Teaching has long been considered as one of the most challenging professions worldwide due to the involvement of numerous linguistic, socio-political, social, and psych-emotional factors. Because of ...these factors, english as a foreign language (EFL) teachers are psychologically, emotionally, and physically pressed in their job. These damaging pressures often result in negative academic outcomes for teachers, students, and educational systems. Despite dire consequences, few studies (if any) have examined the role of psycho-emotional factors in improving teaching performance and reducing negative emotions at the workplace. To fill this gap, this mini-review article aimed to present a theoretical analysis of three constructs of occupational adjustment, psychological hardiness, and burnout. In so doing, the definitions, conceptualizations, dimensions, and empirical studies related to each variable were presented. The study ends with the existing research gaps and offers some implications for EFL teachers and other stakeholders by increasing their knowledge of emotions in occupational environments and the consequences that such emotions can have for an organization.
A new type of quantum interferometer was recently realized that employs parametric amplifiers (PAs) as the wave splitting and mixing elements. The quantum behavior stems from the PAs, which produce ...quantum entangled fields for probing the phase change signal in the interferometer. This type of quantum entangled interferometer exhibits some unique properties that are different from traditional beam splitter-based interferometers such as Mach–Zehnder interferometers. Because of these properties, it is superior to the traditional interferometers in many aspects, especially in the phase measurement sensitivity. We will review its unique properties and applications in quantum metrology and sensing, quantum information, and quantum state engineering.
Throughout the evolution of the global teaching model, from the traditional face-to-face teaching to the later Web 2.0, the integration of Weibo, blogs, and other media enriched the teaching model. ...However, with the emergence of Web 3.0, the mobile Internet makes music teaching further upgraded and become more intelligent, personalized, and adaptive, which provides more powerful technical support for the majority of music educators in the actual teaching process. This paper discusses the application of short video recommendation technology in classical music teaching and establishes a personalized short video recommendation method, which can realize the personalized and targeted push of classical music. The results show that the recommendation technology established in this paper has better superiority than the traditional method. Combined with the short video recommendation technology established in this paper, the hot word retrieval, push platform, audience age, and education effect of short video recommendation technology are studied. The research results show that the short video recommendation technology established in this paper can analyze the hot word retrieval volume of each platform, the main push platform, and the age of the audience. Based on this, further analysis is carried out, and the educational effect of classical music combined with short video recommendation technology is obtained. The research results have promoted the way of classical music education.
•Increased precipitation decreased the variation amplitude and mean soil temperatures.•Strong precipitation events resulted in rising of soil temperatures by 0.3–0.5 °C.•Intrapermafrost water ...conserved for warm permafrost with saline soils.•Higher water content reduced the variation amplitude of soil temperatures.
Permafrost is mostly warm and thermally unstable on the Tibetan Plateau (TP), particularly in some marginal areas, thereby being susceptible to degrade or even disappear under climate warming. The degradation of permafrost consequently leads to changes in hydrological cycles associated with seasonal freeze-thaw processes. In this study, we investigated seasonal hydrothermal processes of near-surface permafrost layers and their responses to rain events at two warm permafrost sites in the Headwater Area of the Yellow River, northeastern TP. Results demonstrated that water content in shallow active layers changed with infiltration of rainwater, whereas kept stable in the perennially frozen layer, which serves as an aquitard due to low hydraulic conductivity or even imperviousness. Accordingly, the supra-permafrost water acts as a seasonal aquifer in the thawing period and as a seasonal aquitard in the freezing period. Seasonal freeze-thaw processes in association with rain events correlate well with the recharge and discharge of the supra-permafrost water. Super-heavy precipitation (44 mm occurred on 2 July 2015) caused a sharp increase in soil water content and dramatic rises in soil temperatures by 0.3–0.5 °C at shallow depths and advancement thawing of the active layer by half a month. However, more summer precipitation amount tends to reduce the seasonal amplitude of soil temperatures, decrease mean annual soil temperatures and thawing indices and thin active layers. High salinity results in the long remaining of a large amount of unfrozen water around the bottom of the active layer. We conclude that extremely warm permafrost with TZAA (the temperature at the depth of zero annual amplitude) >−0.5 °C is likely percolated under heavy and super-heavy precipitation events, while hydrothermal processes around the permafrost table likely present three stages concerning TZAA of <−0.5 °C, −0.5–0 °C, and >0 °C.
There is strong evidence to support that mutations and dysregulation of miRNAs are associated with a variety of diseases, including cancer. However, the experimental methods used to identify ...disease-related miRNAs are expensive and time-consuming. Effective computational approaches to identify disease-related miRNAs are in high demand and would aid in the detection of lncRNA biomarkers for disease diagnosis, treatment, and prevention. In this study, we develop an ensemble learning framework to reveal the potential associations between miRNAs and diseases (ELMDA). The ELMDA framework does not rely on the known associations when calculating miRNA and disease similarities and uses multi-classifiers voting to predict disease-related miRNAs. As a result, the average AUC of the ELMDA framework was 0.9229 for the HMDD v2.0 database in a fivefold cross-validation. All potential associations in the HMDD V2.0 database were predicted, and 90% of the top 50 results were verified with the updated HMDD V3.2 database. The ELMDA framework was implemented to investigate gastric neoplasms, prostate neoplasms and colon neoplasms, and 100%, 94%, and 90%, respectively, of the top 50 potential miRNAs were validated by the HMDD V3.2 database. Moreover, the ELMDA framework can predict isolated disease-related miRNAs. In conclusion, ELMDA appears to be a reliable method to uncover disease-associated miRNAs.
Poly (ADP‐ribose) polymerase (PARP) inhibitors have provided great clinical benefits to ovarian cancer patients. To date, three PARP inhibitors, namely, olaparib, rucaparib and niraparib have been ...approved for the treatment of ovarian cancer in the United States. Homologous recombination deficiency (HRD) and platinum sensitivity are prospective biomarkers for predicting the response to PARP inhibitors in ovarian cancers. Preclinical data have focused on identifying the gene aberrations that might generate HRD and induce sensitivity to PARP inhibitors in vitro in cancer cell lines or in vivo in patient‐derived xenografts. Clinical trials have focused on genomic scar analysis to identify biomarkers for predicting the response to PARP inhibitors. Additionally, researchers have aimed to investigate mechanisms of resistance to PARP inhibitors and strategies to overcome this resistance. Combining PARP inhibitors with HR pathway inhibitors to extend the utility of PARP inhibitors to BRCA‐proficient tumours is increasingly foreseeable. Identifying the population of patients with the greatest potential benefit from PARP inhibitor therapy and the circumstances under which patients are no longer suited for PARP inhibitor therapy are important. Further studies are required in order to propose better strategies for overcoming resistance to PARP inhibitor therapy in ovarian cancers.
Increasing the information capacity per unit bandwidth has been a perennial goal of scientists and engineers. Multiplexing of independent degrees of freedom, such as wavelength, polarization and more ...recently space, has been a preferred method to increase capacity in both radiofrequency and optical communication. Orbital angular momentum, a physical property of electromagnetic waves discovered recently, has been proposed as a new degree of freedom for multiplexing to achieve capacity beyond conventional multiplexing techniques, and has generated widespread and significant interest in the scientific community. However, the capacity of orbital angular momentum multiplexing has not been established or compared to other multiplexing techniques. Here, we show that orbital angular momentum multiplexing is not an optimal technique for realizing the capacity limits of a free-space communication channel and is outperformed by both conventional line-of-sight multi-input multi-output transmission and spatial-mode multiplexing.
Long noncoding RNAs (lncRNAs) are emerging as crucial contributors to the development of breast cancer and are involved in the stemness regulation of breast cancer stem cells (BCSCs). LncRNAs are ...closely associated with the prognosis of breast cancer patients. It is critical to identify BCSC-related lncRNAs with prognostic value in breast cancer.
A co-expression network of BCSC-related mRNAs-lncRNAs from The Cancer Genome Atlas (TCGA) was constructed. Univariate and multivariate Cox proportional hazards analyses were used to identify a stemness risk model with prognostic value. Kaplan-Meier analysis, univariate and multivariate Cox regression analyses and receiver operating characteristic (ROC) curve analysis were performed to validate the risk model. Principal component analysis (PCA) and Gene Set Enrichment Analysis (GSEA) functional annotation were conducted to analyze the risk model.
In this study, BCSC-related lncRNAs in breast cancer were identified. We evaluated the prognostic value of these BCSC-related lncRNAs and eventually obtained a prognostic risk model consisting of 12 BCSC-related lncRNAs (Z68871.1, LINC00578, AC097639.1, AP003119.3, AP001207.3, LINC00668, AL122010.1, AC245297.3, LINC01871, AP000851.2, AC022509.2 and SEMA3B-AS1). The risk model was further verified as a novel independent prognostic factor for breast cancer patients based on the calculated risk score. Moreover, based on the risk model, the low- risk and high-risk groups displayed different stemness statuses.
These findings suggested that the 12 BCSC-related lncRNA signature might be a promising prognostic factor for breast cancer and can promote the management of BCSC-related therapy in clinical practice.
Dysregulated expression of microRNAs (miRNAs) in various tissues has been associated with a variety of diseases, including cancers. Here we demonstrate that miRNAs are present in the serum and plasma ...of humans and other animals such as mice, rats, bovine fetuses, calves, and horses. The levels of miRNAs in serum are stable, reproducible, and consistent among individuals of the same species. Employing Solexa, we sequenced all serum miRNAs of healthy Chinese subjects and found over 100 and 91 serum miRNAs in male and female subjects, respectively. We also identified specific expression patterns of serum miRNAs for lung cancer, colorectal cancer, and diabetes, providing evidence that serum miRNAs contain fingerprints for various diseases. Two non-small cell lung cancer-specific serum miRNAs obtained by Solexa were further validated in an independent trial of 75 healthy donors and 152 cancer patients, using quantitative reverse transcription polymerase chain reaction assays. Through these analyses, we conclude that serum miRNAs can serve as potential biomarkers for the detection of various cancers and other diseases.
Summary
The prevalence of diabetes in China has increased rapidly from 0.67% in 1980 to 10.4% in 2013, with the aging of the population and westernization of lifestyle. Since its foundation in 1991, ...the Chinese Diabetes Society (CDS) has been dedicated to improving academic exchange and the academic level of diabetes research in China. From 2003 to 2014, four versions of Chinese diabetes care guidelines have been published. The guidelines have played an important role in standardizing clinical practice and improving the status quo of diabetes prevention and control in China. Since September 2016, the CDS has invited experts in cardiovascular diseases, psychiatric diseases, nutrition, and traditional Chinese medicine to work with endocrinologists from the CDS to review the new clinical research evidence related to diabetes over the previous 4 years. Over a year of careful revision, this has resulted in the present, new version of guidelines for prevention and care of type 2 diabetes in China. The main contents include epidemiology of type 2 diabetes in China; diagnosis and classification of diabetes; primary, secondary, and tertiary diabetes prevention; diabetes education and management support; blood glucose monitoring; integrated control targets for type 2 diabetes and treatments for hyperglycaemia; medical nutrition therapy; exercise therapy for type 2 diabetes; smoking cessation; pharmacologic therapy for hyperglycaemia; metabolic surgery for type 2 diabetes; prevention and treatment of cardiovascular and cerebrovascular diseases in patients with type 2 diabetes; hypoglycaemia; chronic diabetic complications; special types of diabetes; metabolic syndrome; and diabetes and traditional Chinese medicine.
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