Objectives This study sought to report full 1-year results, detailed magnetic resonance imaging analysis, and determinants of efficacy in the prospective, randomized, controlled CADUCEUS ...(CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction) trial. Background Cardiosphere-derived cells (CDCs) exerted regenerative effects at 6 months in the CADUCEUS trial. Complete results at the final 1-year endpoint are unknown. Methods Autologous CDCs (12.5 to 25 × 106 ) grown from endomyocardial biopsy specimens were infused via the intracoronary route in 17 patients with left ventricular dysfunction 1.5 to 3 months after myocardial infarction (MI) (plus 1 infused off-protocol 14 months post-MI). Eight patients were followed as routine-care control patients. Results In 13.4 months of follow-up, safety endpoints were equivalent between groups. At 1 year, magnetic resonance imaging revealed that CDC-treated patients had smaller scar size compared with control patients. Scar mass decreased and viable mass increased in CDC-treated patients but not in control patients. The single patient infused 14 months post-MI responded similarly. CDC therapy led to improved regional function of infarcted segments compared with control patients. Scar shrinkage correlated with an increase in viability and with improvement in regional function. Scar reduction correlated with baseline scar size but not with a history of temporally remote MI or time from MI to infusion. The changes in left ventricular ejection fraction in CDC-treated subjects were consistent with the natural relationship between scar size and ejection fraction post-MI. Conclusions Intracoronary administration of autologous CDCs did not raise significant safety concerns. Preliminary indications of bioactivity include decreased scar size, increased viable myocardium, and improved regional function of infarcted myocardium at 1 year post-treatment. These results, which are consistent with therapeutic regeneration, merit further investigation in future trials. (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction CADUCEUS; NCT00893360 )
This is the second paper in our series about the search for multiple populations in Magellanic Cloud star clusters using the Hubble Space Telescope. Here we report the detection of multiple stellar ...populations in the colour-magnitude diagrams of the intermediate-age clusters Lindsay 1, NGC 416 and NGC 339. With ages between 6.0 and 7.5 Gyr, these clusters are the youngest ones in which chemical abundance spreads have been detected so far. This confirms that the appearance of multiple populations is not restricted to only ancient globular clusters, but may also be a common feature in clusters as young as 6 Gyr. Our results are in agreement with a recent spectroscopic study of Lindsay 1. We found that the fraction of enriched stars in NGC 416 is ~45 per cent whereas it is ~25 per cent in NGC 339 and ~36 per cent in Lindsay 1. Similar to NGC 121, these fractions are lower than the average value for globular clusters in the Milky Way.
ABSTRACT
In our HST photometric survey, we have been searching for multiple stellar populations (MPs) in Magellanic Clouds (MCs) massive star clusters which span a significant range of ages ...(∼1.5–11 Gyr). In the previous papers of the series, we have shown that the age of the cluster represents one of the key factors in shaping the origin of the chemical anomalies. Here, we present the analysis of four additional clusters in the MCs, namely Lindsay 38, Lindsay 113, NGC 2121, and NGC 2155, for which we recently obtained new UV HST observations. These clusters are more massive than ∼104 M⊙ and have ages between ∼2.5 and ∼6 Gyr, i.e. located in a previously unexplored region of the cluster age/mass diagram. We found chemical anomalies, in the form of N spreads, in three out of four clusters in the sample, namely in NGC 2121, NGC 2155, and Lindsay 113. By combining data from our survey and HST photometry for three additional clusters in the Milky Way (namely 47 Tuc, M15, and NGC 2419), we show that the extent of the MPs in the form of N spread is a strong function of age, with older clusters having larger N spreads with respect to the younger ones. Hence, we confirm that cluster age plays a significant role in the onset of MPs.
Abstract
We have recently shown that the ∼2 Gyr old Large Magellanic Cloud star cluster NGC 1978 hosts multiple populations in terms of star-to-star abundance variations in N/Fe. These can be seen as ...a splitting or spread in the subgiant and red giant branches (SGB and RGB) when certain photometric filter combinations are used. Because of its relative youth, NGC 1978 can be used to place stringent limits on whether multiple bursts of star formation have taken place within the cluster, as predicted by some models for the origin of multiple populations. We carry out two distinct analyses to test whether multiple star formation epochs have occurred within NGC 1978. First, we use ultraviolet colour--magnitude diagrams (CMDs) to select stars from the first and second population along the SGB, and then compare their positions in optical CMDs, where the morphology is dominantly controlled by age as opposed to multiple population effects. We find that the two populations are indistinguishable, with age differences of 1 ± 20 Myr between them. This is in tension with predictions from the asymptotic giant branch scenario for the origin of multiple populations. Second, we estimate the broadness of the main-sequence turn-off (MSTO) of NGC 1978 and we report that it is consistent with the observational errors. We find an upper limit of ∼65 Myr on the age spread in the MSTO of NGC 1978. This finding is in conflict with the age spread scenario as origin of the extended MSTO in intermediate-age clusters, while it fully supports predictions from the stellar rotation model.
Several recent studies have reported the detection of an anomalous color spread along the red giant branch (RGB) of some globular clusters (GC) that appears only when color indices including a near ...ultraviolet band (such as Johnson U or Strömgren u) are considered. This anomalous spread in color indexes such as U − B or cy has been shown to correlate with variations in the abundances of light elements such as C, N, O, Na, etc., which, in turn, are generally believed to be associated with subsequent star formation episodes that occurred in the earliest few 108 yr of the cluster’s life. Here we use publicly available u, g, r Sloan Digital Sky Survey photometry to search for anomalous u − g spreads in the RGBs of nine Galactic GCs. In seven of them (M 2, M 3, M 5, M 13, M 15, M 92 and M 53), we find evidence of a statistically significant spread in the u − g color, not seen in g − r and not accounted for by observational effects. In the case of M 5, we demonstrate that the observed u − g color spread correlates with the observed abundances of Na, the redder stars being richer in Na than the bluer ones. In all the seven clusters displaying a significant u − g color spread, we find that the stars on the red and blue sides of the RGB, in (g, u − g) color magnitude diagrams, have significantly different radial distributions. In particular, the red stars (generally identified with the second generation of cluster stars, in the current scenario) are always more centrally concentrated than blue stars (generally identified with the first generation) over the range sampled by the data (0.5 rh ≲ r ≲ 5 rh), in qualitative agreement with the predictions of some recent models of the formation and chemical evolution of GCs. Our results suggest that the difference in the radial distribution between first and second generation stars may be a general characteristic of GCs.
ABSTRACT
The Pristine survey uses narrow-band photometry to derive precise metallicities down to the extremely metal-poor regime ($ \rm Fe/H \lt -3$), and currently consists of over 4 million ...FGK-type stars over a sky area of $\sim 2500\, \mathrm{deg}^2$. We focus our analysis on a subsample of ∼80 000 main-sequence turn-off stars with heliocentric distances between 6 and 20 kpc, which we take to be a representative sample of the inner halo. The resulting metallicity distribution function (MDF) has a peak at $ \rm Fe/H =-1.6$, and a slope of Δ(LogN)/$\Delta \rm Fe/H = 1.0 \pm 0.1$ in the metallicity range of $-3.4\; \lt\; \rm Fe/H\; \lt -2.5$. This agrees well with a simple closed-box chemical enrichment model in this range, but is shallower than previous spectroscopic MDFs presented in the literature, suggesting that there may be a larger proportion of metal-poor stars in the inner halo than previously reported. We identify the Monoceros/TriAnd/ACS/EBS/A13 structure in metallicity space in a low-latitude field in the anticentre direction, and also discuss the possibility that the inner halo is dominated by a single, large merger event, but cannot strongly support or refute this idea with the current data. Finally, based on the MDF of field stars, we estimate the number of expected metal-poor globular clusters in the Milky Way halo to be 5.4 for $ \rm Fe/H\; \lt\; -2.5$ and 1.5 for $ \rm Fe/H\; \lt\; -3$, suggesting that the lack of low-metallicity globular clusters in the Milky Way is not due simply to statistical undersampling.
It is now well established that globular clusters (GCs) exhibit star-to-star light-element abundance variations (known as multiple populations, MPs). Such chemical anomalies have been found in ...(nearly) all the ancient GCs (more than 10 Gyr old) of our Galaxy and its close companions, but so far no model for the origin of MPs is able to reproduce all the relevant observations. To gain new insights into this phenomenon, we have undertaken a photometric Hubble Space Telescope survey to study clusters with masses comparable to that of old GCs, where MPs have been identified, but with significantly younger ages. Nine clusters in the Magellanic Clouds with ages between similar to 1.5 and 11 Gyr have been targeted in this survey. We confirm the presence of MPs in all clusters older than 6 Gyr and we add NGC 1978 to the group of clusters for which MPs have been identified. With an age of similar to 2 Gyr, NGC 1978 is the youngest cluster known to host chemical abundance spreads found to date. We do not detect evident star-to-star variations for slightly younger massive clusters (similar to 1.7 Gyr), thus pointing towards an unexpected age dependence for the onset of MPs. This discovery suggests that the formation of MPs is not restricted to the early Universe and that GCs and young massive clusters share common formation and evolutionary processes.
We started a photometric survey using the WFC3/UVIS instrument onboard the Hubble Space Telescope to search for multiple populations within Magellanic Cloud star clusters at various ages. In this ...paper, we introduce this survey. As first results of this programme, we also present multiband photometric observations of NGC 121 in different filters taken with the WFC3/UVIS and ACS/WFC instruments. We analyse the colour-magnitude diagram (CMD) of NGC 121, which is the only 'classical' globular cluster within the Small Magellanic Cloud. Thereby, we use the pseudo-colour C sub( F336W,F438W,F343N) = (F336W - F438W) - (F438W - F343N) to separate populations with different C and N abundances. We show that the red giant branch splits up in two distinct populations when using this colour combination. NGC 121 thus appears to be similar to Galactic globular clusters in hosting multiple populations. The fraction of enriched stars (N rich, C poor) in NGC 121 is about 32 per cent plus or minus 3 per cent, which is lower than the median fraction found in Milky Way globular clusters. The enriched population seems to be more centrally concentrated compared to the primordial one. These results are consistent with the recent results by Dalessandro et al. The morphology of the horizontal branch in a CMD using the optical filters F555W and F814W is best produced by a population with a spread in helium of ...Y = 0.025 plus or minus 0.005. (ProQuest: ... denotes formulae/symbols omitted.)
Atomic data for the Gaia -ESO Survey Heiter, U.; Lind, K.; Bergemann, M. ...
Astronomy and astrophysics (Berlin),
2021, Letnik:
645
Journal Article
Recenzirano
Odprti dostop
Context.
We describe the atomic and molecular data that were used for the abundance analyses of FGK-type stars carried out within the
Gaia
-ESO Public Spectroscopic Survey in the years 2012 to 2019. ...The
Gaia
-ESO Survey is one among several current and future stellar spectroscopic surveys producing abundances for Milky-Way stars on an industrial scale.
Aims.
We present an unprecedented effort to create a homogeneous common line list, which was used by several abundance analysis groups using different radiative transfer codes to calculate synthetic spectra and equivalent widths. The atomic data are accompanied by quality indicators and detailed references to the sources. The atomic and molecular data are made publicly available at the CDS.
Methods.
In general, experimental transition probabilities were preferred but theoretical values were also used. Astrophysical
gf
-values were avoided due to the model-dependence of such a procedure. For elements whose lines are significantly affected by a hyperfine structure or isotopic splitting, a concerted effort has been made to collate the necessary data for the individual line components. Synthetic stellar spectra calculated for the Sun and Arcturus were used to assess the blending properties of the lines. We also performed adetailed investigation of available data for line broadening due to collisions with neutral hydrogen atoms.
Results.
Among a subset of over 1300 lines of 35 elements in the wavelength ranges from 475 to 685 nm and from 850 to 895 nm, we identified about 200 lines of 24 species which have accurate
gf
-values and are free of blends in the spectra of the Sun and Arcturus. For the broadening due to collisions with neutral hydrogen, we recommend data based on Anstee-Barklem-O’Mara theory, where possible. We recommend avoiding lines of neutral species for which these are not available. Theoretical broadening data by R.L. Kurucz should be used for Sc
II
, Ti
II
, and Y
II
lines; additionally, for ionised rare-earth species, the Unsöld approximation with an enhancement factor of 1.5 for the line width can be used.
Conclusions.
The line list has proven to be a useful tool for abundance determinations based on the spectra obtained within the
Gaia
-ESO Survey, as well as other spectroscopic projects. Accuracies below 0.2 dex are regularly achieved, where part of the uncertainties are due to differences in the employed analysis methods. Desirable improvements in atomic data were identified for a number of species, most importantly Al
I
, S
I
, and Cr
II
, but also Na
I
, Si
I
, Ca
II
, and Ni
I
.
Summary Background Cardiosphere-derived cells (CDCs) reduce scarring after myocardial infarction, increase viable myocardium, and boost cardiac function in preclinical models. We aimed to assess ...safety of such an approach in patients with left ventricular dysfunction after myocardial infarction. Methods In the prospective, randomised CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction (CADUCEUS) trial, we enrolled patients 2–4 weeks after myocardial infarction (with left ventricular ejection fraction of 25–45%) at two medical centres in the USA. An independent data coordinating centre randomly allocated patients in a 2:1 ratio to receive CDCs or standard care. For patients assigned to receive CDCs, autologous cells grown from endomyocardial biopsy specimens were infused into the infarct-related artery 1·5–3 months after myocardial infarction. The primary endpoint was proportion of patients at 6 months who died due to ventricular tachycardia, ventricular fibrillation, or sudden unexpected death, or had myocardial infarction after cell infusion, new cardiac tumour formation on MRI, or a major adverse cardiac event (MACE; composite of death and hospital admission for heart failure or non-fatal recurrent myocardial infarction). We also assessed preliminary efficacy endpoints on MRI by 6 months. Data analysers were masked to group assignment. This study is registered with ClinicalTrials.gov , NCT00893360. Findings Between May 5, 2009, and Dec 16, 2010, we randomly allocated 31 eligible participants of whom 25 were included in a per-protocol analysis (17 to CDC group and eight to standard of care). Mean baseline left ventricular ejection fraction (LVEF) was 39% (SD 12) and scar occupied 24% (10) of left ventricular mass. Biopsy samples yielded prescribed cell doses within 36 days (SD 6). No complications were reported within 24 h of CDC infusion. By 6 months, no patients had died, developed cardiac tumours, or MACE in either group. Four patients (24%) in the CDC group had serious adverse events compared with one control (13%; p=1·00). Compared with controls at 6 months, MRI analysis of patients treated with CDCs showed reductions in scar mass (p=0·001), increases in viable heart mass (p=0·01) and regional contractility (p=0·02), and regional systolic wall thickening (p=0·015). However, changes in end-diastolic volume, end-systolic volume, and LVEF did not differ between groups by 6 months. Interpretation We show intracoronary infusion of autologous CDCs after myocardial infarction is safe, warranting the expansion of such therapy to phase 2 study. The unprecedented increases we noted in viable myocardium, which are consistent with therapeutic regeneration, merit further assessment of clinical outcomes. Funding US National Heart, Lung and Blood Institute and Cedars-Sinai Board of Governors Heart Stem Cell Center.
PDF
