Accumulating evidence has demonstrated that microRNAs (miRNAs) are involved in multiple processes in cancer development and progression. miR-326 has been identified as a tumor suppressor miRNA in ...several types of human cancer. However, the specific function of miR-326 and its target the nin one binding protein (NOB1) in colorectal carcinoma (CRC) remains unclear. In the present study, we found that miR-326 inhibited cell proliferation, migration and invasion, and induced cell apoptosis and cell cycle arrest of CRC cells by directly targeting NOB1. Furthermore, the upregulation of miR-326 in CRC cells was revealed to be associated with a feedback loop involving downregulation of the NOB1, which mimics the phenotype induced by miR-326. Importantly, we found that the CRC patients with high expression of miR-326 or low expression of NOB1 tend to obtain a better prognosis. Thus, for the first time, we provide convincing evidence that downregulation of miR-326 inhibited tumor proliferation and tumor metastasis by directly targeting NOB1 in CRC. NOB1 and miR-326 could be potential therapeutic targets for CRC.
The potential use of poultry by-product meal (PBM) and meat and bone meal (MBM) as alternative dietary protein sources for juvenile
Macrobrachium nipponense was studied by a 70-day growth trial. ...Triplicate groups of
M. nipponense (initial body weight: 0.37
g) were fed at 20.7–22.4
°C on each of the five isoenergetic and isonitrogenous diets (protein content about 38%) with different replacement of fish meal by MBM or PBM. The control diet used white fish meal as the sole protein source, the other four diets were prepared with 15% or 50% fish meal protein substituted by either MBM (MBM
15, MBM
50) or PBM (PBM
15, PBM
50). The results showed that replacement of fish meal by MBM in diets did not affect growth performance of
M. nipponense (
P>0.05), while specific growth rate in PBM
15 was significantly higher than that in other groups (
P<0.05). Survival rates of shrimp fed with MBM
15 diet were significantly higher than that in other groups (
P<0.05). No significant differences in immunological parameters, including total haemocyte count (THC), phenoloxidase activity (PO) and respiratory burst (O
2
−), were observed between the shrimps that were fed five experimental diets, and all determined immunological parameters in control groups were slightly higher than those in replacement groups. In conclusion, either MBM or PBM investigated could replace up to 50% fish meal protein in diets for
M. nipponense.
The electrical transport behavior of SnS under high pressure has been investigated by the temperature dependence of electrical resistivity measurement, the in situ Hall-effect measurement, and the ...first-principle calculation. The experimental results show that SnS undergoes a semiconductor to semimetal transition at ∼10.3 GPa, and this transition is further substantiated by the band-structure calculation. The total and partial density of states predict that the semimetal character of SnS is attributed to the enhanced coupling of Sn-5s, Sn-5p, and S-3p states with application of pressure. In addition, dramatic changes in electrical transport parameters such as the electrical resistivity, the carrier concentration, and the carrier mobility are observed at 12.6 GPa, which are correlated to the pressure-induced Pnma-Cmcm structural phase transition.
To investigate the fructose-water caramel reactions, the type I fructose caramel products (FCPs) were prepared and collected at different reaction stages. The reaction rate, caramel flavor compounds, ...UV absorptions, antioxidant, and antibacterial activities were determined. The results showed that the reaction rate was increased quickly to 90.1% at the end of middle stage. The exponentially growth of UV305nm suggested the caramel pigments and flavor compounds were rapidly formed along with the reaction. The FCP obtained at arriving of 180 °C possessed the highest contents of total flavor compounds and 5-hydroxymethylfurfural, and the fructose caramel reaction was fast than those of glucose. Total eight characteristic caramel flavor compounds were revealed from FCPs and their formation pathway were also speculated. An optimized condition was suggested at arriving of 180 °C and the FCP under this condition also exhibited potent antioxidant and antibacterial activities. All these results suggested that such kind of type I fructose caramel products could be used as food additive in food industry for the further development.
During October 21-26, 2007, wildfires consumed hundreds of thousands of acres and forced the evacuation of more than 300,000 persons in San Diego County, California. During large-scale emergencies, ...data are needed to assess health effects, plan response, and evaluate response adequacy. This report describes some of the health effects of the wildfires based on data from the CDC BioSense system, which receives emergency department (ED) patient chief complaint information and physician diagnosis codes from six hospitals in San Diego County. Analysis of these data indicated that ED visits for respiratory disease, especially those associated with dyspnea and asthma, increased during a 5-day fire period compared with the preceding 20 weekdays. For the six hospitals combined, visits for dyspnea increased from 48.6 to 72.6 per day, and visits with diagnoses of asthma increased from 21.7 to 40.4 per day. Local, state, and federal public health personnel should continue collaborative efforts to expand and
Although scholarly articles play an important role in the work life of academics, specific patterns of seeking and reading scholarly articles vary. Subject discipline of the reader influences many ...patterns, including amount of reading, format of reading, and average time spent per reading. Faculty members in different disciplines exhibit quite distinct patterns of reading. Medical/health faculty read more than others and mainly for current awareness purposes, while engineering faculty spend more time on average per article reading, and they also read more for research. Other factors that influence some reading patterns include work responsibilities (weighted towards more teaching or more research), age (young faculty are more likely to read on-screen from the open Web) and productivity of the reader, and purpose of the reading (readings for research and writing are more likely to be from a library collection). The ability to predict scholarly article seeking and reading patterns will assist journal editors, publishers, and librarians design better, more targeted journal systems and services.
•Highly uniform double cauliflower-like Sb2S3 particles were synthesized via hydrothermal method.•Influence of reaction conditions on the morphology of the products was discussed.•Double ...cauliflower-like Sb2S3 superstructures revealed broad spectrum response.
The double cauliflower-like Sb2S3 superstructures assembled by nanorods were prepared using SbCl3 and Na2S⋅9H2O as raw materials, dodecyltrimethylammonium bromide (DTAB, C15H31BrN) as surfactant under acidic condition at 180°C for 30h. The structure, morphology and composition of the product were characterized by X-ray diffraction pattern (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) and energy diffraction spectroscopy (EDS). The effect of reaction conditions including temperature, reaction time and surfactants on the sample morphology was discussed and a possible mechanism for the formation of cauliflower-like Sb2S3 was proposed. The cauliflower-like Sb2S3 microcrystallines revealed broad spectrum response, which may have a good application prospect in solar energy utilization and photoelectric conversion fields.
Angle-dependent Raman scattering is performed on an m-plane AlN bulk crystal. The angular dependence of A1(TO) phonon mode shows strongly anisotropic behavior that the Raman intensity in xx ...polarization is 6.5 times larger than that in zz polarization. Both anisotropy ratio and phase difference between the independent Raman tensor elements Rxx and Rzz of the A1(TO) mode are derived from the Raman spectra. It is found that the |Rxx|/|Rzz| ratio is up to 2.54, which is noticeably higher than that of wurtzite GaN (1.30) and ZnO (1.02).
n-Type redox-active poly (3,4-dihexylthiophene) was synthesized by oxidative coupling polymerization and found to exhibit exceptionally high reversible electric storage capacity of −300mAhg−1 through ...Lithium insertion/extraction reactions, possibly serving as a high capacity anodic material for all organic Li-ion batteries. Display omitted
► n-Type redox-active polythiophene/carbon composite was synthesized via an oxidative coupling polymerization. ► The polythiophene/carbon composite demonstrates a superior high capacity and reversibility as an organic anodic material. ► The polythiophene/carbon composite was successfully used for constructing all-organic Li-ion batteries.
All-organic rechargeable batteries may have low cost, materials sustainability and environmental friendliness, particularly suitable for large scale electric energy storage applications. However, development of such a new generation of batteries is now hindered by the lack of appropriate organic anode materials. In this paper, we report a novel polythiophene/carbon composite, where n-dopable poly (3,4-dihexylthiophene) is in situ chemically polymerized on carbon nanofibers. This organic-carbon composite exhibits an exceptionally high reversible electrochemical capacity of ∼300mAhg−1 (or ∼ 200AhL−1) through n-type redox reactions and superior capacity retention of ⩾95% after a hundred cycles. Based on this n-type redox-active material, an all-organic Li-ion cell using polytriphenylamine as cathode-active material was constructed and found to operate successfully, demonstrating possible applications of this composite as a high capacity anode material for all-organic storage batteries.
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