Spiral Structure of the Outer Milky Way in Hydrogen Levine, E.S; Blitz, Leo; Heiles, Carl
Science (American Association for the Advancement of Science),
06/2006, Letnik:
312, Številka:
5781
Journal Article
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Odprti dostop
We produce a detailed map of the perturbed surface density of neutral hydrogen in the outer Milky Way disk, demonstrating that the Galaxy is a non-axisymmetric multiarmed spiral. Spiral structure in ...the southern half of the Galaxy can be traced out to at least 25 kiloparsecs, implying a minimum radius for the gas disk. Overdensities in the surface density are coincident with regions of reduced gas thickness. The ratio of the surface density to the local median surface density is relatively constant along an arm. Logarithmic spirals can be fit to the arms with pitch angles of 20° to 25°.
We examine the outer Galactic H I disk for deviations from the b = 0 plane by constructing maps of disk surface density, mean height, and thickness. We find that the Galactic warp is well described ...by a vertical offset plus two Fourier modes of frequency m = 1 and 2, all of which grow with galactocentric radius. Adding the m = 2 mode accounts for the large asymmetry between the northern and southern warps. We use a Morlet wavelet transform to investigate the spatial and frequency localization of higher frequency modes; these modes are often referred to as "scalloping." We find that the m = 10 and 15 scalloping modes are well above the noise, but localized; this suggests that the scalloping does not pervade the whole disk, but only local regions.
We measure the Galactic rotation curve and its first two vertical derivatives in the first and fourth quadrants of the Milky Way using the 21 cm VGPS and SGPS. We find tangent velocities of the ...atomic gas as a function of Galactic longitude and latitude by fitting an analytic line profile to the edges of the velocity profiles. The shape of the analytic profile depends only on the tangent velocity and the velocity dispersion of the gas. We use two complementary methods to analyze the tangent velocities: a global model to fit typical parameter values and a local fitting routine to examine spatial variations. We confirm the validity of our fitting routines by testing simple models. Both the global and local fits are consistent with a vertical falloff in the rotation curve of -image km s super(-1) kpc super(-1) within 100 pc of the Galactic midplane. The magnitude of the falloff is several times larger than what would be expected from the change in the potential alone, indicating some other physical process is important. The falloff we measure is consistent in magnitude with that measured in the halo gas of other galaxies.
Newton and the Big Apple Levine, E S
Science (American Association for the Advancement of Science),
2016-Sep-09, 2016-09-09, 20160909, Letnik:
353, Številka:
6304
Journal Article
We report on the discovery of stellar occultations, observed with Kepler, which recur periodically at 15.685 hr intervals, but which vary in depth from a maximum of 1.3% to a minimum that can be less ...than 0.2%. The star that is apparently being occulted is KIC 12557548, a V = 16 mag K dwarf with T sub(eff, s) Asymptotically = to 4400 K. The out-of-occultation behavior shows no evidence for ellipsoidal light variations, indicating that the mass of the orbiting object is less than ~3 M sub(J) (for an orbital period of 15.7 hr). Because the eclipse depths are highly variable, they cannot be due solely to transits of a single planet with a fixed size. We discuss but dismiss a scenario involving a binary giant planet whose mutual orbit plane precesses, bringing one of the planets into and out of a grazing transit. This scenario seems ruled out by the dynamical instability that would result from such a configuration. We also briefly consider an eclipsing binary, possibly containing an accretion disk, that either orbits KIC 12557548 in a hierarchical triple configuration or is nearby on the sky, but we find such a scenario inadequate to reproduce the observations. The much more likely explanation-but one which still requires more quantitative development-involves macroscopic particles escaping the atmosphere of a slowly disintegrating planet not much larger than Mercury in size. The particles could take the form of micron-sized pyroxene or aluminum oxide dust grains. The planetary surface is hot enough to sublimate and create a high-Z atmosphere; this atmosphere may be loaded with dust via cloud condensation or explosive volcanism. Atmospheric gas escapes the planet via a Parker-type thermal wind, dragging dust grains with it. We infer a mass-loss rate from the observations of order 1 M sub(+ in circle) Gyr super(-1), with a dust-to-gas ratio possibly of order unity. For our fiducial 0.1 M sub(+ in circle) planet (twice the mass of Mercury), the evaporation timescale may be ~0.2 Gyr. Smaller mass planets are disfavored because they evaporate still more quickly, as are larger mass planets because they have surface gravities too strong to sustain outflows with the requisite mass-loss rates. The occultation profile evinces an ingress-egress asymmetry that could reflect a comet-like dust tail trailing the planet; we present simulations of such a tail.
Abstract
STUDY QUESTION
Do naturally occurring, hyperandrogenic (≥1 SD of population mean testosterone, T) female rhesus monkeys exhibit traits typical of women with polycystic ovary syndrome (PCOS)?
...SUMMARY ANSWER
Hyperandrogenic female monkeys exhibited significantly increased serum levels of androstenedione (A4), 17-hydroxyprogesterone (17-OHP), estradiol (E2), LH, antimullerian hormone (AMH), cortisol, 11-deoxycortisol and corticosterone, as well as increased uterine endometrial thickness and evidence of reduced fertility, all traits associated with PCOS.
WHAT IS KNOWN ALREADY
Progress in treating women with PCOS is limited by incomplete knowledge of its pathogenesis and the absence of naturally occurring PCOS in animal models. A female macaque monkey, however, with naturally occurring hyperandrogenism, anovulation and polyfollicular ovaries, accompanied by insulin resistance, increased adiposity and endometrial hyperplasia, suggests naturally occurring origins for PCOS in nonhuman primates.
STUDY DESIGN, SIZE, DURATION
As part of a larger study, circulating serum concentrations of selected pituitary, ovarian and adrenal hormones, together with fasted insulin and glucose levels, were determined in a single, morning blood sample obtained from 120 apparently healthy, ovary-intact, adult female rhesus monkeys (Macaca mulatta) while not pregnant or nursing. The monkeys were then sedated for somatometric and ultrasonographic measurements.
PARTICIPANTS/MATERIALS, SETTING, METHODS
Female monkeys were of prime reproductive age (7.2 ± 0.1 years, mean ± SEM) and represented a typical spectrum of adult body weight (7.4 ± 0.2 kg; maximum 12.5, minimum 4.6 kg). Females were defined as having normal (n = 99) or high T levels (n = 21; ≥1 SD above the overall mean, 0.31 ng/ml). Electronic health records provided menstrual and fecundity histories. Steroid hormones were determined by tandem LC–MS-MS; AMH was measured by enzymeimmunoassay; LH, FSH and insulin were determined by radioimmunoassay; and glucose was read by glucose meter. Most analyses were limited to 80 females (60 normal T, 20 high T) in the follicular phase of a menstrual cycle or anovulatory period (serum progesterone <1 ng/ml).
MAIN RESULTS AND THE ROLE OF CHANCE
Of 80 monkeys, 15% (n = 12) exhibited classifiable PCOS-like phenotypes. High T females demonstrated elevations in serum levels of LH (P < 0.036), AMH (P < 0.021), A4 (P < 0.0001), 17-OHP (P < 0.008), E2 (P < 0.023), glucocorticoids (P < 0.02–0.0001), the serum T/E2 ratio (P < 0.03) and uterine endometrial thickness (P < 0.014) compared to normal T females. Within the high T group alone, anogenital distance, a biomarker for fetal T exposure, positively correlated (P < 0.015) with serum A4 levels, while clitoral volume, a biomarker for prior T exposure, positively correlated (P < 0.002) with postnatal age. Only high T females demonstrated positive correlations between serum LH, and both T and A4. Five of six (83%) high T females with serum T ≥2 SD above T mean (0.41 ng/ml) did not produce live offspring.
LARGE SCALE DATA
N/A.
LIMITATIONS, REASONS FOR CAUTION
This is an initial study of a single laboratory population in a single nonhuman primate species. While two biomarkers suggest lifelong hyperandrogenism, phenotypic expression during gestation, prepuberty, adolescence, mid-to-late reproductive years and postmenopause has yet to be determined.
WIDER IMPLICATIONS OF THE FINDINGS
Characterizing adult female monkeys with naturally occurring hyperandrogenism has identified individuals with high LH and AMH combined with infertility, suggesting developmental linkage among traits with endemic origins beyond humans. PCOS may thus be an ancient phenotype, as previously proposed, with a definable pathogenic mechanism(s).
STUDY FUNDING/COMPETING INTEREST(S)
Funded by competitive supplement to P51 OD011106 (PI: Mallick), by P50 HD028934 (PI: Marshall) and by P50 HD044405 (PI: Dunaif). The authors have no potential conflicts of interest.
Antithrombotic therapy for intracranial arterial stenosis was recently evaluated in the Warfarin versus Aspirin for Symptomatic Intracranial Disease (WASID) trial. A prespecified aim of WASID was to ...identify patients at highest risk for stroke in the territory of the stenotic artery who would be the target group for a subsequent trial comparing intracranial stenting with medical therapy.
WASID was a randomized, double-blinded, multicenter trial involving 569 patients with transient ischemic attack or ischemic stroke due to 50% to 99% stenosis of a major intracranial artery. Median time from qualifying event to randomization was 17 days, and mean follow-up was 1.8 years. Multivariable Cox proportional hazards models were used to identify factors associated with subsequent ischemic stroke in the territory of the stenotic artery. Subsequent ischemic stroke occurred in 106 patients (19.0%); 77 (73%) of these strokes were in the territory of the stenotic artery. Risk of stroke in the territory of the stenotic artery was highest with severe stenosis > or =70% (hazard ratio 2.03; 95% confidence interval 1.29 to 3.22; P=0.0025) and in patients enrolled early (< or =17 days) after the qualifying event (hazard ratio 1.69; 95% confidence interval 1.06 to 2.72; P=0.028). Women were also at increased risk, although this was of borderline significance (hazard ratio 1.59; 95% confidence interval 1.00 to 2.55; P=0.051). Location of stenosis, type of qualifying event, and prior use of antithrombotic medications were not associated with increased risk.
Among patients with symptomatic intracranial stenosis, the risk of subsequent stroke in the territory of the stenotic artery is greatest with stenosis > or =70%, after recent symptoms, and in women.
Despite significant medical advances, infective endocarditis (IE) remains an infection associated with high morbidity and mortality. The objective was to assess the safety and efficacy of high-dose ...daptomycin, defined as ≥ 8 mg/kg/day, in patients with confirmed or suspected staphylococcal and/or enterococcal IE.
This was a multicentre, retrospective observational study (2005-11). Adult patients, not undergoing haemodialysis, with blood cultures positive for staphylococci or enterococci and a definitive or possible diagnosis of IE, who received daptomycin ≥ 8 mg/kg/day (based on total body weight) for ≥ 72 h were included.
Seventy patients met the inclusion criteria and comprised 33 (47.1%) with right-sided IE (RIE), 35 (50%) with left-sided IE (LIE) and 2 with both RIE and LIE. Several patients had concomitant sites of infection, with bone/joint infection being most prevalent (12.9%). Sixty-five patients received daptomycin as salvage therapy. Pathogens were isolated from 64 patients, with methicillin-resistant Staphylococcus aureus as the most common organism (84.4%), followed by vancomycin-resistant Enterococcus faecium (7.8%). The median (IQR) daptomycin dose was 9.8 mg/kg/day (8.2-10.0 mg/kg/day), and was similar in RIE and LIE patients (9.8 and 9.3 mg/kg/day, respectively). A total of 24 (34.3%) received combination therapy. For those patients with pathogens isolated (n = 64), the organism was eradicated in 57 (89.1%) patients. Among 64 clinically evaluable patients, 55 (85.9%) achieved clinical success. No patients required discontinuation of high-dose daptomycin due to creatine phosphokinase elevations.
Patients with both RIE and LIE had successful outcomes with high-dose daptomycin therapy. Additional clinical trials evaluating high daptomycin dosages in patients with IE are warranted.
The WASID trial showed no advantage of warfarin over aspirin for preventing the primary endpoint of ischemic stroke, brain hemorrhage, or vascular death. In analyses of selected subgroups, there was ...no definite benefit from warfarin. Warfarin reduced the risk of the primary endpoint among patients with basilar artery stenosis, but there was no reduction in stroke in the basilar artery territory or benefit for vertebral artery stenosis or posterior circulation disease in general.
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