Temperature observations of the upper-air atmosphere are now available for more than 40 years from both ground- and satellite-based observing systems. Recent years have seen substantial improvements ...in reducing long-standing discrepancies among datasets throughmajor reprocessing efforts. The advent of radio occultation (RO) observations in 2001 has led to further improvements in vertically resolved temperature measurements, enabling a detailed analysis of upper-troposphere/lower-stratosphere trends. This paper presents the current state of atmospheric temperature trends from the latest available observational records. We analyze observations from merged operational satellite measurements, radiosondes, lidars, and RO, spanning a vertical range fromthe lower troposphere to the upper stratosphere. The focus is on assessing climate trends and on identifying the degree of consistency among the observational systems. The results showa robust cooling of the stratosphere of about 1–3 K, and a robust warming of the troposphere of about 0.6–0.8K over the last four decades (1979–2018). Consistent results are found between the satellite-based layer-average temperatures and vertically resolved radiosonde records. The overall latitude–altitude trend patterns are consistent between RO and radiosonde records. Significant warming of the troposphere is evident in the RO measurements available after 2001, with trends of 0.25–0.35K per decade. Amplified warming in the tropical upper-troposphere compared to surface trends for 2002–18 is found based on ROand radiosonde records, in approximate agreement withmoist adiabatic lapse rate theory. The consistency of trend results from the latest upper-air datasets will help to improve understanding of climate changes and their drivers.
In the lowermost layer of the atmosphere—the troposphere—ozone is an important source of the hydroxyl radical, an oxidant that breaks down most pollutants and some greenhouse gases. High ...concentrations of tropospheric ozone are toxic, however, and have a detrimental effect on human health and ecosystem productivity. Moreover, tropospheric ozone itself acts as an effective greenhouse gas. Much of the present tropospheric ozone burden is a consequence of anthropogenic emissions of ozone precursors resulting in widespread increases in ozone concentrations since the late 1800s. At present, east Asia has the fastest-growing ozone precursor emissions. Much of the springtime east Asian pollution is exported eastwards towards western North America. Despite evidence that the exported Asian pollution produces ozone, no previous study has found a significant increase in free tropospheric ozone concentrations above the western USA since measurements began in the late 1970s. Here we compile springtime ozone measurements from many different platforms across western North America. We show a strong increase in springtime ozone mixing ratios during 1995–2008 and we have some additional evidence that a similar rate of increase in ozone mixing ratio has occurred since 1984. We find that the rate of increase in ozone mixing ratio is greatest when measurements are more heavily influenced by direct transport from Asia. Our result agrees with previous modelling studies, which indicate that global ozone concentrations should be increasing during the early part of the twenty-first century as a result of increasing precursor emissions, especially at northern mid-latitudes, with western North America being particularly sensitive to rising Asian emissions. We suggest that the observed increase in springtime background ozone mixing ratio may hinder the USA’s compliance with its ozone air quality standard.
The evolution of the aerosols in the tropical stratosphere since the beginning of the Cloud‐Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) mission in June 2006 is investigated ...using Cloud‐Aerosol Lidar with Orthogonal Polarization (CALIOP) lidar data. It is shown that the current operational calibration requires adjustment in the tropics. Indeed, on the basis of the assumption of pure Rayleigh scattering between 30 and 34 km the current calibration leads to an average underestimation of the scattering ratio by 6% because of the significant amount of aerosols up to 35 km altitude in the tropics, in contrast to midlatitudes. A better result is obtained by adjusting the calibration to higher altitudes, 36–39 km, where past Stratospheric Aerosol and Gas Experiment (SAGE) II extinction measurements showed an almost complete absence of aerosols. After recalibration the tropical stratospheric aerosol picture provided by CALIOP during the first 2 years of the mission reveals significant changes in the aerosol concentration associated with different transport processes. In the stratosphere the slow ascent of several volcanic layers and their meridional transport toward the subtropics are very consistent with the Brewer‐Dobson circulation. The near‐zero vertical velocity observed around 20 km during the Northern Hemisphere (NH) summer is in good agreement with radiative heating calculation. In the Tropical Tropopause Layer (TTL), weak depolarizing particles are observed during land convective periods, particularly intense over South Asia during the monsoon season. Finally, seasonal fast occurrence of apparent clean air in the TTL during the NH winter requires more investigations to understand its origin.
The Tropospheric Ozone Assessment Report (TOAR) is an activity of the International Global Atmospheric Chemistry Project. This paper is a component of the report, focusing on the present-day ...distribution and trends of tropospheric ozone relevant to climate and global atmospheric chemistry model evaluation. Utilizing the TOAR surface ozone database, several figures present the global distribution and trends of daytime average ozone at 2702 non-urban monitoring sites, highlighting the regions and seasons of the world with the greatest ozone levels. Similarly, ozonesonde and commercial aircraft observations reveal ozone’s distribution throughout the depth of the free troposphere. Long-term surface observations are limited in their global spatial coverage, but data from remote locations indicate that ozone in the 21st century is greater than during the 1970s and 1980s. While some remote sites and many sites in the heavily polluted regions of East Asia show ozone increases since 2000, many others show decreases and there is no clear global pattern for surface ozone changes since 2000. Two new satellite products provide detailed views of ozone in the lower troposphere across East Asia and Europe, revealing the full spatial extent of the spring and summer ozone enhancements across eastern China that cannot be assessed from limited surface observations. Sufficient data are now available (ozonesondes, satellite, aircraft) across the tropics from South America eastwards to the western Pacific Ocean, to indicate a likely tropospheric column ozone increase since the 1990s. The 2014–2016 mean tropospheric ozone burden (TOB) between 60°N–60°S from five satellite products is 300 Tg ± 4%. While this agreement is excellent, the products differ in their quantification of TOB trends and further work is required to reconcile the differences. Satellites can now estimate ozone’s global long-wave radiative effect, but evaluation is difficult due to limited in situ observations where the radiative effect is greatest.
Allogeneic hematopoietic stem cell transplantation (HSCT) offers the potential to cure patients with an inherited bone marrow failure syndrome (IBMFS). However, the procedure involves the risk of ...treatment-related mortality and may be associated with significant early and late morbidity. For these reasons, the benefits should be carefully weighed against the risks. IBMFS are rare, whereas case reports and small series in the literature illustrate highly heterogeneous practices in terms of indications for HSCT, timing, stem cell source and conditioning regimens. A consensus meeting was therefore held in Vienna in September 2012 on behalf of the European Group for Blood and Marrow Transplantation to discuss HSCT in the setting of IBMFS. This report summarizes the recommendations from this expert panel, including indications for HSCT, timing, stem cell source and conditioning regimen.
In core binding factors (CBF) acute myeloid leukemia (AML), the disruption of CBFalpha/beta genes impairs normal hematopoietic differentiation and is supposed to cooperate with additional mutations ...promoting proliferation. The incidence and the prognosis of receptor tyrosine kinase (RTK) c-Kit and FLT3 mutations and Ras mutations were evaluated in 103 pediatric and adult patients with CBF-AML. c-Kit mutations were present in 17% patients. c-Kit exon 8 mutations were more frequent in inv(16) than in t(8;21) subset (20 versus 6%). Only one patient had FLT3-ITD but FLT3-D835 was as frequent as reported in AML population (7%). Ras mutations were significantly more frequent in inv(16) than in t(8;21) subset (36 versus 8%, P=0.001). RTK mutations were associated with a higher white blood cell count (WBC) (36 versus 21 G/L, P=0.05). FLT3 mutations were significantly associated with a shorter EFS and survival (P<0.0001 and P=0.0002) owing to an excess of early events. c-Kit mutations were associated with a shorter EFS and RFS (P=0.002 and P=0.003) in t(8;21) but not inv(16) patients. As previously observed, Ras mutations did not affect prognosis. Screening for RTK mutations may help to identify patients with a more adverse outcome and thus susceptible to benefit from intensified protocols or RTK inhibitors.
Abstract
STUDY QUESTION
How efficacious is transplantation of ovarian cortex previously exposed to chemotherapy?
SUMMARY ANSWER
Prior exposure to chemotherapy did not disrupt the function of ...cryopreserved ovarian tissue after transplantation.
WHAT IS KNOWN ALREADY
Ovarian tissue cryopreservation (OTC) followed by ovarian tissue transplantation (OTT) is an efficacious technique for restoration of female fertility. At least 130 children have been born following this procedure. To date, little is known about the efficacy of OTT in patients exposed to cancer chemotherapy prior to OTC.
STUDY DESIGN, SIZE, DURATION
This study evaluates the recovery of ovarian function and fertility in 31 consecutive patients who had received OTT, between 2005 and 2015.
PARTICIPANTS/MATERIALS, SETTING, METHODS
Thirty one patients, wanting children, were transplanted with autologous ovarian cortex, among which 22 patients (71%) had been exposed to chemotherapy before OTC. Recovery of ovarian function was considered total once menstruation occurred. Ovarian function recovery (OFR), ovarian graft survival, and incidence of pregnancy were related to previous chemotherapy exposure, type of chemotherapy and graft characteristics (number of grafted fragments and follicular density).
MAIN RESULTS AND ROLE OF CHANCE
The amount of ovarian tissue collected was the only parameter to show any significant change between patients with versus without previous chemotherapy. At 1 year after OTT, the cumulative incidence of OFR was 83% (93% in patients exposed to chemotherapy and 67% in others (P = 0.14)). A low follicular density (<0.3 foll/mm2) in the transplant and a low number of grafted fragments (<16) were significantly associated with a delayed OFR. Graft survival at 2 years after OTT was 77%. It was significantly lower in patients exposed to bifunctional alkylating agents before ovarian cryopreservation and in patients with a low follicular density. The proportion of women who succeeded in having at least one live birth was 23% in the total population, 0% (0/9) in the group ‘no previous chemotherapy’, and 32% (7/22) in the group ‘previous chemotherapy’. The cumulative incidence of pregnancy (Kaplan–Meier) at 3 years after OTT was 36% overall and 49% in case of previous chemotherapy, with no difference related to previous chemotherapy exposure. In total there were 13 pregnancies and 8 births in 7 patients.
LIMITATIONS, REASONS FOR CAUTION
The pathology in the two groups of patients was not comparable. In the group of patients who had chemotherapy before OTC, there were 95% of hematological malignancies. In the group of patients who did not have chemotherapy before OTC only 1 out of 9 patients had a malignant hematological disease while 44% had some pathology affecting the ovaries. Few women are available for study and only large changes are likely to have statistical significance.
WIDER IMPLICATIONS OF THE FINDINGS
These results suggest that prior cancer chemotherapy should no longer be considered a limitation to cryopreservation of ovarian tissue and current recommendations in this regard should be revised.
STUDY FUNDING/COMPETING INTEREST(S)
This study was supported by the Agence de la Biomédecine (France’s biomedical office). There are no competing interests to report.
TRIAL REGISTRATION NUMBER
NCT02184806.
The objective of the work presented here is to estimate the characteristics of the power balance, i.e. the power and the surface power density that the electric arc brings to Ag-SnO 2 electrodes. ...This work is first based on an experimental study carried out using an IR camera with which we measured the temperature in a zone close to the area impacted by the arc, but not flashed by it. In a second step, the temperature distributions obtained are compared with the results of a numerical model of the electrode heating. The model input parameters are the power P and the surface power density Q . Solving this inverse problem thus makes it possible to estimate values of P and Q leading to measured and calculated heating (temperature distribution) that are as similar as possible. Such a method has been applied for Ag-SnO 2 cathodes and anodes and for various intensities of the arc current in a range 80 - 200 A.
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