\,\mathrm{TeV}$$ s = 8 TeV in the squared ...four-momentum transfer range $$0.2\,\mathrm{GeV^{2}}< |t| < 1.9\,\mathrm{GeV^{2}}$$ 0.2 GeV 2 < | t | < 1.9 GeV 2 . This interval includes the structure with a diffractive minimum (“dip”) and a secondary maximum (“bump”) that has also been observed at all other LHC energies, where measurements were made. A detailed characterisation of this structure for $$\sqrt{s} = 8\,\mathrm{TeV}$$ s = 8 TeV yields the positions, $$|t|_{\mathrm{dip}} = (0.521 \pm 0.007)\,\mathrm{GeV^2}$$ | t | dip = ( 0.521 ± 0.007 ) GeV 2 and $$|t|_{\mathrm{bump}} = (0.695 \pm 0.026)\,\mathrm{GeV^2}$$ | t | bump = ( 0.695 ± 0.026 ) GeV 2 , as well as the cross-section values, $$\left. {\mathrm{d}\sigma /\mathrm{d}t}\right| _{\mathrm{dip}} = (15.1 \pm 2.5)\,\mathrm{{\mu b/GeV^2}}$$ d σ / d t dip = ( 15.1 ± 2.5 ) μ b / GeV 2 and $$\left. {\mathrm{d}\sigma /\mathrm{d}t}\right| _{\mathrm{bump}} = (29.7 \pm 1.8)\,\mathrm{{\mu b/GeV^2}}$$ d σ / d t bump = ( 29.7 ± 1.8 ) μ b / GeV 2 , for the dip and the bump, respectively.
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