Meta-analysis was used to review and synthesize existing empirical research concerning the career benefits associated with mentoring for the protégé. Both objective (e.g., compensation) and ...subjective (e.g., career satisfaction) career outcomes were examined. Comparisons of mentored versus nonmentored groups were included, along with relationships between mentoring provided and outcomes. The findings were generally supportive of the benefits associated with mentoring, but effect sizes associated with objective outcomes were small. There was also some indication that the outcomes studied differed in the magnitude of their relationship with the type of mentoring provided (i.e., career or psychosocial).
To estimate the impact of parametrial lymphovascular and perineural involvement on nodal metastasis and failure pattern of women with early-stage, surgically treated cervical cancer.
Clinical records ...and pathologic slides of 93 patients with early-stage cervical cancer (2 IA2, 52 IB1, 31 IB2, and 8 IIA) treated with radical hysterectomy and pelvic lymphadenectomy with or without paraaortic lymphadenectomy were reviewed. The study group comprised 80 patients with squamous cell carcinoma and 13 patients with adenocarcinoma of the cervix. Median follow-up time was 33 months. The association among the various histopathologic predictors of outcome was determined with chi2 analysis. The influence of the predictors on outcome was examined with log rank survival methods and the Cox regression model.
The presence of parametrial lymphovascular space invasion is a predictor of disease in the pelvic (P<.001) and paraaortic (P<.05) lymphatics independently. Large tumor size (greater than 4 cm), parametrial perineural invasion, cervical lymphovascular space invasion, and tumor depth (greater than two thirds) were found to be simultaneous predictors of recurrence on multivariate analysis (P<.05). Using these four binary predictor variables, we have computed a model-based relative risk. Based on this model, the presence of perineural invasion in the parametria more than doubles the risk of recurrence in the cohort of patients with large (greater than 4 cm) tumors (P<.05). In a subset analysis of patients with negative nodal disease, parametrial perineural invasion and tumor size were independent predictors of poor outcome (P<.05).
Presence of parametrial lymphovascular space invasion correlates significantly with the risk of nodal metastasis in women with early-stage cervical cancer. Parametrial perineural invasion is an independent poor prognostic factor. Histopathologic findings within the parametria are a valuable independent predictor of recurrence and thus may influence the selection of patients for adjuvant treatment.
Searching for axion dark matter, the ADMX Collaboration acquired data from January to October 2018, over the mass range 2.81–3.31 μeV, corresponding to the frequency range 680–790 MHz. Using an ...axion haloscope consisting of a microwave cavity in a strong magnetic field, the ADMX experiment excluded Dine-Fischler-Srednicki-Zhitnisky (DFSZ) axions at 90% confidence level and 100% dark matter density over this entire frequency range, except for a few gaps due to mode crossings. This paper explains the full ADMX analysis for run 1B, motivating analysis choices informed by details specific to this run.
Sediment budget analyses conducted for annual to decadal timescales report variable magnitudes of littoral transport along the south shore of Long Island, New York. It is well documented that the ...primary transport component is directed alongshore from east to west, but relatively little information has been reported concerning the directions or magnitudes of cross-shore components. Our review of budget calculations for the Fire Island coastal compartment (between Moriches and Fire Island Inlets) indicates an average deficit of 217,700 m3/y. Updrift shoreline erosion, redistribution of nourishment fills, and reworking of inner-shelf deposits have been proposed as the potential sources of additional sediment needed to rectify budget residuals. Each of these sources is probably relevant over various spatial and temporal scales, but previous studies of sediment texture and provenance, inner-shelf geologic mapping, and beach profile comparison indicate that reworking of inner-shelf deposits is the source most likely to resolve budget discrepancies over the broadest scales. This suggests that an onshore component of sediment transport is likely more important along Fire Island than previously thought. Our discussion focuses on relations between geomorphology, inner-shelf geologic framework, and historic shoreline change along Fire Island and the potential pathways by which reworked, inner-shelf sediments are likely transported toward the shoreline.
Major vascular resection with reconstruction in patients with gynecologic malignancy is rarely performed and infrequently reported.
A 40-year-old woman undergoing surgery for stage IIIc ovarian ...papillary serous adenocarcinoma was left with a 7-cm aortic metastasis not separable from the infrarenal abdominal aorta. An aortic resection with prosthetic graft placement was performed to achieve complete tumor resection. She remains disease-free in excess of 10 years with no evidence of graft complication.
Major vascular reconstructive procedures for the management of malignancy need not be precluded in properly selected circumstances.
We discuss advancements in modeling core-collapse supernovae with our code CHIMERA. We describe the status and details of our tracer particle method and its uses for post-processing nucleosynthesis ...and as a tool for broad core-collapse supernova (CCSN) model analyses. We also introduce our progress towards expanding a nuclear reaction network beyond the alphanetwork for the purpose of accurate in-situ nucleosynthesis, not only for core-collapse supernovae (CCSNe) in general, but for a special sub-class of supernovae called electron capture supernovae (ECSNe), which stem from progenitors stars between 8 and 10 M⊙. By using an advanced nuclear reaction network, our 2D and 3D code will allow for unparalleled studies of CCSNe and ECSNe ejecta.
Abstract Objective Prior studies have shown that age ≥ 70 years is associated with more aggressive non-endometrioid histology and worse survival in endometrial cancer. The purpose of this study is to ...assess if age is an independent poor prognostic factor in endometrioid histologies. Methods Under an IRB-approved protocol, we identified patients with surgical stage I to II endometrioid endometrial adenocarcinoma from 1995 to 2008 at two institutions. Patients were divided into two groups based on age at diagnosis: Group A (age 50–69 years) and Group B (age ≥ 70 years). All patients underwent hysterectomy, bilateral salpingoophorectomy, +/−pelvic/aortic lymphadenectomy and adjuvant therapy. Prognostic factors were evaluated by univariate and multivariate analyses. Results We identified 338 patients with stage IA to IIB endometrioid endometrial adenocarcinoma. The median age in Group A was 59 years (range 50–69) and Group B was 75 years (range 70–92). Patients in Group B were more likely to have hypertension (51% vs. 68%, p = 0.006) and coronary artery disease (9% vs. 18%, p = 0.03). There were no differences in progression-free or disease-specific survival, however, Group B had a worse overall survival (OS) (50.1 vs. 62.6 months, p = 0.03). On univariate analysis, age ( p = 0.04), grade ( p = 0.006), and coronary artery disease ( p = 0.01) were associated with worse OS. After adjusting for grade and coronary artery disease, age was no longer a significant variable for OS ( p = 0.17). Conclusions After adjusting for other poor prognostic factors, age ≥ 70 years alone may not be a significant variable affecting overall survival in patients with early stage endometrioid endometrial adenocarcinoma.
Although patients with early-stage cervical cancer have in general a favorable prognosis, 10% to 40% patients still recur depending on pathologic risk factors. The objective of this study was to ...evaluate if the presence of lymph node micrometastasis (LNmM) had an impact on patient's survival. We performed a multi-institutional retrospective review on patients with early-stage cervical cancer, with histologically negative lymph nodes, treated with radical hysterectomy and pelvic lymphadenectomy for the study period 1994 to 2004. Tissue blocks of lymph nodes from the patient's original surgery were recut and then evaluated for the presence of micrometastases. One hundred twenty-nine patients were identified who met inclusion criteria. LNmM were found in 26 patients (20%). In an average follow-up time of 70 mo, there were 11 recurrences (8.5%). Of the 11 recurrences, 2 (18%) patients had LNmM. Patients with LNmM were more likely to have received adjuvant radiation and chemotherapy. In stratified log-rank analysis, LNmM were not associated with any other high-risk clinical or pathologic variables. Survival data analysis did not demonstrate an association between the presence of LNmM and recurrence or overall survival. The presence of LNmM was not associated with an unfavorable prognosis nor was it associated with other high-risk clinical or pathologic variables predicting recurrence. Further study is warranted to understand the role of micrometastases in cervical cancer.
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