Optical logic gates play a crucial role in all-optical signal processing systems. Traditional methods of designing logic gates require manual adjustment of structural parameters. In this paper, we ...utilize a genetic algorithm for inverse design, and the optical AND, OR, and NOT logic gates are achieved on a silicon platform at the working wavelength of 1.55 μm. The total area of the logic gates is fixed at 2.2 μm × 2.2 μm, convenient to be integrated with other functional devices, the optimized structural parameters are acquired for different logic gates and the contrast ratios of the OR, AND, and NOT gates are 8.55, 5.32, and 4.14 dB, respectively. The design is characterized by a compact structure, high contrast, and a high degree of freedom, offering a valuable reference for photonic integrated circuits.
•A compact optical logic gate with rectangular air hole array is designed and high performance is achieved.•The optimization efficiency was enhanced by GA, and optical logic gates were achieved with ultra-small size.•The influence of air hole’s variation to device’s performance was studied, and it guided the actual fabrication.
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•An alternative bead-shaped photo-Fenton catalytic platform is provided.•Fe species are well immobilized on the bead due to the pDA modification.•The beads are self-floating, ...facilitating the light harvest and their recovery.•The beads maintain high and long-term photocatalytic activity for dye removal.
Fe species/biochar fiber composite (FCF) has become one of promising materials for wastewater treatment via heterogeneous photo-Fenton reaction. However, the powdered form always suffers from inefficient recovery and inherent iron loss, limiting their practical application. Herein, we provide an alternative polydopamine (pDA)-modified PVDF bead as excellent photo-Fenton support for immobilizing FCF by phase inversion, which not only limits the loss of iron ions, but also promotes the H2O2 decomposition. Moreover, these beads can float on the wastewater due to their inner structure, favoring the harvest of light. Thanks to these unique characteristics, these beads displayed almost 100% of decolorization in self-designed flowing dyes wastewater systems. Particularly, the self-floating beads structure makes catalysts be easily recovered and maintains long-term high activity, which significantly eliminates the inherent challenge of powdered catalyst (e.g. FCF) based degradation process. This work provides an “easily applicable platform” for large-scale applications of powdered photo-Fenton catalyst in wastewater treatment.
Pyroptosis plays a crucial role in bronchopulmonary dysplasia (BPD) and is associated with various lung injury illnesses. However, the function of pyroptosis-related genes (PRGs) in BPD remains ...poorly understood. The gene expression omnibus (GEO) database was searched for information on genes associated with BPD. Twenty-five BPD-related DE-PRGs were identified, all of which were closely associated with pyroptosis regulation and immunological response. LASSO and SVM-RFE algorithms identified CHMP7, NLRC4, NLRP2, NLRP6, and NLRP9 among the 25 differentially expressed PRGs as marker genes with acceptable diagnostic capabilities. Using these five genes, we also generated a nomogram with excellent predictive power. Annotation enrichment analyses revealed that these five genes may be implicated in BPD and numerous BPD-related pathways. In addition, the ceRNA network showed an intricate regulatory link based on the marker genes. In addition, CIBERSORT-based studies revealed that alterations in the immunological microenvironment of BPD patients may be associated with the marker genes. We constructed a diagnostic nomogram and gave insight into the mechanism of BPD. Its diagnostic value for BPD must be evaluated in further research before it can be used in clinical practice.
Ferroptosis is a recently identified form of cell death that is distinct from the conventional modes such as necrosis, apoptosis, and autophagy. Its role in bronchopulmonary dysplasia (BPD) remains ...inadequately understood. To address this gap, we obtained BPD-related RNA-seq data and ferroptosis-related genes (FRGs) from the GEO database and FerrDb, respectively. A total of 171 BPD-related differentially expressed ferroptosis-related genes (DE-FRGs) linked to the regulation of autophagy and immune response were identified. Least absolute shrinkage and selection operator and SVM-RFE algorithms identified 23 and 14 genes, respectively, as marker genes. The intersection of these 2 sets yielded 9 genes (ALOX12B, NR1D1, LGMN, IFNA21, MEG3, AKR1C1, CA9, ABCC5, and GALNT14) with acceptable diagnostic capacity. The results of the functional enrichment analysis indicated that these identified marker genes may be involved in the pathogenesis of BPD through the regulation of immune response, cell cycle, and BPD-related pathways. Additionally, we identified 29 drugs that target 5 of the marker genes, which could have potential therapeutic implications. The ceRNA network we constructed revealed a complex regulatory network based on the marker genes, further highlighting their potential roles in BPD. Our findings offer diagnostic potential and insight into the mechanism underlying BPD. Further research is needed to assess its clinical utility.
To screen rare blood groups Fy(a-), s-, k-, Di(b-) and Js(b-) in an ethnic Zhuang population.
Sequence-specific primers were designed based on single nucleotide polymorphism (SNP) sites of blood ...group antigens Fy(b) and s. A specific multiplex PCR system I was established. Multiplex PCR system II was applied to detect alleles antigens Di(b), k, Js(b)1910 and Js(b) 2019 at the same time. The two systems was were used to screen for rare blood group antigens in 4490 randomly selected healthy donors of Guangxi Zhuang ethnic origin.
We successfully made the multiplex PCR system I. We detected the rare blood group antigens using the two PCR system. There are five Fy(a-), three s(-), two Di(b-) in 4490 Guangxi zhuang random samples. The multiplex PCR system I has achieved good accuracy and stability. With multiplex PCR systems I and II, 4490 samples were screened. Five Fy(a-), three s(-) and two Di(b-) samples were discovered.
Multiplex PCR is an effective methods, which can be used for high throughput screening of
