Two of the biggest challenges for future HEP experiments at hadron colliders are triggering and track reconstruction of high-multiplicity events, where collisions have multiple primary vertices. The ...highly-non-linear scaling of computing power required for these tasks encourages the adoption of non-traditional, specialized architectures. Amongst them, the “artificial retina” approach, inspired by the architecture of the vision system in the living brain, promises large efficiency of hardware utilization, low-power and low-latency when implemented in state-of-art FPGA devices.
The INFN-RETINA project has been a 3-year effort dedicated to investigate the potential of that approach in a real-time tracking processor at Level-0 of the LHC HEP experiments. We present results from studies performed on a prototype system capable of carrying out track reconstruction in a generic 6-layer silicon-strip detector with sub-μs latency at an event rate in excess of 30 MHz, and how a large-scale system can be implemented on multiple boards interconnected with high-speed optical links. Possible applications to real experimental environments will be also discussed.
The preferential loss of dopaminergic neurons in the substantia nigra pars compacta is one of the pathological hallmarks characterizing Parkinson’s disease. Although the pathogenesis of this disorder ...is not fully understood, oxidative stress plays a central role in the onset and/or progression of Parkinson’s disease and dopamine itself has been suggested to participate in the preferential neuronal degeneration through the induction of oxidative conditions. In fact, the accumulation of dopamine into the cytosol can lead to the formation of reactive oxygen species as well as highly reactive dopamine-quinones. In the present work, we first analyzed the cellular damage induced by the addition of dopamine (DA) in the culture medium of SH-SY5Y cells, discriminating whether the harmful effects were related to the generation of reactive oxygen species or to the toxicity associated to dopamine-derived quinones. Then, we tested and demonstrated the capability of the antioxidant enzymes SOD1 and SOD2 to protect cells from the noxious effects induced by DA treatment. Our results support further exploration of superoxide dismutating molecules as a therapeutic strategy against Parkinson’s disease.
