The nutritional status of mothers affects their babies. However, the factors responsible for the control of fetal retinol levels are unknown. This study evaluates the role of maternal social factors ...in the determination of fetal serum retinol.
Consecutive mothers with normal pregnancy as judged by obstetrician (excluding those with sepsis and medical illnesses) were recruited. The maternal social factors and antenatal history were determined using questionnaires and the retinol level of the cord blood of the neonates were estimated using the high performance liquid chromatography.
There were 106 mothers (ages between 21 and 39 years, mean of 26 years) and neonates, made up of 57 females and 49 males with gestational age 30-45 weeks, mean of 373 weeks). The range of the neonatal serum retinol level was 0.12 ig/L--1.57 ig/L, with a mean of 0.94 ig/L (SD = 0.17) and median value of 0.98 ig/L. The mean serum retinol in the females was 0.94 ig/L while males were 1.13 ig/L. Ihe mean serum retinol according to the socioeconomic classes were high (I and II) 1.2 ig/L, middle (III) 1.1 ig/L and low (IV and V) 0.9 ig/L. The mean fetal serum retinol among the mothers with fever in pregnancy (31/106), incomplete vaccination in pregnancy (17/106) and neonates with low birthweight (<2.5 Kg) was 0.9 ig/L. Bivariate analysis revealed significant correlation between the mean serum retinol and the socioeconomic class (P = 0.038), but there was no correlation with maternal age (P = 0.7), sex (P = 0.07), gestational age (P = 0.39), birth weight (P = 0.7), maternal tetanus vaccination (P = 0.28), fever (P = 0.64) and antenatal care (P = 0.97).
Socioeconomic status of the mothers was a significant factor in the determination of neonatal serum retinol level, suggesting that maternal retinol supplementation may help in control of neonatal hyporetinolaemia.
Background: The aetiology of tinnitus and the factors that contribute to the exacerbation from mild to severe tinnitus are poorly known. Particularly, a role of genetics has been proposed for ...tinnitus, although this has not been conclusive. In order to establish a possible role for heritability in our population, we explored the history of tinnitus among first degree family members of those suffering from tinnitus using cross-sectional community-based strategy.
Methods: There were 300 subjects with idiopathic tinnitus with mean (±SD) age of 51.88 (±15.11, range=19-80 years) comprising 169 males and 131 females.
Results: Tinnitus was severe in 37.9% and bilateral in 65.1% while 26.6% reported having family members with history of tinnitus. TInnitus was significantly more severe (p<0.001) and more frequent (p<0.001); and the psychological distress related to tinnitus (p<0.001) measured by the mini-TQ was worse among those with family history compared to those without. Bivariate analysis reveals that the presence of tinnitus in other family members, occurrence of tinnitus for more than 3 months (p=0.003), increasing age (0.001) and higher mean mini-TQ scores (0.001) showed significant association with severity of tinnitus. Logistic regression reveals that presence of tinnitus in other family members increases the odds of frequency of tinnitus by 5.08 (95% CI=1.70-15.12), elevates the mean scores of the mini-TQ by 1.31 (95% CI=1.20-1.44) while increasing age greater than 50 years increases the odds of severity of disease by 2.81 (95%CI=1.59-4.94).
Conclusions: We conclude that the findings of significant correlation between presence of tinnitus in first degree relatives and severity of tinnitus among the subjects provides an empirical evidence to explore a possible genetic aetiology for severe tinnitus in our population.
Hearing loss (HL) is the most common sensory deficit in humans with causative variants in over 140 genes. With few exceptions, however, the population-specific distribution for many of the identified ...variants/genes is unclear. Until recently, the extensive genetic and clinical heterogeneity of deafness precluded comprehensive genetic analysis. Here, using a custom capture panel (MiamiOtoGenes), we undertook a targeted sequencing of 180 genes in a multi-ethnic cohort of 342
GJB2
mutation-negative deaf probands from South Africa, Nigeria, Tunisia, Turkey, Iran, India, Guatemala and the United States (South Florida). We detected causative DNA variants in 25% of multiplex and 7% of simplex families. The detection rate varied between 0% and 57% based on ethnicity, with Guatemala and Iran at the lower and higher end of the spectrum, respectively. We detected causative variants within 27 genes without predominant recurring pathogenic variants. The most commonly implicated genes include
MYO15A, SLC26A4, USH2A, MYO7A, MYO6
and
TRIOBP
. Overall, our study highlights the importance of family history and generation of databases for multiple ethnically discrete populations to improve our ability to detect and accurately interpret genetic variants for pathogenicity.
To determine the pattern of hearing loss among patients with chronic renal failure (CRF).
This is a case control study carried out jointly by the Otorhinolaryngology and Nephrology Departments of the ...University College Hospital Ibadan, Nigeria between December 2004 and March 2006. Consecutive CRF patients who satisfied the inclusion criteria were recruited, the patients had not had hemodialysis prior to inception of the study. Parameters like age, gender, duration of illness and blood pressure were recorded and pure tone audiometry was carried out. The data was analyzed using the Statistical Package for Social Sciences.
Thirty-three CRF patients and 28 healthy controls (34 males and 27 females) were used. The age range was 16-72 years, mean of 45.30 (SD 16.20). Sensorineural hearing loss was found in 67% of CRF and 32% of controls. The mean hearing threshold of CRF was 47.42 (SD 18.55) while the controls was 35 db, unpaired t-test (value -5.155) and Pearson correlation p=0.0008, r=0.614 showed the difference was significant. There was a correlation between duration of renal disease and hearing threshold p=0.00387 (r=0.73). There was no correlation between the hearing threshold and the diastolic blood pressure p=0.056 dosage of diuretics p=-0.155 (r=0.12) and creatinine level of the patients p=0.35 (r=0.31).
Sensorineural hearing loss is common among patients with CRF and related to the duration of renal disease, we recommend periodic audiological assessment incorporated in the care of these patients.
This study was based on the hypothesis that suboptimal immune response and low serum immunoglobulin G (IgG) may predispose to age-related hearing loss (ARHL), and the objective was to determine the ...serum levels of IgG and hearing thresholds of apparently healthy elderly subjects and assess their correlation.
This prospective study involved 126 participants ≥ 60 years old who were found to be free of any medical conditions. Pure-tone averages for both the speech (500-2,000 Hz) and high frequencies (3,000-8,000 Hz) and serum IgG levels were determined. Using 30 dB as cut-off for hearing loss, the correlation with serum IgG was assessed.
There were 59 males and 67 females with a mean age ± SD of 67.0 ± 2.7 years. Speech frequency hearing loss was seen in 30.2%, while high-frequency hearing loss accounted for 74.6%. In the speech frequencies, the mean ± SD of serum IgG among subjects with normal hearing was 11.3 ± 3.9 g/l, while among those with hearing loss it was 8.3 ± 3.3 g/l (p = 0.01). In the high frequencies, the mean ± SD values of serum IgG among the subjects with normal hearing was 11.1 ± 2.3 g/l, while among those with hearing loss it was 8.7 ± 1.9 g/l (p = 0.01).
Low serum IgG may be a contributory factor to the development of ARHL among the elderly. However, a longitudinal study involving intervention with immunoglobulin supplementation may further confirm this role.
PDF
