Pregnancy‐dependent Cushing's syndrome in three pregnancies Kasperlik‐Zaluska, Anna A.; Szczupacka, Iwona; Leszczynska‐Bystrzanowska, Jadwiga ...
BJOG : an international journal of obstetrics and gynaecology,
June 2000, Letnik:
107, Številka:
6
Journal Article
In the sample of 734 women, randomly chosen from the Warsaw population, we collected interviews dealing with menstrual cycle abnormalities. The frequency of amenorrhoea in this sample was 0.3% and ...that of oligomenorrhoea was 6.7%. Dysmenorrhoea (more or less pronounced) was apparent in 56.3% of women, and premenstrual syndrome (PMS) was claimed by 40.5% women. For the assessment of the potential risk factors causing the menstrual cycle abnormalities we used an univariate and multivariate unconditional logistic analysis. The highest values of the oligo/amenorrhoea relative risk (RR = 5.6) were found in the youngest (< or = 16.4 y) group and among women using oral contraceptives. Dysmenorrhoea was more frequent among women who had no children (RR = 1.7) and RR for PMS was higher in women, who were previously pregnant (RR = 1.5) and in women who used oral contraceptives.
The authors evaluated the diurnal rhythm of the secretion of hCG in patients in the first trimester of normal pregnancy. The examination was carried out in a group of 22 patients (chosen at random) ...who came to hospital to undergo abortion (for social indications). The patients stayed in normal hospital conditions and were not given any drugs. All of them were informed of the aim and method of the examination and agreed to it. The blood to be examined was taken every two hours during 24 hours. The determination of hCG was made by means of the radioimmunological method. The statistical analysis was made by means of the Halberg cosinor method. In 14 patients the authors found the existence of the diurnal rhythm (p less than 0.05), in 4 cases the rhythm was circadian (p less than 0.1), in 4 remaining patients no rhythm was found. For the values obtained from 14 patients with a clear diurnal rhythm the authors drew an ellipse of errors by the Halberg method. The ellipse does not cover the centre of the cosinor circle, which confirms the compatibility of the results obtained. The medium value of the amplitude in this group was 20.72% of mesor and acrophase appeared at 16(01).
