We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese individuals and performed further transancestry meta-analyses with data from the Psychiatry Genomics Consortium ...(PGC2). Approximately 95% of the genome-wide significant (GWS) index alleles (or their proxies) from the PGC2 study were overrepresented in Chinese schizophrenia cases, including ∼50% that achieved nominal significance and ∼75% that continued to be GWS in the transancestry analysis. The Chinese-only analysis identified seven GWS loci; three of these also were GWS in the transancestry analyses, which identified 109 GWS loci, thus yielding a total of 113 GWS loci (30 novel) in at least one of these analyses. We observed improvements in the fine-mapping resolution at many susceptibility loci. Our results provide several lines of evidence supporting candidate genes at many loci and highlight some pathways for further research. Together, our findings provide novel insight into the genetic architecture and biological etiology of schizophrenia.
A 56‐day feeding trial was carried out to investigate the effect of dietary glutamate (Glu) supplementation on growth performance, digestive enzyme activities and intestinal antioxidant capacity of ...grass carp (Ctenopharyngodon idella). A total of 540 grass carp with average initial weight of 370 ± 3.8 g were fed three diets supplemented with 0, 8 and 16 g kg⁻¹ Glu. The per cent weight gain, specific growth rate, feed conversion ratio, and protein and lipid productive value were significantly improved by dietary Glu supplementation. Feed intake, condition factor, visceral somatic index and perivisceral fat ratio were not significantly different between dietary groups. Hepatosomatic index, intestinal somatic index, intestine length index, intestine protein content, trypsin activity in hepatopancreas and intestine, lipase activity in proximal and mid‐intestine (MI) and hepatopancreas, alkaline phosphatase and gamma‐glutamyl transpeptidase activities in intestine, creatine kinase activities in the mid‐ and distal intestine, intestinal folds height in the proximal and MI were significantly increased with increased Glu. Malondialdehyde and protein carbonyl contents in the intestine decreased with increased Glu. Superoxide anion and hydroxyl radical scavenging ability, glutathione reducase, catalase and total superoxide dismutase activities, and glutathione content in the intestine were increased with increased Glu. These results suggested that dietary Glu supplementation increased intestinal antioxidant capacity, digestive and absorptive ability and improved fish growth.
Graphene nanosheets (GNs) were synthesized and used as a substitute for platinum as counter-electrode materials for dye-sensitized solar cells (DSSCs). The as-synthesized GNs were dispersed in a ...mixture of terpineol and ethyl cellulose. GN films were screen-printed on fluorine-doped tin oxide (FTO) slides using the formed GN dispersions. GN counter-electrodes were produced by annealing the GN films at different temperatures. The annealed GN films revealed an unusual 3D network structure. Structural and electrochemical properties of the formed GN counter-electrodes were examined by field emission scanning electron microscopy, Raman spectroscopy and electrochemical impedance spectroscopy. It was found that the annealing temperature of GN materials played an important role in the quality of the GN counter-electrode and the photovoltaic performance of the resultant DSSC. The grown DSSCs with graphene-based counter-electrodes exhibited a conversion efficiency high up to 6.81%.
Superconductivity arises from two distinct quantum phenomena: electron pairing and long-range phase coherence. In conventional superconductors, the two quantum phenomena generally take place ...simultaneously, while in the underdoped high- Tc cuprate superconductors, the electron pairing occurs at higher temperature than the long-range phase coherence. Recently, whether electron pairing is also prior to long-range phase coherence in single-layer FeSe film on SrTiO3 substrate is under debate. Here, by measuring Knight shift and nuclear spin-lattice relaxation rate, we unambiguously reveal a pseudogap behavior below Tp∼60 K in two kinds of layered FeSe-based superconductors with quasi2D nature. In the pseudogap regime, a weak diamagnetic signal and a remarkable Nernst effect are also observed, which indicates that the observed pseudogap behavior is related to superconducting fluctuations. These works confirm that strong phase fluctuation is an important character in the 2D iron-based superconductors as widely observed in high-Tc cuprate superconductors.
A homo-dinuclear Cu(II) complex Cu
2
(L)
2
with the stoichiometric ratio of Cu(II) : (L)
2–
= 2 : 2 was synthesized by the reaction of the ligand ...(4-methyl-6-aldehyde-6′-methoxy-2,2′-ethylenediyldioxybis(nitrilomethylidyne)diphenol) with Cu(OAc)
2
·H
2
O in the mixed CH
2
Cl
2
–MeOMe–EtOH solution (an unexpected ligand is the intermediate of condensation reaction of starting ligand with acetone). The Cu(II) complex was characterized by elemental analysis, IR, UV-Vis and X-ray crystallography. The Cu(II) complex crystallizes in monoclinic space group
P
2
1
/
n
and consists of two Cu(II) atoms and two completely deprotonated ligand (L)
2–
units. Through the analysis of intermolecular interactions, the Cu(II) complex units can form a 2D supramolecular structure through intermolecular hydrogen bonds and C–H···π interactions, respectively, meanwhile, the molecular interactions were quantitatively studied by Hirshfeld surfaces analyses. The fluorescence properties and DFT calculations were performed.
Based upon eight field surveys conducted between May 2011 and May 2012, we investigated seasonal variations in pH, carbonate saturation state of aragonite (Ωarag), and ancillary data on the Chinese ...side of the North Yellow Sea, a western North Pacific continental margin of major economic importance. Subsurface waters were CO2-undersaturated in May and nearly in equilibrium with atmospheric CO2 in June. From July to October, the fugacity of CO2 (fCO2) of bottom water gradually increased from 438 ± 44 μatm to 630 ± 84 μatm, and pHT decreased from 8.02 ± 0.04 to 7.88 ± 0.06 due to local aerobic remineralization of primary-production-induced biogenic particles. The subsurface community respiration rates in summer and autumn were estimated to be from 0.80 to 1.08 μmol-O2 kg−1 d−1 within a relatively high salinity range of 31.63 to 32.25. From November to May in the next year, however, subsurface fCO2 gradually decreased and pH increased due to cooling and water column ventilation. The corresponding bottom water Ωarag was 1.85 ± 0.21 (May), 1.79 ± 0.24 (June), 1.75 ± 0.27 (July), 1.76 ± 0.29 (August), 1.45 ± 0.31 (October), 1.52 ± 0.25 (November), and 1.41 ± 0.12 (January). Extremely low Ωarag values (from 1.13 to 1.40) were observed mainly in subsurface waters within the high salinity range of 31.63 to 32.25, which covered a major fraction of the study area in October and November. Of the China seas, the North Yellow Sea represents one of the systems most vulnerable to the potential negative effects of ocean acidification.
Abstract
As a novel X-ray focusing technology, lobster-eye micropore optics (MPO) feature both a wide observing field of view and true imaging capability, promising sky monitoring with significantly ...improved sensitivity and spatial resolution in soft X-rays. Since first proposed by Angel, the optics have been extensively studied, developed and trialed over the past decades. In this Letter, we report on the first-light results from a flight experiment of the Lobster Eye Imager for Astronomy, a pathfinder of the wide-field X-ray telescope of the Einstein Probe mission. The piggyback imager, launched in 2022 July, has a mostly unvignetted field of view of 18.°6 × 18.°6. Its spatial resolution is in the range of 4′–7′ in FWHM and the focal spot effective area is 2–3 cm
2
, both showing only mild fluctuations across the field of view. We present images of the Galactic center region, Sco X-1, and the diffuse Cygnus Loop nebular taken in snapshot observations over 0.5–4 keV. These are truly wide-field X-ray images of celestial bodies observed, for the first time, by a focusing imaging telescope. Initial analyses of the in-flight data show excellent agreement between the observed images and the on-ground calibration and simulations. The instrument and its characterization are briefly described, as well as the flight experiment. The results provide a solid basis for the development of the present and proposed wide-field X-ray missions using lobster-eye MPO.
A Nationwide Nitrogen Deposition Monitoring Network (NNDMN) containing 43 monitoring sites was established in China to measure gaseous NH3, NO2, and HNO3 and particulate NH4+ and NO3− in air and/or ...precipitation from 2010 to 2014. Wet/bulk deposition fluxes of Nr species were collected by precipitation gauge method and measured by continuous-flow analyzer; dry deposition fluxes were estimated using airborne concentration measurements and inferential models. Our observations reveal large spatial variations of atmospheric Nr concentrations and dry and wet/bulk Nr deposition. On a national basis, the annual average concentrations (1.3–47.0 μg N m−3) and dry plus wet/bulk deposition fluxes (2.9–83.3 kg N ha−1 yr−1) of inorganic Nr species are ranked by land use as urban > rural > background sites and by regions as north China > southeast China > southwest China > northeast China > northwest China > Tibetan Plateau, reflecting the impact of anthropogenic Nr emission. Average dry and wet/bulk N deposition fluxes were 20.6 ± 11.2 (mean ± standard deviation) and 19.3 ± 9.2 kg N ha−1 yr−1 across China, with reduced N deposition dominating both dry and wet/bulk deposition. Our results suggest atmospheric dry N deposition is equally important to wet/bulk N deposition at the national scale. Therefore, both deposition forms should be included when considering the impacts of N deposition on environment and ecosystem health.
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