To evaluate the clinical application value of electrochemiluminescence immunoassay analyzer (ECLIA) and chemiluminescent magnetic microparticle immunoassay (CMIA) in the detection of Treponema ...pallidum (TP).A total of 1225 patients in Peking University Third Hospital was enrolled from June 2014 to October 2014. ECLIA and CMIA were applied to detect the serum anti-TP. The positive rate was analyzed. RIBA was taken as a golden standard to evaluate the sensitivity, the specificity, the positive predictive value, the negative predictive value, and the accuracy of ECLIA and CMIA. A correlation analysis between 2 assays was conducted, and that between assay and RIBA. We also evaluate the clinical value of TPPA in the detection of T pallidum.The positive rate of CMIA and ECLIA is 10.63% and 9.89%, respectively, showing no statistically significant difference (P > .05). For CMIA, ECLIA, and TPPA, the sensitivity is 99.16%, 99.16%, and 99.16%, the specificity is 98.99%, 99.82%, and 100%, the positive predictive value is 91.47%, 98.33%, and 100%, the negative predictive value is 99.91%, 99.91%, and 99.91%, the coincidence rate is 99.01% (Kappa = 0.895), 99.75% (Kappa = 0.997), and 99.92% (Kappa = 0.998), respectively.The result shows high correlation between ECLIA and CMIA. Both have high sensitivity and specificity and can be used as screening tests for the diagnosis of T pallidum in common condition.
Abstract
Spatial inhomogeneity is one of the important features for understanding the reionization process; however, it has not yet been fully quantified. To map this inhomogeneous distribution, we ...simultaneously detect Ly
α
emitters (LAEs) and Lyman-break galaxies (LBGs) at
z
∼ 6.6 from the Subaru/Hyper Suprime-Cam large-area (∼1.5 deg
2
= 34,000 cMpc
2
) deep survey. We estimate the neutral fraction,
x
HI
, from the observed number density ratio of LAEs to LBGs,
n
(LAE)/
n
(LBG), using numerical radiative transfer simulations, in which model galaxies are selected to satisfy the observed selection function. While the average
x
HI
within the field of view is found to be
x
HI
< 0.4, which is consistent with previous studies, the variation of
n
(LAE)/
n
(LBG) within the field of view for every 140 pMpc
2
area is found to be as large as a factor of 3. This may suggest a spatially inhomogeneous topology of reionization, but it also leaves open the possibility that the variation is based on the inherent large-scale structure of the galaxy distribution. Based on the simulations, it may be difficult to distinguish between the two from the current survey. We also find that LAEs in the high-LAE-density region are more numerous at high EW
0
, supporting the fact that the observed
n
(LAE)/
n
(LBG) is more or less driven by the neutral fraction, though the statistical significance is not high.
Abstract
We present the environmental properties around high-
z
radio galaxies (HzRGs) at
z
∼ 4, which have been poorly investigated because of their rarity. We use the largest samples of HzRGs and
g
...-dropout galaxy overdense regions at
z
∼ 4, which were constructed from the Hyper Suprime-Cam Subaru Strategic Program, to characterize the HzRG environments statistically. We measure the
g
-dropout galaxy overdensities around 21 HzRGs whose rest-frame 1.4 GHz radio luminosities (
L
1.4 GHz
) are 10
26–27
W Hz
−1
. We find that the overdensities around the faint HzRGs with
L
1.4 GHz
∼ 10
26.0–26.5
W Hz
−1
tend to be higher than those of the
g
-dropout galaxies. On the other hand, no significant difference of density environments is found between the luminous HzRGs with
L
1.4 GHz
∼ 10
26.5–27.0
W Hz
−1
and the
g
-dropout galaxies. The HzRGs are found to occupy more massive halos than
g
-dropout galaxies through a cross-correlation between the HzRGs and
g
-dropout galaxies. This trend is more pronounced in the faint HzRGs. These results are consistent with a scenario where HzRGs get older and more massive as the radio luminosity decreases. The HzRGs are expected to trace the progenitors of Local Cluster halos from their calculated halo mass. In addition, we find that surrounding galaxies tend to distribute along the radio jet major axis of the HzRGs at angular distances of ≲500 physical kpc. Our findings imply the onset of the filamentary structures around the HzRGs at
z
∼ 4.
Essential trace metals (ETMs) may play important roles in the pathophysiology of benign and malignant breast cancers. Our study aimed to find associations between ETMs and benign and malignant breast ...cancers. We recruited 146 patients with benign (
n
= 73) and malignant (
n
= 73) breast tumors and 95 healthy controls (HCs) from Peking University Third Hospital, Beijing, China. The serum concentrations of seven ETMs (Zn, Mn, Cu, Fe, Co, Ni, and Mo) were evaluated using inductively coupled plasma mass spectrometry (ICP-MS). The serum concentrations of Zn were significantly lower in the malignant group than in the HC group, whereas the concentrations of Cu (
p
< 0.001) were significantly higher in the malignant group. The concentrations of Fe were significantly lower in both malignant and benign groups than in the HC group (
p
< 0.05). We observed that the Fe/Cu ratio was lower and the Cu/Ni ratio was higher in the malignant group than in the HCs, as well as in the benign group than in the HCs. The serum concentration of Fe (OR = 0.454; 95% CI, 0.263, 0.784;
p
= 0.005) was negatively associated with breast tumors after adjusting for potential confounders, including age, BMI, and smoking, drinking and menopause statuses; that of Cu (OR = 2.274; 95% CI, 1.282, 4.031;
p
= 0.005) was positively associated. Changes in the concentrations of ETMs (Zn, Cu, Fe, and Ni) may be involved in the development of malignant breast cancer. The findings provide foundations for further exploration of ETMs in the prevention and treatment of breast tumors.
A novel poly(para-phenylene) containing imidazolium cation, poly2,5-bis4-(3-methyl-1-imidazolium)-butyloxy)-1,4-benzene dihexafluorophosphate (PPP-IL), has been synthesized.
Background
Laboratory tests play an important role in the diagnosis of syphilis. This study aimed to compare and assess the performance of the Abbott chemiluminescent microparticle immunoassay (CMIA) ...and the ChIVD light‐initiated chemiluminescent assay (LICA) in the detection of Treponema pallidum (TP) antibody.
Methods
A total of 10 498 serum samples were detected with two assays, and the Treponema pallidum particle agglutination assay (TPPA) and recombinant immunoblot assay (RIBA) methods were used for confirmation. The sensitivity, specificity, positive predictive value, and negative predictive value of the Abbott CMIA and ChIVD LICA were calculated. The coincidence rate between two assays was also evaluated. The causes of false positive and false negative of two assays were studied.
Results
For the Abbott CMIA and ChIVD LICA, the sensitivity was 94.44% and 98.15%, the specificity was 99.89% and 99.81%, the positive predictive value was 93.29% and 88.83%, and the negative predictive value was 99.91% and 99.97%, respectively. The coincidence rate between Abbott CMIA and ChIVD LICA was 99.26%, and κ value was .790. The disease of infertility, hypertensive disease, liver disease, and cancer were the common causes of false positive in both assays, while infertility was also the main reason lead to false negative.
Conclusion
Our results demonstrated that the Abbott CMIA and ChIVD LICA generally had high sensitivity and specificity and therefore may be suitable for the detection of TP antibody and screening for syphilis.
The correlation between neutral hydrogen (H i) in the intergalactic medium (IGM) and galaxies attracts great interest. We select four fields that include several coherently strong Ly absorption ...systems at z ∼ 2.2 detected using background quasars from the whole SDSS/(e) Baryon Oscillation Spectroscopic Survey (BOSS) database. Deep narrowband and g-band imaging are performed using the Hyper Suprime-Cam on the Subaru Telescope. We select 2642 Ly emitter (LAE) candidates at z = 2.177 0.023 down to the Ly luminosity of LLy 2 × 1042 erg s−1 to construct the galaxy overdensity maps, covering an effective area of 5.39 deg2. Combining the sample with the Ly absorption estimated from 64 (e) BOSS quasar spectra, we find a moderate to strong correlation between the LAE overdensity δLAE and the effective optical depth τLoS in lines of sight, with P value = 0.09% or <0.01% when the field containing a significant quasar overdensity is included or excluded. Cross-correlation analysis also clearly suggests that up to 4 1 pMpc, LAEs tend to cluster in regions rich in H i gas, as indicated by the high τLoS, and avoid the low τLoS regions where the H i gas is deficient. By averaging the τLoS as a function of the projected distance (d) to LAEs, we find a 30% excess signal at 2 level at d < 200 pkpc, indicating the dense H i in the circumgalactic medium, and a tentative excess at 400 < d < 600 pkpc in the IGM regime, corroborating the cross-correlation signal detected at about 0.5 pMpc. These statistical analyses suggest that galaxy−IGM H i correlations exist on scales ranging from several hundred pkpc to several pMpc at z ∼ 2.2.
Abstract
The correlation between neutral hydrogen (H
i
) in the intergalactic medium (IGM) and galaxies attracts great interest. We select four fields that include several coherently strong Ly
α
... absorption systems at
z
∼ 2.2 detected using background quasars from the whole SDSS/(e) Baryon Oscillation Spectroscopic Survey (BOSS) database. Deep narrowband and
g
-band imaging are performed using the Hyper Suprime-Cam on the Subaru Telescope. We select 2642 Ly
α
emitter (LAE) candidates at
z
= 2.177 ± 0.023 down to the Ly
α
luminosity of
L
Ly
α
≈ 2 × 10
42
erg s
−1
to construct the galaxy overdensity maps, covering an effective area of 5.39 deg
2
. Combining the sample with the Ly
α
absorption estimated from 64 (e) BOSS quasar spectra, we find a moderate to strong correlation between the LAE overdensity
δ
LAE
and the effective optical depth
τ
LoS
in lines of sight, with
P
value = 0.09% or <0.01% when the field containing a significant quasar overdensity is included or excluded. Cross-correlation analysis also clearly suggests that up to 4 ± 1 pMpc, LAEs tend to cluster in regions rich in H
i
gas, as indicated by the high
τ
LoS
, and avoid the low
τ
LoS
regions where the H
i
gas is deficient. By averaging the
τ
LoS
as a function of the projected distance (
d
) to LAEs, we find a 30% excess signal at 2
σ
level at
d
< 200 pkpc, indicating the dense H
i
in the circumgalactic medium, and a tentative excess at 400 <
d
< 600 pkpc in the IGM regime, corroborating the cross-correlation signal detected at about 0.5 pMpc. These statistical analyses suggest that galaxy−IGM H
i
correlations exist on scales ranging from several hundred pkpc to several pMpc at
z
∼ 2.2.
Abstract
To determine the dominant sources for cosmic reionization, the evolution history of the global ionizing fraction, and the topology of the ionized regions, we have conducted a deep imaging ...survey using four narrow-band (NB) and one intermediate-band (IB) filters on the Subaru/Hyper Suprime-Cam (HSC), called Cosmic HydrOgen Reionization Unveiled with Subaru (CHORUS). The central wavelengths and full-widths-at-half-maximum of the CHORUS filters are, respectively, 386.2 nm and 5.5 nm for NB387, 526.0 nm and 7.9 nm for NB527, 717.1 nm and 11.1 nm for NB718, 946.2 nm and 33.0 nm for IB945, and 971.2 nm and 11.2 nm for NB973. This combination, including NB921 (921.5 nm and 13.5 nm) from the Subaru Strategic Program with HSC (HSC SSP), is carefully designed, as if they were playing a chorus, to observe multiple spectral features simultaneously, such as Lyman continuum, Lyα, C iv, and He ii for $z$ = 2–7. The observing field is the same as that of the deepest footprint of the HSC SSP in the COSMOS field and its effective area is about 1.6 deg2. We present an overview of the CHORUS project, which includes descriptions of the filter design philosophy, observations and data reduction, multiband photometric catalogs, assessments of the imaging quality, measurements of the number counts, and example use cases for the data. All the imaging data, photometric catalogs, masked pixel images, data of limiting magnitudes and point spread functions, results of completeness simulations, and source number counts are publicly available through the HSC SSP database.
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