PurposeThe aim of this paper is reviewing the discipline development course of the history of socialist political economy with Chinese characteristics and recognising the changes of its development ...and its historic mission in the new stage will be beneficial to the construction of socialist political economy with Chinese characteristics from the perspective of doctrinal history.Design/methodology/approachIn this paper from the aspect of discipline formation and development, the history of China’s socialist political economy has experienced two stages: emergence and formation (the first stage) and steady development (the second stage). It has explored new research fields and improved the quality of research levels. However, the role of studying the history of socialist political economy with Chinese characteristics has not been fully played regarding satisfying the needs of constructing socialist political economy with Chinese characteristics.FindingsIn this study when the construction of socialist political economy with Chinese characteristics entered a new era, the study of the history of socialist political economy also entered a new stage, showing new features in terms of research objectives, principles, scale and methods.Originality/valueTherefore, the research on the history of socialist political economy with Chinese characteristics should be highly emphasised, and the focus on serving the construction of socialist political economy with Chinese characteristics should be its historic mission and core task. Also, researchers should pay attention to changing ideas, laying a good foundation, highlighting key points, building platforms and broadening horizons.
Large lattice distortion is an essential feature of high-entropy alloys (HEAs). Herein, the deformation behaviors of three types of as-cast CoCrFeNi-based HEAs, which contained 0, 7.9, and 17.1 wt% ...Mo, were comparatively studied through compressive tests and microstructural observations. The intrinsic lattice distortion increased mainly as a function of the Mo content. By virtue of both the local strain incompatibility inside the coarse columnar grains of the as-cast microstructures and low dislocation mobility in HEAs, domain rotations were induced at low strains. Meanwhile, simple shear occurred between domains and produced a new boundary network in the microstructure. The large lattice distortion of the high-Mo HEA (17.1 wt%) gave rise to intense planar slip bands, on which a large number of dislocations slipped and impinged on strain-induced boundaries. As a result of the high back-stress hardening, the high-Mo HEA exhibited enhanced strain-hardening. At high strains, the stress concentration events increased as the lattice distortion of the HEAs increased; this promoted twin growth in the high-Mo HEA. The high-Mo HEA was highlighted with a high strain-hardening rate over a wide strain range. In this study, high-strength as-cast HEAs were developed based on the utilization of the lattice-distortion effect.
Parthanatos is a form of regulated cell death involved in the pathogenesis of many diseases, particularly neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, Huntington’s ...disease, and amyotrophic lateral sclerosis. Parthanatos is a multistep cell death pathway cascade that involves poly (ADP-ribose) polymerase 1 (PARP-1) overactivation, PAR accumulation, PAR binding to apoptosis-inducing factor (AIF), AIF release from the mitochondria, nuclear translocation of the AIF/macrophage migration inhibitory factor (MIF) complex, and MIF-mediated large-scale DNA fragmentation. All the key players in the parthanatos pathway are pleiotropic proteins with diverse functions. An in-depth understanding of the structure-based activity of the key factors, and the biochemical mechanisms of parthanatos, is crucial for the development of drugs and therapeutic strategies. In this review, we delve into the key players of the parthanatos pathway and reveal the multiple levels of therapeutic opportunities for treating parthanatos-based pathogenesis.
The selection of native greening plants to improve rural greening technology is crucial for enriching methods of building rural plant landscapes. However, there are few studies from the perspective ...of visual preference using quantitative methods. By using eye-tracking technology, this study studies students in the Central South University of Forestry and Technology and villagers in Changkou Village, Fujian Province, employing pictures of plant organs-leaves, flowers, and fruits-as stimulating materials to analyze five indicators: the total duration of fixations, the number of fixations, average duration of fixations, average pupil size and average amplitude of saccades. A number of findings came from this research First, people visually prefer leaves, followed by flowers and fruits. In terms of species, Photinia × fraseri, Metasequoia glyptostroboides, Photinia serratifolia, Cunninghamia lanceolata and Koelreuteria bipinnata have higher overall preference. Families such as Malvaceae, Fabaceae, Araliaceae, Myricaceae and Cupressaceae have stronger visual attraction than others. Second, there are distinct differences in the preference of shapes and textures of leaves: aciculiform, strip, cordiform, sector and jacket-shape are more attractive; leather-like leaves have a higher visual preference than paper-like leaves; different colors and whether leaves are cracked or not have little effect on leaf observation. Third, the preference for flowers with different inflorescence and colors is significant. Capitulum, cymes and panicles are more attractive; purple is the most preferred color, followed by white, yellow and red. Finally, there are significant differences in preferences for fruit characteristics, with medium-sized fruits and black fruits preferred, while kidney-shaped and spoon-shaped fruits are considered more attractive. Pomes, pods, samaras, and berries have received relatively more attention.
Phase-separated condensates participate in various biological activities. Liquid-liquid phase separation (LLPS) can be driven by collective interactions between multivalent and intrinsically ...disordered proteins. The manner in which chromatin-with various morphologies and activities-is organized in a complex and small nucleus still remains to be fully determined. Recent findings support the claim that phase separation is involved in the regulation of chromatin organization and chromosome behavior. Moreover, phase separation also influences key events during mitosis and meiosis. This review elaborately dissects how phase separation regulates chromatin and chromosome organization and controls mitotic and meiotic chromosome behavior.
Plants play a very important role in landscape construction. In order to explore whether different living environment will affect people's preference for the structural features of plant organs, this ...study examined 26 villagers and 33 college students as the participants, and pictures of leaves, flowers and fruits of plants as the stimulus to conduct eye-tracking and EEG detection experiments. We found that eye movement indicators can explain people's visual preferences, but they are unable to find differences in preferences between groups. EEG indicators can make up for this deficiency, which further reveals the difference in psychological and physiological responses between the two groups when viewing stimuli. The final results show that the villagers and the students liked leaves best, preferring aciculiform and leathery leaves; solitary, purple and capitulum flowers; and medium-sized, spathulate, black and pear fruits. In addition, it was found that the overall attention of the villagers when watching stimuli was far lower than that of the students, but the degree of meditation was higher. With regard to eye movement and EEG, the total duration of fixations is highly positively correlated with the number of fixations, and the average pupil size has a weak negative correlation with attention. On the contrary, the average duration of fixations has a weak positive correlation with meditation. Generally speaking, we believe that Photinia×fraseri, Metasequoia glyptostroboides, Photinia serratifolia, Koelreuteria bipinnata and Cunninghamia lanceolata are superior landscape building plants in rural areas and on campuses; Pinus thunbergii, Myrica rubra, Camellia japonica and other plants with obvious features and bright colours are also the first choice in rural landscapes; and Yulania biondii, Cercis chinensis, Hibiscus mutabilis and other plants with simple structures are the first choice in campus landscapes. This study is of great significance for selecting plants for landscape construction and management according to different environments and local conditions.
We systematically studied the effect of annealing on damping capacity of pre-deformed magnesium alloy and demonstrated the close relationship between damping capacity and twin boundary mobility. The ...damping capacity of pre-compressed AZ31 alloy can be improved by annealing for short period as a result of increased twin boundary mobility. In contrast, the damping capacity will be deteriorated after prolonged annealing in pre-compressed AZ91 alloy, which is ascribed to the stabilization of twin boundary by significant segregation and precipitation. In addition, we firstly succeeded to distinguish the damping capacity contributed by TB motion from that by dislocation motion in Mg alloys. This study provides the strategy to enhance damping capacity by improving twin boundary mobility after appropriate annealing, the time of which depends on the alloying element concentration.
•MSWI fly ash and EMR were successfully co-disposed based on geopolymeric system.•Alkaline products of MSWI together with NaOH activated geopolymeric system.•The S/S mechanism includes alkaline ...surroundings and geopolymeric encapsulation.•The S/S effects for heavy metals show the following order: Pb > Cu > Cr > Zn > Mn.
MSWI fly ash (MSWI FA) and electrolytic manganese residue (EMR) were successfully co-disposed by use of a geopolymeric system. Alkaline products of MSWI FA and NaOH were used to elicit chemical reactions to promote solidification. The best performing formulation of EMR-based geopolymer for immobilization of heavy metals was composed of 75 wt% MSWI FA and 25 wt% EMR with NaOH solution (7.5 M)/solid of 0.5. Solidification was most effective for the heavy metals: Pb > Cu > Cr > Zn > Mn, respectively. The EMR-based geopolymer had high structural stability likely due to the high ratio of SiO2/Al2O3. The Solidification/Stabilization (S/S) mechanism for heavy metals of geopolymers is likely due to alkaline conditions and geopolymeric encapsulation, highlighting the utility and feasibility of this approach.
Upper limb tremor is a prominent symptom of both Parkinson's disease and essential tremor. Its kinematic parameters overlap substantially for these two pathological conditions, thus leading to high ...rate of misdiagnosis, especially for community doctors. Several groups have proposed various methods for improving differential diagnosis. These prior studies have attempted to identify better kinematic parameters, however they have mainly focused on single limb features including tremor intensity, tremor frequency, and tremor variability. In this paper, we propose a wearable system for multi-segment assessment of upper limb tremor and differential diagnosis of Parkinson's disease versus essential tremor. The proposed system collected tremor data from both wrist and fingers simultaneously. From this data, we extracted multi-segment features in the form of phase relationships between limb segments. Using support vector machine classifiers, we then performed differential diagnosis from the extracted features. We evaluated the performance of the proposed system on 19 Parkinson's disease patients and 12 essential tremor patients. Moreover, we also assessed the performance cost associated with reducing task load and sensor array size. The proposed system reached perfect accuracy in leave-one-out cross validation. Task reduction and sensor array reduction were associated with penalties of 2% and 9-10% respectively. The results demonstrated that the proposed system could be simplified for clinical applications, and successfully applied to the differential diagnosis of Parkinson's disease versus essential tremor in real-world setting.
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