The Small Magellanic Cloud (SMC) provides a unique laboratory for the study of the lifecycle of dust given its low metallicity (~1/5 solar) and relative proximity (~60 kpc). This motivated the ...SAGE-SMC (Surveying the Agents of Galaxy Evolution in the Tidally-Stripped, Low Metallicity Small Magellanic Cloud) Spitzer Legacy program with the specific goals of studying the amount and type of dust in the present interstellar medium, the sources of dust in the winds of evolved stars, and how much dust is consumed in star formation. This program mapped the full SMC (30 sq. deg.) including the Body, Wing, and Tail in 7 bands from 3.6 to 160 micron using the IRAC and MIPS instruments on the Spitzer Space Telescope. The data were reduced, mosaicked, and the point sources measured using customized routines specific for large surveys. We have made the resulting mosaics and point source catalogs available to the community. The infrared colors of the SMC are compared to those of other nearby galaxies and the 8 micron/24 micron ratio is somewhat lower and the 70 micron/160 micron ratio is somewhat higher than the average. The global infrared spectral energy distribution shows that the SMC has ~3X lower aromatic emission/PAH (polycyclic aromatic hydrocarbon) abundances compared to most nearby galaxies. Infrared color-magnitude diagrams are given illustrating the distribution of different asymptotic giant branch stars and the locations of young stellar objects. Finally, the average spectral energy distribution (SED) of HII/star formation regions is compared to the equivalent Large Magellanic Cloud average HII/star formation region SED. These preliminary results are expanded in detail in companion papers.
Astrophys.J.632:L103-L106,2005 We present infrared observations of the young, oxygen-rich supernova remnant
1E 0102.2-7219 (E0102) in the Small Magellanic Cloud, obtained with the Spitzer
Space ...Telescope. The remnant is detected at 24 um but not at 8 or 70 um and has
a filled morphology with two prominent filaments. We find evidence for the
existence of up to 8x10^-4 Msolar of hot dust (T~120 K) associated with the
remnant. Most of the hot dust is located in the central region of E0102 which
appears significantly enhanced in infrared and radio continuum emission
relative to the X--ray emission. Even if all of the hot dust was formed in the
explosion of E0102, the estimated mass of dust is at least 100 times lower that
what is predicted by some recent theoretical models.
Astrophys.J.655:212-232,2007 We present the initial results from the Spitzer Survey of the Small
Magellanic Cloud (S3MC), which imaged the star-forming body of the Small
Magellanic Cloud (SMC) in all ...seven MIPS and IRAC wavebands. We find that the
F_8/F_24 ratio (an estimate of PAH abundance) has large spatial variations and
takes a wide range of values that are unrelated to metallicity but
anticorrelated with 24 um brightness and F_24/F_70 ratio. This suggests that
photodestruction is primarily responsible for the low abundance of PAHs
observed in star-forming low-metallicity galaxies. We use the S3MC images to
compile a photometric catalog of ~400,000 mid- and far-infrared point sources
in the SMC. The sources detected at the longest wavelengths fall into four main
categories: 1) bright 5.8 um sources with very faint optical counterparts and
very red mid-infrared colors (5.8-8.0>1.2), which we identify as YSOs. 2)
Bright mid-infrared sources with mildly red colors (0.16<5.8-8.0<0.6),
identified as carbon stars. 3) Bright mid-infrared sources with neutral colors
and bright optical counterparts, corresponding to oxygen-rich evolved stars.
And, 4) unreddened early B stars (B3 to O9) with a large 24 um excess. This
excess is reminiscent of debris disks, and is detected in only a small fraction
of these stars (<5%). The majority of the brightest infrared point sources in
the SMC fall into groups one to three. We use this photometric information to
produce a catalog of 282 bright YSOs in the SMC with a very low level of
contamination (~7%).
ObjectiveREFLECT is the first randomised, double-masked, placebo-controlled multicentre phase 3 clinical trial that evaluated the efficacy and safety of bilateral intravitreal (IVT) injection of ...lenadogene nolparvovec in subjects with Leber hereditary optic neuropathy carrying the m.11778G>A mutation.Methods and analysisA total of 98 subjects were enrolled with vision loss of ≤12 months. The subjects were randomised to one of two treatment arms with all subjects receiving an intravitreal (IVT) injection of lenadogene nolparvovec in their first affected eye and the second-affected eye randomised to receive IVT of either lenadogene nolparvovec or placebo.ResultsThe majority of subjects were male with a mean duration of vision loss of 8.3 months. All but one subject experienced bilateral loss of vision at the time of injection. The mean best-corrected visual acuity of first-affected eyes was worse compared with second/not-yet-affected eyes. Analysis of retinal anatomical parameters showed increased thinning in the first-affected eyes when compared with the second/not-yet-affected eyes with both treatment arms showing significant changes compared with unaffected individuals.ConclusionThe REFLECT trial is the third and the largest phase 3 clinical study evaluating lenadogene nolparvovec in m.11778G>A Leber hereditary optic neuropathy (LHON) subjects. The observed demographics in REFLECT are consistent with previous reports in LHON subjects in the acute and dynamic phases of LHON disease. Combined with the visual function and anatomical parameters obtained in the previous RESCUE and REVERSE trials, REFLECT has provided a uniformly collected data set that should help direct future LHON clinical trials.
Hematopoietic stem cells (HSCs) have self-renewal capacity and multilineage developmental potentials. The molecular mechanisms that control the self-renewal of HSCs are still largely unknown. Here, a ...systematic approach using bioinformatics and array hybridization techniques to analyze gene expression profiles in HSCs is described. To enrich mRNAs predominantly expressed in uncommitted cell lineages, 54 000 cDNA clones generated from a highly enriched population of HSCs and a mixed population of stem and early multipotent progenitor (MPP) cells were arrayed on nylon membranes (macroarray or high-density array), and subtracted with cDNA probes derived from mature lineage cells including spleen, thymus, and bone marrow. Five thousand cDNA clones with very low hybridization signals were selected for sequencing and further analysis using microarrays on glass slides. Two populations of cells, HSCs and MPP cells, were compared for differential gene expression using microarray analysis. HSCs have the ability to self-renew, while MPP cells have lost the capacity for self-renewal. A large number of genes that were differentially expressed by enriched populations of HSCs and MPP cells were identified. These included transcription factors, signaling molecules, and previously unknown genes.
We present infrared observations of the young, oxygen-rich supernova remnant 1E 0102.2-7219 (E0102) in the Small Magellanic Cloud, obtained with the Spitzer Space Telescope. The remnant is detected ...at 24 um but not at 8 or 70 um and has a filled morphology with two prominent filaments. We find evidence for the existence of up to 8x10^-4 Msolar of hot dust (T~120 K) associated with the remnant. Most of the hot dust is located in the central region of E0102 which appears significantly enhanced in infrared and radio continuum emission relative to the X--ray emission. Even if all of the hot dust was formed in the explosion of E0102, the estimated mass of dust is at least 100 times lower that what is predicted by some recent theoretical models.
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