Double neutron star (DNS) merger events are promising candidates of short gamma-ray burst (sGRB) progenitors as well as high-frequency gravitational wave (GW) emitters. On August 17, 2017, such a ...coinciding event was detected by both the LIGO-Virgo gravitational wave detector network as GW170817 and Gamma-Ray Monitor on board NASA's Fermi Space Telescope as GRB 170817A. Here, we show that the fluence and spectral peak energy of this sGRB fall into the lower portion of the distributions of known sGRBs. Its peak isotropic luminosity is abnormally low. The estimated event rate density above this luminosity is at least Formula: see text Gpc
yr
, which is close to but still below the DNS merger event rate density. This event likely originates from a structured jet viewed from a large viewing angle. There are similar faint soft GRBs in the Fermi archival data, a small fraction of which might belong to this new population of nearby, low-luminosity sGRBs.
Aberrant p62 overexpression has been implicated in breast cancer development. Here, we found that p62 expression was elevated in breast cancer stem cells (BCSCs), including CD44
CD24
fractions, ...mammospheres, ALDH1
populations and side population cells. Indeed, short-hairpin RNA (shRNA)-mediated knockdown of p62 impaired breast cancer cells from self-renewing under anchorage-independent conditions, whereas ectopic overexpression of p62 enhanced the self-renewal ability of breast cancer cells in vitro. Genetic depletion of p62 robustly inhibited tumor-initiating frequencies, as well as growth rates of BCSC-derived tumor xenografts in immunodeficient mice. Consistently, immunohistochemical analysis of clinical breast tumor tissues showed that high p62 expression levels were linked to poorer clinical outcome. Further gene expression profiling analysis revealed that p62 was positively correlated with MYC expression level, which mediated the function of p62 in promoting breast cancer stem-like properties. MYC mRNA level was reduced upon p62 deletion by siRNA and increased with p62 overexpression in breast cancer cells, suggesting that p62 positively regulated MYC mRNA. Interestingly, p62 did not transactivate MYC promoter. Instead, p62 delayed the degradation of MYC mRNA by repressing the expression of let-7a and let-7b, thus promoting MYC mRNA stabilization at the post-transcriptional level. Consistently, let-7a and let-7b mimics attenuated p62-mediated MYC mRNA stabilization. Together, these findings unveiled a previously unappreciated role of p62 in the regulation of BCSCs, assigning p62 as a promising therapeutic target for breast cancer treatments.
Coupled magmatic and tectonic activity plays an important role in high-temperature hydrothermal circulation at mid-ocean ridges. The circulation patterns for such systems have been elucidated by ...microearthquakes and geochemical data over a broad spectrum of spreading rates, but such data have not been generally available for ultra-slow spreading ridges. Here we report new geophysical and fluid geochemical data for high-temperature active hydrothermal venting at Dragon Horn area (49.7°E) on the Southwest Indian Ridge. Twin detachment faults penetrating to the depth of 13 ± 2 km below the seafloor were identified based on the microearthquakes. The geochemical composition of the hydrothermal fluids suggests a long reaction path involving both mafic and ultramafic lithologies. Combined with numerical simulations, our results demonstrate that these hydrothermal fluids could circulate ~ 6 km deeper than the Moho boundary and to much greater depths than those at Trans-Atlantic Geotraverse and Logachev-1 hydrothermal fields on the Mid-Atlantic Ridge.
The origin of the shallow decay segment in Swift XRT light curves remains a puzzle. We analyze the properties of this segment with a sample of 53 long Swift GRBs detected before 2007 February. We ...show that the distributions of the sample's characteristics are lognormal or normal, and its isotropic X-ray energy ( unk) is linearly correlated with the prompt gamma-ray energy but with a steeper photon spectrum, aside from some X-ray flashes. No significant spectral evolution is observed from this phase to the following phase, and the latter is usually consistent with external-shock models, implying that the shallow decay is also of external-shock origin, likely a refreshed external shock. Within the refreshed-shock model, the data are generally consistent with a roughly constant injection luminosity up to the end of this phase, tb. A positive correlation between unk and tb also favors this scenario. Among the 13 bursts that have well-sampled optical light curves, six have an optical break around tb and the breaks are consistent with being achromatic. However, the other seven either do not show an optical break or have a break at an epoch different from tb. This raises a concern for the energy injection scenario, suggesting that the optical and X-ray emission may not be the same component, at least for some bursts. There are four significant outliers in the sample, GRBs 060413, 060522, 060607A, and 070110. The shallow decay phase in these bursts is immediately followed by a very steep decay after tb, which is inconsistent with any external-shock model. The optical data for these bursts evolve independently from the X-ray data. These X-ray plateaus likely have an internal origin and demand continuous operation of a long-term central engine. We conclude that the observed shallow decay phase likely has diverse physical origins.
Fast radio bursts (FRBs) are millisecond-duration radio transients of unknown physical origin observed at extragalactic distances
. It has long been speculated that magnetars are the engine powering ...repeating bursts from FRB sources
, but no convincing evidence has been collected so far
. Recently, the Galactic magnetar SRG 1935+2154 entered an active phase by emitting intense soft γ-ray bursts
. One FRB-like event with two peaks (FRB 200428) and a luminosity slightly lower than the faintest extragalactic FRBs was detected from the source, in association with a soft γ-ray/hard-X-ray flare
. Here we report an eight-hour targeted radio observational campaign comprising four sessions and assisted by multi-wavelength (optical and hard-X-ray) data. During the third session, 29 soft-γ-ray repeater (SGR) bursts were detected in γ-ray energies. Throughout the observing period, we detected no single dispersed pulsed emission coincident with the arrivals of SGR bursts, but unfortunately we were not observing when the FRB was detected. The non-detection places a fluence upper limit that is eight orders of magnitude lower than the fluence of FRB 200428. Our results suggest that FRB-SGR burst associations are rare. FRBs may be highly relativistic and geometrically beamed, or FRB-like events associated with SGR bursts may have narrow spectra and characteristic frequencies outside the observed band. It is also possible that the physical conditions required to achieve coherent radiation in SGR bursts are difficult to satisfy, and that only under extreme conditions could an FRB be associated with an SGR burst.
We present a systematic temporal and spectral study of all Swift-X-ray Telescope observations of gamma-ray burst (GRB) afterglows discovered between 2005 January and 2007 December. After constructing ...and fitting all light curves and spectra to power-law models, we classify the components of each afterglow in terms of the canonical X-ray afterglow and test them against the closure relations of the forward shock models for a variety of parameter combinations. The closure relations are used to identify potential jet breaks with characteristics including the uniform jet model with and without lateral spreading and energy injection, and a power-law structured jet model, all with a range of parameters. With this technique, we survey the X-ray afterglows with strong evidence for jet breaks (~12% of our sample), and reveal cases of potential jet breaks that do not appear plainly from the light curve alone (another ~30%), leading to insight into the missing jet break problem. Those X-ray light curves that do not show breaks or have breaks that are not consistent with one of the jet models are explored to place limits on the times of unseen jet breaks. The distribution of jet break times ranges from a few hours to a few weeks with a median of ~1 day, similar to what was found pre-Swift. On average, Swift GRBs have lower isotropic equivalent gamma -ray energies, which in turn result in lower collimation corrected gamma -ray energies than those of pre-Swift GRBs. Finally, we explore the implications for GRB jet geometry and energetics.
To determine the usefulness of new two-dimensional strain indices, based on speckle tracking imaging, for assessment of systemic right ventricular (RV) function after an atrial switch operation for ...transposition of the great arteries.
Cross-sectional study.
Tertiary paediatric cardiac centre.
26 patients, mean (SD) age 21.0 (3.6) years at 19.9 (3.2) years after an atrial switch operation, and 27 age-matched controls were studied. Two-dimensional imaging at the four-chamber view was obtained with tracing of the entire RV endocardial border. The RV global longitudinal strain (GLS) and GLS rate were derived using automated software (EchoPAC, GE Medical) and correlated with tissue Doppler-derived RV isovolumic acceleration (IVA), and, in the patient cohort, with cardiac magnetic resonance-derived RV ejection fraction.
Intra- and interobserver variability for measurement of GLS, as determined from the mean (SD) of differences in two consecutive results from 20 studies, were 0.06 (1.39)% and 0.24 (1.77)%, respectively. Compared with controls, patients had lower RV GLS (17.1 (1.9)% vs 26.3 (2.9)%, p<0.001), a reduced GLS rate (0.78 (0.11)/s vs 1.33 (0.23)/s, p<0.001), lower RV IVA (1.10 (0.36) m/s(2) vs 1.56 (0.53) m/s(2), p<0.001) and increased RV myocardial performance index (0.52 (0.09) vs 0.38 (0.09), p<0.001). Both RV GLS and GLS rate correlated positively with RV IVA (r = 0.43, p = 0.001 and r = 0.46, p<0.001, respectively), and negatively with RV myocardial performance index (r = -0.65, p<0.001 and r = -0.57, p<0.001, respectively). In patients, the GLS rate correlated positively with RV ejection fraction (r = 0.62, p = 0.001).
Two-dimensional RV GLS and GLS rate are new, potentially useful indices for assessment of systemic RV function.
Aims. A model of jet precession driven by a neutrino-cooled disk around a spinning black hole is presented to explain the temporal structure and spectral evolution of gamma-ray bursts (GRBs). ...Methods. The differential rotation of the outer part of a neutrino-dominated accretion disk may result in precession of the inner part of the disk and the central black hole, hence driving a precessed jet via neutrino annihilation around the inner part of the disk. Results. Both analytic and numeric results for our model are presented. Our calculations show that a black-hole, accretion-disk system with the black hole mass M $\simeq$ 3.66 $M_\odot$, accretion rate $\dot{M}$ $\simeq$ 0.54 $M_\odot$ s-1, spin parameter a = 0.9, and viscosity parameter α = 0.01 may drive a precessed jet with period P = 1 s and luminosity L = 1051 erg s-1, corresponding to the scenario for long GRBs. A precessed jet with P = 0.1 s and L = 1050 erg s-1 may be powered by a system with M $\simeq$ 5.59 $M_\odot$, $\dot{M}$ $\simeq$ 0.74 $M_\odot$ $s^{-1}$, a = 0.1, and α = 0.01, and is possibly responsible for the short GRBs. Both the temporal and spectral evolution in GRB pulse may be explained with our model. Conclusions. GRB central engines most likely power a precessed jet driven by a neutrino-cooled disk. The global GRB lightcurves thus could be modulated by the jet precession during the accretion timescale of the GRB central engine. Both the temporal and spectral evolution in GRB pulse may stem from a viewing effect of the jet precession.
An early steep decay component following the prompt GRBs is commonly observed in Swift XRT light curves, which is regarded as the tail emission of the prompt gamma rays. Prompted by the observed ...strong spectral evolution in the tails of GRBs 060218 and 060614, we present a systematic time-resolved spectral analysis for the Swift GRB tails detected between 2005 February and 2007 January. We select a sample of 44 tails that are bright enough to perform time-resolved spectral analyses. Among them 11 tails are smooth and without superimposing significant flares, and their spectra have no significant temporal evolution. We suggest that these tails are dominated by the curvature effect of the prompt gamma rays due to delay of propagation of photons from large angles with respect to the line of sight. More interestingly, 33 tails show clear hard-to-soft spectral evolution, with 16 of them being smooth tails directly following the prompt GRBs, and the others being superimposed with large flares. We focus on the 16 clean, smooth tails and consider three toy models to interpret the spectral evolution. The curvature effect of a structured jet and a model invoking superposition of the curvature effect tail and a putative underlying soft emission component cannot explain all the data. The third model, which invokes an evolving exponential spectrum, seems to reproduce both the light curve and the spectral evolution of all the bursts, including GRBs 060218 and 060614. More detailed physical models are called for to understand the apparent evolution effect.
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